Publications

• Hartig JS, Najafi-Shoushtari SH, GrIne I, Yan A, Ellington AD, Famulok M. Protein-dependent ribozymes report molecular interactions in real time. Nature Biotechnology. 2002;20(7) :717-22.
• Hartig JS, GrIne I, Najafi-Shoushtari SH, Famulok M. Sequence-specific detection of microRNAs by signal-amplifying ribozymes. Journal of the American Chemical Society. 2004; 126(3): 722-3.
• Najafi-Shoushtari SH, Mayer G, Famulok M. Sensing complex regulatory networks by conformationally controlled hairpin ribozymes. Nucleic Acids Research. 2004;32(10):3212-9.
• Najafi-Shoushtari SH, Famulok M. Competitive regulation of modular allosteric aptazymes by a small molecule and oligonucleotide effector. RNA. 2005; 11(10): 1514-20.
• Najafi-Shoushtari SH, Famulok M. DNA aptamer-mediated regulation of the hairpin ribozyme by human a-thrombin. Blood Cells, Molecules, and Diseases. 2007;38(1):19-24.
• Najafi-Shoushtari SH, Malakooti J, Dudeja PK, Ramaswamy K. Thyroid Hormone Regulated Expression of Sodium/Hydrogen Exchanger Isoform-2 (NHE-2) in Human Colonic Cells. Gastroenterology 2007; 132:A576.
• Najafi-Shoushtari SH, Famulok M. Modular reporter hairpin ribozymes for analyzing molecular interactions. Methods in Molecular Biology. 2008;429 :237-50.
• Najafi-Shoushtari SH, Kristo F, Li Y, Shioda T, Cohen DE, Gerszten RE, Näär AM. MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science. 2010;328(5985) :1566-9.
• Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss 0, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM. Conserved role of SIRTi orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes and Development. 2010;24(13) :1403-17.
• Najafi-Shoushtari SH. MicroRNAs in cardiometabolic disease. Current Atherosclerosis Reports. oii; 13(3): 202-7.
• Näär AM, Walker AK, Yang FJ, Najafi-Shoushtari SH, Rottiers V, Kristo F, Li IX, Shioda T, Cohen DE, Gerszten RE .Conserved Gene Regulatory Mechanisms Controlling Cholesterol and Fat. FASEB Journal oii; 25.
• Mulligan P, Yang F, Di Stefano L, Ji JY, Ouyang J, Nishikawa JL, Toiber D, Kulkarni M, Wang Q, Najafi-Shoushtari SH, Mostoslavsky R, Gygi SP, Gill G, Dyson NJ, Näär AM. A SIRTi-LSDi corepressor complex regulates notch target gene expression and development. Molecular Cell. 2011;42(5):689-99.
• Rottiers V, Najafi-Shoushtari SH, Kristo F, Gurumurthy 5, Zhong L, Li Y, Cohen DE, Gerszten RE, Bardeesy N, Mostoslavsky R, Näär AM. MicroRNAs in Metabolism and Metabolic Diseases. Cold Spring Harb Symp Quant Biol. 2011 Dec 12.
• Rottiers V, Obad 5, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha 5, Goody RJ, Lawrence MS, deLemos AS, Hansen HF, Whittaker 5, Henry 5, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen 5, Näär AM, Pharmacological inhibition of a microRNA family in non-human primates by a seed-targeting 8-mer antimiR oligonucleotide. Science Translational Medicine. 2013, in press
• Abente, E & Najafi-Shoushtari SH, MicroRNAs in Obesity associated-disorders, invited review article, ABB 2014, in press
• Ramachandran V & Najafi-Shoushtari SH, How microRNAs intervene in metabolic regulations: from mechanisms to therapeutic modalities. Chemistry & Biology 2015, in press
  
  Meeting Presentations:
• J.S. Hartig, S.H. Najafi-Shoushtari, A. Yan, A.D. Ellington, M. Famulok: Real-time Tracing of Molecular Interactions by Reporter Ribozymes. 7th RNA Society Meeting, 2002, Madison, WT, USA.
• S.H. Najafi-Shoushtari, J.S. Hartig, M. Famulok: Detecting Protein-protein Interactions Using Novel Protein-Responsive Ribozymes. 7th RNA Society Meeting, 2002, Madison, WT, USA.
• M. Famulok, J.S. Hartig, S.H. Najafi-Shoushtari: Real-time Detection of Molecular Interactions Through Protein-responsive Ribozymes. EMBO Workshop on Ribozymes and RNA Catalysis, 2002, Dundee, UK.
• S.H. Najafi-Shoushtari: Modular Reporter Hairpin Ribozymes for Analyzing Molecular Interactions in Real-time. Frontiers of Gastrointestinal Research Seminars, 2006, Chicago, USA.
• S.H. Najafi-Shoushtari, S. H, et al.: Thyroid Hormone Regulated Expression of Sodium/Hydrogen Exchanger Isoform-2 (NHE-2) in Human Colonic Cells. Digestive Disease Week, 2007, Washington DC.
• A.W. Walker, F. Yang, K. Jiang, J.Y. Ji, S.H. Najafi-Shoushtari, J.K. Thakur, J. Xiao, R. Mostoslavsky, N.J. Dyson, P. Puigserver, A.C. Hart, A.M. Näär: Conserved Role for SIRTi Orthologues in Regulating Lipid Homeostasis During Fasting in Metazoans. SAC Meeting, 2009, Boston-USA.
• S. H. Najafi-Shoushtari: MicroRNA-33 Regulation of the Cholesterol Transport Pathway. Epigenetics and Disease Symposium, 2010, Boston-USA.
• S. H. Najafi-Shoushtari: Intronic MicroRNA-33 and SREBP host genes cooperate to control cholesterol homeostasis. Keystone Meeting: MicroRNAs and Human Disease, 2011, Banif-CANADA.
• Anders M. Näär, Veerle Rottiers, Susanna Obad, Robert McGarrah, Joshua C. Black, Robert J. Goody, Matthew S. Lawrence, Marie Lindholm, Andrew S. Delemos, S. Hani Najafi-Shoushtari, Raymond T. Chung, Johnathan R. Whetstine, Robert E. Gerszten, Sakari
  Kauppinen.. Therapeutic targeting of the cholesterol/lipid-regulating miR-33 microRNA family, REGULATORY & NON-CODING RNAs, Cold Spring Harbor Laboratories, 2012, New York-USA.