Publications

Report of Scholarship

Research Investigations

Peer-reviewed publications in print

  1. Weaver, C., Burgess, S., Nelson, P., Wilkinson, M., Ryan, P., Nail, C., Kelly Quagliana, K., May, M., Reeves, R. K., Boyle, C., and Coats, K. S.  2005.  Placental immunopathology and reproductive failure in the FIV-infected cat.  Placenta 26(2-3): 138-147.
  2. Reeves, R. K. and Fultz, P. N.  2007.  Disparate effects of acute and chronic infection with SIVmac239 versus SHIV-89.6P on macaque plasmacytoid dendritic cells. Virology 365(2):356-368.
  3. Reeves, R. K. and Fultz, P. N. 2008. Characterization of plasmacytoid dendritic cells in bone marrow of pig-tailed macaques.  Clin. Vaccine Immunol. 15(1):35-41.
  4. Reeves, R. K., Gillis, J., Wong, F. E., and Johnson, R. P.  2009. SIVmac239Δnef activates CD4+ T cells in the absence of CD4+ T cell loss.  J. Med. Primatol.  38(S1):8-16.
  5. Reeves, R. K., Wei, Q., Stallworth, J., and Fultz, P. N. 2009. Systemic dendritic cell mobilization associated with administration of FLT3-ligand to SIV/SHIV-infected macaques. AIDS Res. Hum. Retroviruses.  25(12):1313-1328. Reeves, R. K., Wei, Q., and Fultz, P. N. 2010. Mobilization of CD34+ progenitor cells in association with decreased proliferation in bone marrow of macaques after FLT3-L administration. Clin. Vaccine Immunol.  17(8):1269-1273.
  6. Reeves, R. K., Evans, T. I., Gillis, J., and Johnson, R. P.  2010. SIV infection induces an expansion of α4β7+ and cytotoxic CD56+ NK cells.  J. Virol. 84(17):8959-8963.
  7. Reeves, R. K., Gillis, J., Wong, F. E., Yu, Y., Connole, M., and Johnson, R. P.  2010. CD16— natural killer cells: Enrichment in mucosal and secondary lymphoid tissues and altered function during chronic SIV infection.  Blood. 115(22):4439-4446. **Highlighted in Faculty of 1000
  8. Salisch, N.C., Kaufmann, D. E., Awad, A.S., Reeves, R. K., Tighe, D., Li, Y., Piatak, M., Lifson, J.D., Evans, D.T., Pereyra, F., Freeman, G. J., and R. P. Johnson.  2010. Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1.  J. Immunol. 184(1):476-487.
  9. Reeves, R. K., Evans, T. I., Gillis, J., Wong, F. E., Connole, M., Carville, A. and Johnson, R. P.
    10. 2011. Quantification of mucosal mononuclear cells with a fluorescent bead-based polychromatic flow cytometry assay. J. Immunol. Methods. 367(1-2):95-98.
  10. Reeves, R. K., Evans, T. I., Fultz, P.N., and Johnson, R. P.  2011. Potential confusion of contaminating CD16+ mDCs with anergic CD16+ NK cells in chimpanzees. Eur. J. Immunol. 41(4):1070-1074.
  11. Reeves, R. K., Rajakumar, P., Evans, T. I., Connole, M., Gillis, J., Wong, F. E., Kuzmichev, Y. V., Carville, A. and Johnson, R. P.  2011. Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44+ mucosal NK cells during SIV infection. Blood.
    12. 118(12): 3321-3330.
  12. Moreland, A. J., Guethlein, L. A., Reeves, R. K., Broman, K. W., Johnson, R. P., Parham, P., O’Connor, D. H., and Bimber, B. N. 2011. Characterization of killer immunoglobulin-like receptor genetics and comprehensive genotyping by pyrosequencing in rhesus macaques. BMC Genomics. 12(1):295.
  13. Colantonio, A. D., Bimber, B. N., Neidermeyer Jr., W. J., Reeves, R. K., Alter, G., Altfeld, M., Johnson, R. P., Carrington, M., O’Connor, D. H., and Evans, D. T. 2011. KIR3DL polymorphisms modulate peptide-dependent binding to an MHC class I ligand with a Bw6 motif. PLoS Path. 7(3): e1001316.
  14. Fofana, I. B. F., Colantonio, A. D., Reeves, R. K., Connole, M. A., Gillis, J. M., Hall, L. R., Sato, S., Evans, D. T., Johnson, R. P., and Johnson, W. E. 2011. Identification of SIV gp140-binding B Cells from rhesus macaque peripheral blood. J. Immunol. Methods. 370(1-2):75-85.
  15. Reeves, R. K., Evans, T. I., Gillis, J., Wong, F. E., Kang, G., Li, Q., and Johnson, R. P. 2012. SIV infection induces increased trafficking of plasmacytoid dendritic cells to the gut mucosa. Journal of Infect. Dis. 206(9):1462-1468.  **Cover article    **Highlighted in Faculty of 1000
  16. Alpert, M. D., Harvey, J. D., Lauer, W. A., MacKenzie, E., Reeves, R. K., Piatak, M., Carville, Mansfield, K. G., Lifson, J. D., Li, W., Desrosiers, R. C., Johnson, R. P., and Evans, D. T. 2012. Antibody-dependent cell-mediated cytotoxicity develops over time during persistent infection with live-attenuated SIV and correlates with protection against pathogenic SIV infection. PLoS Path. 8(8): e1002890.
  17. Li, H., Gillis, J., and Reeves, R. K. 2013. Multifunctional plasmacytoid dendritic cells redistribute to gut tissues during SIV infection. Immunology. 140(2):244-249. **Highlighted in MDLinx
  18. Carville, A., Evans, T. I., and Reeves, R. K. 2013. Characterization of circulating natural killer cells in neotropical primates. PLoS One. 8(11):e78793  **Highlighted in Faculty of 1000
  19. Evans, T. I. and Reeves, R. K. 2013.  all-trans-retinoic acid imprints expression of the gut-homing marker α4β7 while suppressing lymph node-homing of dendritic cells. Clin. Vaccine
    20. Immunol.  20(10):1642-1646.
  20. Li, H., Evans, T. I., and Reeves R. K.  2013. Loss of bone marrow NK cells during SIV infection is associated with increased turnover rates and cytotoxicity but not changes in trafficking. J. Med. Primatol.  42(5):230-236.
  21. Li, H. and Reeves, R. K. 2013. Functional perturbation of classical natural killer and innate lymphoid cells in the oral mucosa during SIV infection. Front. Immunol. 3:417. doi: 10.3389/fimmu.2012.00417
  22. Song, H., Josleyn, N., Janosko, K., Skinner, J., Reeves, R. K., Cohen, M., Johnson, R., Jett, C., Blaney, J. E., Bollinger, L., Jennings, G. and Jahrling, P. B.  2013. Monkeypox virus infection of rhesus macaques induces massive expansion of natural killer cells but suppresses natural killer cell functions. PLoS One. 8(10):e77804
  23. Sasikala-Appukuttan, A. K., Kim, H. O., Kinzel N. J., Hong, J. J., Smith, A. J., Wagstaff, R., Reilly, C., Piatak, M., Lifson, J. D., Reeves, R. K., Johnson R. P., Haase, A. T., and Skinner, P. J. 2013. Location and dyanmics of the immunodominant CD8 T cell response to SIVΔnef immunization and SIVmac251 vaginal challenge. PLoS One 8(12):e81623.
  24. Shang, L., Smith, A., Duan, L., Perkey, K. E., Lucy, Q. Wietgrefe, S., Zupanic, M., Southern, P. J., Reeves, R. K., Johnson, R. P., and Haase, A. T. 2014. NK cell responses to SIV vaginal exposure in naïve and vaccinated rhesus macaques. J. Immunol.  193(1):277-84
  25. Li, Q., Duan, S., Zeng, M., Shang, L., Smith, A., Wietgrefe, S., Southern, P. J., Reilly, C. S., Pambuccian, S., Skinner, P. J., Zupancic, M., Piatak, M., Waterman, D., Reeves, R. K., Lifson, J. D., Johnson, R. P., and Haase, A. T. 2014. Vaccine-induced antibody concentrated at the mucosal border correlates with limited local and systemic SIV infection. J. Immunol.  193(6):3113-25
  26. Li, H., Goepfert, P., and Reeves, R. K. 2014. pDCs from HIV-1 Elite Controllers maintain a gut- homing phenotype associated with immune activation. In press at AIDS Research and Human Retroviruses
  27. George, M. D., Hu, W., Billingsley, J. M., Reeves, R. K., Sankaran-Walters, S., Johnson, R. P., and Dandekar, S. 2014. Transcriptional profiling of peripheral CD8+ T cell responses to SIVΔnef and SIVmac251 challenge reveals a potential link between protective immunity and induction of systemic regulatory mechanisms.   Virology.   468-470C:581-591.

Submitted or in Revision

  1. Li, H., Evans, T. I., Gillis, J., Reeves, R. K. 2014. Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection. In Revision at PLoS Pathogens
  2. Li, Q., Duan, S., Wietgrefe, S., Piatak, M., Li, Y., Lifson, J., Reeves, R. K., Johnson, R. P., and Haase, A. T. 2014. Attenuating effects of restricted SIVΔnef replication in T follicular helper cells and potential mechanisms of protection by live attenuated virus vaccination. Submitted to Journal of Virology
  3. Reeves, R. K., Li, H., Jost, S., Blass, E., Li, H., Eslamizar, L., Altfeld, M., von Andrian, U. H., and Barouch, D. H. 2014. Antigen-specific NK cell memory in rhesus macaques.  In Revision at Nature.
  4. Adnan, S., Colantonio, A. D., Yu, Y., Gillis, J., Wong, F. E., Becker, E. A., Piatak, M., Reeves, R. K., Lifson, J. D., O’Connor, S. L., and R. P. Johnson.  2014. CD8+ T cell response maturation defined by anentropic specificity and repertoire depth correlates with protection in SIVΔnef-vaccinated animals. Submitted to PLoS Pathogens
  5. Billingsley, J. M., Rajakumar, P. A., Connole, M. A., Salisch, N. C., Kuzmichev, Y. V., Hong, H. S., Reeves, R. K., Kang, H.-J, Li, W., Haase, A. T., and Johnson, R. P. 2014. Characterization of CD8+ T cell differentiation following SIVΔnef vaccination by transcription factor expression profiling. Submitted to PLoS Pathogens.
  6. Li, H., Evans, T. I., Gillis, J., Connole, M., and Reeves, R. K. 2014. Bone marrow-imprinted gut- homing of pDCs in acute SIV infection results in massive accumulation of hyperfunctional CD4+ pDCs in the mucosae.  Submitted to Journal of Infectious Diseases.
  7. Reeves, R. K., Kang, G., Li, H., and Li, Q. Depletion of lamina propria innate lymphoid cells in SIV infection.  Submitted to AIDS Research and Human Retroviruses.

Reviews, editorials, and commentaries

  1. Hong, H., Rajakumar, P., Billingsley, J. M., Reeves, R. K., and Johnson, R. P. 2013.  No monkey business: Why studying NK cells in nonhuman primates pays off.  Front. Immunol. 4:32. doi: 10.3389/fimmu.2013.00032.
  2. Reeves, R. K. 2014. Mechanisms, consequences, and treatment of chronic inflammation in HIV disease. J. Antivir. Antiretrovir. 6:2. e117.
  3. Manickam, C. and Reeves, R. K. 2014. Virology and Immunology of GBV-B Infection: Modeling HCV in Small Primates.  Submitted to Frontiers in Virology.

Published abstracts

  1. Reeves, R. K. and Fultz, P. N. 2005. Progressive loss of plasmacytoid and natural killer cells during SIV/SHIV infection of macaques.  J. Med. Primatol. 34 (5-6): 313-358. Abstract #97.
  2. Reeves, R. K. and Fultz, P. N.  2006. Plasmacytoid dendritic cell dynamics during acute and chronic SIV/SHIV infection of macaques.  J. Med. Primatol. 35 (4-5): 270-320. Abstract #51.
  3. Reeves, R. K. and Fultz, P. N. 2007. Depletion and restoration of plasmacytoid dendritic cells in multiple tissues by FLT3-ligand treatment during SIV infection.  J. Med. Primatol. 36: 285-333. Abstract #76.
  4. Reeves, R. K., R. C. Desrosiers, J. D. Lifson, M. Piatak, and R. P. Johnson. 2009. Rapid induction of protection against homologous challenge by SIVmac239Δnef.  AIDS Res. Hum. Retroviruses. 24(s1): 1-175.  Abstract OA02-05.
  5. Salisch, N. C., R. K. Reeves, J. Gillis, Y. Yu, F. E. Wong, A. Carville, M. Piatak, J. Lifson, A. Haase, and R. P. Johnson. 2009. Maturation of SIV-specific CD8+ T cells after vaccination with SIVΔnef. J. Med. Primatol.  38 (S1): 8-16. 2008.  Abstract #27.
  6. Reeves, R. K., J. Gillis, F. E. Wong, Y. Yu, A. Carville, L. Giavedoni, A. Haase, and R. P. Johnson.
    7. 2009. Modulation of natural killer cells by SIVΔnef.  J. Med. Primatol.  38 (S1): 8-16. Abstract #60.
  7. Reeves, R. K. and R. P. Johnson. 2010. Natural killer cell heterogeneity in the mucosae and secondary lymphoid tissues of SIV-infected rhesus macaques.  Muc. Immunol. 2 (S1): Abstract T- 106.
  8. Li, Y., J. Schmitz, M. de la Rosa, N. Letvin, R. P. Johnson, N. Salisch, R. K. Reeves, R. C. Desrosiers, J. D. Lifson, and M. Piatak.  2010.  Independent quantification of SIVmac239Δnef and unmodified challenge viruses in dual-infected macaques. J. Med. Primatol. 39 (4): 267-301. Abstract
    9. #48.
  9. Reeves, R. K., J. Gillis, F. E. Wong, Y. Yu, M. Piatak, J. Lifson, and R. P. Johnson.  2010.
    10. Evolution of SIVmac239Δnef-induced protection against vaginal challenge is associated with maturation of CD8+ T cell response. J. Med. Primatol. 39 (4): 267-301. Abstract # 13.
  10. Fofana, I. B. F., A. D. Colantonio, R. K. Reeves, M. A. Connole, J. M. Gillis, L. R. Hall, S. Sato, D. T. Evans, R. P. Johnson, and W. E. Johnson.  2011. Identification of SIV gp140-binding B cells from rhesus macaque peripheral blood. J. Med. Primatol. 40 (4): 282. Abstract #106.
  11. Colantonio, A. D., B. N. Bimber, W. J. Neidermeyer, R. K. Reeves, G. Alter, M. Altfeld, R. P. Johnson, M. Carrington, D. H. O’Connor and D. T. Evans. 2011.  KIR polymorphisms modulate peptide-specific binding to a common MHC class I molecule in the rhesus macaque. J. Med. Primatol. 40 (4): 257. Abstract #26.
  12. Reeves, R. K., J. Gillis, T. I. Evans and R. P. Johnson.  2011.  Chronic SIV infection induces an expansion of gut-homing and cytotoxic NK cells. J. Med. Primatol. 40 (4): 251-252. Abstract # 10.
  13. Alpert, M. D., J. D. Harvey, W. A. Lauer, R. K. Reeves, M. Piatak, A. Carville, K. G. Mansfield, J. D. Lifson, W. Li, R. C. Desrosiers, R. P. Johnson, and D. T. Evans. 2012. Antibody-dependent cell- mediated cytotoxicity (ADCC) is a correlate of protection by live-attenuated SIV. AIDS Res. Hum. Retroviruses. 27(10): A-1-A-148.  Abstract P19.27.
  14. Billingsley, J. M., P. A. Rajakumar, N. C. Salisch, Y. V. Kuzmichev, M. A. Connole, R. K. Reeves  and R. Johnson. 2012. Differential expression of transcription factors in SIV-specific CD8+ T cells at week 5 and week 20 after vaccination with SIV239Δnef.  AIDS Res. Hum. Retroviruses. 27(10): A-1- A-148.  Abstract P03.01.
  15. Reeves, R. K., T. Evans, J. Gillis, M. Connole, F. Wong, Y. Yu, and R. Johnson. 2012. SIVΔnef vaccination mobilizes systemic and mucosal natural killer cells in A*01+ macaques. Retrovirology. 9 (S2):OA03.01.
  16. H. Li, T. Evans, J. Gillis, and R. K. Reeves. 2012. Chronic SIV infection induces differentiation and accumulation of cytotoxic CD16+ NK cells in lymph nodes followed by transmigration to the mucosae. Retrovirology. 9 (S2):P07.11.
  17. Billingsley, J. M., P. A. Rajakumar, N. C. Salisch, Y. V. Kuzmichev, H. S. Hong, M. A. Connole, R. K. Reeves, H. Kang, W. Li, and R. P. Johnson. 2012. Maturation of protective immunity induced by SIVΔnef correlates with differential expression of the transcription factors in SIV-specific CD8+ T cells. Retrovirology. 9 (S2):P02.10.
  18. Billingsley, J. M., P. A. Rajakumar, N. C. Salisch, Y. V. Kuzmichev, M. A. Connole, H. S. Hong, R. K. Reeves and R. P. Johnson. 2012. Highly-parallel real time qRT-PCR analysis of transcription factor expression in SIV-specific CD8+ T cells at week 5 and week 20 after vaccination with SIVmac239Δnef. J. Med. Primatol. Abstract #8.
  19. Reeves, R. K., P. Rajakumar, T. I. Evans, M. Connole, J. Gillis, F. E. Wong, Y. Kuzmichev, and R. Johnson. 2012. Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and induce cytoxicity in RORγt NKp44+ mucosal NK cells during SIV infection. J. Med. Primatol. Abstract #21.
  20. Alpert, M. D., J. D. Harvey, W. A. Lauer, R. K. Reeves, M. Piatak, Jr., A. Carville, K. G. Mansfield, J.
    21. D. Lifson, W. Li, R. C. Desrosiers, R. P. Johnson, and D. T. Evans. 2012. Antibody-dependent cell- mediated cytotoxicity develops over time during persistent infection with live-attenuated SIV and correlates with protection against SIVmac251. J. Med. Primatol. Abstract #39.
  21. Reeves, R. K., P. Rajakumar, T. I. Evans, M. Connole, J. Gillis, Y. Kuzmichev, and R. Johnson.
    22. 012. Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and induce cytoxicity in RORγt NKp44+ mucosal NK cells during SIV infection.  AIDS Res. Hum. Retroviruses. 27(10): A- 1-A-148.  Abstract OA11.02.
  22. Zeng, M., L. Duan, Q. Li, A. Smith, S. Wietgrefe, P. J. Southern, C. S. Reilly, S. Pambuccian, L. Shang, P. J. Skinner, M. Zupancic, M. Piatak, Jr., D. Waterman, R. K. Reeves, J. D. Lifson, P. Johnson, and A. T. Haase.  2012. SIV attenuated vaccine-induced plasma cells and antibodies limit infection at the portal of entry and systemically following vaginal challenge. AIDS Res. Hum. Retroviruses. 27(10): A-1-A-148.   Abstract OA11.06.
  23. Johnson, and A. T. Haase. 2012. SIV attenuated vaccine-induced plasma cells and antibodies limit infection at the portal of entry and systemically following vaginal challenge. AIDS Res. Hum. Retroviruses. 27(10): A-1-A-148.   Abstract OA11.06LB.
  24. Li, H., T. I. Evans, R. K. Reeves. 2013. Gut-homing of plasmacytoid dendritic cells persists in the absence of HIV/SIV replication and contributes to residual chronic immune activation. AIDS Res. Hum. Retroviruses. 29(11): Abstract OA08.01.
  25. Li, H., T. I. Evans, M. Connole, J. Gillis, F. E. Wong, Y. Yu, R. K. Reeves. 2013. Acute SIV infection induces hypercytotoxicity and massive numerical loss of innate lymphoid cells in the gastrointestinal tract. AIDS Res. Hum. Retroviruses. 29(11): Abstract P02.3LB.
  26. Li, H., T. I. Evans, J. Gillis, R. P. Johnson, R. K. Reeves. 2013.  Loss and aberrant function of NKp44+ ILCs in the SIV-infected gut are associated with RORγt suppression. J. Med. Primatol. 42 (4): 254-285. Abstract # 23.
  27. Li, H., T. I. Evans, J. Gillis, Q. Li, R. K. Reeves. 2013.  Polyfunctional plasmacytoid dendritic cells redistribute to gut tissues during SIV infection. J. Med. Primatol. 42 (4): 254-285. Abstract # 27.

Book Chapters

  1. R. Keith Reeves and Steven Bosinger. 2014.  Innate Immunity in SIV infection.  Natural Hosts of SIV: Implications in AIDS. Elsevier Publishing.

Thesis

  1. Pathogenesis and therapeutic potential of plasmacytoid dendritic cells in SIV/SHIV-infected macaques. © 2007, R. K. Reeves. University of Alabama at Birmingham

Abstracts, Poster Presentations And Exhibits Presented At Professional Meetings

Oral Abstract Presentations

Oct. 2008

AIDS Vaccine 2008, Cape Town, South Africa
Rapid Induction of Protection Against Homologous Challenge by SIVΔnef
Feb. 2009

17th  Annual Conference on Retroviruses and Opportunistic Infections, Montreal, CAN SIVΔnef Vaccination Systemically Mobilizes Natural Killer Cells
Oct. 2009

27th Annual Symposium on Nonhuman Primate Models for AIDS, Boston, MA Evolution of SIVΔnef-induced Protection Against Vaginal Challenge is Associated with Maturation of CD8+  T Cell Responses
Jun. 2010

10th  Annual Harvard University CFAR Symposium, Harvard Medical School, Boston, MA Chronic SIV Infection Induces an Expansion of Gut-homing and Cytotoxic NK Cells
Sep. 2010

Natural Killer Cells in Veterinary Species Symposia, Cavtat, Croatia Phenotypic and Functional Heterogeneity of NK Cell Subsets in Primates
Oct. 2010

28th Annual Symposium on Nonhuman Primate Models for AIDS, New Orleans, LA
Chronic SIV Infection Induces an Expansion of Gut-homing and Cytotoxic NK Cells
Feb. 2011

18th  Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA
SIV infection Induces Increased Trafficking of pDCs to the Gut Mucosa
Sep. 2011

AIDS Vaccine 2011, Bangkok, Thailand
Gut Inflammation and Indoleamine Deoxygenase Inhibit IL-17 Production and Induce Cytotoxicity in RORγt+ NKp44+ Mucosal NK Cells During SIV Infection
Oct. 2011

29th  Annual Symposium on Nonhuman Primate Models for AIDS, Seattle, WA
Gut Inflammation and Indoleamine deoxygenase Inhibit IL-17 Production and Induce Cytotoxicity in RORγt+ NKp44+ Mucosal NK Cells During SIV Infection
Sep. 2012

AIDS Vaccine 2012, Boston, MA
SIVΔnef vaccination mobilizes systemic and mucosal natural killer cells in A*01+ macaques
Oct. 2012

30th Annual Symposium on Nonhuman Primate Models for AIDS, San Antonio, TX
Polyfunctional plasmacytoid dendritic cells redistribute to gut tissues during SIV infection
Oct. 2012 30th Annual Symposium on Nonhuman Primate Models for AIDS, San Antonio, TX Loss and aberrant function of NKp44+ ILCs in the SIV-infected gut are associated with RORγt suppression
Oct. 2013

AIDS Vaccine 2013, Barcelona, Spain
Gut-homing of plasmacytoid dendritic cells persists in the absence of HIV/SIV replication and contributes to residual chronic immune activation
Feb. 2014

15th  International Conference on Lymphocyte Activation and Immune Regulation: Innate Lymphoid Cells, Irvine, CA
Acute loss and dysfunction of NKp44+ILCs in the SIV-infected gut are associated with RORγt suppression
Mar. 2014

21st Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA Rapid gut-homing of plasmacytoid dendritic cells during acute SIV infection
Oct. 2014

HIV Research for Prevention 2014, Cape Town, South Africa
SIV- and vaccine-elicited NK cell memory in rhesus macaques

Poster Abstract Presentations

Nov. 2004 22nd  Annual Symposium on Nonhuman Primate Models for AIDS, San Antonio, TX Progressive Loss of Plasmacytoid and Natural Killer cells During SIV/SHIV Infection of Macaques
Sep. 2005 23rd  Annual Symposium on Nonhuman Primate Models for AIDS, Portland, OR Plasmacytoid Dendritic Cell Dynamics During Acute and Chronic SIV/SHIV Infection of Macaques
Oct. 2006

24th Annual Symposium on Nonhuman Primate Models for AIDS, Atlanta, GA  Depletion and Restoration of Plasmacytoid Dendritic Cells in Multiple Tissues by FLT3- ligand Treatment During SIV Infection
May 2007

107th  General Meeting of the American Society for Microbiology, Toronto, CAN
Mobilization of Plasmacytoid Dendritic Cells During FLT3-Ligand Treatment of SIV/SHIV- Infected Macaques
Dec. 2008

26th Annual Symposium on Nonhuman Primate Models for AIDS, San Juan, Puerto Rico
Modulation of Natural Killer Cells by SIVΔnef
Mar. 2009

Prevention of HIV/AIDS – Keystone Symposia, Keystone, CO
Modulation of Circulating and Mucosal NK Cells by SIVΔnef vaccination
Jul. 2009

14th  International Congress of Mucosal Immunology (ICMI 2009), Boston, MA
NK Cell Heterogeneity in the Mucosae and Secondary Lymphoid Tissues of SIV-infected Macaques
Sep. 2010

NK2010, 12th Meeting for the Society for Natural Immunity, Cavtat, Croatia
Chronic SIV Infection Induces an Expansion of Gut-homing and Cytotoxic NK Cells
Oct. 2010

CHAVI Annual Retreat, Durham, NC
Chronic SIV Infection Induces an Expansion of Gut-homing and Cytotoxic NK Cells
Feb. 2011

18th  Annual Conference on Retroviruses and Opportunistic Infections, Boston, MA Depletion and Dysfunction of IL-17/IL-22-producing Mucosal NKp44+  NK cells During SIV Infection
Mar. 2011 HIV Evolution, Genomics and Pathogenesis – Keystone Symposia, Whistler, BC Depletion and Dysfunction of IL-17/IL-22-producing NKp44+  NK Cells During Chronic SIV Infection is Mediated by Gut Inflammation
Mar. 2012 19th Annual Conference on Retroviruses and Opportunistic Infections, Seattle, WA SIVΔnef Vaccination Mobilizes Systemic and Mucosal Natural Killer Cells in Mamu A*01+  Macaques
Feb. 2013

20th  Annual Conference on Retroviruses and Opportunistic Infections, Atlanta, GA Polyfunctional Plasmacytoid Dendritic Cells Redistribute to Gut Tissues During SIV infection
Feb. 2013 20th  Annual Conference on Retroviruses and Opportunistic Infections, Atlanta, GA Loss and aberrant function of NKp44+ Innate Lymphoid Cells in the SIV+ gut are associated with RORgammat suppression.

 

 

R. Keith Reeves

Assistant Professor

:(713) 348-2759

  • DEPARTMENTCenter for Virology/Vaccine Research
    Harvard Medical School
    Harvard University
  • COUNTRYUSA