John R Tuttle
John R Tuttle
Orthopaedic Surgeon
  • :(401) 444-3581

Department of Orthopedic Surgery
Warren Alpert Medical School of Brown University


2006-2010 Case Western Reserve Medical School, Cleveland, Ohio, Doctorate of Medicine
2006-2010 Case Western Reserve Medical School, Cleveland, Ohio, Masters of Science in Anatomy, Dual Degree Program
2003-2006 The Ohio State University, Columbus, Ohio, Bachelor of Science with Honors and Distinction in Molecular Genetics
2002-2003 University of Tampa - Tampa, Florida, Transferred to Ohio State after first year for family reasons



He is an Orthopedic Surgeon at Brown University. I've done a good deal of research on Tranexamic Acid use in order to reduce the need for blood transfusion preoperatively.


Research Interest

Tranexamic acid cytotoxicity,Orthopaedics


Professional Activities:

2014 Kilfoyle Award Awarded by the New England Orthopedic Society“Tranexamic acid cytotoxicity on in vitro chondrocytes”
2014 The Michael G. Ehrlich Basic Science Research AwardAwarded by Brown University, Department of Orthopaedics“Tranexamic acid cytotoxicity on in vitro chondrocytes”
2008 Lepow Abstract Award, Awarded by Case Western Reserve University School of Medicine“Design and testing of a mast cell culture platform for STAT5 structure/function studies”
2003-2006 Honors Program, Ohio State University
2005 Arts and Sciences Research Scholarship, Ohio State University




  1. Tuttle JR, Feltman PR, Ritterman SA, Ehrlich MG. Tranexamic acid cytotoxicity on in vitro chondrocytes. Am J Orthop. 2015;44(12):E497-E502.
  2. Tuttle JR, Ritterman SA, Cassidy D, Anazonwu W, Rubin LE, Froehlich JA. Cost Benefit Analysis of Topical Tranexamic Acid in Primary Total Hip and Knee Arthroplasty. Journal of Arthroplasty. 2014 August; 29(8):1512–5.
  3. Tuttle JR, Ramos P, Dasilva M. Dual Camera Technique for Arthroscopic Rotator Cuff Repair. Arthroscopy Techniques, Vol. 3, Issue 6, e647–e651.
  4. Tuttle JR, Anazonwu W, Rubin LE. Subgroup Analysis of Topical Tranexamic Acid in Total Knee Arthroplasty. Reconstructive Review. 2014 July 1;4(2).
  5. Anazonwu W, Tuttle JR, Rubin LE. Subgroup Analysis of Topical Tranexamic Acid in Total Hip Arthroplasty. Reconstructive Review 2015 March 5:(1):13-17.
  6. Rubin LE, Tuttle JR, Ritterman SA. Simultaneous Bilateral Direct Anterior Total Hip Arthroplasty Utilizing a Modular Neck-Sparing Arthroplasty Femoral Stem.  Reconstructive Review. 2012 August; Vol 2 Num 2, 67-71.
  7. Maiti B, Li J, de Bruin A, Gordon F, Timmers C, Opavsky R, Patil K, Tuttle J, Cleghorn W, Leone G, A Leukemia and Lymphoma Society Scholar.Cloning and Characterization of Mouse E2F8, a Novel Mammalian E2F Family Member Capable of Blocking Cellular Proliferation. J. Biol. Chem. 2005 May;18:18211-20.
  8. Tuttle JR, Shalvoy RM. Displacement of the femoral component during closed reduction of a dislocated press-fit, bipolar hemiarthroplasty: Case report. Submitted to the Journal of Orthopedic Case Reports, 2015.
  9. Ritterman SA, Feltman PR, Tuttle JR, Rubin LE, Froehlich JA, Ehrlich ME. Glycosaminoglycan release from Cartilage Exposed to Tranexamic Acid. Orthopaedic Research Society Annual Meeting, New Orleans, 2014.


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