Publications

(names of trainees are underlined; * senior correspondence author). 

70. Purwana I, Zheng J, Li X, Deurloo M, Son DO, Zhang ZY, Liang C, Shen E, Tadkase1 A, Feng ZP, Li YM, Hasilo C, Paraskevas S, Bortell R, Greiner DL, Atkinson M,  Prud’homme GJ,  Wang Q -cellGABA promotes human  proliferation and modulates glucose homeostasis. Diabetes 2014 Jul 9. pii: DB_140153. [Epub ahead of print].
71. Liu R, Ma D, Li YM, Hu RM, Peng Y, Wang Q The anorexic effect of Ex4/Fc through GLP-1 receptor activation in high-fat diet fed mice. Acta Biochimica et Biophysica Sinica 2014 (accepted).
72.  Prud'homme GJ, Glinka Y, Hasilo C, Paraskevas S, Li X, Wang Q. GABA Protects Human Islet Cells Against the Deleterious Effects of Immunosuppressive Drugs and Exerts Immunoinhibitory Effects Alone.  Transplantation. 2013 Oct 15;96(7):616-23
73. Wu L, Zhai YJ, Lu JW, Wang Q* Sun F.* Expression, purification and preliminary characterization of glucagon receptor extracellular domain. Protein Expr Purif 2013 Apr 15;89(2):232-240
74.  Shao W, Wang Z, Ip W, Chiang YT, Xiong X, Chai T, Xu C, Wang Q, and Jin T. GLP-1(28-36) improves β-cell mass and glucose disposal in streptozotocin induced diabetes mice and activates PKA-β-catenin signaling in beta-cells in vitro Am J Physiol Endocrinol Metab. 2013 Jun 15;304(12):E1263-72.
75. Gagnon J, Zhu L,  Anini Y*, Wang Q* Neutralizing Circulating Ghrelin by Expressing a Growth Hormone Secretagogue Receptor Based Protein Protects Against High-Fat Diet Induced Obesity in Mice. Gene Ther 2013 (in press)
76. Zhao F, Wang Q.* The protective effect of peroxiredoxin II on oxidative stress induced apoptosis in pancreatic β-cells. Cell Biosci. 2012 Jun 18;2(1):22
77.  Wang Q,* Liang X, Wang S. Intra-islet glucagon secretion and action in the regulation of glucose homeostasis. Front Physiol. 2012;3:485. doi: 10.3389/fphys.2012.00485. Epub 2013 Jan 3
78.  Wang Z, Purwana I, Zhao F, Zhao S, Chan K, He B, Soukhov L, Korytnikov R, Li X, Wang Q.* beta-cell proliferation is associated with increased GABAA receptor expression in pancreactomized mice. Pancreas 2013 Apr;42(3):545-548.
79.  Shao W, Wang D, Chiang YT, Ip W, Zhu L, Xu F, Columbus J, Belsham DD, Irwin DM, Zhang H, Wen X, Wang Q, Jin T.  The Wnt Signaling Pathway Effector TCF7L2 Controls Gut and Brain Proglucagon Gene Expression and Glucose Homeostasis. Diabetes. 2013 Mar;62(3):789-800
80.  Liu S, Liu R, Chiang YT, Song L, Jin T, and Wang Q.* Insulin detemir enhances proglucagon gene expression in the intestinal L cells via stimulating β-catenin and CREB activities. Am J Physiol Endocrinol Metab. 2012 Sep 15;303(6):E740-51.
81.  Zhao F, Huang F, Tang M, Li X, Zhang N, Amfilochiadis A, Li Y, Hu R, Jin T, Peng C, Wang Q.*  Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells. Am J Physiol Endocrinol Metab. 2012 Jul;303(1):E132-43.
82.  Maharaj A., Zhu L., Qiu H., Qu J., Li H., Wang Y., Chen K., Zhang C-Y, Jin T., and Wang Q* Ectopic expression of glucagon receptor in skeletal muscle improves glucose homeostasis in diabetic animal models. Diabetologia (2012)  55(5):1458-68.
83. Liang Y, Qiu H, Glinka Y, Lazarus AH, Ni H, Prud'homme GJ, Wang Q*. Immunity against a therapeutic xenoprotein/Fc construct delivered by gene transfer is reduced through binding to the inhibitory receptor FcγRIIb. J Gene Med. 2011 Sep;13(9):470-7.
84. Soltani N, Qiu H, Aleksic M, Glinka Y, Zhao F, Liu R, Zhang N, Chakrabarti R, Ng T, Jin T, Zhang H, Lu W-L, Feng Z-P, Prud’homme GJ, and Wang Q.* GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes. Proc Natl Acad Sci U S A 2011 Jul 12;108(28):11692-7.
85.  Bansal P, Wang S, Zhang N, Xiang Y.Y., Lu W. Y*., and Wang Q* GABA coordinates with insulin in regulating secretory function in pancreatic INS-1 β-cells. PLoS ONE (2011) 6(10): e26225.
86.  Liu R, Li Y, Hu R, Jin T, Deng S, Liang W, Zhang N, Chen J, Prud'homme G, Jia WW, Ma D, and Wang Q.* A site-specific genomic integration strategies for sustained glucagon-like peptide-1 receptor-dependent control of energy and glucose homeostasis. Biochem Biophys Res Commun. 2010 403(2): 172-177
87.  Wang Q.* Chen K, Liu R, Liu R, Fang Z, Gupta S, Zhang N, and Prud'homme G. Novel GLP-1 fusion chimera as potent long acting GLP-1 receptor agonist. PLoS ONE Sept 2010 Volume 5 | Issue 9 | e12734
88. Columbus J, Chiang YT, Shao W, Zhang N, Wang D, Gaisano HY, Wang Q, Irwin DM, and Jin T.  Insulin treatment and high fat diet feeding reduces the expression of three Tcf genes in rodent pancreas. J Endocrinol. 2010 Oct;207(1):77-86.
89.  Liu R, Hu R, Wang Q.  Insulin resistance of β cells contributes to the pathogenesis of diabetes.  Chinese Journal of Diabetes.  2010 18(8):634-36.
90.  Wang Q*, Jin T. The role of insulin signaling in the development of beta-cell dysfunction and diabetes. Islet 2009 1(2):1-7.
91.  Islam D., Zhang N., Lam P., Wang P., Li H., Brubaker, P., Gaisano H., Wang Q., Jin T. EpacII pathway stimulates proglucagon gene expression but not glucagon secretion in pancreatic A cell lines. Am J Physiol 2009 Jan;296(1):E174-81.
92. Wang P, Wang Q, Sun J, Wu J, Li H, Zhang N, Huang Y, Su B, Li RK, Liu L, Zhang Y, Elsholtz HP, Hu J, Gaisano HY, Jin T. POU homeodomain protein oct-1 functions as a sensor for both cyclic AMP and oxidative stress J Biol Chem  2009 Sep 25;284(39):26456-65
93. Zhang Y, Qu J, Zhang N, Diao J, Gao1 X, Strijbos PJ, Gaisano HY,Robinson RB, Tsushima1 R, Wang Q*, Wheeler MB. Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic beta cells.  J Endocrinology. 2009 Oct;203(1):45-53. (*senior co-correspondence author).
94.  Zhang Y, Zhang N, Gyulkhandanyan AV, Xu E, Gaisano HY, Wheeler1 MB*, Wang Q*. Presence of functional hyperpolarisation-activated cyclic nucleotide-gated channels in clonal alpha cell lines and rat islet alpha cells. Diabetologia 2008 Dec;51(12):2290-8. (*senior co-correspondence author).
95. Liu R, Li Y, Wang Q. The role of declined islet β cell mass in the development of diabetes.  International Journal of Internal Medicine. 2008, 35(5):265-268.
96.  Liu R, Hu R, Wang Q.  Dysregulation of glucagon secretion in the pathogenisis of diabetes. Chinese Journal of Diabetes. 2008, 16(11): 704-706.
97. Bensal P Wang Q*, Insulin as a physiological modulator of glucagon secretion. Am J Physiol Endocrinol Metab. 2008 Oct;295(4):E751-61.
98. Zhao J, Zhang N, He M, Yang Z.H, Tong W, Wang Q*, Hu R*. Increased β-Cell Apoptosis and Impaired Insulin Signaling Pathway Contributes to the Onset of Diabetes in OLETF Rats. Cell Physiol Biochem 2008;21:445-454 (*senior co-correspondence author)
99. Li J, Zhang N, Ye B, Ju W, Orser B, Manning Fox JE, Wheeler M, Wang Q and Lu WY. Non-steroidal Anti-inflammatory Drugs Increase Insulin Release from β-Cells by Inhibiting ATP-Sensitive Potassium Channel. Br J Pharmacol 2007 Jun;151(4):483-93.
100.  Prud'homme G.J., Draghia-Akli R., Wang Q. Plasmid-based gene therapy of diabetes mellitus. Gene Ther. 14, 553–564, 2007
101. Soltani N., Kumar M., Glinka Y., Prud’homme G.J., Wang Q*.  In vivo expression of GLP-1/IgG-Fc fusion protein enhances beta cell mass and protects against streptozotocin-induced diabetes. Gene Ther. 2007 Jun 14(12):981-8.
102. Kumar M, Hunag K, Glinka Y, Prud’homme GJ, Wang Q*. Gene Therapy of diabetes using a novel GLP-1/IgG-FC fusion construct normalizes glucose levels in db/db mice. Gene Ther. 2007 Jan 14(2):162-72.
103. Dai FF, Zhang Y, Kang Y, Wang Q, Gaisano HY, Braunewell KH, Chan CB, Wheeler MB. The neuronal Ca2+-sensor protein visinin-like-protein-1 (VILIP-1) is expressed in pancreatic islets and regulates insulin secretion. J Biol Chem. 2006 Aug 4; 281(31):21942-53.
104. Zhao J, Wang D, Hu R, Zhang S, Wang D, Zhou L, Wu Y, Wang Q, Hu R.  The impact of exercise on the function and mass of islet β cells in type 2 diabetes OLETE mice. Chinese Journal of Endocrinology and Metabolism. 2006 22(4) i004-i005.
105. Xu G, Zhou H, Wang Q, Auersperg N, Peng C. Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines. Mol Cancer Res. 2006 Apr;4(4):235-46.
106. Dong H, Kumar M, Zhang Y, Gyulkhandanyan A, Xiang YY, Ye B, Perrella J, Hyder A, Zhang N, Wheeler M, Lu WY, Wang Q*. GABA up- and down-regulates insulin secretion from β-cells in concert with changes in glucose concentration. Diabetologia. 2006 Apr;49(4):697-705.
107. Zhang N, Kumar M, Xu G, Ju W, Yoon T, Xu E, Huang, X, Giasano, Peng C, Wang Q*.  Activin receptor-like kinase 7 induces apoptosis of pancreatic beta cells and beta cell lines. Diabetologia, 2006 27:506-18.
108.  Xu E, Kumar M, Zhang Y, Ju W, Obata Y, Zhang N, Liu S, Wendt A, Deng S, Ebina Y, Wheeler MB, Braun M, Wang Q*. Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system. Cell Metab. 2006 Jan;3(1):47-58 (this work has been introduced by Sci. STKE as Editors' Choice, 24 January 2006, Vol. 2006, Issue 319, p. tw36).
109.  Zhao Y, Liu T, Zhang N, Yi F, Wang Q, Fantus IG, and Jin T. Activation of insulin gene expression in the rat insulinoma cell line RIN-1056A by inducibly over expressing the caudal homeobox gene Cdx-2. J Endocrinol. 2005 Jul;186(1):179-92.
110. Wang Q, Li L, Xu E, Wong V, Rhodes C and Brubaker P. Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of Akt1 in pancreatic (INS-1) beta-cells. Diabetologia. 2004 Mar;47(3):478-87.  
111. Wang Q, Liu L, Pei L, Ju W, Ahmadian G, Liu J, Wang Y, Liu F, and Wang Y.  Control of Synaptic Strength, a Novel Function of Akt.  Neuron, 38(6):915-928, 2003.
112. Man HY, Wang Q, Lu WY, Ju W, Ahmadian G, Liu L, D'Souza S, Wong TP, Taghibiglou C, Lu J, Becker LE, Pei L, Liu F, Wymann MP, MacDonald JF, Wang YT. Activation of PI3-Kinase Is Required for AMPA Receptor Insertion during LTP of mEPSCs in Cultured Hippocampal Neurons. Neuron.38(4):611-24, 2003.
113. El-Kholy W, Macdonald PE, Lin JH, Wang J, Fox JM, Light PE, Wang Q, Tsushima RG, Wheeler MB. The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism.  FASEB J. 17(6):720-2, 2003.
114. Wang Q, Brubaker PL. Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice. Diabetologia. 45(9):1263-73, 2002.
115. Wang, Q*, Wu, Y., Aerts, T., Slegers, H., Clauwaert, J. Purification of C6 glioma plasma membranes by affinity partitioning. Biol. Signals Recept. 9(1):45-52, 2000.
116. Wang, Q., Somwar, R., Bilan, P.J., Liu, Z., Jing, J., Woodgett, J., and Klip, A. Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol. Cell. Biol. 19(6):4008-18, 1999.
117. Wang, Q*., Slegers, H., Clauwaert, J. Isolation of plasma membranes from rat C6 glioma cell cultivated on microcarriers. Acta Histochem. 101(3):327-39, 1999.
118. Li, D. Sweeney, G, Wang, Q, Klip, A. Participation of PI3K and atypical PKC in Na+-K+-pump stimulation by IGF-I in VSMC. Am. J. Physiol.276(6 Pt 2): H2109-H2116, 1999.
119. Ueyama, A., Yaworsky, K., Wang Q., Ebina, Y., Klip A. GLUT-4myc ectopic expression in L6 myoblasts generates a GLUT-4-specific pool conferring insulin sensitivity. Am. J. Physiol.277(3 Pt 1):E572-E578, 1999.
120. Wang, Q, Khayat, Z., Kishi, K., Ebina, Y.,  Klip, A. GLUT4 translocation by insulin in intact muscle cells: detection by a fast and quantitative assay. FEBS Lett. 427(2):193-197, 1998.
121. Wang, Q. Bilan, P.J., Tsakiridis, T., Hinek, A., Klip, A. Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes. Biochem. J.  331(3):917-928, 1998.
122. Wang, Q. Bilan, P.J., Klip, A. Opposite effects of insulin on focal adhension proteins in cells overexpressing insulin receptor and their parental cell lines. Mol. Biol. Cell  9(11):3057-3069, 1998.
123. Wang Q*, Wu Y, Aerts T, Slegers H, Clauwaert J. Expression of IGF-I and IGF-II receptors in rat C6 glioma cells as a function of the growth phase. Cell Physiol Biochem. 1998;8(6):304-13.
124. Wang, Q., J. Guo., and Jia, W. Intracerebral recombinant HSV-1 vector does not reactivate latent HSV-1. Gene Ther. 4(12) 1300-1304, 1997.
125. Volchuk, A., Wang, Q., Ewart, H.S., Liu, Z., He, L., Bennett, M.K., Klip, A. Syntaxin 4 in 3T3-L1 adipocytes: regulation by insulin and participation in insulin-dependent glucose transport. Mol. Biol. Cell 7(7):1075-1082, 1996.
126.  Xia JZ, Wang Q, Tatarkova S, Aerts T, Clauwaert J. Structural basis of eye lens transparency: light scattering by concentrated solutions of bovine alpha-crystallin proteins. Biophys J. 71(5):2815-22, 1996.
127. Aerts, T., Wang, Q, Tatarkova, S., and Clauwaert, J. Physical-chemical characterization of the different cortical a-crystallin populations from bovine lenses. Colloid Polym. Sci. 99:94-100, 1995.
128. Gu ZZ, Shan GX, Wang Q. Effects of hyperbaric oxygen on erythropoietin in mice.  Chinese Appl. Physiol. 1991(04): 78-79.
129. Wang, Q*, Gu, ZZ, Cui, RJ, Shen, W, Bi, ZM. The study of erythrocyte immune function of decompression sickness in rats. Chinese Sci. Bull. 12:949‑951, 1988.
130. Wang, Q*, Cui, RJ, Gu, ZZ, Shen, W, Deng, TS, Bi, ZM. Observations of erythrocyte immune function in divers in the 300 M. He2‑N2‑O2 saturation diving. Shanghai J. Immunol. 8(6), 409‑411, 1988.
131. Gu, ZZ, Jia, W, Wang, Q, Wu, W. A primary investigation on mechanism of the effect of hyperoxygen on intracranial pressure. Chinese Sci. Bull.31(9) 706‑710, 1986 (Chinese, English abstract).
132. Yu, LH, Jin, XY, Jia, W, Wang, Q, Liu, J, Wu, W, Cui, RJ, and Gu, ZZ. An experimental study of regional cephalic hypothermia and brain resuscitation. J. PLA Medicine 11(6), 439‑442, 1986.
133. Gu, ZZ, Jia, W, Wang, Q, Wu, W. A primary investigation on mechanism of the effect of HPO2 on intracranial pressure. Chinese Sci. Bull. 31(24) 1716‑1719, 1986.
134. Gu, ZZ, Jia, W, Wang, Q. The effect of hyperbaric pressure on cerebral circulation. Chinese Appl. Physiol. 1(3), 171‑176, 1985.
135. Jia, W, Wang, Q, Cui, RJ, and Gu, ZZ. Observation of eye ground on divers under simulated high altitude diving. Underwater Tech. 3:17, 1985.
136. Jia, W, Wang, Q, Cui, RJ, Gu, ZZ. Changes in ICP of conscious rabbits at various oxygen pressure. J. Chinese Neurol. 18(1), 17‑20, 1985.
137. Cui, RJ, Jia, W, Wang, Q, Gu, ZZ. Effect of hyperbaric‑oxygen exposure on intracranial pressure in anaesthetized rabbits. Chinese Sci. Bull.  29(1), 1551‑1554, 1984.