Publications

Cheng D, Vemulapalli V, Bedford. Methods applied to the study of protein arginine methylation. Methods Enzymol. 2012;512:71-92.

Castellano S, Spannhoff A, Milite C, Dal Piaz F, Cheng D, Tosco A, Viviano M, Yamani A, Cianciulli A, Sala M, Cura V, Cavarelli J, Novellino E, Mai A, Bedford MT, Sbardella G. Identification of small-molecule enhancers of arginine methylation catalyzed by coactivatorassociated arginine methyltransferase 1. J Med Chem. 2012 Nov 26;55(22):9875-90.

Cheng D*, Valente S, Castellano S, Sbardella G,. Bedford, MT* and Mai A*. Novel 3,5- Bis(bromohydroxybenzylidene)piperidin-4-ones as CARM1 Inhibitors: Enzyme Selectivity and Cellular Activity. J Med Chem. 2011 Jul 14;54(13):4928-32.

*Corresponding author
Cheng D and Bedford MT. Xenoestrogens Regulate the activity of Arginine Methyltransferases. Chembiochem. 2011 Jan 24;12(2):323-9. 5. Castellano S, Milite C, Ragno R, Simeoni S, Mai A, Limongelli V, Novellino E, Bauer I, Brosch G, Spannhoff A, Cheng D, Bedford MT, Sbardella G. Design, Synthesis and Biological Evaluation of Carboxy Analogues of Arginine Methyltransferase Inhibitor 1 (AMI-1). ChemMedChem. 2010 Mar 1;5(3):398-414.

Kim D, Lee J, Cheng D, Li j, Carter C, Richie E, Bedford MT. Enzymatic activity is required for CARM1’s in vivo functions. J Biol Chem. 2010 Jan 8;285(2):1147-52.

Mai A, Cheng D, Bedford MT, Valente S, Nebbioso A, Perrone A, Brosch G,  bardella G, De Bellis F, Miceli M, Altucci L. Epigenetic Multiple Ligands: Mixed Histone/Protein Methyltransferase, Acetyltransferase, and Class III Deacetylase (Sirtuin) Inhibitors. J Med Chem. 2008 Apr 10;51(7):2279-90.

Yadav N, Cheng D, Richard S, Morel M, Iyer VR, Aldaz CM, Bedford MT. CARM1 promotes adipocyte differentiation by coactivating PPARgamma. EMBO Rep. 2008 Feb;9(2):193-8. Iberg AN, Espejo A, Cheng D, Kim D, Michaud-Levesque J, Richard S, Bedford MT.Arginine methylation of the histone H3 tail impedes effector binding. J Biol Chem. 2008 Feb 8;283(6):3006-10. Sayegh J, Webb K, Cheng D, Bedford MT, Clarke SG. Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. J Biol Chem. 2007 ec
14;282(50):36444-53.

 Mai A, Valente S, Cheng D, Perrone A, Ragno R, Simeoni S, Sbardella G, Brosch G, Nebbioso A, Conte M, Altucci L, Bedford MT. Synthesis and Biological Validation of Novel Synthetic Histone/Protein Methyltransferase Inhibitors. ChemMedChem. 2007 Jul 9;2(7):987-991.
Swiercz R, Cheng D, Kim D, Bedford MT. Ribosomal protein rpS2 is  ypomethylated in PRMT3-deficient mice. J Biol Chem. 2007 Jun 8;282(23):16917-23.

Cheng D, Côté J, Shaaban S, Bedford MT. The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Mol Cell. 2007 Jan 12;25(1):71-83.

Naeem H, Cheng D, Zhao Q, Underhill C, Tini M, Bedford MT, Torchia J. The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol Cell Biol. 2007 Jan;27(1):120-34.

El Messaoudi S, Fabbrizio E, Rodriguez C, Chuchana P, Fauquier L, Cheng D, Theillet C, Vandel L, Bedford MT, Sardet C. Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene. Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13351-6.

Cheng D, Yadav N, King RW, Swanson MS, Weinstein EJ, Bedford MT. Small molecule regulators of protein arginine methyltransferases. The Journal of Biological Chemistry 279(23):23892-92004, 2004.

Cheng DH, Shen Q, Nan FJ, Qian Z, Ye QZ. Purification and characterization of catalytic domains of gelatinase A with or without fibronectin insert for inhibitor screening. Protein Expression and Purification 27(1):63-74, 2003.

Cheng DH, Shen Q, Qian J, Qian Z, Ye QZ. Expression, purification, and characterization of active catalytic domain of macrophage elastase for high-throughput screening. Acta Pharmacologica Sinica 23(2):143-51, 2002.

Xiong ZQ, Cheng DH, Tang XC. Effects of huperzine A on nuleus basalis magnocellularis lesion-induced spatial working memory deficit. Acta Pharmacologica Sinica 19: 128-132, 1998.

Cheng DH and Tang XC. Comparative studies of huperzine A, E2020, and tacrine on behaviour and cholinesterase activities. Pharmacology Biochemistry and Behavior 60: 377-386, 1998.

Cheng DH, Run H, Tang XC. Huperzine A, a novel promising cetylcholinesterase inhibitor. Neuroreport 8: 97-101,1996.


Li YF, Cheng DH, Ai L, Feng YS, Tao SY. Pharmacodynamics studies of Chinese medicine “Red Drug” spray. Liaoning Pharmacy and Clinical Remedies 2000; Vol.3 No.1.6-7.

BOOK CHAPTER

Lee J, Cheng DH, Bedford MT. “Techniques in Protein Methylation” in Signal Transduction Protocols. Methods in Molecular Biology. 284:195-208, 2004

ABSTRACT PRESENTATIONS

Cheng D and Bedford MT. PRMT6 Methylates H3R17 and Functions as a Transcriptional Coactivatior. Cancer Epigenetics. Keystone Symposia on Molecular and Cellular Biology, Santa Fe, 2014.

Cheng D and Bedford MT. PRMT6 Methylates H3R17 and Functions as a Transcriptional Coactivatior. Epigenetics, Chromatin&Transcription. Cold Spring Harbor Asia Conference, SuZhou, China, 2012.

Cheng D, Kim J, and Bedford MT. Characterizing CAS3, a prominent substrate for CARM1. FASEB Summer Research Conferences Biological Methylation, Carefree, Arizona 2010.

Cheng D, Mai A, and Bedford MT. Arginine Methyltransferases as Novel  herapeutic Targets. Keystone Symposia Molecular Basis for Chromatin Modifications and Epigenetic Phenomena. Snowmass, Colorado, 2008 (Selected for oral presentation)

Cheng D, Jocelyn Cote, Salam Shaaban, Bedford MT. The arginine   thyltransferase
CARM1 regulates the coupling of transcription and mRNA Processing. FASEB Summer Research Conferences Biological Methylation, Saxtons River, Vermont, 2006.

Cheng D, Yadav N, King RW, Swanson MS, Weinstein EJ, Bedford MT. Small molecule inhibitors of protein arginine methyltransferases. FASEB Summer Research Conferences Biological Methylation, Saxtons River, Vermont, 2004.

Cheng D, and Bedford MT. Small molecule inhibitors of protein arginine methyltransferases. Comparative Mouse Genomic Centers Consortium Symposium Cell Cycle and DNA Repair Variants. Expression Profiles and Pathway Analysis Section. Austin, 2004.

Cheng D, Yadav N , King RW, Swanson MS, Weinstein EJ, Bedford MT. Small molecule inhibitors of protein arginine methyltransferases. Lost Pines Conference 207, Smithville, 2003.

Cheng D and Bedford MT. Identifying Methylated proteins using small pool screening. Lost Pines Conference. 211, Smithville, 2002

Feng YS, Ai L, Li YF, Cheng DH. Influence of “DaHuangZheChong pill and capulae” on hemodynamic effects in rats. Chinese Cardiovascular Pharmacological Communication. 1991;9: 206 China.

Ai L, Feng YS, Li SB, Li YF, Cheng DH. Cardiovascular effects of “YiXinFuMai”. Chinese Cardiovascular Pharmacological Communication. 1991;9: 207 China.

 

D Donghang Cheng

Assistant Professor

 

  • : 512) 237-6602 ,
    Cell : (512) 924-5659
    Fax No.: (512) 237-2475
  • DEPARTMENTDepartment of Molecular Carcinogenesis
    University of Texas MD Anderson Cancer Center
  • COUNTRY USA