Selected Relevent Publications (from 600+ Peer-reviewed publications and 30+ patents, H-index 70)

  • Y.E.L. Koo, G.R. Reddy, M. Bhojani, R. Schneider, B.D. Ross, A. Rehemtulla, M.A. Philbert, and R. Kopelman, Brain Cancer Diagnosis and Therapy with Nano-platforms, Advanced Drug Delivery Reviews, 58,1556–1577 (2006). [Invited review] PMID: 17107738
  • G.R. Reddy, M.S. Bhojani, P. McConville, J. Moody, B.A. Moffat, D.E. Hall, G. Kim, Y.E. Koo, M.J. Woolliscroft, J.V. Sugai, T.D. Johnson, M.A. Philbert, R. Kopelman, A. Rehemtulla, and B.D. Ross, Vascular Targeted Nanoparticles for Imaging and Treatment of Brain Tumors, Clinical Cancer Research 12(22), 6677-6686 PMID: 17121886 (2006).
  • Y.E.L. Koo, R. Smith, and R. Kopelman, Nanoparticle PEBBLE Sensors in Live Cells and In Vivo, Annual Review of Analytical ChemistryVolume 2, edited by E. Yeung and R. Zare, pp. 57-76 PMID: 20098636 (2009). [Invited Review]
  • Y.E.L. Koo, D. Orringer and R. Kopelman, Nanoparticles for Cancer Diagnosis and Therapy, Royal Society of Chemistry book series, 333-353, (2010). [Book Chapter]
  • D.A. Orringer, T. Chen, D.L. Huang, W.M  Armstead, B.A. Hoff, Y.E.L. Koo, R.F. Keep, M.A. Philbert, R. Kopelman, O.Sagher, “The Brain Tumor Window Model: A Combined Cranial Window and Implanted Glioma Model for Evaluating Intraoperative Contrast Agents” Neurosurgery, 66 (4),   736-743 PMID: 20305495 (2010)
  • Y.E.L. Koo. and R. Kopelman, OptochemicalNanosensors, Handbook of Nanophysics, Edited by K.D. Sattler , Taylor & Francis Group, 33-1-33-16 (2011)
  • H.J. Hah, G. Kim, Y.E.K. Lee, D.A. Orringer, O. Sagher, M.A. Philbert, R. Kopelman, Methylene Blue-Conjugated Hydrogel Nanoparticles and Tumor-Cell Targeted Photodynamic Therapy, Macromolecular Bio Science11, p. 90-99 (2011) PMID: 20976722
  • Ray, X. Wang, Y.E. Koo Lee, H.J. Hah, G. Kim, T. Chen, D. Orringer, O. Sagher, X. Liu, R. Kopelman, Targeted blue nanoparticles as photoacoustic contrast agent for brain tumor delineation, Nano Research 4(11): 1163–1173, ISN:1998-0124(2011).
  • Ray, Y.E. Koo Lee, T. Epstein, G. Kim, and R. Kopelman, Two-Photon Nano-PEBBLE sensors: Subcellular pH Measurements, Analyst, 136 (18), 3616 – 3622, PMID: 21773602 (2011).
  • Y.E.K. Lee and R. Kopelman, Nanoparticle PEBBLE Sensors in Live Cells, editor: Michael Conn; Imaging and Spectroscopic Analysis of Living Cells MIE (Methods in Enzymology), UK: Academic Press, Vol. 504, Chapter 21, pp. 419-470 (2012).
  • Ray , Y.E. Koo Lee , G. Kim, R. Kopelman, Two-photon fluorescence imaging super-enhanced by multi-shell nanophotonic particles, with application to subcellular pH, Small, 8(14): 2213–2221, (2012).
  • Ray, J. Rajian, Y.E.K Lee, X. Wang, R. Kopelman, Lifetime based photoacoustic oxygen sensing in-vivo, JBO, 17(5): 057004, (2012). PMID: 22612143.
  • U. Avula, K. Gwangseong, YE.K. Lee, F. Morady, R. Kopelman, J. Kalifa, Cell-Specific Nanoplatform-Enabled Photodynamic Therapy for Cardiac Cells, HeartRhythm 9(9):1504-9. PMID 22579922 (2012).
  • Ray, X. Wang, R. Kopelman,SonophoricNanoprobe aided pH Measurement in vivo using Photoacoustic Spectroscopy, Analyst, 138 (11), 3126 – 3130.PMID: 23598348 (2013).
  • Overcoming Cancer Multidrug Resistance by Codelivery of Doxorubicin and Verapamil with Hydrogel Nanoparticles, M. Qin, Y.E.K. Lee, A. Ray and R. Kopelman, Macromolecular Bioscience(2014) PMID: 24771682


Raoul Kopelman

Professor of Biomedical Engineering and Chemical Biology
The University of Michigan
Ann Arbor, Michigan, USA 
Phone: (734) 764-7541