Publications

    Original Investigations
  • Takenaka T., Qin G., Brady R.O., and Medin J.A., Circulating alpha-galactosidase A derived from transduced bone marrow cells: relevance for corrective gene transfer for Fabry disease. Hum Gene Ther, 1999. 10(12): p. 1931-9.
  • Takenaka T., Murray G.J., Qin G., Quirk J.M., Ohshima T., Qasba P., Clark K., Kulkarni A.B., Brady R.O., and Medin J.A., Long-term enzyme correction and lipid reduction in multiple organs of primary and secondary transplanted Fabry mice receiving transduced bone marrow cells. Proc Natl Acad Sci U S A, 2000. 97(13): p. 7515-20.
  • Zentilin L.*, Qin G.*, Tafuro S., Dinauer M.C., Baum C., and Giacca M., Variegation of retroviral vector gene expression in myeloid cells. Gene Ther, 2000. 7(2): p. 153-66.
  • Qin G., Takenaka T., Telsch K., Kelley L., Howard T., Levade T., Deans R., Howard B.H., Malech H.L., Brady R.O., and Medin J.A., Preselective gene therapy for Fabry disease. Proc Natl Acad Sci U S A, 2001. 98(6): p. 3428-33.
  • Ii M., Nishimura H., Kusano K.F., Qin G., Yoon Y.S., Wecker A., Asahara T., and Losordo D.W., Neuronal nitric oxide synthase mediates statin-induced restoration of vasa nervorum and reversal of diabetic neuropathy. Circulation, 2005. 112(1): p. 93-102.
  • Iwakura A., Dean J., Hamada H., Eaton E., Qin G., Losordo D.W., and Aikawa R., Use of recombinant adeno-associated viral vectors as a tool for labeling bone marrow cells. J Mol Cell Cardiol, 2005. 38(5): p. 799-802.
  • Kishore R., Qin G., Luedemann C., Bord E., Hanley A., Silver M., Gavin M., Yoon Y.S., Goukassian D., and Losordo D.W., The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A. J Clin Invest, 2005. 115(7): p. 1785-96.
  • Luedemann C., Bord E., Qin G., Zhu Y., Goukassian D., Losordo D.W., and Kishore R., Ethanol modulation of TNF-alpha biosynthesis and signaling in endothelial cells: synergistic augmentation of TNF-alpha mediated endothelial cell dysfunctions by chronic ethanol. Alcohol Clin Exp Res, 2005. 29(6): p. 930-8.
  • Yoon Y.S., Wecker A., Heyd L., Park J.S., Tkebuchava T., Kusano K., Hanley A., Scadova H., Qin G., Cha D.H., Johnson K.L., Aikawa R., Asahara T., and Losordo D.W., Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. J Clin Invest, 2005. 115(2): p. 326-38.
  • Fu J., Lin G., Wu Z., Ceng B., Wu Y., Liang G., Qin G., Li J., Chiu I., and Liu D., Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury. Biochem Biophys Res Commun, 2006. 349(2): p. 504-12.
  • Fu J., Lin G., Zeng B., Wu Z., Wu Y., Chu H., Qin G., Liang G., Li J., Gan X., Yu X., Li C., and Liu D., Anti-ischemia/reperfusion of C1 inhibitor in myocardial cell injury via regulation of local myocardial C3 activity. Biochem Biophys Res Commun, 2006. 350(1): p. 162-8.
  • Hamada H., Kim M.K., Iwakura A., Ii M., Thorne T., Qin G., Asai J., Tsutsumi Y., Sekiguchi H., Silver M., Wecker A., Bord E., Zhu Y., Kishore R., and Losordo D.W., Estrogen receptors alpha and beta mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction. Circulation, 2006. 114(21): p. 2261-70.
  • Iwakura A., Shastry S., Luedemann C., Hamada H., Kawamoto A., Kishore R., Zhu Y., Qin G., Silver M., Thorne T., Eaton L., Masuda H., Asahara T., and Losordo D.W., Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9. Circulation, 2006. 113(12): p. 1605-14.
  • Qin G., Ii M., Silver M., Wecker A., Bord E., Ma H., Gavin M., Goukassian D.A., Yoon Y.S., Papayannopoulou T., Asahara T., Kearney M., Thorne T., Curry C., Eaton L., Heyd L., Dinesh D., Kishore R., Zhu Y., and Losordo D.W., Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. J Exp Med, 2006. 203(1): p. 153-63.
  • Qin G. , Kishore R., Dolan C.M., Silver M., Wecker A., Luedemann C.N., Thorne T., Hanley A., Curry C., Heyd L., Dinesh D., Kearney M., Martelli F., Murayama T., Goukassian D.A., Zhu Y., and Losordo D.W., Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF. Proc Natl Acad Sci U S A, 2006. 103(29): p. 11015-20.
  • Rajasingh J., Bord E., Luedemann C., Asai J., Hamada H., Thorne T., Qin G., Goukassian D., Zhu Y., Losordo D.W., and Kishore R., IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression. FASEB J, 2006. 20(12): p. 2112-4.
  • Cho H.J., Lee N., Lee J.Y., Choi Y.J., Ii M., Wecker A., Jeong J.O., Curry C., Qin G., and Yoon Y.S., Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart. J Exp Med, 2007. 204(13): p. 3257-69.
  • Goukassian D.A., Qin G., Dolan C., Murayama T., Silver M., Curry C., Eaton E., Luedemann C., Ma H., Asahara T., Zak V., Mehta S., Burg A., Thorne T., Kishore R., and Losordo D.W., Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization. Circulation, 2007. 115(6): p. 752-62.
  • Liu D., Lu F., Qin G., Fernandes S.M., Li J., and Davis A.E., 3rd, C1 inhibitor-mediated protection from sepsis. J Immunol, 2007. 179(6): p. 3966-72.
  • Rajasingh J., Bord E., Hamada H., Lambers E., Qin G., Losordo D.W., and Kishore R., STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction. Circ Res, 2007. 101(9): p. 910-8. Rajasingh J., Bord E., Qin G., Ii M., Silver M., Hamada H., Ahluwalia D., Goukassian D., Zhu Y., Losordo D.W., and Kishore R., Enhanced voluntary alcohol consumption after estrogen supplementation negates estrogen-mediated vascular repair in ovariectomized mice. Endocrinology, 2007. 148(8): p. 3618-24.
  • Zhang H., Li J., Barrington R.A., Liang G., Qin G., and Liu D.X., An anti-endotoxin peptide that generates from the amino-terminal domain of complement regulatory protein C1 inhibitor. Biochem Biophys Res Commun, 2007. 359(2): p. 285-91.
  • Zhang H., Qin G., Liang G., Li J., Barrington R.A., and Liu D.X., C5aR-mediated myocardial ischemia/reperfusion injury. Biochem Biophys Res Commun, 2007. 357(2): p. 446-52.
  • Zhang H., Qin G., Liang G., Li J., Chiu I., Barrington R.A., and Liu D., Suppression of complement regulatory protein C1 inhibitor in vascular endothelial activation by inhibiting vascular cell adhesion molecule-1 action. Biochem Biophys Res Commun, 2007. 358(4): p. 1120-7.
  • Cheng Z.D., Liu M.Y., Chen G., Zhang H.M., Qin G.J., Liang G., and Liu D.X., Anti-vascular permeability of the cleaved reactive center loop within the carboxyl-terminal domain of C1 inhibitor. Mol Immunol, 2008. 45(6): p. 1743-51.
  • Rajasingh J., Lambers E., Hamada H., Bord E., Thorne T., Goukassian I., Krishnamurthy P., Rosen K.M., Ahluwalia D., Zhu Y., Qin G., Losordo D.W., and Kishore R., Cell-free embryonic stem cell extract-mediated derivation of multipotent stem cells from NIH3T3 fibroblasts for functional and anatomical ischemic tissue repair. Circ Res, 2008. 102(11): p. e107-17.
  • Hua D., Liu M.Y., Cheng Z.D., Qin X.J., Zhang H.M., Chen Y., Qin G.J., Liang G., Li J.N., Han X.F., and Liu D.X., Small interfering RNA-directed targeting of Toll-like receptor 4 inhibits human prostate cancer cell invasion, survival, and tumorigenicity. Mol Immunol, 2009. 46(15): p. 2876-84.
  • Krishnamurthy P., Rajasingh J., Lambers E., Qin G., Losordo D.W., and Kishore R., IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR. Circ Res, 2009. 104(2): p. e9-18.
  • Tang Y.L., Zhu W., Cheng M., Chen L., Zhang J., Sun T., Kishore R., Phillips M.I., Losordo D.W., and Qin G., Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ Res, 2009. 104(10): p. 1209-16 (Editorial commended). PMCID: PMC2756190
  • Zhou J., Zhu Y., Cheng M., Dinesh D., Thorne T., Poh K.K., Liu D., Botros C., Tang Y.L., Reisdorph N., Kishore R., Losordo D.W., and Qin G., Regulation of vascular contractility and blood pressure by the E2F2 transcription factor. Circulation, 2009. 120(13): p. 1213-21. (Circulation Editors pick) PMCID: PMC2785027
  • Krishnamurthy P., Lambers E., Verma S., Thorne T., Qin G., Losordo D.W., and Kishore R., Myocardial knockdown of mRNA-stabilizing protein HuR attenuates post-MI inflammatory response and left ventricular dysfunction in IL-10-null mice. FASEB J, 2010. 24(7):p. 2484-94.
  • Rosen K.M., Moussa C.E., Lee H.K., Kumar P., Kitada T., Qin G., Fu Q., and Querfurth H.W., Parkin reverses intracellular beta-amyloid accumulation and its negative effects on proteasome function. J Neurosci Res, 2010. 88(1): p. 167-78.
  • Coleman C., Levine D., Kishore R., Qin G., Thorne T., Lambers E., Sasi S., Yaar M., Gilchrest B.A., and Goukassian D.A., Inhibition of melanoma angiogenesis by telomere homolog oligonucleotides. J Oncol, 2010. 2010: p. 1-14.
  • Renault M.A., Roncalli J., Tongers J., Thorne T., Klyachko E., Misener S., Volpert O.V., Mehta S., Burg A., Luedemann C., Qin G., Kishore R., and Losordo D.W., Sonic hedgehog induces angiogenesis via Rho kinase-dependent signaling in endothelial cells. J Mol Cell Cardiol, 2010. 49(3): p. 490-8.
  • Cheng M., Zhou J., Wu M., Boriboun C., Thorne T., Liu T., Xiang Z., Zeng Q., Tanaka T., Tang Y.L., Kishore R., Tomasson M.H., Miller R.J., Losordo D.W., and Qin G., CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res, 2010. 107(9): p. 1083-93. (Cover featured; Editors pick) PMCID: PMC2966940
  • Sahoo S, Klyachko E, Thorne T, Misener S, Shinnick K, Millay M, Ito A, Liu T, Kamide C, Agarwal H, Perlman H, Qin G, Kishore R, Losordo DW. Exosomes from Human CD34+ Stem Cells Mediate Their Proangiogenic Paracrine Activity. Cir Res, 2011. 109(7):p. 724-8.
  • Krishnamurthy P., Thal M., Verma S.K., Hoxha E., Lambers E., Ramirez V., Qin G., Losordo D.W., and Raj Kishore. IL-10 deficiency impairs bone marrow-derived endothelial progenitor cell survival and function in ischemic myocardium. Circ Res, 2011. 109(11):p1280-9.
  • Nishimura Y, Ii M, Qin G, Hamada H, Asai J, Takenaka H, Sekiguchi H, Renault MA, Jujo K, Katoh N, Kishimoto S, Ito A, Kamide C, Kenny J, Millay M, Misener S, Thorne T, and Losordo D.W. CXCR4 Antagonist AMD3100 Accelerates Impaired Wound Healing in Diabetic Mice. J Invest Dermatol 2011. 132(3 Pt 1):711-20
  • Sasi SP, Yan X, Enderling H, Park D, Gilbert HY, Curry C, Coleman C, Hlatky L, Qin G, Kishore R, Goukassian DA. Breaking the 'harmony' of TNF- signaling for cancer treatment. Oncogene 2011 Dec 12 [Epub ahead of print]
  • Chen L, Ashraf M, Wang Y, Zhou M, Zhang J, Qin G, Rubinstein J, Weintraub NL, Tang YL. The role of Notch1 activation in cardiosphere derived cell differentiation. Stem Cells Dev 2012 Feb 28 [Epub ahead of print]
  • Poh K-K, Lu P, Qin G, Silver M, Losordo DW, Mendelsohn ME, Zhu Y. Endothelial dysfunction and systemic hypertension by selective cGMP-dependent protein kinase I inhibition using novel cell-penetrating peptide delivered in vivo . Int’l J Cardiol 2012 Jun 27 (Epub ahead of Print)
  • Thal MA, Krishnamurthy P, Mackie AR, Hoxha E, Lambers E, Verma S, Ramirez V, Qin G, Losordo DW, Kishore R. Enhanced Angiogenic and Cardiomyocyte Differentiation Capacity of Epigenetically Reprogrammed Mouse and Human Endothelial Progenitor Cells Augments their Efficacy for Ischemic Myocardial Repair. Circ Res 2012;111(2):180-90
  • Verma SK, Krishnamurthy P, Barefield D, Singh N, Gupta R, Lambers E, Thal M, Mackie A, Hoxha E, Ramirez V, Qin G, Sadayappan S, Ghosh A, Kishore R. IL-10 Treatment Attenuates Pressure Overload-Induced Hypertrophic Remodeling and Improves Heart Function via Signal Transducers and Activators of Transcription 3-dependent Inhibition of Nulcear Factor-kB. Circulation 2012;126(4):418-29
  • Lu Q, Yao Y, Yao Y, Liu S, Huang Y, Lu S, Bai Y, Zhou B, Xu Y, Li L, Wang N, Wang L, Zhang J, Cheng X, Qin G, Ma W, Xu C, Tu X, Wang Q. Angiogenic Factor AGGF1 Promotes Therapeutic Angiogenesis in a Mouse Limb Ischemia Model. PLoS One. 2012;7(10):e46998. doi: 10.1371/journal.pone.0046998. Epub 2012 Oct 23.
  • Zhang L, Chen B, Zhao Y, Dubielecka PM, Wei L, Qin GJ, Chin YE, Wang Y, Zhao TC. Inhibition of Histone Deacetylase-induced Myocardial Repair Is Mediated by c-kit in Infarcted Hearts. J Biol Chem. 2012 Nov 16;287(47):39338-48.
  • Jujo K, Ii M, Sekiguchi H, Klyachko E, Misener S, Tanaka T, Tongers J, Roncalli J, Renault M-A, Thorne T, Ito A, Clarke T, Kamide C, Tsurumi Y, Hagiwara N, Qin G, Asahi M, MD, Losordo DW. CXC-Chemokine Receptor 4 Antagonist AMD3100 Promotes Cardiac Functional Recovery After Ischemia/Reperfusion Injury via Endothelial Nitric Oxide Synthase–Dependent Mechanism. Circulation 2012;127:63-73 PMID: 23204107 (Editorial commended).
  • Chen L, Wang Y, Pan Y, Zhang L, Shen C, Qin G, Ashraf M, Weintraub N, Ma G, Tang Y. Cardiac progenitor-derived Exosomes protect ischemic myocardium from acute ischemia/reperfusion injury. BBRC 2013;431(3):566-71
  • Zhou J, Xu S, Cheng M, Kishore R, and Qin G. Contrasting roles of E2F2 and E2F3 in cardiac neovascularization PLoS ONE 2013;8(6):doi:10.1371/journal.pone.0065755
  • Zhou J, Cheng M, Liao Y, Hu Y, Wu M, Wang Q, Qin B, Hong W, Zhu Y, Gao YM, Goukassian D, Zhao TC, Tang YL, Raj Kishore, Qin G. Rosuvastatin enhances angiogenesis via eNOS–dependent mobilization of endothelial progenitor cells PLoS ONE 2013;8(5):e63126:1-7
  • Zhou J, Cheng M, Wu M, Boriboun C, Jujo K, Xu S, Zhou TC, Tang YL, Kishore R, and Qin G. Contrasting roles of E2F2 and E2F3 in endothelial cell growth and ischemic angiogenesis J Mol Cell Cardiol 2013;60:68-71
  • Mackie AR, Krishnamurthy P, Verma S, Thorne T, Ramirez V, Qin G, Abramova TV, Hamada H, Losordo DW, Raj Kishore. Alcohol Consumption Negates Estrogen-mediated Myocardial Repair in Ovariectomized Mice by Inhibiting Endothelial Progenitor Cell Mobilization and Function. J Biol Chem 2013 May 3 [Epub ahead of print]
  • Renault MA, Vandierdonck S, Chapouly C, Yu Y, Qin G, Metras A, Couffinhal T, Losordo DW, Yao Q, Reynaud A, Jaspard-Vinassa B, Belloc I, Desgranges C, Gadeau AP. Gli3-regulation of myogenesis is necessary for ischemia-induced angiogenesis. Circ Res 2013;113(10):1148-58. PMID: 24044950
  • Zhang L, Pan Y, Qin G, Chatterjee TK, Weintraub NL, and Tang Y. Inhibition of stearoyl-coA desaturase selectively eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium. Cell Cycle 2014;13(5) [Epub ahead of print] (Highlighted in ESC & iPSC News 9.00)
  • Zhang L, Zhou M, Qin G, Weintraub N, Tang Y. MiR-92a regulates viability and angiogenesis of endothelial cells under oxidative stress. BBRC 2014 (in press)
  • Sai WB, Yu MF, Wei MY, Lu Z, Zheng YM, Wang YX, Qin G, Guo D, Ji G, Shen J, Liu QH. Bitter tastants induce relaxation of rat thoracic aorta precontracted with high K+. Clin Exp Pharmacol Physiol. 2014;41(4):301-8
  • Zhang L, Zou M, Wang Y, Huang W, Qin G, Weintraub NL, and Tang YL. MiR-92a inhibits vascular smooth muscle cell apoptosis: role of the MKK4-JNK pathway. Apoptosis 2014 (in press)
  • Tongers J, Webber MJ, Vaughan EE, Sleep E, Renault M-A, Roncalli JG, Klyachko E, Thorne T, Yu Y, Marquardt K-T, Kamide CE, Ito A, Misener S, Millay M, Liu T, Jujo K, Qin G, Losordo DW, Stupp SI, Kishore R. Enhanced potency of cell-based therapy for ischemic tissue repair using an injectable bioactive epitope presenting nanofiber support matrix, J Mol Cell Cardiol 2014;74:231-9.
  • Wu M., Zhou J., Cheng M., Boriboun C., Biyashev D., Wang H., Mackie A., Thorne T., Cho J., Wu Y., Chen Z., Yan H., Kishore R., Taylor R.N., Losordo D.W., Qin G. E2F1 Suppresses Cardiac Neovascularization by Downregulating VEGF and PlGF Expression. Cardiovasc Res (in press)
  • Zhao L, DeNicola M, Qin X, Du J, Ma J, Zhao T, Zhuang S, Liu P, Wei L, Qin G, Tang Y, and Zhao T. Specific Inhibition of HDAC4 in Cardiac Progenitor Cells Enhances Myocardial Repairs. AJP: Cell Physiology 2014 (in press) 60. Chen L, Weintraub N, Phillips I, Qin G, and Tang Y. Infrared fluorescent protein 1.4 genetic labeling tracks engrafted cardiac progenitor cells in mouse ischemic hearts. PLOS ONE 2014 (in press)
  • DeNicola M, Du J, Wang Z, Yano N, Zhang L,Wang Y, Qin G, Zhuang S, Zhao TC. Stimulation of glucagon-like peptide-1 receptor through exendin-4 preserves myocardial performance and prevents cardiac remodeling in infarcted myocardium. Am J Physiol Endocrinol Metab 2014 (Cover Featured; in press) Research articles submitted or under revision
  • Biyashev D., Cheng M., Boriboun C, and Qin G. E2F1 inhibits Angiotensin II-induced cardiac fibrosis (submitted to Circ Res)
  • Cheng M, Zhou J, Jujo K, Wu M, Thorne T, Zeng Q, Shou W, Kishore R, Miller RJ, Qin G. Genetic deletion of CXCR4 in cardiomyocytes increases susceptibility to apoptotic cell death induced by Gs stress (submitted)
  • Wang H, Tang Y, Wang B, Xiao L, Zhang B, Zhu Y, Gao X, Qin G. Tetrandrine, an inducer of VEGF for ischemic disease (submitted)
  • Luo X-J, Peng Y, Li W-E, Guo D, Qin G, Zheng Y-M, Wang Y-X, Shen J, Ji G, and Liu Q-H. Ca2+–activated Cl– channels dominates the differential effects of Ca2+ sparks on the tension in mouse cerebral artery and airway smooth muscle cells. Biophysical Journal (under review)
  • Du J, Zhang L, Zhuang S, Qin G, Zhao T. HDAC4 degradation mediates HDAC inhibition-induced protective effects against hypoxia/reoxygenation injury. J Cell Physiol (under review)

    • B. Reviews, Case Reports, Letters, Editorials
  • Zentilin L, Qin G, Tafuro S, Priore R, Ventura A, Giacca M. Molecular genetics of chronic granulomatous disease in Italian patients. Atti Associazione Genetica Italiana Vol. XLII (Proceedings of Italian Association of Genetics) 1996;42:247-8
  • Biyashev D. and Qin G., E2F and microRNA regulation of angiogenesis (Review), Am J Cardivasc Dis 2011;1(2):110-8 (Invited Review)
  • Cheng M. and Qin G., Progenitor cell mobilization and recruitment: SDF-1, CXCR4, 4-integrin, and c-kit, Prog Mol Biol Transl Sci. 2012;111:243-64 (Invited Review)
  • Cheng M and Qin G. SDF-1/CXCR4 signaling: A new target for cell therapy of ischemic disease. The Chinese Hypertension Journal 2012 (in press) (Invited Editorial Review)
  • Zhou J. and Qin G. Adipocyte dysfunction and hypertension (Review), Am J Cardiovasc Dis 2012;2(2):143-149 PMCID: PMC3371623
  • Wang Z, Qin G, Zhao TC. HDAC4: mechanism of regulation and biological functions. Epigenomics.2014 Feb;6(1):139-50.
  • Liu SQ, Ma X-L, Qin G, Liu Q, Li Y-C, and Wu YH. Trans-system Mechanisms for Myocardial Protection. Comprehensive Physiology. 2014 (in press)

    • C. Books and Book Chapters
  • Qin G. and Losordo D.W., E2F transcription factors in cardiovascular physiology, in Control of Cellular Physiology by E2F Transcription Factors., K. Yoshida, Editor. 2008, Research Signpost: Kerala. 2008:341-366. (Invited Book Chapter)
  • Xu S. and Qin G., Hypoxic preconditioning of cardiac progenitor cells for ischemic heart, in Inflammatory Response in Cardiovascular Surgery., E.A. Gabriel, Editor, Springer 2012 (in press) (Invited Book Chapter)
  • Zhao X, Arnone B, Qin G, Cheng M. Diagnostic and Prognostic Applications of MicroRNA-abundant Circulating Exosomes Mesenchymal Stem Cell Derived Exosome. 2014 (in press)

    • D. Abstracts
  • Zentilin L, Qin G, Tafuro S, Priore R, Ventura A, and Giacca M. Molecular genetics of chronic granulomatous disease in Italian patients. Atti Associazione Genetica Italiana Vol. XLII (Proceedings of Italian Association of Genetics), 1996. 42:247-8.
  • Zentilin L, Tafuro S, Qin G, Priore R, Rossi R, and Giacca M. Development of gene transfer vectors for gene therapy of chronic granulomatous disease. Blood, 1997. 90((10)(part 2, Suppl, 1)):420b.
  • Deans R, Kowalski R, Buyaner D, Slawecki M, Qin G, Lee K, Mosca J, Moseley A, Hoffman R, and Medin JA. Fabry's disease: A clinical application of gene transfer into mesenchymal stem cells. Blood, 1999. 94((Supple 2)):418b.
  • Keralavarma BK, Qin G, Kelley L, Reddy D, Devine S, and Medin JA. Improved "Suicide" Retroviral Vector Containing Mutant HSV-TK Gene Confers Increased Sensitivity to Gancyclovir. Blood, 1999. 94((Suppl 2)):329b.
  • Takenaka T MG, Qin G, Quirk M, Ohshima T, Qasba P, Tei C, Brady RO, Kulkarni AB, Medin JA. Long-Term Lipid Reduction and Enzyme Correction in Multiple Organs of alpha-Galactosidase A Deficient Mice Receiving Transduced Bone Marrow Cells. . Blood, 1999. 94((suppl 1)):642a.
  • Peace D, Qin G, Kelley L, and Medin JA. Immunogene Therapy for Prostate Cancer by Engineered Expression of Prostate Specific Membrane Antigen (PSMA). Cancer Gene Ther, 2000. 7(12):S29.
  • Qin G, Clark K, Kelley L, Mulder C, Turin J, Keralavarma B, Chung T, and Medin JA. Preselection of Retrovirally-Transduced Cells Improves The Therapeutic Outcome After Transplantation In A Mouse Model Of Fabry Disease. Mol Ther, 2000. 1((5, part 2)):S73.
  • Qin G, Kelley L, Peace D, and Medin JA. Retrovirus-Mediated Gene Transfer of Prostate Specific Antigen (PSA) Into Dendritic Precursors for the Immunotherapy of Prostate Cancer. Cancer Gene Ther, 2000. 7(12):S27.
  • Takenaka T, Biro S, Tei C, Murray GJ, Kulkarni AB, Brady RO, Qin G, Medin JA.. An Experimental Study of Gene Therapy for Cardiac Fabry Disease Using α-Galactosidase Deficient Mice. Japanese Circulation Journal 2000, 64:128
  • Medin JA, Qin G, Hou J, Kelley L, Peace D, and Fowler D. Dendritic Cells Engineered To Express Prostate-Specific Antigens for Immunotherapy Of Prostate Cancer. Experimental Hematology, 2001. 29(8 (Suppl 1)):55.
  • Siatskas C, Qin G, Smith SL, Moldwin RL, Brady RO, and Medin JA. Enrichment and Functional Assessment of alpha-gal A Transduced Murine and Human Primitive Hematopoietic Cells: Implications for the Treatment of Fabry Disease. Mol Ther, 2001. 3(5 (part 2)):S222.
  • Goukassian. DA, Dolan. C, Silver. M, Murayama. T, Qin. G, and Kishore. R. Ischemia-induced neovascularization requires tumor necrosis factor-alpha receptor p75 signaling pathway. Circulation, 2002. 106(19):1405.
  • Qin. G, Dolan. CM, Murayama. T, Leudemann. CN, Kearney. M, Goukassian. DA, Shastry. S, Curry. C, Wecker. A, and Kishore. R. Endogenous E2F-1 inhibits angiogenesis by down-regulation of vascular endothelial growth factor. Circulation, 2002. 106(19):1208.
  • Qin. G, Dolan. CM, Silver. M, Murayama. T, Ii. M, Hanley. A, Ma. H, Leudemann. CN, and Shastry. S. Statins biphasically and kinetically increase circulating endothelial progenitor cells (circEPCs) and promote their de novo differentiation for neovasculogenesis. Circulation, 2002. 106(19):322.
  • Goukassian. DA, Dolan. C, Luedemann. C, Silver. M, Murayama. T, Qin. G, and Kishore. R. Ischemic-induced Neovascularization is Suppressed in TNF-alpha Receptor p75 KO Mice: Transplantation of Bone Marrow from Wild Type Mice Augments Ischemia Induced Angiogenesis. Circulation, 2003. 108(17):972.
  • Goukassian. DA, Dolan. C, Silver. M, Myrayama. T, Qin. G, Leudeman. C, Hanley. A, Ma. H, and Kishore. R. Ischemia-induced Neovascularization Requires TNA-alpha Receptor p75 Signaling Pathway. Circulation, 2003. 108(17):1415.
  • Kishore. R, Luedemann. C, Hanley. A, Qin. G, Goukassian. D, Yoon. Y-s, and Losordo. GW. A Novel Transcription Regulatory Function of Cytoskeletal Protein Ezrin: Implication in TNFalpha Induced Cyclin A Repression in Endothelial Cell. Circulation, 2003. 108(17):235.
  • Qin. G, Kishore. R, Dolan. CM, Leudemann. CN, Silver. M, Murayama. T, Goukassian. DA, Shastry. S, Kearney. M, and Losordo. DW. Endogenous E2F-1 inhibits Angiogenesis by p53-mediated Downregulation of Vascular Endothelial Growth Factor. Circulation, 2003. 108(17):806.
  • Shastry. S, Dolan. CM, Qin. G, Iwakura. A, Masuda. H, Asahara. T, and Losordo. DW. Estradiol Plays a Regulatory Role in Endothelial Progenitor Cell Kinetics and Mobilization in Vitro. Arteriosclerosis, Thrombosis, and Vascular Biology, 2003. 23(5).
  • Goukassian. DA, Dolan. C, Myrayama. T, Silver. M, Curry. C, Eaton. E, Leudeman. C, Yoon. Y-s, Asahara. T, Isner. J, Qin. G, and Kishore. R. Tumore Necrosis Factor-alpha Receptor p75 is Required in Signaling of Adult Ischemia-induced Neovascularization. Circulation, 2004. 110(17):III-223.
  • Lee. N, Wecker. A, Thorne. T, Scadova. H, Gavin. M, Kim. MK, Shintani. S, Kusano. K, Qin. G, Losordo. D, and Yoon. Y-s. Noncellular Differentiation Effects of Endothelial Progenitor Cells in a Model of Myocardial Infarction. Circulation, 2004. 110(17):III-138.
  • Qin. G, Ii. M, Wecker. A, Bord. E, Ma. H, Goukassian. DA, Yoon. Y-s, Kishore. R, Zhu. Y, and Losordo. DW. Blockade of Alpha4 Integrin Mobilizes Bone Marrow EPCs and Improves Vascularization. Circulation, 2004. 110(17):III-2.
  • Goukassian DA, Dolan C, Murayama T, Silver M, Curry C, Eaton E, Luedemann C, Bord E, Asahara T, Qin G, Kishore R, and Losordo DW. Tumor Necrosis Factor-alpha P75 Receptor and Neovascularization. Circulation, 2005. 112(17):II-244.
  • Hamada H, Iwakura A, Kim MK, Ii M, Qin G, Asai J, Tsutsumi Y, Thorne T, Luedemann C, Curry C, Bord E, Silver M, Eaton E, Ma H, Gavin M, Heyd L, Kishore R, and Losordo DW. Role of Estrogen Receptors Alpha and Beta in Estradiol Enhanced Contribution of Bone Marrow-Derived Endothelial Progenitor Cells to Neovascularization after Ischemic Injury. Circulation, 2005. 112(17):II-136.
  • Kishore R, Bord E, Iwakura A, Luedemann C, Qin G, Goukassian G, and Losordo DW. Inhibition of Inflammatory Cell Recruitment and Intimal Hyperplasia and Enhancement of Endothelial Recovery by Recombinant IL-10 Treatment following Endothelial Denudation: Two Distinct, Gene Specific Molecular Mechanisms for IL-10 Suppression of Pro-Inflammatory Cytokine Expression. Circulation, 2005. 112(17):II-26.
  • Lu. P, Poh. K-K, Silver. M, Qin. G, Mindelsohn. ME, and Zhu. Y. Selective Inhibition of cGMP-Dependent Protein Kinase Ialpha In Vivo in Adult Mice Induces Endothelial Dysfunction and Hypertension. Circ Res, 2005. 97(2):16.
  • Luedemann C, Bord E, Qin G, Zhu Y, Goukassian D, Losordo D, and Kishore R. Chronic Ethanol synergistically Exacerbates the Negative Inhibitory Effects of TNF on Endothelial bell Growth and Function INFLAMMATION RESEARCH, 2005. 54(Suppl. 2):S203.
  • Poh KK, Lu P, Silver M, Qin G, Mendelsohn ME, and Zhu Y. Selective Inhibition of cGMP-Dependent Protein Kinase Ia in vivo in Adult Mice Induces Endothelial Dysfunction and Hypertension. Circulation, 2005. 112(17):II-138.
  • Qin G, Kishore R, Dolan CM, Silver M, Wecker A, Luedemann CN, Thorne T, Hanley A, Curry C, Kearney M, Martelli F, Murayama T, Goukassian DA, Zhu Y, and Losordo DW. Enhanced Angiogenesis in Mice Deficient in E2F1. Circulation, 2005. 112(17):II-136.
  • Goukassian DA, Dolan C, Myrayama. T, Silver M, Curry C, Eaton E, Leudeman. C, Bord E, Mehta S, Thorne T, Heyd L, Asahara T, Qin G, Kishore R, and Losordo DW. Tumor Necrosis Factor-alpha p75 Receptor, Sattelite-Cell Activation and Neovascularization. Circulation, 2006. 114(18):II-120.
  • Hamada H, Iwakura A, Thorne T, Ii M, Silver M, Burg A, Wecker A, Qin G, Zhu Y, Kishore R, and Losordo DW. Differential Role of Estrogen Receptor Alpha and Beta in Estradiol (E2) Enhanced Contribution of Bone Marrow-Derived Endothelial Progenitor Cells to Neovascularization after Ischemic Injury. Circulation, 2006. 114(18):II-36.
  • Tang YL, Qin G, Shen L, Qian K, and Phillips MI. Functional CXCR4 induction by hypoxia promotes mobilization of cardiosphere-derived cells. Circulation, 2006. 114(18):II-164.
  • Zhu Y, Dinesh D, Wecker A, Poh KK, Lu P, Thorne T, Hamada H, Liu D, Tang TL, Kishore R, Losordo DW, and Qin G. Isoform-specific dysregulation of endothelin converting enzyme-1 and hypertension in E2F2-deficient mice. Circulation, 2006. 114(18):II-107.
  • Goukassian DA, Levine D, Coleman C, Eller MS, Arad S, Bord E, Thorne T, Qin G, Kishore R, and Gilchrest BA. Inhibition of tumor angiogenesis and melanoma growth by T-oligos JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007. 127:S1.
  • Qin G, Zhu Y, Kishore R, Dinesh D, Thorne T, Poh KK, and Losordo DW. Transcription factor E2F2 regulates vessel contractile function and blood pressure via isoform-specific expressions of endothelin converting enzyme-1 Circulation, 2007. 116:II_74.
  • Rajasingh J, Lambers EM, Bord E, Hamada H, Goukassian D, Qin G, Losordo DW, and Kishore R. De-differentiation of Somatic Fibroblasts by Mouse Embryonic Stem Cell-free Extracts: Multi-lineage Re-differentiation and Therapeutic Efficacy of Re-programmed Cells in Mouse Models of Hind limb and Acute Myocardial Ischemia. Circulation, 2007. 116:II_105.
  • Goukassian DA, Tkebuchava T, Bord E, Silver M, Curry C, Mehta S, Gilbert H, Sasi S, Qin G, Kishore R, and Losordo DW. Tumor Necrosis Factor- p75 Receptor, Satellite-Cell Survival, Activation and Muscle Regeneration. Circulation, 2007. 116:II_42.
  • Rajasingh J, Lambers EM, Bord E, Hamada H, Qin G, Losordo DW, and Kishore R. STAT3-dependent mouse Embryonic Stem Cell Differentiation into Cardiomyocytes: Analysis of Molecular Signaling and Therapeutic Efficacy of Cardiomyocyte Pre-committed mES in a Mouse Model of Myocardial Infarction. Circulation, 2007. 116:II_260.
  • Rajasingh J, Hamada H, Qin G, Losordo DW, and Kishore R. STAT3-dependent cross-talk signaling mechanism of LIF and BMP-2 in mouse embryonic stem cell differentiation into cardiomyocytes and its therapeutic efficacy in mouse model of myocardial infarction Circ Res, 2007. 101(5):E68.
  • Rajasingh J, Hamada H, Qin G, Losordo DW, and Kishore R. Dedifferentiation and epigenetic reprogramming of somatic cells into pluripotent stem-like cells and its therapeutic efficacy in mouse model of acute myocardial ischemia Circ Res, 2007. 101(5):E68.
  • Cheng M, Zhou J, Zhu W, Tanaka T, Zeng Q, Kishore R, Losordo DW, and Qin G. CXCR4-mediated Bone Marrow Stem Cell Homing and Niche Maintenance Is Modulated by the Functional Status of c-kit. Circulation, 2008. 118:S412-3.
  • Coleman C, Levine D, Yaar M, Bord E, Thorne T, Qin G, Kishore R, Goukassian DA, and Gilchrest BA. Inhibition of melanoma angiogenesis by telomere homolog oligonucleoticles JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2008. 128(Suppl. 1):S5.
  • Johnson R, Krishnamurthy P, Lambers E, Sekiguchi H, David CJT, T., Qin G, Losordo DW, and Kishore R. Derivation of Multipotent Stem Cells from Epigenetically Modified Endothelial Progenitor Cells. Circulation, 2008. 118:S392.
  • Krishnamurthy P, Rajasingh J, Lambers E, Qin G, Losordo DW, and Kishore R. IL-10 Suppresses Pro-Inflammatory Cytokine Mediated Cardiac Dysfunction and Remodeling after Myocardial Infarction. Circulation, 2008. 118:S546.
  • Krishnamurthy P, Rajasingh J, Lambers E, Qin G, Losordo DW, and Kishore R. IL-10 Modulates Proinflammatory Cytokine-Mediated Left Ventricular Remodeling with Effects on Cardiac Function, Fibrosis, and Healing After Myocardial Infarction Circ Res, 2008. 103(5):E51-E51.
  • Renault M-A, Roncalli J, Tongers J, Thorne T, Misener S, Volpert OV, Mehta S, Burg A, Qin G, Kishore R, and Losordo DW. Sonic Hedgehog Induces Angiogenesis via Rho Kinase-dependent MMP-9 and Osteopontin Expression. Circulation, 2008. 118:S276.
  • Yao YL, Zhu W, Cheng M, Zhang J, Phillips MI, and Qin G. Transplantation of Hypoxia-preconditioned Cardiac Stem Cells Improves Infarcted Heart Function Via CXCR4 Upregulation and Improved Survival of Implanted Cells Circulation, 2008. 118:S280.
  • Cheng M, Jujo K, Zhou J, Zeng Q, Kishore R, Losordo DW, and Qin G. Genetic Deletion of CXCR4 in Cardiomyocytes Leads to Heart Failure Circulation, 2009. 120:S789.
  • Jujo K, Klyachko E, Misener S, Thorne T, Ii M, Sekiguchi H, Tanaka T, Tongers J, Roncalli J, Clarke T, Ito A, Kamide C, Tsurumi Y, Hagiwara N, Qin G, and Losordo DW. CXCR4 Antagonist AMD3100 Preserves Cardiac Function After Ischemia-Reperfusion Injury via eNOS Dependent Mobilization of Bone Marrow Derived Progenitor Cells Circulation, 2009. 120:S852.
  • Krishnamurthy P, Lambers E, Betkerur K, Qin G, Losordo D, and Kishore R. IL-10 Improves Post-MI Left Ventricular Dysfunction and Remodeling via HuR-Mediated Inhibition of Myocardial Inflammatory Gene Expression, Apoptosis, and Fibrosis, and via Enhancing Retention, Survival, and Function of Intramyocardially Injected Endothelial Progenitor Cells Circ Res, 2009. 105(7):E12-E12.
  • Krishnamurthy P, Lambers E, Johnson R, Hoxha E, Thorne T, Qin G, Losordo D, and Kishore R. HuR Knockdown Attenuates Post-MI Left Ventricular Dysfunction and Remodeling via Enhanced mRNA Degradation of Pro-inflammatory Cytokines and Inhibition of P53-mediated Apoptosis and TGF-beta-mediated Fibrosis in IL-10 Knock-out Mice. Circulation, 2009. 120:S720.
  • Nishimura Y, Ii M, Asai J, Takenaka H, Katoh N, Hamada H, Qin G, Losordo DW, and Kishimoto S. CXCR4-selective antagonist AMD3100 accelerates impaired wound healing in diabetic mice JOURNAL OF INVESTIGATIVE DERMATOLOGY 2009. 129(Suppl. 1):S4-S4.
  • Sasi S, Gilbert H, Silver M, Coleman C, Hlatky L, Qin G, Kishore R, and Goukassian DA. Breaking the "harmony' of signaling via TNFR1/p55 or TNFR2/p75 for cancer treatment JOURNAL OF INVESTIGATIVE DERMATOLOGY 2009. 129(Suppl. 1):S4-S4.
  • Renault MA, Roncalli J, Tongers J, Thorne T, Misener S, Volpert OL, Metha S, Burg A, Luedemann C, Qin G, Kishore R, Losordo DW. Sonic hedgehog induces angiogenesis via Rho kinase—dependent MMP-9 and osteopontin expression. Archives of Cardiovascular Diseases 2009. 102(Suppl. 1):S36
  • Tang YL, Chen LJ, Qin G, Phillips I, and Zhang J. MIR-17-HIF-1 alpha Crosstalk Tunes the Expression of Paracrine Factors From Cardiac Progenitor Cells Under Hypoxia. Circ Res, 2009. 105(12):E61-E61.
  • Zhou J, Jujo K, Cheng M, Thorne T, Kishore R, Losordo DW, and Qin G. An Essential Role of the E2F3 Transcription Factor in Ischemic Angiogenesis. Circ Res, 2009. 105(12):5172-5172.
  • Krishnamurthy P, Thal MA, Hoxha E, Lambers E, Verma S, Qin G, Losordo DW, and Kishore R. IL-10 Enhances Survival and Angiogenic Properties of Intra-myocardially Injected Endothelial Progenitor Cells. Circulation 2010;122:A15788.
  • Jujo K, Sekiguchi H, Misener S, Klyachko E, Tongers J, Ito A, Kamide C, Liu T, Thorne T, Qin G, and Losordo DW. Cardioprotection by Exogenously Administered Endothelial Progenitor Cells (EPCs) After Ischemia-Reperfusion Injury is eNOS Dependent. Circulation, 2010. 122:A17903.
  • Chen L, Anjak A, Zhou M, Jiang M, Qin G, Weintraub N, Rubinstein J, and Tang Y. Direct Nicd1 Overexpression Enhances Cardiac Commitment of Cpcs and Improve Heart Repair After Acute Myocardial Infarction via Notch1/gata4 Signaling. Circulation, 2010. 122:A21055.
  • Cheng M, Zhou J, Wu M, Zeng Q, Kishore R, Losordo DW, and Qin G. CXCR4 Mediated Bone Marrow Progenitor Cell Maintenance and Mobilization are Modulated by c-kit Activity. Circulation, 2010. 122:A12148.
  • Cheng M, Zhou J, Wu M, Zeng Q, Kishore R, Miller RJ, Losordo DW, and Qin G. A Critical Role of Src Family Kinase (SFK) in SDF-1/CXCR4-Mediated Bone-Marrow Progenitor-Cell Homing to Ischemic Cardiac Tissue. Circulation, 2010. 122:A18544.
  • Wu M, Zhou J, Cheng M, Boriboun C, Wu Y, Chen Z, Kishore R, and Qin G. E2F1 Stabilizes P53 and Suppresses Neovascularization In The Ischemic Myocardium. Circulation, 2010. 122:A17503.
  • Wu M, Zhou J, Cheng M, Wu Y, Chen Z, and Qin G. E2F1 stabilises p53 to suppress VEGF expression and neovasculrization in the ischemic myocardium. BMJ Heart, 2010. 96(Suppl 3):A16 e0049
  • Thal MA, Krishnamurthy P, Hoxha E, Lambers E, Verma S, Qin G, Losordo DW, and Kishore R. In Vivo Differentiation of Epigenetically Reprogrammed Mouse and Human Endothelial Progenitor Cells into Cardiomyocytes Enhances Functional and Anatomical Post-Infarct Myocardial Repair. Circulation 2011.124:A547
  • Thal MA, Krishnamurthy P, Hoxha E, Lambers E, Verma S, Qin G, Losordo DW, and Kishore R. In vivo Differentiation of Epigenetically Reprogrammed Mouse and Human Endothelial Progenitor Cells Into Cardiomyocytes Enhances Functional and Anatomical Post-Infarct Myocardial Repair. Circulation 2011.124:A13139
  • Krishnamurthy P, Thal MA, Verma S, Hoxha E, Lambers E, Ramirez R, Qin G, Losordo DW, and Kishore R. Myocardial Infarction-Induced Mobilization of Bone Marrow-Endothelial Progenitor Cells is Modulated By IL-10 Signaling and is Influenced by SDF1-CXCR4 Signaling Axis. Circulation 2011.124:A15491.
  • Zhou J, Zhu Y, Dinesh D, Thorne T, Liu D, Reisdorph N, Kishore R, Losordo DW, and Qin G. Sam68 Is A Novel Cofactor of E2F2 in the Regulation of Endothelin-Converting Enzyme-1b Transcription and Blood Pressure. Hypertension, 2011
  • Wu M, Zhou J, Cheng M, Boriboun C, Biyashev D, Wang H, Kishore R, Losordo DW, Qin G. E2F1 Suppresses Cardiac Neovascularization by Downregulating VEGF and PlGF Expression. Circulation 2011.124:A11252
  • Zhou J, Wu M, Cheng M, Jujo K, Boriboun C, Thorne T, Kishore R, Losordo DW, and Qin G. Ablation of E2F3 in Endothelial Cells Impairs the Functional Recovery of Heart and Limb from Ischemic Injury. Circulation 2011.124:A15882
  • Cheng M, Zhou J, Wu M, Boriboun C, Zeng Q, Kishore R, Miller R, Losordo DW, Qin G. CXCR4 Protects Cardiomyocytes From Beta-Adrenergic Stress-Induced Apoptosis. Circulation 2011.124:A14519.
  • Verma SK, Krishnamurthy P, Barefield D, Singh N, Gupta R, Lambers E, Thal M, Mackie A, Hoxha E, Ramirez V, Qin G, Sadayappan S, Ghosh A, and Kishore R. Interleukin-10 Treatment Attenuates Mechanical Stress-Induced Hypertrophic Remodeling and Improves Left Ventricular Function via Stat3-Dependent Inhibition of NFkB. Circulation. 2012;126:A13338
  • Wu M, Zhou J, Cheng M, Boriboun C, Biyashev D, Wang H, Kishore R, Losordo DW, and Qin G. Genetic Deletion of E2F1 Protects Myocardium from Ischemic Injury by Upregulating Angiogenic Growth Factors. Circulation. 2012;126:A19295.
  • Zhou J, and Qin G. A Novel Function of Sam68 in the Regulation of Blood Pressure. Circulation. 2012;126:A14514
  • Zhou J, and Qin G. Contrasting Roles Of E2F2 And E2F3 in Endothelial Cell Growth and Ischemic Angiogenesis. Circulation. 2012;126:A18783
  • Cheng M, Zhou J, Wu M, Kishore R, Miller RJ, and Qin G. A Novel Mechanism Underlying SDF-1/CXCR4-mediated Bone-Marrow Progenitor Cell Homing to the Ischemic Heart: The Role of Src Family Kinase (SFK). Circulation. 2012;126:A18115
  • Khan M, Lambers E, Verma SK, Mackie AR, Vaughan E, Srikanth G, Ramirez V, Abramova T, Ito A, Misener A, Qin G, and Kishore R. Embryonic Stem Cell Dervied Exosomes Enhance Cardiac Progenitor Cell Reparative Response After Myocardial Infarction. Circulation. 2013;128:A15163
  • Verma SK, Krishnamurthy P, Mackie AR, Vaughan EE, Srikanth G, Khan M, Ramirez V, Abramova T, Misener S, Klingler AI, Qin G, and Kishore R. IL-10 Reduces Pressure Overload-induced Fibrotic Remodeling by Inhibiting Homing and Differentiation of Bone Marrow-derived Fibroblasts Progenitor Cells- A Novel Mechanism. Circulation. 2013;128:A14014
  • Xu S, Tao J, and Qin G. A Novel Role of E2f1 in the Regulation of Bone Marrow Progenitor Cell Oxidative Metabolism and Ischemic Cardiac Repair. Circulation. 2013;128:A19071
  • Mackie AR, Ramirez V, Abramova T, Misener S, Vaughan EE, Khan M, Cooper JG, Garikipati S, Verma S, Krishnamurthy P, Qin G, and Kishore R. Post-ischemic Cardiac Functional Changes Caused by Prior Chronic Alcohol Consumption Correlate with Alterations to Epigenetic Histone Modifications in the Heart. Circulation. 2013;128:A13236
  • Xu S, Jung H, Tao J, Miller R, and Qin G. MCP-1/CCR2 Desensitizes the SDF-1/CXCR4 Signaling in Bone Marrow Stem/Progenitor Cells. Circulation. 2013;128:A18167
  • Yu Y, Sleep E, Stupp SI, and Qin G. Novel Bioactive Peptide Amphiphiles Nanofibers for Enhancement of Human Cd34+ Cell Mediated Ischemic Tissue Repair. Circulation. 2013;128:A19043
    • E. Patents
  • Methods of Using E2F2 for the Treatment of Hypertension (USPTO No. 60/855,986) (Inventors: DW Losordo, G Qin).

 

Gangjian Qin, MD

Associate Professor

 

  • : 312-503-1652
    Fax No. : 847-730-9572
  • DEPARTMENTDepartment of Cardiology and Pharmacology
    Northwestern University
  • COUNTRY USA