Publication

Research Articles

• Patel KK, Webley WC. Evidence of Infectious Asthma Phenotype: Chlamydia-Induced Allergy and Pathogen-Specific IgE in a Neonatal Mouse Model. PLoS One. 2013 Dec 20;8(12)
• Wilmore Webley. A fast-paced guide to the Chlamydiales. The Lancet Infectious Diseases, Volume 13, Issue 10, Page 842, October 2013. doi :10.1016/S1473-3099(13)70282-2
• Tawanna S. Childs and Wilmore C. Webley*. In-vitro Assessment of Halobacterial Gas Vesicles as a Chlamydia Vaccine Display and Delivery System. Vaccine. 2012 Sep 7;30(41):5942-8.
• Katir K. Patel§, Erica Anderson§, Paul S. Salva and Wilmore C. Webley*. The Prevalence and Identity of Chlamydia-Specific IgE in Children with Asthma and Other Chronic Respiratory Symptoms. Respiratory Research. 2012 Apr; 1 8;1 3 (1 ):32
• David L. Hahn MD MS, Allison Schure MS, Katir Patel MS, Tawanna Childs, Eduard Drizik MS, Wilmore Webley PhD. Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity. 2012 Apr; PLosOne. 7 (4): e35945.
• Wilmore C. Webley* and David L. Hahn. Chlamydia pneumoniae Resides Primarily in The Lower Airway. Eur Respir J. 2011 Oct;38 (4):994-5.
• Katir K. Patel§, Paul S. Salva and Wilmore C. Webley*. Colonization of Pediatric Lower Respiratory Tract with Genital Mycoplasma Species. Respirology. RES-1 0-463. 2011 Oct; 16 (7) 1081-7
• Katir K Patel§, Alf in G Vicencio, Zhongfang Du, Kalliope Tsirilakis, Paul S Salva and Wilmore C. Webley*. Infectious Chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthma. Pediatr Infect Dis J. 2010 Dec; 29 (12):1093-8.
• Wilmore C. Webley*, Yaphet Tilahun§, Kimberly Lay§, Katir Patel§, Elizabeth S. Stuart, Chester Andrzejewski, Paul S. Salva. Occurrence of Chlamydia trachomatis and Chlamydia pneumoniae in paediatric respiratory infections. The European respiratory journal, 2009. 33(2): p. 360-7.
• Wilmore Webley*, Elizabeth Stuart, Frances Cirino, Fran Cahill, Theresa Stec, Chester Andrzejewski. Successful Removal of Chlamydia pneumoniae from Plateletpheresis Products Collected Using Automated Leukoreduction Hemapheresis Techniques. J Clin Apher. 2006 Oct; 21 (3):1 95-201.
• Frances Cirino, Wilmore C. Webley, Chester Andrzejewski, Elizabeth S. Stuart. Detection of Chlamydia in the peripheral blood cells of normal donors by in vitro culture, immunofluorescence microscopy and flow cytometry techniques. BMC Infect Dis. 2006 Feb 10; 6:23.
• Webley WC*, Salva PS, Andrzejewski C, Cirino F, West CA, Tilahun Y§, Stuart ES., The Bronchial Lavage of Pediatric Patients With Asthma Contains Infectious Chlamydia. Am J Respir Crit Care Med. 2005. 171(1 0): p. 1083-8.
• Webley WC, Norkin LC, Stuart ES*. Caveolin-2 associates with intracellular chlamydial inclusions independently of caveolin-1. BMC Infect Dis. 2004. 4(1): 23
• W. C. Webley, G. J. Vora, E. S. Stuart*. Cell surface display of the chlamydial glycolipid exoantigen [G LXA] demonstrated by antibody-dependent complement-mediated cytotoxicity. Curr Micro biol. 2004; 49(1):1 3-21.
• Stuart, Webley, Norkin. Lipid Rafts, Caveolae, Caveolin-1, and Entry by Chlamydiae into Host Cells. Exp Cell Res. 2003. 287(1): 67-78.

Books

• Wilmore Webley. Biology of AIDS. 3 Edition (Paperback), Kendall Hunt Pub. Co. 2013. ISBN-978-1-4652-2838-3, 160 Pages. eBook edition ISBN-978-1 -4652-3596-1
• Wilmore Webley.        Biology of AIDS second Edition (Paperback), Kendall Hunt Pub. Co., 2008, ISBN: 978-0-7575-5531 -2, 91 pages
• Wilmore Webley. Biology of AIDS, 1st Edition; ISBN10: 0757540309 and ISBN13: 978075754030. Format: Paperback; Pub. Date: 1/30/2007; Publisher: Kendall Hunt Pub Co.

Peer Reviewed Conference Proceedings

• P. S. Salva, J. Salva§, K. K. Patel§, W. C. Webley*. Airway Colonization By Chlamydia Promotes The Release Of Th2 Cytokines In The BAL But Not Serum Of Asthmatic Patients. Am J Respir Crit Care Med, 183; 2011, A6204
• Dr. David Hahn, Mr. Katir Patel§, Mr. Eduard Drizik§, and Dr. Wilmore Webley*. Chlamydia pneumoniae (Cp)-specific IgE is associated with asthma severity. ERJ 2011; 850529.
• K. Patel§, P. Salva and W. Webley*. Increased Secretion Of Interleukin-5 (IL-5) And IL-13 In The Lungs Of Pediatric Patients Infected With Chlamydia Organisms. Am J Respir Crit Care Med 181; 2010: A3276
• Alfin G. Vicencio, M.D., K. Patel§, Ph.D., Z. Du, M.D., K. Tsirilakis, M.D., and W. C. Webley*, Ph.D. Increased IL-8 in Bronchoalveolar Lavage (BAL) Fluid from C. pneumoniae DNA-Positive Asthmatic Children. Am J Respir Crit Care Med 179; 2009 :A5986
• Katir Patel§, Paul S. Salva, Chester Andrzejewski, Wilmore C. Webley*. High Prevalence of Urogenital Mycoplasma in the Bronchial Lavage of Pediatric Respiratory Disease Patients. Chest. 2008 134: p138003.
• Wilmore C. Webley, PhD*, Kimberly Lay§, BSc, Elizabeth S. Stuart, PhD, Chester Andrzejewski, Jr., MD, PhD and Paul S. Salva, MD, PhD. Chronic Respiratory Disease in Children: The Prevalence of Chlamydia and Mycoplasma. CHEST. 2007. 132 (4): 607. October 24,.
• P.S. Salva, MD, PhD, Y. Tilahun§, MA, C. Andrzejewski, MD, PhD, E.S. Stuart, PhD, W.C. Webley, PhD*. Prevalence of Chlamydia pneumoniae and Chlamydia trachomatis in the Lungs of Children with Chronic Respiratory Disease. Am J Respir Crit Care Med 173; 2006: A285
• W. C. Webley*, F. Cirino, C. West, C. Andrzejewski, E. S. Stuart, P. S. Salva. Detection of Viable Chlamydophila pneumoniae Organisms in the Blood and Bronchial Lavages of Pediatric Patients with Chronic Bronchial Asthma. Am. J. Respir. Crit. Care Med. Apr 2004. 169(7): A586,
• W. Webley*, E. Stuart, F. Cirino, F. Cahill, T. Stec, C. Andrzejewski. Successful removal of Chlamydophila pneumoniae from blood by Apheresis leukoreduction. Journal of Clinical Apheresis. Jul 2003. 18(2).

Published Abstracts

• M. DiNardo, T. S. Childs, M. Geldart, D. Tovar, M. Nault, W. C. Webley. Gas Vesicle Displayed Chlamydia trachomatis antigens Elicit Protective T-cell and Antibody Responses in a Mouse Model. 1 4-A-21 1 2-GM-ASM. May 2014, Boston MA.
• K. Aldridge, P. S. Salva and W. C. Webley. Infectious Asthma Phenotype: The Association Between Respiratory Infections and Asthma in Children. 14-A-2060-GM-ASM. May 2014, Boston MA.
• W. C. Webley, K. K. Patel. Chlamydia Airway infection Induces Hepoxilin Release and Infiltration of Histamine-producing Neutrophils in a Mouse Model. 13-GM-A-1470-ASM. May 2013, Denver Colorado.
• S. Childs, W. C. Webley. Evaluation of Recombinant Gas Vesicles as Multisubunit-Fusion Protein Delivery Platforms. 13-GM-A-1473-ASM. May 2013, Denver Colorado.
• K. K. Patel, J. Lavoie, and W. C. Webley. Early-Life Respiratory Infections with Chlamydia Significantly Increases mRNA Expression of Histidine decarboxylase, IgE and its High - and Low - Affinity Receptors. 1 2-GM-A-3919-ASM. June 2012, San Francisco, CA.
• M. Calapai and W. C. Webley. Development and Evaluation of a Point-of-Care LAMP Assay for Detection of Animal Chlamydiosis. June 2012, San Francisco, CA
• T. S. Childs and W. C. Webley. In vitro Assessment of Innate Immune Responses to Gas Vesicle Delivery of a Chlamydia Vaccine . 1 2-GM-A-728-ASM. June 2012, San Francisco, CA.
• David Hahn, Katir Patel, Eduard Drizik, Wilmore Webley. Chlamydia pneumoniae (Cp)-specific IgE is associated with asthma severity. Eur Respir J 2011; 38: Suppl. 55, 458s. P2512. Amsterdam.
• E. Drizik, K. K. Patel, D. L. Hahn, W. C. Webley. C. pneumoniae-specificIgE is a strong Biomarker for Physician-diagnosed Severe Adult Asthma. 11-GM-A-3301-ASM. New Orleans, LA, May 2011
• K. K. Patel, J. E. Salva, P. S. Salva, W. C. Webley. Chlamydia-Specific Induction of Th2 Cytokines in the Lungs of Pediatric Respiratory Disease Patients. 11-GM-A-3331-ASM. New Orleans, LA, May 2011
• T. S. Childs, W. C. Webley. In Vitro Assessment of Chlamydial Antigen Display, Delivery and Processing by Halobacterial Gas Vesicles. New Orleans, LA, May 2011
• K. K. Patel, W. C. Webley. Evidence of Infectious Asthma Phenotype: Chlamydia-induced Allergy in a Neonatal Mouse Model. E-674; San Diego, CA, May 2010.
• L. Schure, K. K. Patel, D. L. Hahn, W. C. Webley. The Occurrence of Chlamydia-Specific IgE in Physician-diagnosed Asthma. D-1182; San Diego, CA, May 2010
• T. S. Childs, W. C. Webley. Recombinant Gas Vesicles Displaying Chlamydial Proteins are Recognized by Human Immune Sera; E-1234. San Diego, CA, May 2010
• M. C. Victor, C. Andrzejewski, W. Webley. Chlamydia Mediates Platelet Aggregation through Binding Platelet Surface Proteins: An Implication for Thromboembolic Diseases. D-066; Philadelphia, PA, May 2009.
• O. Lavoie, Jr., K. Patel, M. Calapai, W. C. Webley. Tissue Infiltration of Intranasal Chlamydia trachomatis Infection in a Mouse Model. B-171. Philadelphia, PA, May 2009
• K. Patel, J. O. Lavoie, Jr., W. C. Webley. Early Life Chlamydial Infection Modulates Allergic Airway Disease. B-176. Philadelphia, PA, May 2009
• T. S. Childs, W. Webley. Recombinant Gas Vesicles: A Novel Immunostimulatory Display and Delivery System for Chlamydial Antigens. E-064. Philadelphia, PA, May 2009
• E. S. Anderson, K. Patel, P. Silva, W. Webley. Association of Chlamydia-Specific IgE in the Serum and Bronchial Lavage of Asthmatic Patients. B-227. Philadelphia, PA, May 2009
• K. K. Patel, P. Salva, C. Andrzejewski, Jr., E. S. Stuart, W. C. Webley. Prevalence of Mycoplasma species in Pediatric Patients with Chronic Respiratory Disease. D-153; 08-GM-A-3464-ASM, Boston, May 2008.
• M. Victor, C. Andrzejewski, Jr., W. C. Webley. Chlamydia Induces Consumptive Platelet Aggregation in Vitro. D-137; 08-GM-A-3648-ASM, Boston, May 2008.
• G. I. Vladimer, D. V. Pollack, W. C. Webley, E. S. Stuart. Re-Arrangement of Host Cell Intermediate Filament Protein during Chlamydia Infection and Identification of Vimentin-Positive Low Molecular Weight Species by Western Blot. B-387, Boston, May 2008
• E. Clark, S. Purdy, W. Webley, E. Stuart. White Blood Cell Borne Chlamydial Prevalence among Alpaca, Sheep, and Goat Cohorts in Western Massachusetts. Z-006, Boston, May 2008
• K. K. Patel, C. Andrzejewski, Jr, W. C. Webley. Chlamydia Presence in Commercial Albumin Preparations. C-260; 08-GM-A-3496-ASM, Boston, May 2008
• J. Kelly, E.S. Stuart, C. Andrzejewski Jr, W.C. Webley. An Investigation into the Role of Chlamydia pneumoniae and Mannose Binding lectin in the Development of Severe Coronary Artery Disease. D-043. 06-GM-A-1976-ASM, Orlando FL, 2006
• C. Victor, E.S. Stuart, C. Andrzejewski Jr., W.C. Webley. The Putative Role of Chlamydia in Thrombotic Thrombocytopenic Purpura. D-041. 06-GM-A-1853-ASM, Orlando FL, 2006
• K. Lay, M. Bonet, Y. Tilahun, C. Andrzejewski Jr., E.S. Stuart, P.S. Salva, W. Webley. Increased Prevalence of Chlamydia in Pediatric Patients With Asthma. D-042. 06-GM-A-1856-ASM, Orlando FL, 2006
• L. Croteau, F. Cirino, W. C. Webley, C. Andrzejewski, E. S. Stuart. Presence of Immunoglobulin Co-associated with Chlamydial Inclusions in Various Cell Types in vitro and in vivo. D-085. 05-GM-A-1974-ASM, Atlanta GA, 2005
• Ramsdell, W. C. Webley. Isolating Protein-Protein Complexes in Geobacter sulfurreducens by Immunoprecipitation and MALDI-TOF Mass Spectrometry Techniques. I-01 1; 05-GM-A-3646-ASM, Atlanta GA, 2005
• N. Brown, S. J. Kelly, E. S. Stuart, C. Andrzejewski, Jr, W. C. Webley. Transplacental Chlamydial Passage: Prevalence and Species Specificity. D-013. 05-GM-A-1893-ASM, Atlanta GA, 2005
• Y. Tilahun, E. S. Stuart, P. Salva, C. Andrzejewski, Jr., W. C. Webley. C. trachomatis and C. pneumoniae Co-Infection in The Bronchial Lavages of Children with Chronic Respiratory Symptoms. D-086. 05-GM-A-1856-ASM, Atlanta GA, 2005
• Mauricia Victor, Chester Andrzejewski Jr, Wilmore Webley. Prevalence of Chlamydia in Thrombotic Thrombocytopenic Purpura: causal Effect or Innocent Bystander? D204, ABRCMS, Atlanta GA, 2005
• Cirino F, West C, Webley WC, Andrzejewski C, Stuart ES. Chlamydophila pneumoniae in Random Blood Samples from Different Age Groupings: Flow Cytometric and Blood Smear Analysis. V - 010 ASM, New Orleans LA, 2004
• Webley WC, Cirino F, West C, Andrzejewski C, Salva P, Stuart ES. Viable Chlamydophila pneumoniae Organisms in the Blood and Bronchial Lavages of a Respiratory Cohort of Pediatric Patients. D-1 74; 04-GM-A-1145-ASM. New Orleans, LA, 2004
• Cirino F, Webley WC, Andrzejewski, Jr C., Stuart ES. Antibody Sero-positivity and Carriage of Chlamydophila pneumoniae in Normal Blood Donors. 03-GM-A-2508-ASM, 2003
• Webley WC, Norkin LN, Stuart ES. Caveolin proteins in the intracellular developmental cycle of the Chlamydiae. 03-GM-A-3422-ASM, 2003
• Webley WC Norkin LN,. Stuart ES. Caveolae and Caveolin in the Entry of Chlamydia psittaci and Chlamydia pneumoniae into Host Cells. 02-GM-A-41 03-ASM, 2002
• Webley WC, Vora G.J., Actor JK, Stuart ES. GLXA in Chlamydial Infection Mediated Sequelae: Cytokine Responses and Classical Complement Activation. GM01 -A-31217-ASM, 2001

Invited Professional Talks

• Massachusetts Department of Public Health. William A. Hinton State Laboratory Institute, Jamaica Plain, Boston MA. “Evaluation of a Gas Vesicle Nanoparticle-based Chlamydia Vaccine: New Hope for The Future?” May 29th, 2014.
• American River Nutrition Inc. Hadley MA. “Mechanisms and Treatment of an Infectious Asthma Phenotype”. February 24th, 2014
• American River Nutrition Inc. Hadley MA. C. pneumoniae: A New Etiology for Non-Allergic Asthma. February 8th, 2014
• UMass Amherst. Commonwealth Honors College Lecture Series. “A Cure for Severe Asthma: New Hope for the Future”. October 1st, 2013 and February 10th, 2014.
• Alabama State University, Center for Nanobiotechnology and Life Sciences Research. “Development of a Novel, Multisubunit Platform for the Delivery of Chlamydia Vaccine Antigens”. April 4th, 2013.
• Chlamydia Basic Research Society Meeting, San Antonio, Texas. “From floatation to vaccination: Use of gas vesicles as a multisubunit platform for delivery of Chlamydia vaccine.” March 20th, 2013
• Selecta Biosciences Inc., Watertown, MA. “Use of Halobacteria Nanoparticles as a Chlamydia Vaccine Delivery System”. May 16th, 2012.
• UMass Amherst, MA; Assessment of Halobacterial Gas Vesicles as a Chlamydia Vaccine Delivery System. Junior Fellows seminar series. March 7th, 2012
• University Health Services, Amherst MA. “Why Have a Smoke Free Campus Policy?” February, 16th, 2012.
• Biosci Club, UMass Amherst. Chlamydial infections and Possible New Treatments for Hard to Control Asthma. November 30th, 2011.
• Elms College, Chicopee MA. “Design and Development of a Chlamydia Vaccine”. Dept. of Biology. February 24th, 2011 (Host. Nina Theis)
• Pioneer Valley Life Sciences Institute, Springfield MA. “Discovery of a Chlamydia-inducedInfectious Asthma Phenotype in Physician Diagnosed Asthma and a Neonatal Mouse Model”. July 14th, 2010 (Host: Sallie Schneider)
• University of Massachusetts Amherst, MA, "Infectious Asthma Phenotype: Evidence of Chronic, Chlamydia-inducedAirway Hyperresponsiveness." Dept. of Veterinary and Animal Sciences. May 24, 2010. (Host: Lisa Minter).
• University of Massachusetts Amherst MA. “The Role of Chlamydia in Asthma Initiation and Pathogenesis.” HHMI Junior Fellows Seminar. April 26th 2010.
• Smith College, Northampton MA, Title: "Early Life Chlamydia Respiratory Tract Infection and Asthma Pathogenesis: More than Mere Exacerbations." Dept. of Biological Sciences. October 26th, 2009
• Albert Einstein College of Medicine, NY, “Is Early Life Chlamydia Respiratory Infection Important in Asthma?” Division of Pediatric Pulmonology. April 20th, 2009. Symposium on Atypical infections and asthma pathogenesis.
• University of Massachusetts Amherst MA. Microbiology Retreat. “Blood, Sex, Drugs & Asthma: Chlamydia Keeps Bad Company”. February 2009.
• Loma Linda University, Loma Linda CA, “Innate Immunity and Toll-Like Receptors” Division of Microbiology and Molecular Genetics. April 4th, 2008
• Northern Caribbean University, Jamaica WI. “Tropism of Chlamydial Infections: What You Do Not Know
• Could Hurt You” Centennial Commemorative Public Lecture Series. November 19, 2007
• Northern Caribbean University, Jamaica WI. “Paediatric Infections and Asthma: A Growing Global
• Problem.” Centennial Commemorative Public Lecture Series. November 19, 2007
• Loma Linda University, Loma Linda, CA. “Chlamydia Infections: Expanding Tissue Tropism and Disease Associations” Division of Microbiology and Molecular Genetics, October 1 0th 2006
• University of Massachusetts Amherst, MA. “Chlamydial infections: Casting a wider net”. Microbiology Retreat, March 2004.
• Lake Tahoe, CA. “Successful removal of Chlamydophila pneumoniae from blood by Apheresis leukoreduction. Journal of Clinical Apheresis.” 24th Annual Meeting of the American Society for Apheresis – Plenary Speaker. May 2003