Publications
Peer-Reviewed Publications
- K. Voltzke, T. Millikan, L. Ramsey, E. Dobbs, P. Nash, S. Pavletich, M.V. Wiles, M.T. Firpo. (2015) Feeder cells maintain human pluripotent stem cells in vitro despite similar FGF and laminin expression compared with non-supportive feeders. Stem Cell Research . In press.
- International Stem Cell Banking Initiative (ISCBI). Points to Consider in the Development of Seed Stocks of Pluripotent Stem Cells for Clinical Application Regenerative Medicine 2014 in press.
- B. Weegman, A. Carlson, P. Nash, K. Voltzke, Z. Geng, M. Jahani, B. Becker, K. Papas, M. Firpo. A method for nutrient regulation by continuous feeding of large-scale expansion of mammalian cell spheroids. 2014 JoVE in press
- Kristen M. Maynard, U. Arvindam, M. Cross, MT Firpo. (2014) Potential immunogenic proteins expressed similarly in human embryonic stem cells and induced pluripotent stem cells. Experimental Biology and Medicine. 239(4):484-8. doi: 10.1177/1535370214522936.
- B. Weegman, A. Carlson, P. Nash, K. Voltzke, Z. Geng, M. Jahani, B. Becker, K. Papas, M. Firpo. Nutrient regulation by continuous feeding removes limitations on cell yield in the large-scale expansion of Mammalian cell spheroids. 2013 PLoS ONE, 8(10):e76611
- K. Subramanian, Owens, DK, Raju, R., Firpo, M., O’Brien, T., Verfaillie, C, Hu, WS. Spheroid Culture for Enhanced Differentiation of Human Embryonic Stem Cells to Hepatocyte-Like Cells. Stem cells and development 23(2) (2014)
- J. Chhoun, Voltzke, K., Firpo, MT. September (2012). From Cell Culture to a Cure: Pancreatic Beta Cell Replacement Strategies for Diabetes Mellitus. Regenerative Medicine.
- H. Hirai, Firpo M, Kikyo N. (2012). Establishment of LIF-dependent human iPS cells closely related to basic FGF-dependent authentic iPS cells. PLoS One. 7(6):e39022. Epub 2012 Jun 13.
- H. Hirai, Katoku-Kikyo, N., Karian, P., Firpo, M., Kikyo, N. (2012). Efficient iPS Cell Production with the MyoD Transactivation Domain in Serum-Free Culture. PLoS ONE, 7(3):e34149. Epub 2012 Mar 30.
- H. Zhiying, Zhan, H.,, Zhang, X, Chen, Y., Xie, D., Wangensteen, K., Ekker, S.,, Firpo, M,, Liu1, C., Li, S., Zi, X., Yang, G.,, Ding, X,, Hu, L., and Wang, X. (2011). Liver xeno- repopulation with human hepatocytes in Fah-/-Rag2-/-mice after pharmacological immunosuppression. Am. J. Pathology. Sep;177(3):1311.
- Hirai H, Tani T, Katoku-Kikyo N, Kellner S, Karian P, Firpo M, Kikyo N. (2011). Radical acceleration of nuclear reprogramming by chromatin remodeling with the transactivation domain of MyoD. Stem Cells. 29(9):1349-61.
- Mahpatra S, Firpo MT, Bacanamwo M. (2010) Inhibition of DNA methyltransferases and histone deacetylases induces bone marrow-derived multipotent adult progenitor cells to differentiate into endothelial cells. Ethn Dis. 20(1 Suppl 1):S1-60-4.
- Roelandt P, Pauwelyn KA, Sancho-Bru P, Subramanian K, Ordovas L, Vanuytsel K, Geraerts M, Firpo M, De Vos R, Fevery J, Nevens F, Hu WS, Verfaillie CM. (2010). Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS One. A11;5(8).
- International Stem Cell Banking Initiative. (2009). Consensus guidance for banking and supply of human embryonic stem cell lines for research purposes. Stem Cell Rev. 5(4):301- 314. PMID20016954
- R. Pera, Abeyta, M., Yang, J., Meneses, J., and Firpo, MT. (2009). Gene expression profiles of human inner cell mass cells and embryonic stem cell. Differentiation. 78(1):18- 23. PMID19398262
- R. Rodriguez, Velkey, M., Lutzko, C. Bodnar, M., Kohn, D., O’Shea, K.S., Firpo, M.T. (2007). Manipulation of OCT-4 levels in human embryonic stem cells results in induction of differential cells types. Exp. Biol. Med. 232:1368-80. PMID1799959850
- M.T. Firpo and Chase, L. (2007). Development of serum free culture systems for human embryonic stem cells. Curr Opin Chem Biol. 11(4):367-72. PMID17692558
- Li, Y.L. Chung, E.H., Rodriguez, R.T., Firpo, M.T., Healy, K.E. (2006). Hydrogels as artificial matrices for human embryonic stem cell self renewal J. Biomedical Materials Research 79(1):1-5. PMID16741988
- Brown D, Yu BD, Joza N, Benit P, Meneses J, Firpo M, Rustin P, Penninger JM, Martin GR. 2006. (2006). Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal. Proc Natl Acad Sci U S A. Jun 27;103(26):9918-23. PMID 16788063
- Poon E, Clermont F, Firpo MT, Akhurst RJ. (2006). TGFβ inhibition of yolk sac-like differentiation of human embryonic stem cell-derived embryoid bodies illustrates differences between early mouse and human development. J. Cell Science Feb 14;119(Pt 4):759-68. PMID 16449320
- GM Beattie, Lopez AD, Bucay N, Hinton A, Firpo MT, King CC, Hayek A. (2005). Activin A maintains pluripotentiality of human embryonic stem cells in the absence of feeder layers. Stem Cells. 23(4):489-95. PMID15790770
- Wang Z, Zhai W, Richardson JA, Olson EN, Meneses JJ, Firpo MT, Kang C, Skarnes WC, Tjian R. (2004). Polybromo protein BAF180 functions in mammalian cardiac chamber maturation. Genes Dev. 18(24):3106-16. PMID15601824
- Humphrey RK, Beattie GM, Lopez AD, Bucay N, King CC, Firpo M, Rose-John S, and Hayek A. (2004). Maintenance of pluripotency in human embryonic stem cells is stat3 independent. Stem Cells. 22(4):522. PMID15277698
- Clark AT, Bodnar MS, Fox M, Rodriquez RT, Abeyta MJ, Firpo MT, Pera RA. (2004). Spontaneous differentiation of germ cells from human embryonic stem cells in vitro. Hum Mol Genet. 1;13(7):727-39. PMID14962983
- Bodnar M.S., Meneses J.J., Rodriguez R.R., Firpo M.T. (2004). Propagation and maintenance of undifferentiated human embryonic stem cells. Stem Cells and Development 13(3):243. PMID15186720
- Abeyta MJ, Clark AT, Rodriguez RT, Bodnar MS, Pera RA, Firpo MT. (2004). Unique gene expression signatures of independently-derived human embryonic stem cell lines. Hum Mol Genet. 13(6):601-8. Epub 2004 Jan 28. PMID14749348
- Clark AT, Rodriguez RT, Bodnar MS, Abeyta MJ, Cedars MI, Turek PJ, Firpo MT, Reijo Pera RA. (2004). Human STELLAR, NANOG, and GDF3 Genes Are Expressed in Pluripotent Cells and Map to Chromosome 12p13, a Hotspot for Teratocarcinoma. Stem Cells. 2(2):169-179. PMID14990856
- J. Jaruzelska, Kotecki, M., Kusz, A., Spik, A., Firpo, M.T., Reijo-Pera, R. (2003).
Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells. Dev Genes Evol. 2003 3(3):120-6. PMID12690449
- F.L. Moore, Jaruzelska, J., Firpo, M.T., Turek, P.J., Dorfman, D.M., Reijo-Pera, R. (2003).
A human homologue of Drosophila pumilio is expressed in embryonic stem cells and germ cells and interacts with DAZL (deleted in azoospermia-like) protein Proc Natl Acad Sci U S A. 100(2):538-43. PMID12511597
- J.F. DiMartino, L. Selleri, D. Traver, M.T. Firpo, J. Rhee, R. Warnke, S. O’Gorman, I. Weissman and M.L. Cleary. (2002) The Hox cofactor and proto-oncogene Pbx-1 is required for maintenance of definitive hematopoiesis in the fetal liver. Blood. 98(3):618. PMID11468159
- Agah R, Prasad KS, Linnemann R, Firpo MT, Quertermous T, Dichek DA. (2000).
Cardiovascular overexpression of transforming growth factor-beta(1) causes abnormal yolk sac vasculogenesis and early embryonic death. Circ Res; 86(10). PMID10827131
- Namikawa R, Muench MO, Firpo MT, Humeau L, Xu Y, Menon S, Roncarolo MG (1999).
Administration of Flk2/Flt3 ligand induces expansion of human high-proliferative potential colony-forming cells in the SCID-hu mouse. Exp Hematol 27:1029. PMID10378892
- L. Humeau, C. Chabannon, M.T. Firpo, P. Mannoni, C. Bagnis, M.-G. Roncarolo, R. Namikawa. (1997). Successful reconstitution of multilineage human hematopoiesis in the SCID-hu mouse by genetically modified, highly enriched fetal liver stem cells. Blood; 90(9). PMID9345033
- M. Kennedy, M. Firpo*, K. Choi, C. Wall, S. Robertson, N. Kabrun, G. Keller. Identification of a common precursor for primitive erythropoiesis and definitive multilineage hematopoiesis. Nature 386:488 (1997). PMID9087406 * First two authors contributed equally to this work
- C. Gasparetto, C. Smith, M. Firpo, D. Dennig, T. Small, A.P. Gillio, R. Lichtenberg, R.J. O'Reilly and M.A.S. Moore. (1994). Dyshematopoiesis in combined immune deficiency with congenital neutropenia. Am. J. Hematol. 45:63 PMID8250011.
- M.O. Muench, M.T. Firpo, M.A.S. Moore. (1993). Bone marrow Transplantation with interleukin-1 plus kit-ligand ex vivo expanded bone marrow accelerates hematopoietic reconstitution in mice without the loss of stem cell lineage and proliferative potential. Blood 81:3463 PMID 7685206.
Non Peer-Reviewed Publications
- Firpo M, Wagner J. (2011). Stem cell research in Minnesota: here today, gone tomorrow? Minn Med. May;94(5):34-5.
- Firpo M., Kikyo NK. (2007). A primer on stem cell research. Minn Med. 90(5):36-8. PMID17550085
Articles Submitted for Publication
- Z. Geng, Greder, L., Lauren Stein, L., Jahani, M., Carlson, A., Voltzke, K., Stelzig, K., Graham, M., Janecek, J., James Dutton, J., Firpo, MT. Induced Pluripotent Stem Cell- derived Insulin-producing Cells Reverse Diabetes in Mice. Stem Cells Translational Medicine, submitted.
- Kristin Voltzke*, Taylor Millikan*, Lucas Ramsey, Erica Dobbs, Peter Nash, Scott Pavletich, Michael Wiles, Meri T. Firpo. Feeder cells maintain human pluripotent stem cells in vitro despite similar FGF and laminin expression compared with non-supportive feeders Stem Cell Reports 2014
- Taylor Millikan, Kristin Voltzke, Lucas Ramsey, Sam Falde, Peter Nash, Zhaohui Geng, Marjan Jahani-Kondori, Meri T. Firpo Commercially available xeno-free culture systems can be modified to improve iPS cell viability during transition to differentiation and derivation of new iPS cell lines Stem Cell Reports 2014
Electronic Publications
Author(s), article title, journal title, volume, year, page numbers (e.g., 225-243) (Indicate the candidate’s role in multi-author papers)
Educational Videos-Physician Education Material
- B. Weegman, A. Carlson, P. Nash, K. Voltzke, Z. Geng, M. Jahani, B. Becker, K. Papas, M. Firpo. A method for nutrient regulation by continuous feeding of large-scale expansion of mammalian cell spheroids. 2014 JoVE in press
Chapters in Books
- Firpo, MT.. Derivation of Human Embryonic Stem Cell Lines. In: Stem Cell Banking Eds.
Crook J and Nakatsuji Methods Mol. Biol. Springer. Ch. 10. 2014 In Press
- M.T. Firpo, and Kaufman, D. (2002. Embryonic Stem Cells in the Field of Hematopoietic Stem Cells and Immune Therapy In: Clinical Bone Marrow and Blood Stem Cell Transplantation, third edition. Editors: K. Atkinson, et. al.
- MO Muench, Firpo MT, Barcena A. (2006). Developmental erythropoiesis: Turning embryonic and fetal stem cells into red cells. In Progress in Stem Cell Research. Ed. Frank Columbus. Nova Science Publishers, New York.
- Firpo, M.T. World Book Encyclopedia “Stem Cells” 2001-2007
- Chase, L., Firpo M.T. (2008). Using embryonic stem cells as a model of pancreatic development. In Stem Cells and Regenerative Medicine Ed. Catherine Verfaillie and Walter Low. World Scientific Publishing Singapore.