khue-vu-nguyen
Khue vu nguyen, PhD
Full Project Scientist in the Departments of Medicine and Pediatric
  • University of California
    California, USA
    Phone: (760) 481-4520
    E-mail: kvn006@ucsd.edu

Education

Degree Institution and Location Year
PhD Université Louis Pasteur, Strasbourg, France 1986
MS Université Louis Pasteur, Strasbourg, France 1980
BS Université Louis Pasteur, Strasbourg, France 1979

Biography

Dr. Khue Vu Nguyen (born in Ha Noi, Viet Nam) is currently Full Project Scientist in the Departments of Medicine and Pediatrics, University of California, San Diego, School of   Medicine, San Diego, California, U.S.A.  He has studied at University Louis Pasteur,   Strasbourg, France:  B.S. in Biochemistry, M.S. in Molecular Biology, Ph.D. in Macromolecular Physical Chemistry, Ph.D. in Physical Sciences (Doctorat d’Etat es Sciences Physiques).  He has worked as Scientist in different French and U.S. Research Institutions and Companies.  He is author and co-author of numerous publications and holder of many patents.  He is listed in Who’s Who in the World, Who’s Who in America, etc.  He is member of different academic organizations such as American Society for Microbiology, American Chemical Society. He is invited reviewer of different scientific journals such as Molecular Genetics and Metabolism,   AGE: Journal of the American Aging Association.  He is also editorial board member of different scientific journals such as International Journal of Medicine and Molecular Medicine, Open Journal of Endocrine and Metabolic Diseases.  He is Scientist Reviewer for grant proposals of the Metabolic Disease Two (MB-2) of the Peer Review Medical Research Program (PRMRP) for the U.S. Department of Defense Congressionally Directed Medical Research Programs (CDMRP).  Current research includes genetic diseases, neurodevelopmental and neurodegenerative disorders, and cancer.

Research Interest

  • Polymer chemistry
  • Cell culture
  • Physical chemistry
  • Molecular biology
  • Analytical chemistry
  • Genetics
  • Methods of enzymatic analysis

Scientific Activities

Full Project Scientist University of California, San Diego, CA (U.S.A.), School of Medicine, Departments of Medicine and Pediatrics, Biochemical Genetics and Metabolism, The Mitochondrial and Metabolic Disease Center 2013
Associate Project Scientist   University of California, San Diego, CA (U.S.A.), School of Medicine, Departments of Medicine and Pediatrics, Biochemical Genetics and Metabolism, The Mitochondrial and Metabolic Disease Center 2009 - 2013
Associate Project Scientist University of California, San Diego, CA (U.S.A.), School of Medicine, Departments of Medicine and Pediatrics, Biochemical Genetics and Metabolism, The Mitochondrial and Metabolic Disease Center 2009  - 2013
Visiting Research Scientist Biotechnology Center of Ho Chi Minh City, Viet Nam 2007
Visiting Research Professor University Training Center for Health Care Professionals (UTC) of Ho Chi Minh City, Viet Nam, Department of Biochemistry and Molecular Biology 2006
Research Scientist Vista Biologicals Corporation, Carlsbad, CA (U.S.A.) 2001 - 2008
Assistant Project Scientist  University of California, San Diego, CA (U.S.A.), School of Medicine, Department of Medicine, Biochemical Genetics and Metabolism, The Mitochondrial and Metabolic Disease Center 1999-2001
Research Scientist  Neurofit Company in Strasbourg, France 1998 - 1999
Research Scientist Anda Biologicals Company in Strasbourg, France 1987 - 1997
Post Doctoral Research Scientist  Université Louis Pasteur, Strasbourg, France, Institut de Bactériologie de la Faculté de Médecine de Strasbourg, France  (Grant award from the Faculté de Médecine de Strasbourg, Université Louis Pasteur, Strasbourg, France) 1986 - 1987
Fellow Preparation for the Ph.D. degree in Physical Sciences (Doctorat d’Etat es Sciences Physiques) – Université Louis Pasteur, Strasbourg, France, Ecole Européenne des Hautes Etudes des Industries Chimiques de Strasbourg, France (Grant award from ELF Aquitaine, France) 1983 - 1986
Fellow Preparation for the Ph.D. degree in Macromolecular Physical Chemistry –  Université Louis Pasteur, Strasbourg, France, Centre de Recherches sur les Macromolécules, Strasbourg, France (Grant award from the Direction Générale de la Recherche Scientifique et Technique, D.G.R.S.T., Université Louis Pasteur, Strasbourg, France) 1980 - 1983
Fellow Preparation for the M.S. degree in Molecular Biology – Université Louis Pasteur, Strasbourg, France, Centre de Neurochimie, Strasbourg, France  (Grant award for the 3eme cycle, Université Louis Pasteur, Strasbourg, France). 1979 -1980

Publications

  1. K.V. NGUYEN and J.C. GALIN, Anti-inflammatory polymer-bound steroids for topical applications I: Synthesis and characterization. Journal of Applied Polymer Science, 30, 2761-2778 (1985).
  2. K.V. NGUYEN and L. JUNG, Study of the retention of child-dose drugs on cellulose ester membranes during in-line intravenous filtration. Sciences Techniques et Pratiques Pharmaceutiques, 1, 201-207 (1985).
  3. K.V. NGUYEN, L. JUNG, G. COUPIN and P. POINDRON, Anti-inflammatory polymer-bound steroids for topical applications II: Controlled release of the steroids. Journal of Polymer Science: Polymer Chemistry Edition, 24, 359-373 (1986).
  4. B. RIHN, F. BISSERET, R. GIRARDOT, J.M. SCHEFTEL, K.V. NGUYEN and H. MONTEIL, Fast protein purification of Clostridium difficile cytotoxin. Journal of Chromatography, 428, 408-414 (1988).
  5. K.V. NGUYEN, C. HECKEL, F. BISSERET, B. RIBIN, R. GIRARDOT and H. MONTEIL, Enzyme-linked immunosorbent assay for detection of Clostridium difficile toxine B. Archives of Toxicology, Suppl. 12, 453-456 (1988).
  6. F. BISSERET, G. KEITH, B. RIHN, I. AMIRI, B. WERNEBURG, R. GIRARDOT, O. BALDACINI, G. GREEN, K.V. NGUYEN and H. MONTEIL, Clostridium difficile toxin B: Characterization and sequence of three peptides. Journal of Chromatography, 490, 91-100 (1989).
  7. K.V. NGUYEN, B. RIHN, C. HECKEL, F. BISSERET, R. GIRARDOT and H. MONTEIL, Enzyme immunoassay (ELISA) for detection of Clostridium difficile toxin B in specimens of faeces. Journal of Medical Microbiology, 31, 251-257 (1990).
  8. K.V. NGUYEN, C.M. WOLFF, J.L. SERIS and J.P. SCHWING, Study on a complete lyophilizate for rapid colorimetric enzymatic creatinine assay. Analysis, 18, 582-587 (1990).
  9. K.V. NGUYEN, C.M. WOLFF, J.L. SERIS and J.P. SCHWING, Immobilized enzyme electrode for creatinine determination in serum. Analytical Chemistry, 63, 611-614 (1991).
  10. K.V. NGUYEN and R.F. MAES, Evaluation of an enzyme-linked immunosorbent assay for detection of antibodies to bovine leukemia virus in serum and milk. Journal of Clinical Microbiology, 31, 979-981 (1993).
  11. K.V. NGUYEN, L.E. SABATIER, M. GOELDNER, C. BOUDIER, G. JAMET, J.M. WARTER and P. POINDRON, Stabilization of dry immobilized acetyl cholinesterase on micro titration plates for colorimetric determination of its inhibitors in water and biological fluids. Enzyme and Microbial Technology, 20, 18-23 (1997).
  12. K.V. NGUYEN, C.M. WOLFF, J.M. WARTER and P. POINDRON, Stabilization of dry immobilized acetyl cholinesterase on nitrocellulose membrane for rapid colorimetric screening of its inhibitors in water and biological fluids. Analytical Letters, 31, 2457-2473 (1998).
  13. K.V. NGUYEN, N. LECLERC, C.M. WOLFF, P. KENNEL, P. FONTENEAU, R. DEYES, J.M. WARTER and P. POINDRON Protection of immunoreactivity of dry immobilized proteins on microtitration plates in ELISA: Application for detection of autoantibodies in Myasthenia gravis. Journal of Biotechnology, 72, 115-125 (1999).
  14. K.V. NGUYEN, C.M. WOLFF, D. MEYER, P. POINDRON and J.M. WARTER Utilization of nucleotide probes for the measurement of specific messenger RNA: Application for molecular diagnosis of autosomal recessive spinal muscular atrophy. Analytical Letters, 35, 1135-1148 (2002).
  15. K.V. NGUYEN, J.L. GENDRAULT and C.M. WOLFF Poly-L-lysine dissolves fibrillar aggregation of the Alzheimer β-amyloid peptide in vitro. Biochemical and Biophysical Research Communications, 291, 764-768 (2002).
  16. C.M. WOLFF, K.V. NGUYEN and P. REMY Cloning and expression of the Surfeit locus member Surf-6 during embryogenesis in Xenopus laevis. DNA Sequence, 13, 149-152 (2002). The nucleotide sequence reported in this paper has been deposited in the GenBank data base under the accession number AJ276843.1.
  17. R.K. NAVIAUX and K.V. NGUYEN POLG mutations associated with Alpers syndrome and mitochondrial DNA depletion. Annals of Neurology, 55, 706-712 (2004).
  18. K.V. NGUYEN RT-PCR-based cloning of the human beta-amyloid precursor protein gene and the construction of its expression plasmids. Analytical Letters, 38, 71-88 (2005).
  19. K.V. NGUYEN RT-PCR-based cloning of human SMN, the SMA determining gene, and the construction of its expression plasmids. Analytical Letters, 38, 1351-1365 (2005).
  20. R.K. NAVIAUX and K.V. NGUYEN POLG mutations associated with Alpers syndrome and mitochodrial DNA depletion. Annals of Neurology, 58, 491 (2005).
  21. K.V. NGUYEN, E. OSTERGAARD, S.H. RAVN, T. BALSLEV, E.R. DANIELSEN, VARDAG, P.J. McKIERNAN, G. GRAY and R.K. NAVIAUX POLG mutations in Alpers syndrome. Neurology, 65, 1493-1495 (2005).
  22. K.V. NGUYEN Selection of peptide ligands specific for baculovirus DNA-binding protein from the FliTrxTM random peptide display library. Analytical Letters, 39, 99-112 (2006).
  23. K.V. NGUYEN, F. SHARIEF, S. S. L. CHAN, W.C. COPELAND and R.K. NAVIAUX Molecular diagnosis of Alpers syndrome. Journal of Hepatology, 45, 108-116 (2006).
  24. K.V. NGUYEN Utilization of nucleotide probes in ELISA procedure for the quantitative determination of baculovirus titer. Analytical Letters, 40, 513-528 (2007).
  25. K.V. NGUYEN Utilization of nucleotide probes in PCR-ELISA procedure for the quantitative determination of Plasmodium falciparum DNA in malaria. Analytical Letters, 40, 2045- 2065 (2007).
  26. K.V. NGUYEN Human p53 and Hdm2: Cloning and construction of expression plasmid. Analytical Letters, 43, 323-334 (2010).
  27. K.V. NGUYEN, R.K. NAVIAUX, S. PATRA, B.A. BARSHOP and W.L. NYHAN Novel mutations in the human MCCA and MCCB gene causing methylcrotonylglycinuria. Molecular Genetics and Metabolism, 102, 218-221 (2011).
  28. K.V. NGUYEN, R.K. NAVIAUX, K.K. PAIK and W.L. NYHAN Novel mutations in the human HPRT gene. Nucleosides, Nucleotides and Nucleic Acids, 30, 440-445 (2011).
  29. K.V. NGUYEN, R.K. NAVIAUX, K.K. PAIK and W.L. NYHAN Lesch-Nyhan syndrome: mRNA expression of HPRT in patients with enzyme proven deficiency of HPRT and normal HPRT coding region of the DNA Molecular Genetics and Metabolism, 106, 498-501 (2012).
  30. K.V. NGUYEN, R.K. NAVIAUX, K.K. PAIK, T. NAKAYAMA and W.L. NYHAN Lesch-Nyhan variant syndrome: real-time RT-PCR for mRNA quantification in variable presentation in three affected family members. Nucleosides, Nucleotides and Nucleic Acids, 31, 616-629 (2012).
  31. K.V. NGUYEN, R. NGUYEN and W.L. NYHAN The human folate receptor 1 gene: molecular diagnostic of folate deficiency. International Journal of Medicine and Molecular Medicine, 3(6):WMC003461 (2012).
  32. K.V. NGUYEN Antithrombin Hanoi: Arg 393 to His missense point mutation in antithrombin gene and cancer. International Journal of Medicine and Molecular Medicine, 3(9):WMC003720 (2012).
  33. K.V. NGUYEN and W.L. NYHAN Identification of novel mutations in the human HPRT gene. Nucleosides, Nucleotides and Nucleic Acids, 32, 155-160 (2013).
  34. R. FU, I.C. PICOT, R.J. TORRES, L.E. LAROVERE, Y. YAMADA, K.V. NGUYEN, M. HEGDE, J.E. VISSER, D.J. SCHRETLEN, W.L. NYHAN, J.G. PUIG, P.J. O’NEILL, H.A. JINNAH and for the Lesch-Nyhan Disease International Group. Genotype-phenotype correlations in neurogenetics: Lesch-Nyhan disease as a model disorder. Brain, 137, 1282-1303 (2014).
  35. K.V. NGUYEN Epigenetic regulation in amyloid precursor protein and the Lesch-Nyhan syndrome. Biochemical and Biophysical Research Communications, 446, 1091-1095 (2014).
  36. K.V. NGUYEN The human β-amyloid precursor protein: biomolecular and epigenetic aspects. Biomolecular Concepts, 6, 11-32 (2015).
  37. K.V. NGUYEN and W.L. NYHAN Lesch-Nyhan syndrome in a family with a deletion followed by an insertion within the HPRT1 gene. Nucleosides, Nucleotides and Nucleic Acids, 34, 442-447 (2015).
  38. K.V. NGUYEN Epigenetic regulation in amyloid precursor protein with genomic rearrangements and the Lesch-Nyhan syndrome. Nucleosides, Nucleotides and Nucleic Acids, 34, 674-690 (2015).
  39. K.V. NGUYEN and W.L. NYHAN Mutation in the human HPRT1 gene and the Lesch-Nyhan syndrome. Nucleosides, Nucleotides and Nucleic Acids, 35, 426-433 (2016).
  40. K.V. NGUYEN, R.K. NAVIAUX and W.L. NYHAN Human HPRT1 gene and the Lesch-Nyhan disease: substitution of alanine for glycine and inversely in the HGprt enzyme protein. Nucleosides, Nucleotides and Nucleic Acids, 36, 151-157 (2017).
  41. K.V. NGUYEN and W.L. NYHAN Quantification of various APP-mRNA isoforms and epistasis in Lesch-Nyhan disease. Neuroscience Letters, 643, 52-58 (2017).
  42. K.V. NGUYEN, K. LEYDIKER, R. WANG, J. ABDENUR and W.L. NYHAN A neurodevelopmental disorder with a nonsense mutation in the Ox-2 antigen domain of the amyloid precursor protein (APP) gene. Nucleosides, Nucleotides and Nucleic Acids, 36, 317-327 (2017).
  43. K.V. NGUYEN, S. SILVA, M. TRONCOSO, R.K. NAVIAUX and W.L. NYHAN Lesch-Nyhan disease in two families from Chiloe Island with mutations in the HPRT1 gene. Nucleosides, Nucleotides and Nucleic Acids, 36, 452-462 (2017).
  44. K.V. NGUYEN Epigenetics in rare diseases. Journal of Rare Disorders: Diagnosis & Therapy, 3:1 (2017).
  45. K.V. NGUYEN, R.K. NAVIAUX and W.L. NYHAN Novel mutation in the human HPRT1 gene and the Lesch-Nyhan disease. Nucleosides, Nucleotides anNucleic Acids (submitted).
  46. K.V. NGUYEN Epigenetics in rare diseases and the target for epigenetic therapy. Biomolecular Concepts (submitted).
     
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