Publications

Peer-Reviewed Original Research Articles

  1. Shen Q, Zhang BY, Lan H. Lipiodo/Cisplatin-hepatic artery embolization for the treatment of primary liver cancer of middle-advanced stages: clinical study. China J Commu Med 11:51, 1989.
  2. Shao S, Shen Q, Weng G. Malignant primary gastric lymphoma and a report of three cases. China J Commu Med 9:41-42, 1995.
  3. Shao S, Shen Q, Weng G, Wang Y. Clinical applications of somatostatin in four patients. China J Commu Med 10:103-104, 1996.
  4. Shao S, Weng G, Wang Y, Shen Q. Report of six cases on the diagnosis and treatment of pancreatic injuries. China J Med Emerg Med Trau 6:1131-1132, 1996.
  5. Shao S, Shen Q, Weng G, Wang Y. Traumatic liver rupture: diagnosis and treatment in 21 patients. Shenshen J Med 9:16-17, 1996.
  6. Fan X, Croll RP, Wu B, Fang L, Shen Q, Painter SD, Nagle GT. Molecular cloning of a cDNA encoding the neuropeptides APGWamide and cerebral peptide 1: localization of APGWamide-like immunoreactivity in the central nervous system and male reproductive organs of Aplysia. J Comp Neurol 387(1):53-62, 10/1997. e-Pub 1997. PMID: 9331171.
  7. Shen Q, Brown PH. Novel agents for the prevention of breast cancer: targeting transcription factors and signal transduction pathways. J Mammary Gland Biol Neoplasia 8(1):45-73, 1/2003. e-Pub . PMID: 14587863.
  8. Lu C, Speers C, Zhang Y, Xu X, Hill J, Steinbis E, Celestino J, Shen Q, Kim H, Hilsenbeck S, Mohsin SK, Wakeling A, Osborne CK, Brown PH. Effect of epidermal growth factor receptor inhibitor on development of estrogen receptor-negative mammary tumors. J Natl Cancer Inst 95(24):1825-33, 12/2003. PMID: 14679152.
  9. Shen Q, Singh P. Identification of a novel SP3 binding site in the promoter of human IGFBP4 gene: role of SP3 and AP-1 in regulating promoter activity in CaCo2 cells. Oncogene 23(14):2454-64, 4/2004. PMID: 14767471.
  10. Liu Y, Lu C, Shen Q, Munoz-Medellin D, Kim H, Brown PH. AP-1 blockade in breast cancer cells causes cell cycle arrest by suppressing G1 cyclin expression and reducing cyclin-dependent kinase activity. Oncogene 23(50):8238-46, 10/2004. PMID: 15378019.
  11. Shen Q, Brown PH. Transgenic mouse models for the prevention of breast cancer. Mutat Res 576(1-2):93-110, 8/2005. PMID: 15888345.
  12. Lu C, Shen Q, DuPré E, Kim H, Hilsenbeck S, Brown PH. cFos is critical for MCF-7 breast cancer cell growth. Oncogene 24(43):6516-24, 9/2005. PMID: 16027729.
  13. Shen Q, Zhang Y, Uray IP, Hill JL, Kim HT, Lu C, Young MR, Gunther EJ, Hilsenbeck SG, Chodosh LA, Colburn NH, Brown PH. The AP-1 transcription factor regulates postnatal mammary gland development. Dev Biol 295(2):589-603, 7/2006. e-Pub 4/2006. PMID: 16678816.
  14. Li Y, Zhang Y, Hill J, Shen Q, Kim HT, Xu X, Hilsenbeck SG, Bissonnette RP, Lamph WW, Brown PH. The Rexinoid LG100268 prevents the development of preinvasive and invasive estrogen receptor negative tumors in MMTV-erbB2 mice. Clin Cancer Res 13(20):6224-31, 10/2007. PMID: 17947490.
  15. Shen Q, Uray IP, Li Y, Krisko TI, Strecker TE, Kim HT, Brown PH. The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors. Oncogene 27(3):366-77, 1/2008. e-Pub 7/2007. PMID: 17637753.
  16. Li Y, Zhang Y, Hill J, Kim HT, Shen Q, Bissonnette RP, Lamph WW, Brown PH. The rexinoid, bexarotene, prevents the development of premalignant lesions in MMTV-erbB2 mice. Br J Cancer 98(8):1380-8, 4/2008. e-Pub 3/2008. PMCID: PMC2361704.
  17. Shen Q, Uray IP, Li Y, Zhang Y, Hill J, Xu XC, Young MR, Gunther EJ, Hilsenbeck SG, Colburn NH, Chodosh LA, Brown PH. Targeting the activator protein 1 transcription factor for the prevention of estrogen receptor-negative mammary tumors. Cancer Prev Res (Phila Pa) 1(1):45-55, 6/2008. e-Pub 3/2008. PMCID: PMC2577387.
  18. Strecker TE, Shen Q, Zhang Y, Hill JL, Li Y, Wang C, Kim HT, Gilmer TM, Sexton KR, Hilsenbeck SG, Osborne CK, Brown PH. Effect of lapatinib on the development of estrogen receptor-negative mammary tumors in mice. J Natl Cancer Inst 101(2):107-13, 1/2009. e-Pub 1/2009. PMCID: PMC2639315.
  19. Uray IP, Shen Q, Seo HS, Kim H, Lamph WW, Bissonnette RP, Brown PH. Rexinoid-induced expression of IGFBP-6 requires RARbeta-dependent permissive cooperation of retinoid receptors and AP-1. J Biol Chem 284(1):345-53, 1/2009. e-Pub 10/2008. PMCID: PMC2610495.
  20. Li Y, Shen Q, Kim HT, Bissonnette RP, Lamph WW, Yan B, Brown PH. The rexinoid bexarotene represses cyclin D1 transcription by inducing the DEC2 transcriptional repressor. Breast Cancer Res Treat 128(3):667-77, 8/2011. e-Pub 9/2010. PMID: 20821348.
  21. Chen H, Yang Z, Ding C, Chu L, Zhang Y, Terry K, Liu H, Shen Q*, Zhou J*. Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents. ACS Med Chem Lett 4(2):180-185, 2/2013. e-Pub 2/2013. PMCID: PMC3583367.
  22. Chen H, Yang Z, Ding C, Chu L, Zhang Y, Terry K, Liu H, Shen Q, Zhou J. Fragment-Based Drug Design and Identification of HJC0123, A Novel Orally Bioavailable STAT3 Inhibitor for Cancer Therapy. Eur J Med Chem 62:498-507, 4/2013. e-Pub 1/2013. PMCID: PMC3750725.
  23. Ding C, Zhang Y, Chen H, Yang Z, Wild C, Chu L, Liu H, Shen Q*, Zhou J*. Novel Nitrogen-Enriched Oridonin Analogues with Thiazole-Fused A-Ring: Protecting Group-Free Synthesis, Enhanced Anticancer Profile, and Improved Aqueous Solubility. J Med Chem 56(1):5048-5058. e-Pub 6/2013. PMID: 23746196.
  24. Meng X, Cai C, Wu J, Cai S, Ye C, Chen H, Yang Z, Zeng H, Shen Q*, Zou F. TRPM7 Mediates Breast Cancer Cell Migration and Invasion Through the MAPK Pathway. Cancer Lett 333(1):96-102, http://dx.doi.org/10.1016/j.canlet.2013.01.031, 6/2013. e-Pub 1/2013. PMID: 23353055.
  25. Ding C, Zhang Y, Chen H, Wild C, Wang T, White MA, Shen Q, Zhou J. Overcoming Synthetic Challenges of Oridonin A-Ring Structural Diversification: Regio- and Stereoselective Installation of Azides and 1,2,3-Triazoles at the C-1, C-2, or C-3 Position. Org Lett 15(14):3718-3721, 7/2013. e-Pub 7/2013. PMCID: PMC3779473.
  26. Zhou F, Shen Q, Claret FX. Novel Roles of Reactive Oxygen Species in the Pathogenesis of Acute Myeloid Leukemia. J Leukoc Biol 94(3):423-9, 9/2013. e-Pub 5/2013. PMCID: PMC4051257.
  27. Ding C, Zhang Y, Chen H, Yang Z, Wild C, Ye N, Ester CD, Xiong A, White MA, Shen Q*, Zhou J. Oridonin Ring A-Based Diverse Constructions of Enone Functionality: Identification of Novel Dienone Analogues Effective for Highly Aggressive Breast Cancer by Inducing Apoptosis. J Med Chem 56(21):8814-25, 11/2013. e-Pub 10/2013. PMCID: PMC3880594.
  28. Zhou Q, Facciponte J, Jin M, Shen Q Lin Q. Humanized NOD-SCID IL2rg-/- Mice as a Preclinical Model for Cancer Research and Its Potential Use for Individualized Cancer Therapies. Cancer Lett 344(1):13-9, 3/2014. e-Pub 10/2013. PMID: 24513265.
  29. Chen H, Yang Z, Ding C, Xiong A, Wild C, Wang L, Ye N, Cai G, Flores RM, Ding Y, Shen Q*, Zhou J. Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Eur J Med Chem 82:195-203, 7/2014. e-Pub 5/2014. PMCID: PMC4096847.
  30. Ye N, Ding Y, Wild C, Shen Q, Zhou J. Small Molecule Inhibitors Targeting Activator Protein 1 (AP-1). J Med Chem 57(16):6930-48, 8/2014. e-Pub 5/2014. PMCID: PMC4148154.
  31. Ding C, Wang L, Chen H, Wild C, Ye N, Ding Y, Wang T, White MA, Shen Q, Zhou J. ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: synthesis of dihydropyran-fused diterpenoids. Org Biomol Chem 12(42):8442-52, 11/2014. PMCID: PMC4192081.
  32. Yin T, Shi P, Gou S, Shen Q, Wang C. Dendritic Cells Loaded with Pancreatic Cancer Stem Cells (CSCs) Lysates Induce Antitumor Immune Killing Effect in Vitro. PLoS One 9(12):e114581, 2014. e-Pub 12/2014. PMCID: PMC4270694.
  33. Tu H, Sun H, Lin Y, Ding J, Nan K, Li Z, Shen Q, Wei Y. Oxidative Stress Upregulates PDCD4 Expression in Patients with Gastric Cancer via miR-21. Curr Pharm Des 20(11):1917-23, 2014. e-Pub 7/2013. PMID: 23888942.
  34. Tang S, Wang X, Shen Q*, Yang X, Yu C, Cai C, Cai G, Meng X, Zou F. Mitochondrial Ca² uniporter is critical for store-operated Ca² entry-dependent breast cancer cell migration. Biochem Biophys Res Commun 458(1):186-93, 2/2015. e-Pub 1/2015. PMID: 25640838.

Invited Articles

  1. Xiong A, Yang Z, Shen Y, Zhou J, Shen Q. Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention. Cancers (Basel) 6(2):926-57, 2014. e-Pub 4/2014. PMCID: PMC4074810.

Editorials
N/A
Other Articles
N/A
Abstracts

  1. Shen Q, Brown PH. Role of the AP-1 Transcription Factor in Cancer Metastasis. AACR Annual Meeting 2009, 2009.
  2. Shen Q, Brown PH. The TASK2 potassium ion channel is differentially expressed in ER-negative breast cancer. 8th Annual AACR International Conference on Frontiers in Cancer Prevention Research, 2009.
  3. Shen Q, Markaverich J. KCNK5 regulates proliferation of ER-negative breast cancer cells. 9th Annual AACR International Conference on Frontiers in Cancer Prevention Research, 2010.
  4. Haijun Chen, Zhengduo Yang, Chunyong Ding, Lili Chu, Shen Q, Jia Zhou. Fragment-Based Drug Design of Novel STAT3 Inhibitors as Potent and Orally Bioavailable Anticancer Agents. 2012 American Chemical Society (ACS) Fall Meeting (Division of Medicinal Chemistry), 3/2012.
  5. Zhengduo Yang, Lili Chu, Shiming Jiang, Powel Brown, Shen Q. Identifying Activated Signal Pathways in Highly Metastatic Breast Cancer Cells. SCBA Texas Chapter Symposium, 5/2012.
  6. Lili Chu, Zhengduo Yang, Powel Brown, Shen Q. The AP-1 Transcription Factor Regulates Expression of E-cadherin in Metastatic Breast Cancer Cells. SCBA Texas Chapter Symposium, 5/2012.
  7. Zhengduo Yang, Haijun Chen, Lili Chu, Yusong Zhang, Chunyong Ding, Kristin Terry, Jia Zhou, Shen Q. Developing Novel STAT3 Inhibitors for the Treatment and Prevention of Cancer. 102nd Frontier of Cancer Prevention Research, AACR, 10/2012.
  8. Haijun Chen, Zhengduo Yang, Chunyong Ding, Lili Chu, Shen Q, Jia Zhou. Fragment-Based Drug Design of Novel STAT3 Inhibitors as Potent and Orally Bioavailable Anticancer Agents. 2012 American Chemical Society (ACS) Fall meeting (Division of Medicinal Chemistry), 2012.
  9. Yusong Zhang, Chunyong Ding, Zhengduo Yang, Haijun Chen, Lili Chu, Jia Zhou, Shen Q. Discovery of Potent Oridonin Derivatives for the Treatment of Breast Cancer. 2013 AACR Annual Meeting, 2013.
  10. Chunyong Ding, Yusong Zhang, Haijun Chen, Zhengduo Yang, Lili Chu, Christopher Wild, Mark A. White, Shen Q, Jia Zhou. Natural Product-Inspired Drug Discovery: Chemistry and Biology of Oridonin Analogs with Unique Scaffolds and Enhanced Anticancer Profiles. 2013 AACR Annual Meeting, 2013.
  11. Zhengduo Yang, Haijun Chen, Lili Chu, Yusong Zhang, Chunyong Ding, Huiling Liu, Jia Zhou, Shen Q. Novel Potent and Orally Active STAT3 Inhibitors for Cancer Therapies. 2013 AACR Annual Meeting, 2013.
  12. Ailian Xiong, Haijun Chen, Zhengduo Yang, Guoshuai Cai, Lili ang, Chunyong Ding, Grace Xu, Christopher Wild, Na Ye, Ivan Uray, Jia Zhou and Shen Q. Anticancer agent HJC0416 inhibits the growth of breast cancer xenografts via downregulating STAT3 signaling. 2014 105th AACR Annual Meeting, San Diego, 4/2014.
  13. Guoshuai Cai, Zhengduo Yang, and Shen Q. Networks Involved in the Metastic Phenotype of Highly Metastasis Variants of Breast Cancer Cells. SCBA-Texas Chapter 28th Annual Symposium Houston, 4/2014.
  14. Naimei Tang, Swapnajit Chakravarty, Hai Yan, Chun-Ju Yang, Yi Zou, Ray T. Chen and Shen Q. Photonic Crystal Microarray Sensing of Breast Cancer Cell Line Lysates. 2014 105th AACR Annual Meeting, San Diego, 4/2014.
  15. Ailian Xiong, Zhengduo Yang, Haijun Chen, Guoshuai Cai, Chunyong Ding, Lili Wang, Yingchao Zhang, Grace Xu, Christopher Wild, Jia Zhou, and Shen Q. Targeting Human Breast Cancer with Novel Potent and Orally Active STAT3 Inhibitors. SCBA-Texas 28th Annual Symposium Houston, 4/2014.
  16. Lili Wang, Zhengduo Yang, Qin Xia, Haijun Chen, Ailian Xiong, Guoshuai Cai, Yingchao Zhang, Chirstopher Wild, Jia Zhou, and Shen Q. The Role of STAT3 in Mediating Radiosensitivity in Breast Cancer Cells. SCBA-Texas Chapter 28th Annual Symposium Houston, 4/2014.
  17. Lili Wang, Zhengduo Yang, Qin Xia, Haijun Chen, Guoshuai Cai, Christopher Wild, Jia Zhou, andShen Q. Targeting STAT3 with Novel Small Molecule Inhibitors to Sensitive Breast Cancer Cells to Radiation Therapy. San Antonio Breast Cancer Symposium, 12/2014.
  18. Shen Q, Zhou J. Developing a New Class of Anti-Cancer Drugs for Breast Cancer Prevention and Treatment. 2015 SCBA 15th International Symposium, 6/2015.

 

 

 

 

 

Qiang Shen

Assistant Professor


  • :713-834-6357

    • DEPARTMENTDepartment of Clinical Cancer Prevention The University of Texas
      MD Anderson Cancer Center
    • COUNTRY USA