Publications

Important Contributions to National Nanotechnology Policy Recommendations and Plans

  1. D. Akin and S.S. Gambhir. Theranostics. Cancer Nanotechnology Plan 2010. National Cancer Institute, NIH. This landmark plan outlines the next 10-year national goals and milestones for the use of nanotechnology in cancer.
  2. C. A. Mirkin, A. Nel, C. S. Thaxton, B.A. Baird, C. Batt, D. Grainger, S.S.Gambhir, D. Akin, O. Zhou, J.F. Stoddart, T.J. Meade, P. Grodzinski, D. Farrell, H.F. Tibbals, J. De Simone. Chapter 7: Nanobiosystems, Medicine and Health. In: Nanotechnology Research Directions for Societal Needs in 2020. M.C. Roco, C.A. Mirkin and M.C. Hersham eds. NSF WTEC Report, Springer 2010, Berlin and Boston. This important publication lays the groundwork for phase 2 of the U.S. National Nanotechnology Initiative, outlining the visions for the next 5 and 10 years, assesses the needs and offers recommendations for the use of nanotechnology in biology and medicine.
  3. S.S. Gambhir and D. Akin. Early-to-Late Stage Cancer Diagnostics. Cancer Nanotechnology Plan 2015. US, National Cancer Institute, NIH. This landmark plan outlines the next 10-year national goals and milestones for the use of nanotechnology in cancer.

Journal Articles

  1. Goldberg, M.S., S.S. Hook, A. Z. Wang,  J.W.M. Bulte, A.K. Patri, F.M. Uckun, V. L. Cryns, J. Hanes, D. Akin, J.B. Hall, N. Gharkholo and R.J. Mumper. BiotargetedNanomedicines for Cancer: Six Tenets Before You Begin. Nanomedicine, 8:299-308, 2013.
  2. Fu, A., Wilson, R.J., Smith, B., Akin, D., Guccione, S., Gambhir, S.S., and  Wang, S.X. Highly Fluorescent Magnetic Nanoprobes for Magnetically Enhanced Cancer Targeting, Imaging and Therapy ACS Nano 6:6862-6869, 2012.
  3. Akin, D and S.S. Gambhir. Mouse models of Cancer. NCI Cancer Bulletin. National Cancer Institute, 2010.
  4. Park, K. H.J. Suk, D. Akin and R. Bashir. Dielectrophoresis-based cell manipulation using electrodes on reusable printed circuit board. Lab on Chip 9:2224-2229, 2009. (Back cover image of the same issue of the journal).
  5. Moon, J.M., D. Akin , Y. Xuan , P.DYe ., P. Guo, and R. Bashir. Capture and alignment of phi29 viral particles in sub-40 nanometer porous alumina membranes.  Biomedical Microdevices 11:135-42, 2009.
  6. Bhattacharya, S., S. Salamat, D. Morisette, P. Banada, D. Akin, Y.S. Liu, A.K. Bhunia, M. Ladisch and R. Bashir. PCR-based detection in a micro-fabricated platform. Lab on Chip, 8:1130–1136, 2008.
  7. Lee, J., J. Jang, D. Akin, C.A. Savran, and R. Bashir. Real-time detection of air-borne viruses on a mass-sensitive device. Applied Physics Letters 93:013901-4, 2008.
  8. Jang, J., D. Akin, R. Bashir. Effects of inlet/outlet configurations on the electrostatic capture of airborne nanoparticles and viruses. Measurement Science and Technology, 19:065204-065212, 2008.
  9. Akin, D., J. Sturgis, K. Ragheb, D. Sherman, K. Burkholder, J. P. Robinson,  A. K. Bhunia, S. Mohammed and R. Bashir.  Bacteria-mediated delivery of nanoparticles and cargo into cancer cells. Nature Nanotechnology, 2:441-449, 2007. (This article was also highlighted by Nature Nanotechnology in the same issue as well as numerous other scientific news sites).
  10. Iqbal, S., D. Akin and R. Bashir. Solid State Nanopores with DNA Selectivity.  Nature Nanotechnology, 2:243-248, 2007.
  11. Choi, M.R., Stanton-Maxey, K.J., Stanley, J.K., Levin, C.S., Bardhan, R., D. Akin, Badve, S., Sturgis, J., Robinson, J.P., Bashi,r R., Halas, N.J., Clare, S.E. A Cellular Trojan Horse for Delivery of Therapeutic Nanoparticles into Tumors. Nano Letters, 7:3759-3765, 2007.
  12. Bajaj, P., D. Akin, A. Gupta, O. Auciello and R.Bashir.  Ultrananocrystalline diamond film as an optimal cell interface for biomedical applications. Biomedical Microdevices, 9:787-794, 2007.
  13. Park, K., D. Akin and R. Bashir. Electrical capture and lysis of vaccinia virus particles using silicon nano-scale probe array. Biomedical Microdevices, 19:787-794, 2007.
  14. Jang, J., D. Akin, K.S. Lim, S. Broyles, M.R. Ladisch and R. Bashir. Capture of airborne nanoparticles in swirling flows using non-uniform electrostatic fields for bio-sensor applications. Sensors and Actuators 121:560-566, 2007.
  15. Bhattacharya, S., J. Jang, L. Yang, D. Akin, and R. Bashir. Biomems and Nanotechnology based approaches for rapid detection of biological entities. J. Rapid Methods & Automation in Microbiology, 15:1-32, 2007.
  16. Gupta, A., P.R. Nair, D. Akin, M, Ladisch, S. Broyles, M. A. Alam and R. Bashir.  Anomalous resonance in a nanomechanicalbioSensor.Proc. Natl. Acad. Sci., USA, 103:13362-13367, 2006.
  17. Johnson, L., A. Gupta, D. Akin, A. Ghafoor, R. Bashir. Characterization of vaccinia virus particles using microscale silicon cantilever resonators and atomic force microscopySensors and Actuators, 115:189-197, 2006.
  18. Ghafoor, A.*, D. Akin*, R. Bashir. Delocalization of vaccinia virus components observed by Atomic Force and Fluorescence Microscopy.  NanoBiotechnology, 4:337-346, 2005.
  19. Akin, D., K. Ragheb, J. Sturgis, A.K. Bhunia, J.P. Robinson and R. Bashir. Bacterial delivery of smart nanoparticles-loaded with therapeutic molecules into cancer cells. Nanomedicine 1:250, 2005.
  20. Li, H., Y. Zheng, D. Akin, and R. Bashir.  Characterization and modeling of a microfluidic dielectrophoresis filter for biological species.  J. MicroElectroMechanical Systems 143:103-112, 2005.
  21. Akin, D., H. Li and R. Bashir.  Real-time virus trapping and fluorescent imaging in micro-fluidic devices.  Nano Letters 4:257-259, 2004.
  22. Gupta, A., D. Akin and R. Bashir.  Detection of bacterial cells and antibodies using surface micromachined thin silicon cantilever resonators.  J. Vacuum Sci. & Tech. B: Microelectronics and Nanometer Structures. 22:2785-2791, 2004. (Also selected to appear in Virtual Journal of Biological Physics Research, December 1, 2004 http://www.vjbio.org)
  23. Gupta, A., D. Akin, and R. Bashir.  Single virus particle mass detection using microresonators with nanoscale thickness.  Applied Physics Letters 84, 1976-1978, 2004. (Also selected to appear in Virtual Journal of Nanoscale Science & Technology, March 22, 2004. http://www.vjnano.org.)
  24. Chang, W.J., D. Akin, R. Bashir.  Poly(dimethylsiloxane) (PDMS) and silicon hybrid biochip for bacterial culture.  Biomedical Microdevices, 5:281-290, 2003.
  25. Elibol, O.H., D. Morisette, D. Akin, J. P. Denton, and R. Bashir.  Integrated nanoscale silicon sensors using top-down fabrication.  Applied Physics Letters 83, 4613, 2003. (Also selected to appear in Virtual Journal of Biological Physics Research, December 1, 2003. http://www.vjbio.org.)
  26. Gupta, A., D. Akin, and R. Bashir.  Resonant mass biosensor for ultrasensitive detection of bacterial cells.  Microfluidics, BioMEMS, and Medical Microsystems, Holger Becker, Peter Woias, Editors, In: Proc. SPIE Int. Soc. Opt. Eng. 4982, January 2003, pp. 21-27.
  27. Huang, T., W.J. Chang, D. Akin, R. Gomez, R. Bashir, N. Mosier and M.R. Ladisch.  Microfiber assisted fabrication of microfluidic channles using Poly(dimethylsiloxane). American Institute for Chemical Engineers (AIChE) Journal, 49:2984-2987, 2003.
  28. Huang, T., T. Geng, D. Akin, W.J. Chang, J. Sturgis, R. Bashir, A.K. Bhunia, J.P. Robinson, and M.R. Ladisch. Microassembly of functionalized particulate monolayer on C18 derivitized SiO2 surfaces.  Biotechnology and Bioengineering 83:416-427, 2003.
  29. Huang, T., W.J. Chang, D. Akin, R. Gomez, R. Bashir, N. Mosier and M.R. Ladisch. Fabrication of microfluidic channels using microfiber with Poly(Dimethylsiloxane), AICHE Journal, 49: 2984-2987, 2003.
  30. Akin, D., C.C. Wu, and T.L. Lin.  Analysis of sequence of nucleocapsid gene reveals genetic recombination between infectious bronchitis virus and turkey coronavirus. ActaVirologica, 45:31-38, 2001.  
  31. Akin, D., C.C. Wu, and T.L. Lin.  A ribozyme targeted to RNA polymerase gene of infectious bursal disease virus effectively cleaves and inhibits expression of the viral gene product. ActaVirologica, 43:341-347, 1999. 
  32. Akin, D., C.C. Wu, and T.L. Lin.  Amplification and cloning of complete infectious bursal disease virus genomic RNA segments by a long and accurate PCR. Jornal of Virological  Methods, 82:55-61, 1999. 
  33. Akin, D., Review: Spotfire-Pro 4.0.HMS Beagle, issue 58, July 1999.
  34. Akin, D., Wu, C.C. and Lin, T.L.  A comparison of two RNA isolation methods for double-stranded RNA of infectious bursal disease virus. Journal of Virological  Methods, 74:179-84, 1998. 
  35. Wu, C.C., Lin, T.L. and Akin, D.  Quantitative competitive polymerase chain reaction for detection and quantification of infectious bursal disease virus cDNA and RNA.  Journal of Virological  Methods, 66:29-33, 1997. 
  36. Akin, D., C.C. Wu, T.L. Lin and R.W.  Keirs.  Chemiluminescent detection of infectious bursal disease virus with a PCR-generated digoxigenin-labeled probe.  Journal of Veterinary Diagnostic Investigations. 5:166-173, 1993.

Papers Highlighted as Frontier Research

  • Nature. Tiny scales weigh virus, February 11, 2004.  Single virus particle mass detection using microresonators with nanoscale thickness, published in Applied Physics Letters 84, 1976 (2004).http://www.nature.com
  • Virtual Journal of Biological Physics Research, December 1, 2004.  Detection of bacterial cells and antibodies using surface micromachined thin silicon cantilever resonators, published in Journal of Vacuum Science & Technology B 22, 2785 (2004).http://www.vjbio.org.
  • Virtual Journal of Nanoscale Science & Technology, March 22, 2004.  Single virus particle mass detection using microresonators with nanoscale thickness, published in Applied Physics Letters 84, 1976 (2004).http://www.vjnano.org.
  • Virtual Journal of Biological Physics Research, December 1, 2003. Integrated nanoscale silicon sensors using top-down fabrication, published in Applied Physics Letters 83, 4613 (2003).http://www.vjbio.org.
  • Microresonator-based Biosensors. Leading Edge Research Supported By National Institutes of Biomedical Imaging and Biological Engineering (NIBIB).

Selected Conference Papers

  1. D. Akin. Cancer Nanotechnology for Cancer Early Detection and Therapy Response Monitoring. Nanotech 2012, NSTI, Santa Clara, CA, June 18-21, 2012.
  2. D. Akin, S.X. Wang, H. Dai, D. Agus, S. Hanash, P. Mallick, M. McIntosh, J. Rao, A. Wu, R. Sinclair, M. Tang, S.S. Gambhir. Translational Nanomedicine: Current Status and the Recent Advances in Early Detection of Cancer and of Response to Therapy. Functionalized Nanobiomaterials for Medical Applications. Materials Research Society Meeting, October 4-7, 2010, Denver, Colorado.
  3. Iqbal, S.M., B.M. Venkatesan, D. Akin, R. Bashir. Biochemistry in the Nanopores. American Physical Society, 2008 APS March Meeting, UCLA, March 10-14, 2008.
  4. Bashir, R. D. Akin and L. Yang. BioMEMS and Bionanotechnology: Interfacing Life Sciences and Engineering at the Micro and Nanoscale 210th Electrochemical Society Meeting, October 29, 2006, Cancun, Mexico. (Invited)
  5. Davila, A., A. Gupta, D. Akin, T. Walter, A. Aronson and R. Bashir. Spore detection in air and fluid using microcantilever sensors. Proceedings of the Materials Research Society, Fall 2005, Boston.
  6. Li, H., L. Yang, D. Akin, T. Geng, A. Bhunia, T. T. Huang, M. Ladisch, R. Bashir Dielectrophoresis and antibody-mediated selective capture of microorganisms in micro-fluidic biochips. Transducers-2005, Seoul, Korea, June 5-9, 2005.
  7. Gupta, A. D. Akin and R. Bashir.  Airborne virus particle detection using nanomechanical resonators with integrated dielectrophoresis concentration electrodes.  Hilton Head, 2004.
  8. Gupta, A., D. Akin and R. Bashir.  Mechanical effects of attaching protein layers on nanoscale-thick cantilever beams for resonant detection of virus particles.  IEEE-MEMS 2005.
  9. R. Bashir, D. Akin, R. Gómez, H. Li, W-J. Chang, A. Gupta.  From BioMEMS to Bionanotechnology: Integrated BioChips for the Detection of Cells and Microorganisms. Proceedings of the MRS Spring Meeting, San Francisco, CA. April 22, 2003.
  10. Bashir, R. and D. Akin.  From BioMEMS to Bionanotechnology: Integrated BioChips for the Detection of Cells and Microorganisms.  Proc. Mat. Res. Soc. 773:911.-914, 2003.
  11. Elibol, O. H., D. Morisette, D. Akin, and R. Bashir.  Integrated nanoelectronic sensor.  CHI, BioMEMS, 2003.
  12. R. Bashir, R. Gómez, H. Li, D. Akin, A. Gupta, Interfacing Micro/NanoTechnology with Life-Sciences for Detection of Cells and Microorganisms, Bipolar / BiCMOS Circuits and Technology Meeting, September 28-30, 2003, Toulouse, France. (Invited)
  13. Gupta, A. D. Akin and R. Bashir.  Thin single-crystal silicon cantilever beam based gravimetric biosensor for detection of bacterial cells. Eighth Annual Micromachining &Microfabrication Symposium, San Jose, CA, January 25-31, 2003.
  14. Gómez, R., T. Geng, T. Huang, D. Akin, A. Bhunia, M. Ladisch and R. Bashir.  Microfluidic BioChips for the electronic detection of microorganisms. Eighth Annual Micromachining &Microfabrication Symposium, San Jose, CA, January 25-31, 2003.
  15. Gupta, A., D. Akin, R. Bashir.  Resonant Mass Biosensor For Ultrasensitive Detection Of Bacterial Cells.  Microfluidics, BioMEMS, And Medical Microsystems Conference At Spie’s Photonics West Micromachining And Microfabrication 2003 Symposium, San Jose, CA Jan. 27th 2003.
  16. Huang, T. T., T. Geng, D. Akin, W. Chang, J. Sturgis, R. Bashir, A. K. Bhunia, J. P. Robinson, and M. R. Ladisch, Biomediated Assembly of Functionalized Microbeads for Capture of Microorganisms, BIOT Division Paper 97, 225th ACS National Meeting, Section: Novel Bioanalyses Using Lab-on-a-Chip Technologies, New Orleans, March 24, 2003.
  17. McNally, H. A., H. Kufluoglu, D. Akin, J. Grimmer, J. Walker, R. Shi, R. Borgens, and R. Bashir A chemical sensor using neurons and a 3-d micro-fluidic chip.  The Materials Research Society (MRS) 2002 Meeting Boston, MA, December 2-6, 2002.

 

Demir Akin, DVM, PhD

Deputy Director, Center for Cancer Nanotechnology Excellence
School of Medicine, Stanford University
Stanford, California, USA 
Phone: (650) 721-2016 
E-mail: demir.akin@stanford.edu