Journal Publications

Research Articles

1. Zhu L, Perche F, Wang T, Torchilin VP*, Matrix Metalloproteinase 2-sensitive Multifunctional Polymeric Micelles for Tumor-specific Co-delivery of siRNA and Hydrophobic Drugs, Biomaterials, 2014, 35 (13), 4213-4222.
2. Perche F, Biswas S, Wang T, Zhu L, Torchilin VP*, Hypoxia-targeted siRNA Delivery, Angewandte Chemie, 2014, 53(13):3362-6.
3. Sawant R, Jhaveri A, Koshkaryev A, Zhu L, Qureshi F, Torchilin, VP*, Targeted Transferrin-Modified Polymeric Micelles: Enhanced Efficacy in Vitro and in Vivo in Ovarian Carcinoma, Molecular Pharmaceutics, 2014, 11 (2), 375–381.
4. Zhu L, Wang T, Perche F, Taigind A, Torchilin VP*, Enhanced Anticancer Activity of Nanopreparation Containing a Novel MMP2-sensitive PEG-drug Conjugate and Cell-penetrating Moiety, Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (42), 17047-17052.
5. Wu H, Zhu L, Torchilin, VP*, pH-Sensitive Poly(histidine)-PEG/DSPE-PEG Copolymer Micelles for Cytosolic Drug Delivery, Biomaterials, 2013, 34(4):1213-1222.
6. Zhu L, Kate P, Torchilin VP*, Matrix Metalloprotease 2-responsive Multifunctional Liposomal Nanocarrier for Enhanced Tumor Targeting, ACS Nano, 2012, 6 (4), 3491–3498.
7. Zhu L, Mahato R*, Targeted Delivery of siRNA to Hepatocytes and Hepatic Stellate Cells by Bioconjugation, Bioconjugate Chemistry, 2010, 21(11), 2119-2127.
8. Zhu L, Huo Z, Wang L, Tong X, Xiao Y, Ni Y*, Targeted Delivery of Methotrexate to Skeletal Muscular Tissue by Thermosensitive Magnetoliposomes, International Journal of Pharmaceutics, 2009, 370(1-2),136-143.
9. Zhu L, Lu Y, Miller DD, Mahato RI*, Structural and Formulation Factors Influencing Pyridinium Lipid-based Gene Transfer, Bioconjugate Chemistry,2008, 19 (12), 2499-2512.
10. Tu Y, Zhu L, Wang G*, Zhao L, Xiang B, Development and Validation of a LC-ESI-MS Assay for Determination of Icariin in Rat Plasma after Administration of Herba Epimedii. Chromatographia. 2008, 67(7-8), 591-597.
11. Zhu L, Ye Z, Cheng K, Miller DD and Mahato RI*, Site-specific Delivery of Oligonucleotides to Hepatocytes after Systemic Administration. Bioconjugate Chemistry, 2008, 19(1), 290-298.
12. Huo Z, Zhu L, Xiao Y, Tong X, Ni K*, Study of the Preparation and Targeting Effect of Thermosensitive Magneto-liposomes, Strait Pharmaceutical Journal, 2008,20(7), 14-17.
13. Cheng G, Zhu L, Mahato RI*, Caspase-3 Gene Silencing for Inhibiting Apoptosis in Insulinoma Cells and Human Islets, Molecular Pharmaceutics, 2008, 5 (6), 1093-1102.
14. Wang L, Zhu L, Ni K*, Tu Y, Peng G, Study on Tissue Distribution of Methotrexate Magnetoliposomes in Mice by HPLC，Chinese Pharmaceutical Journal, 2006, 41(20), 1572-1575.
15. Tu Y, Zhao L*, Zhu L, Wang G, Xiang B, Simultaneous Determination of Acteoside, Astragaloside IV and Icariside-I in the Traditional Chinese Medicinal Preparation Shenbao by HPLC–MS. Chromatographia, 2006, 64(7-8), 453-458.
16. Zhu L, Wang L, Ni K*, Tong X, Dai L, Preparation of Stable Magnetoliposomes with High Encapsulation Efficiency of Methotrexate，Chinese Pharmaceutical Journal, 2006, 41 (17), 1324-1327.
17. Tu Y, Zhao L*, Zhu L, Wang G, Xiang B, Separation and Identification of 20 Chemical Constituents in the Traditional Chinese Medicinal Preparation Shenbao Tablet by LC-ESI-MS3, Journal of Chromatographic Science, 2004, 42(4), 177-183.
18. Tu Y, Zhao L*, Zhu L, Wang G, Xiang B, Shan Z, Separation and Determination of Main Constituents in Traditional Chinese Medicine Shenbao Tablet by Reversed Phase High Performance Liquid Chromatography and Electrospray Ion Trap Mass Spectrometry, Chinese Journal of Analytical Chemistry, 2004,32(12), 1603-1607.
19. Zhu L, Zhu J*, Tu Y, Tian X, The Study of All-trans Retinoic Acid Mixed Micelles Injection, Acta Pharm Sin, 2004, 39(3), 220-222.

Review Articles

1. Tu Y, Zhu L*, Lipids and Their Derivatives: By-products Used as Essential Building Blocks for Modern Drug Delivery Systems, Current Drug Targets, 2014, 15(5), 502-517.
2. Zhu L, Torchilin VP*, Stimuli-Sensitive Nanopreparations for Tumor Targeting, Integrative Biology, 2013, 5, 96-107.
3. Zhu L, Mahato R*, Lipid and Polymeric Carrier Mediated Nucleic Acid Delivery, Expert Opinion on Drug Delivery, 2010, 7(10), 1209-1226.
4. Zhu L, Zhu J*, Microdialysis Sampling Techniques Used in Pharmacokinetics, Foreign Medical Sciences Section on Pharmacy, 2002, 29(5), 296-301.

Book Chapters

1. Zhu L*and Ying Tu, “Matrix Metalloproteinase-sensitive Nanocarriers”, in the book “Smart Pharmaceutical Nanocarriers”, Editor: Dr. Vladimir P. Torchilin, Imperial College Press, 2014. (Invited, under review)
2. Zhu L, Movassaghian S, Torchilin VP*, “Overcoming Biological Barriers with Parenteral Nanomedicines: Physiological and Mechanistic Issues” (Chapter 8.1) in the book “Nanostructured Biomaterials for Overcoming Biological Barriers”, Editor: Dr. Maria Jose Alonso, RSC Drug Discovery Series (RSC Publishing)(ISBN: 978-1-84973-363-2), 2012.
3. Zhu L*, One chapter in the Chinese textbook “Pharmaceutics” (for university students), Chemical Industry Press, March 2004.

Presentations

Podium presentations (* Speaker):

1. Zhu L*, Design of MMP2-sensitive multifunctional nanocarriers for drug delivery. CRS Annual, Chicago, Illinois, July 13-16, 2014. (Award lecture)
2. Zhu L*, Perche F, Wang T, Taigind A, Torchilin VP, Co-delivery of siRNA and Paclitaxel using Matrix Metalloproteinase 2-sensitive Polymeric Micelles, Bouvé College of Health Sciences Pharmaceutical Sciences Research Showcase, Boston, MA, May 24, 2013.
3. Zhu L*, Perche F, Wang T, Taigind A, Torchilin VP, Enhancing Tumor Targeting and Therapeutic Activity Using Nanopreparations Containing Cell-penetrating Moiety and MMP2-sensitive PEG-Paclitaxel Conjugate, 2nd Junior Investigator Conference for NanoScience and Emerging Technology in Cancer Research, La Jolla, CA, Feb. 9-10, 2013. (Invited speaker)
4. Zhu L*, Taigind A, Torchilin VP, Tumor Cell-Specific Delivery of Paclitaxel Using a Self-assembled Matrix Metalloprotease 2-sensitive Nanocarrier, CRS Annual, Québec City, Canada, July 15-18, 2012.
5. Mahato RI*, Yang N, Zhu L, Kumar V, Singh S, Delivery and Targeting of RNA Molecules for Treating Liver Diseases, 15th International Biotechnology Symposium, South Korea, September 13-16, 2012
6. Zhu L*, Lu Y, Ye Z, Cheng K, Miller DD, Mahato RI, Design of Lipid and Polymeric Carriers for Nucleic Acid Delivery, AAPS Annual, Los Angeles, CA, Nov 8-12, 2009.
7. Zhu L*, Lu Y, Miller DD, Mahato RI, Effect of Structure and Formulation Factors of Pyridinium Cationic Lipids on Gene Delivery, AAPS PharmForum, Little Rock, AR, May 18-20, 2008.
8. Mahato RI*, Cheng K, Ye Z, Chen Yong and Zhu L, Site-specific Delivery and Targeting of Oligonucleotides and siRNA for Treating Hepatitis and Liver Fibrosis, 5th Annual Drug Discovery Conference and Expo, Shanghai, China, May, 2007.

Poster presentations:

1. Zhu L, Lu Y, Miller DD, Mahato RI, Pyridinium Cationic Lipid Based Gene and siRNA Delivery, AAPS Annual, Los Angeles, CA, Nov 8-12, 2009.
2. Zhu L, Lu Y, Miller DD, Mahato RI, Enhancing Gene Delivery Using Pyridinium Cationic Lipids, AAPS Annual, Atlanta, GA, Nov 16-20, 2008.
3. Zhu L, Lu Y, Miller DD, Mahato RI, Synthesis and Characterization of Pyridinium Cationic Lipids for Nucleic Acid Delivery, AAPS Annual, San Diego, CA, Nov 11-15, 2007.
4. Zhu L, Ye Z, Cheng K, Miller DD, Mahato RI, Site-specific Delivery of Oligonucleotides to Hepatocytes. CRS Annual, Long Beach, CA, July 07-11, 2007.
5. Zhu L, Lu Y, Miller DD, Mahato RI, Synthesis and Characterization of Pyridinium Cationic Lipids for Nucleic Acid Delivery. AAPS PharmForum, Memphis, TN, May 30-31, 2007.
6. Zhu L, Ye Z, Miller DD, Mahato RI, Site-specific Delivery of Short Interfering RNA to Hepatocytes, AAPS Annual, San Antonio, TX, Oct 29-Nov 02, 2006.