Department of Neuroscience
University of Minnesota
|PhD– thesis title: Effects of estradiol on modulation of apoptotic signals in cerebral cortex and hippocampus of rats during chronic cerebral hypoperfusion; Faculty of Biology, University of Belgrade, Serbia||2010–2014|
|MSc– Molecular biology and physiology; Faculty of Biology, University of Belgrade, Serbia||2002–2010|
Milos received his Master of Science degree, in molecular biology and physiology from the University of Belgrade, Serbia in 2010. He then shifted his academic focus towards neuroscience and began his Ph.D. work in Vinca Institute for Nuclear Science, Serbia under supervision of Dr. Anica Horvat. The focus of his thesis was on the investigation of signaling pathways involved in chronic cerebral hypoperfusion, effects of female sex hormones and gender specific response to this mild type of brain ischemia. Milos was awarded his Ph.D. in 2014 and he continued his work in the Horvat Lab as a postdoc for a year. Further, he was involved in Swedish Match (Stockholm, Sweden) project under Dr. Robert Nilsson before he joined Institute for Translational Medicine, University of Minnesota, US in 2015 as Postdoctoral Associate. His current research focuses are on mechanisms of VEGF mediated neuroprotective properties of Unfolded Protein Response (UPR) signaling pathway activation in olygodendrocytes, as well as defining neuroprotective actions of GADD34 inhibitor drugs in EAE model of Multiple Sclerosis.
Unfolded protein response (UPR) is multi-component signal transduction pathway, which is largely cytoprotective, serving to decrease effects of accumulated unfolded proteins increasing the degradative capacity of the cell. However, if normal homeostasis is not restored during prolonged stress conditions, the UPR can induce apoptosis in these cells in order to protect the organism. My research interest focus on UPR components (ATF-6, PERK, GADD34) involvement in VEGF mediated oligodendrocyte-neuron crosstalk and neuroprotection.
|Coordinator of the workshop for popularization of science in Serbia “Vincine naucionice”, VINCA Institute of Nuclear Sciences, Laboratory of Molecular Biology and Endocrinology, University of Belgrade, Belgrade, Serbia||November 2014|
|Co-supervising undergraduate and graduate students in the laboratory, VINCA Institute of Nuclear Sciences, Laboratory of Molecular Biology and Endocrinology, University of Belgrade, Belgrade, Serbia||2012–2015 present|
|Coordinator of the workshop for popularization of science in Serbia “Vincine naucionice”, VINCA Institute of Nuclear Sciences, Laboratory of Molecular Biology and Endocrinology, University of Belgrade, Belgrade, Serbia||October 2012|
|IAESTE student exchange host, VINCA Institute of Nuclear Sciences, Laboratory of Molecular Biology and Endocrinology, University of Belgrade, Belgrade, Serbia||July– September 2012|
- Mitrović N, Zarić M, Drakulić D, Martinović J, Stanojlović M, Sévigny J, Horvat A, Nedeljković N, Grković I (2016) 17β-estradiol upregulates ecto-5’-nucleotidase (CD73) in hippocampal synaptosomes of female rats through action mediated by estrogen receptor-α and –β. Neuroscience doi:10.1016/j.neuroscience.2016.03.022
- Nilsson R, Mićić M, Filipović J, Šobot AV, Drakulić D, Stanojlović M, Joksiċ G (2016) Inhibition by blueberries (bilberries) and extract from milk thistle of rat forestomach hyperplasia induced by oral smokeless tobacco (Swedish snus). Regul Toxicol Pharmacol. 2016 Jan 28;76:94-101.doi:10.1016/j.yrtph.2016.01.017
- Stanojlovic M, Guševac I, Grkovic I, Mitrovic N, Zlatkovic J, M. Zaric Horvat A, Drakulic D (2015) Effects of chronic cerebral hypoperfusion and low-dose progesterone treatment on apoptotic processes, expression and subcellular localization of key elements within Akt and Erk signaling pathways in rat hippocampus.Neuroscience 311:308–321
- Stanojlovic M, Zlatkovic J, Gusevac I, Grkovic I, Mitrovic N, Zaric M, Horvat A, Drakulic D (2015) Repeated low-dose 17ß-estradiol treatment prevents activation of apoptotic signalling both in the synaptosomal and cellular fraction in rat prefrontal cortex following cerebral ischemia. Neurochemistry International. DOI: 10.1016/j.neuint.2015.03.002
- Drakulic D, Stanojlovic M, Nedeljkovic N, Grkovic I, Velickovic N, Guševac I, Mitrovic N, Buzadžic I, Horvat A (2014) Up-regulation of nucleoside triphosphate diphosphohydrolase-1 and ecto-5'-nucleotidase in rat hippocampus after repeated low-dose dexamethasone administration. Journal of molecular neuroscience 55:959-967
- Stanojlovic M, Gusevac I, Grkovic I, Mitrovic N, Horvat A, Drakulic D (2014) Time related sex differences in cerebral hypoperfusion induced brain. Archives of Biological Sciences 66:1673-1680
- Grkovic I, Bjelobaba I, Nedeljkovic N, Mitrovic N, Drakulic D, Stanojlovic M, Horvat A (2014) Developmental increase in ecto-5'-nucleotidase activity overlaps with appearance of two immunologically distinct enzyme isoforms in rat hippocampal synaptic plasma membranes. Journal of molecular neuroscience 54:109-118
- Stanojlovic M, Horvat A, Gusevac I, Grkovic I, Mitrovic N, Buzadzic I, Drakulic D (2014) Time course of cerebral hypoperfusion-induced neurodegenerative changes in the cortex of male and female rats. Folia biologica 60:123-132
- Drakulic D, Velickovic N, Stanojlovic M, Grkovic I, Mitrovic N, Lavrnja I, Horvat A (2013) Low-dose dexamethasone treatment promotes the pro-survival signalling pathway in the adult rat prefrontal cortex.
- Journal of neuroendocrinology 25:605-616 Petrovic S, Milosevic M, Drakulic D, Grkovic I, Stanojlovic M, Mitrovic N, Horvat A (2012) 17beta-estradiol modulates mitochondrial Ca(2)(+) flux in rat caudate nucleus and brain stem. Neuroscience 220:32-40
- Velickovic N, Drakulic D, Petrovic S, Grkovic I, Milosevic M, Stanojlovic M, Horvat A (2012) Time-course of hypothalamic-pituitary-adrenal axis activity and inflammation in juvenile rat brain after cranial irradiation. Cellular and molecular neurobiology 32:1175-1185
- Petrovic S, Velickovic N, Stanojevic I, Milosevic M, Drakulic D, Stanojlovic M, Horvat A (2011) Inhibition of mitochondrial Na+-dependent Ca(2)+ efflux by 17beta-estradiol in the rat hippocampus. Neuroscience 192:195-204