1. Li Z, Abdullah CS, Jin ZQ. Inhibition of protein kinase C-theta preserves cardiac function and reduces fibrosis in streptozotocin - induced diabetic cardiomyopathy. Br. J. Pharmacol. 2014; 171: 2913 - 2924.
  2. Lovett DH, Mahimkar R, Raffai RL, Cape L, Zhu BQ, Jin ZQ, Baker AJ, Karliner JS. N-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure. PLoS ONE 2013; 8: e68154.
  3. Li Z, Jin ZQ. Ischemic preconditioning enhances integrity of coronary endothelial tight junctions. Biochem. Biophy. Res. Commun. 2012; 425: 630-635.
  4. Bandhuvula P, Honbo N, Wang G, Jin ZQ, Fyrst H, Zhang M, Borowsky AD, Dillard L, Karliner JS, Saba JD. S1P lyase (SPL): a novel therapeutic target for ischemia/reperfusion injury of the heart. Am. J. Physiol. Heart Cir. Physiol. 2011; 300: H1753-H1761.
  5. Vessey DA, Li L, Jin ZQ, Kelley M, Honbo N, Zhang J, Karliner JS. A sphingosine kinase form 2 knockout sensitizes mouse myocardium to ischemia/reperfusion injury and diminishes responsiveness to ischemic preconditioning. Oxidative Medicine & Cellular Longevity. 2011; Article ID: 961059; doi: 10.1155/2011/961059.
  6. Kotlyar AB, Randazzo A, Honbo N, Jin ZQ, Karliner JS, Cecchini G. Cardioprotective activity of a novel and potent competitive inhibitor of lactate dehydrogenase. FEBS Lett. 2010; 584: 159-165.
  7. Jin ZQ, Karliner JS, Vessey DA. Ischemic postconditioning protects isolated mouse hearts against ischemia/reperfusion injury via sphingosine kinase isoform 1 activation. Cardiovasc. Res. 2008; 79: 134-140.
  8. Jin ZQ, Zhang J, Huang Y, Hoover HE, Vessey DA, Karliner JS. A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury. Cardiovasc. Res. 2007; 76: 41-50.
  9. Editorial Comment: Nishino Y, Webb I, and Marber MS. Sphingosine kinase isoforms and cardiac protection. Cardiovasc. Res. 2007; 76: 3-4.
  10. Jin ZQ, Karliner JS. N, N-Dimethylsphinjgosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCe dependent mechanism. Cardiovasc. Res. 2006; 71: 725-734.
  11. Alfonso-Jaume MA, Bergman MR, Mahimkar R, Cheng S, Jin ZQ, Karliner JS, Lovett DH. Cardiac ischemia/ reperfusion injury induces matrix metalloproteinase-2 expression through the Ap-1 components Fos B and Jun B. Am. J. Physiol. Heart Cir. Physiol. 2006; 291: H1838-1846.
  12. Jin ZQ, Zhou HZ, Cecchini G, Gray MO, Karliner JS. Manganese superoxide dismutase in mouse heart: acute responses to ischemic preconditioning and ischemia/ reperfusion injury. Am. J. Physiol. Heart Cir. Physiol. 2005; 288: H2986-H2994.
  13. Jin ZQ, Goetzl EJ, Karliner JS. Sphingosine kinase activation mediates ischemic preconditioning in murine heart. Circulation 2004; 110: 1980-1989.
  14. Jin ZQ, Zhou HZ, Zhu P, Mochly-Rosen D, Messing RO, Goetzl EJ, Karliner JS, Gray MO. Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild type and epsilon PKC knockout mice. Am. J. Physiol. Heart Cir. Physiol. 2002; 282: H1970-1977.

Zhuqiu Jin

Assistant Professor


  • :(605) 688-6646

  • DEPARTMENT Department of Pharmaceutical Sciences
    South Dakota University