Journal Publications

(Please list newest or most current first; published or accepted for publication only; should be segregated into the following categories)

Refereed Original Article in Journal

  1. Shanmugam M., Li D., Gao S., Fefelova N., Shah V., Voit A., Pachon R., Yehia G., Xie L.H., Babu G.J. Cardiac specific expression of threonine 5 to alanine mutant sarcolipin results in structural remodeling and diastolic dysfunction. PLoS One. 2015; 10:e0115822
  2. Zhao Z., Babu G.J., Wen  H.,  Fefelova N., Gordan R., Sui X.,  Yan L., Vatner D.E., Vatner S.F., Xie L.H. Overexpression of Adenylyl Cyclase Type 5 (AC5) Confers a Proarrhythmic Substrate to the Heart. American Journal of Physiology- Heart Circ Physiology. 2015; 308:H240-9
  3. Umemura M., Baljinnyam E., Feske S., De Lorenzo MS., Xie L.H., Feng X., Oda K., Makino A., Fujita T., Yokoyama U., Iwatsubo M., Chen S., Goydos J.S., Ishikawa Y., Iwatsubo K.  Store-Operated Ca2+ Entry (SOCE) Regulates Melanoma Proliferation and Cell Migration. PLoS One 2014; 9: e89292.
  4. Zhao Z., Gordan R., Wen H., Fefelova N., Zang W.J., Xie L.H.  Modulation of intracellular Calcium waves and triggered activities by mitochondrial Ca flux in mouse cardiomyocytes. PLoS One 2013; 8: e80574
  5. Xie L.H., Doye A.A., Conley E., Gwathmey J.K. Sickle Cell Anemia: The Impact of Discovery, Politics, and Business. Journal of Health Care for the Poor and Underserved. 2013; 24: 147-158.
  6. Park M., Vatner S.F., Yan L., Gao S., Yoon G. S., Lee J. A., Xie L.H., Kitsis R.N., Vatner D. E. Caspase Inhibition Prevents Hypertrophy and Improves Cardiac Function with Chronic Pressure Overload. Basic Research in Cardiology. 2013;108:324
  7. Matsushima S., Kuroda J., Ago T., Zhai P., Park J.Y., Xie L.H.,Tian B., Sadoshima J. Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy. Circulation Research 2013; 449 :133-42
  8. Ramachandran J., Schneider J.S., Crassous P.A., Zheng R., Gonzalez J.P., Xie L.H., Beuve A., Fraidenraich D., R. Peluffo D. Nitric Oxide Signaling Pathway in Duchenne Muscular Dystrophy Mice: Upregulation of L-arginine Transporters. Biochemical Journal. 2013; 449:133-42
  9. Zhao Z., Fang M., Xiao D., Liu M.. Fefelova N., Huang C., Zang W.J., Xie L.H. Potential Antiarrhythmic Effect of Methyl-3,4,5-Trimethoxycinnamic Acid, an Bioactive Substance from Roots of Polygalae Radix. Biological and Pharmaceutical Bulletin 2013; 36:238-44.
  10. Wang S.J., Xie L.H., Heng B., Liu Y.Q. Classification of potassium and chlorine ionic currents in retinal ganglion cell line (RGC-5) by whole-cell patch clamp. Visual Neuroscience 2012;29:275-82
  11. Zhao Z., Wen H., Fefelova N., Allen C., Guillaume N., Xiao D., Gwathmey J.K., Xie  L.H. Docosahexaenoic Acid Reduces the Incidence of Early Afterdepolarizations caused by Oxidative Stress in Rabbit Ventricular Myocytes. Frontiers in  Physiology 2012;3:252
  12. Zhao Z., Xie Y., Wen H.,Xiao D.,  Allen C., Fefelova  N., Dun W., Boyden P.A., Qu Z., Xie L.H.Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells. Cardiovascular Research 2012;95:308-16
  13. Xie L.H., Shanmugam M., Park J.Y., Zhao Z., Wen H., Tian B., Periasamy M., Babu G.J. Ablation of sarcolipin results in atrial remodeling.  American Journal of Physiology-Cellular physiology 2012;302:C1762-71
  14. Zhao Z., Wen H., Fefelova N., Allen C., Baba, A., Matsuda, T., Xie L.H.  Revisiting the Ionic Mechanisms of Early Afterdepolarizations in Cardiomyocytes: Predominant by Ca Waves or Ca Currents. American Journal of Physiology- Heart Circ Physiology 2012; 302:H1636-44,
  15. Baljinnyam  E., Umemura M., DeLorenzo M.S., Xie L.H., Nowycky M., Iwatsubo M., Chen S., Goydos J. S., Iwatsubo K.G betagamma subunits inhibit Epac-induced melanoma cell migration. BMC Cancer 11:256, 2011.
  16. Zhao Z., Fefelova N., Mayilvahanan S., Bishara P., Babu G., Xie L.H. Angiotensin II Induces afterdepolarizations via reactive oxygen species and calmodulin kinase II signaling. Journal of Molecular and Cellular Cardiology 50(1):128-36, 2011.
  17. Shanmugam  M., Gao S., Hong C., Fefelova N., Nowycky M.C., Xie L.H., Periasamy M., Babu G. J. Ablation of Phospholamban and Sarcolipin Results in Cardiac Hypertrophy and Decreased Cardiac Contractility. Cardiovascular Research 89:353-61, 2010.
  18. Baljinnyam E., De Lorenzo M.S., Xie L.H., Iwatsubo M., Chen S., Goydos J.S., Nowycky M.C., Iwatsubo K.. Exchange Protein Directly Activated by Cyclic AMP Increases Melanoma Cell Migration by a Ca2+-Dependent Mechanism. Cancer Research 70:5607-17, 2010.
  19. Sato D., Xie L.H., Nguyen T.P., Weiss J.N., Qu Z. Irregularly-Appearing Early Afterdepolarizations in Cardiac Myocytes: Random Fluctuations or Dynamical Chaos? Biophysical Journal 99:765-773, 2010.
  20. Morita N., Sovari A.A., Xie Y., Fishbein M.C., Mandel W.J., Garfinkel A., Lin S.F., Chen P.S., Xie L.H., Chen F., Qu Z., Weiss J.N., Karagueuzian H.S. Increased Susceptibility of Aged Hearts to Ventricular Fibrillation During Oxidative Stress. American Journal of Physiology-Heart Circ Physiol. 297:H1594-605, 2009.
  21.  Xie L.H. (correspondence author), Weiss J.N. Arrhythmogenic consequences of intracellular calcium waves. American Journal of Physiology-Heart Circ Physiology 297:H997-H1002, 2009.
  22.  Sato D. *, Xie L.H. *, Sovari A.A., Tran D.X., Morita N., Xie F., Karagueuzian H., Garfinkel A., Weiss J.N., Qu Z. Synchronization of Chaotic Early Afterdepolarizations in the Genesis of Cardiac Arrhythmias. Proceedings of the National Academy of Sciences, USA 106:2983-8 , 2009; (* co-first author)
  23. Xie L.H., Chen F., Karagueuzian H.S., Weiss J.N. Oxidative Stress-Induced Afterdepolarizations and Calmodulin Kinase II Signaling. Circulation Research 104(1):79-86, 2009. (commented in Nature Medicine 2010; 16: 648-9)
  24. Xie L.H. (correspondence author), John S.A., Ribalet B. and Weiss J.N. Phosphatidylinositol-4,5-bisphosphate (PIP2) Regulation of Strong Inward Rectifier Kir2.1 Channels: Multilevel Positive Cooperativity. Journal Physiology (London). 2008, 586; 1833-48. 2008.
  25. de Diego C., Pai R.K., Chen F.,. Xie L.H, De Leeuw J., Weiss J.N., Valderrábano M. Electrophysiological consequences of acute regional ischemia/reperfusion in neonatal rat ventricular myocyte monolayers. Circulation. 118:2330-7, 2008
  26. Xie L.H., Sato D., Garfinkel A., Qu Z, Weiss J. N. Intracellular Ca Alternans:  Coordinated Regulation by Sarcoplasmic Reticulum Release, Uptake and Leak. Biophysical Journal 95 :3100-10, 2008.
  27.  de Diego C., Pai R.K., Dave A.S., Lynch A., Thu M., Chen F., L.H. Xie, Weiss J.N., Valderrábano M. Spatially discordant alternans in cardiomyocyte monolayers. American Journal of Physiology-Heart Circ Physiol. 294: H1417-25, 2008.
  28. de Diego C., Chen F., Xie L.H., Dave A. S., Thu M., Weiss J.N., Valderrábano M. Cardiac alternans in embryonic mouse hearts. American Journal of Physiology-Heart Circ Physiol.294:H433-40,2008.
  29. Mahajan A., Sato D., Shiferaw Y., Baher A., Xie L.H., Peralta R., Olcese R., Garfinkel A., Qu Z., and Weiss J.N. Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics. Biophysical Journal 94: 411-23,2008.
  30. Mahajan A., Shiferaw Y., Sato D., Baher A., Olcese R., Xie L.H., Yang J., Karma A., Chen P.S., Garfinkel A., Qu Z., and Weiss J.. A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophysical Journal 94:392-410,2008.
  31.  Chen F., De Diego C., Xie L.H., Yang J.H., Klitzner T. S, Weiss J.N. Arrhythmias induced by metabolic inhibitors in mouse embryo hearts. American Journal of Physiology-Heart Circ Physiol.  293(4):H2472-8,2007.
  32. Ramachandran S., Xie L.H., John S.A, Subramaniam S., Lal R.. Hemichannel initiates oxidative stress and smoking-induced apoptosis. PLoS One 2:e712, 2007.
  33. Ruan H., Mitchell S., Vainoriene M., Lou Q., Xie L.H., Ren S., Goldhaber J. I., Wang Y. A Gαi Mediated Mechanism in Cardiac Eletrophysiological Remodeling and Arrhythmia in Hypertrophic Cardiomyopathy. Circulation Research 116(6):596-605,2007.
  34. Ribalet B., John S. A., Xie L.H., and Weiss J. N. ATP-sensitive K channels: Regulation of bursting by the sulfonyurea receptor, PIP2 and regions of Kir6.2. Journal Physiology (London). 571: 303-17, 2006.
  35. Feng J.M., Hu Y.K., Xie L.H., Colwell C.S., Shao, X.M. Sun X.P., Chen B., Tang H., Campagnoni A.T.. Golli protein negatively regulates store depletion-induced calcium influx in T cells. Immunity. 24:717-27, 2006.
  36. Xie L.H., John S., Ribalet B., Weiss J. N. Long polyamines act as co-factors in PIP2 activation of inward rectifier potassium (Kir2.1) channels. Journal of General Physiology.126:541-549, 2005 (Featured in the cover figure).
  37. Goldhaber J.I., Xie L.H., Duong T., Motter C., Khuu K., and Weiss J. N. Action potential duration restitution and alternans in rabbit ventricular myocytes: The key role of intracellular calcium cycling. Circulation Research. 96:459-66, 2005.
  38. John S.A., Xie L.H., Weiss J.N. Mechanism of inward rectification in Kir channels (letter to the editor). Journal of General Physiology. 123:623-5, 2004.
  39. Xie L.H. (correspondence author), John S., Ribalet B., Weiss J. N. Regulation of Gating by Negative Charges in the Cytoplasmic Pore in the Kir2.1 Channel. Journal of Physiology (London). 561:159-68, 2004.
  40. John S.A., Weiss J.N., Xie L.H., Ribalet B. Molecular mechanism for Kir6.2 ATP-dependent closure. Journal of Physiology (London). 552: 23-34, 2003.
  41. Xie L.H., John S., Weiss J. N. Inward rectification by polyamines in Kir2.1 channels: synergy between blocking components. Journal of Physiology (London). 550:67-82, 2003.
  42. Xie L.H., John S., Weiss J. N. Spermine block of the strong inward rectifier potassium channel Kir2.1: Dual roles of surface charge screening and pore block. Journal of General Physiology. 120:53-66, 2002.
  43. Haruna T., Yoshida H., Nakamura T.Y., Xie L.H., Otani H., Ninomiya T., Takano M., Coetzee W.A., Horie M.. a1-Adrenoceptor-mediated breakdown of phosphatidylinosital-4,5-bisphosphate inhibits Pinacidil-activated KATP currents in rat ventricular myocytes. Circulation  Research  91: 232-239, 2002.
  44. Makita T., Horie M., Xie L.H., Okada Y., Sasayama S. Agonist-independent modulation of L-type Ca currents by basal Gs protein activities in single guinea pig ventricular myocytes. Heart  and Vessels. 15:233-9, 2000.
  45. Kono Y., Horie M., Takano M., Otani H., Xie L.H., Akao M., Tsuji K., Sasayama S. The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2A. Pflügers Arch-European Journal of Physiology   440:692-8, 2000.
  46. Xie L.H., Horie M., Takano M. Phospholipase C-linked receptors regulate the ATP-sensitive potassium channel by means of phosphatidylinositol 4,5-bisphosphate metabolism. Proceedings of the National Academy of Sciences, USA 96: 15292-7,1999.
  47. Ishii T.M., Takano M., Xie L.H., Noma A., Ohmori H. Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial node. Journal of  Biological Chemistry 274: 12835-9, 1999
  48. Xie L.H., Takano M., Kakei M., Noma A. Wortmannin, an inhibitor of phosphatidylinositol kinase, blocks the MgATP-dependent recovery of Kir6.2-SUR2A channel. Journal of Physiology (London) 514: 655-665,  1999.
  49. Takano M., Xie L.H., Otano H., Hoire M.. Cytoplasmic terminus domains of Kir6.x confer different nucleotide–dependent gating on the ATP-sensitive K+ channel. Journal of Physiology (London) 512: 395-406, 1998.
  50. Xie L.H. (correspondence author), Takano M., Noma A. The inhibitory effect of propranolol on ATP-sensitive potassium channels in neonatal rat heart. British Journal of Pharmacology 123: 599-604, 1998.
  51. L.H. Xie, Takano M., Noma A. Development of inwardly rectifying K+ channel family in rat ventricular myocytes. American Journal of Physiology 272: H1741-50, 1997.
  52. Obayashi K., Horie M., Xie L.H., Tsuchiya K., Kubota A., Ishida H., Sasayama S. Angiotensin II inhibits protein kinase A-dependent chloride conductance in heart via pertussis toxin-sensitive G proteins. Circulation 95: 197-204,1997.
  53. Takano M., Ishii T., Xie L.H. Cloning and functional expression of the rat brain KIR6.2 channel. Japanese Journal of Physiology 46: 491-5, 1996.
  54. Horie M., Obayashi K., Xie L.H.,. James A.F, Sasayama S. Hormonal regulation of cardiac cystic fibrosis transmembrane conductance regulator chloride channels. Japanese Heart Journal 37: 661-71, 1996.
  55. Xie L.H., Horie M., James A.F., Watanuki M., Sasayama S. Endothelin-1 inhibits L-type Ca currents enhanced by isoproterenol in guinea-pig ventricular myocytes. Pflügers Arch-European Journal of Physiology 431: 533-9, 1996.
  56. Li J.Y., Xie L.H., Li Q., Guo S.D. Effects of resibufogenin and ouabain on transmembrane action potential and extracellular potassium ion activity during triggered activity in guinea pig ventricular muscle. Acta Biophysics Sinica 11: 37-42, 1995. (in Chinese)
  57. James A.F., Xie L.H., Fujitani Y., Hayashi S., Horie M.  Inhibition of the cardiac protein kinase A-dependent chloride conductance by endothelin-1. Nature 370: 297-300,1994.
  58. Oe H., Xie L.H., Horie M. Inhibitory pathway of cardiac PKA-dependent Cl- conductance via pertussis toxin-sensitive G proteins. Japanese Journal of Physiology.44:S219-26, 1994
  59. Jin B.L., Xie L.H., Chen D.C., Li C.L., Xie J.T. The electrophysiological effects of alcoholized rhubarb solution in feline heart in vivo. Methods and Findings in Experimental and Clinical Pharmacology 15: 23-9, 1993.
  60. Xie L.H., Xie J.T. Effects of tetrodoxin and verapamil on triggered activities induced by cesium chloride in cat heart in vivo. Acta Pharmacologica Sinica  13: 38-41,1992. (in Chinese)
  61. Xie L.H., Xie J.T. Electrophysiological studies of after-depolarizations and arrhythmias in the heart in vivo. Acta Physiologica Sinica  43: 257-64, 1991. (In Chinese)
  62. Xie J.T., Xie L.H. Can the MAP technique be applied to study triggered activities of the heart? Intracellular evidence in vivo. Methods and Findings in Experimental and Clinical Pharmacology 12: 419-24, 1990.
  63. Xie J.T., Xie L.H., Li C.L, Liang N., Feng X. Effects of resibufogenin on monophasic action potential and contractile force of rabbit heart in situ. Acta Pharmacologica Sinica 9: 536-8, 1988. (in Chinese)
  64. Xie J.T., Xie L.H., Li C.L., Liang N., Feng X. Resibufogenin-induced delayed afterdepolarization in rabbit heart in situ. Methods and Findings in Experimental and Clinical Pharmacology 10: 475-6,1988.

Other Articles (Reviews, Editorials, etc.) In Journals; Chapters; Books; other Professional Communications

  1. Gordan R., Gwathmey J. K., and Xie L.H. Autonomic and endocrine control of cardiovascular function (review). World Journal of Cardiology 2015 in press
  2. Gordan R., and Xie L.H. Primary Effect of Reactive Oxygen Species on Electrical Remodeling of the Heart. (Editorial) Circulation Journal 2014; 78:1834-6.
  3. Qu Z., Xie L.H., Olcese R., Karagueuzia1 H. S., Chen P.S., Garfinkel A., Weiss J.N. Early Afterdepolarizations in Cardiac Myocytes: Beyond Reduced Repolarization Reserve. (review) Cardiovascular Research 2013; 99:6-15
  4. Wen H., Gwathmey J. K., Xie L.H. Oxidative Stress-Mediated Effects of Angiotensin II in the Cardiovascular System. (review) World Journal of Hypertension 2012;2: 34-44
  5. PengD., WangH., QuC., XieL.H. (correspondence author), WicksS.M., XieJ.T. (correspondence author) Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics. (review) Chinese Medicine 2012;7: 2 (1-6).
  6. Peng L., Sun S., Xie L.H. (correspondence author), Wicks S. M., Xie J.T (correspondence author). Ginsenoside Re: Pharmacological Effects of on Cardiovascular System. (review)  Cardiovascular Therapeutics 2012;  30:e183-e188.
  7. Xie L.H. (correspondence author), John S.A., Ribalet B., and Weiss J.N. Activation of inwardly rectifying potassium (Kir) channels by Phosphatidylinosital-4,5-bisphosphate (PIP2): Interaction with other regulatory ligands. (review) Prog Biophys Mol Biol. 94:320-335, 2007.
  8. Ribalet B., John S.A., Xie L.H. and Weiss J.N. Regulation of the ATP-sensitive K channel Kir6.2 by ATP and PIP2. (review) Journal of Molecular and Cellular Cardiology 39:71-77, 2005.
  9. Horie M., Watanuki M., Tsuchiya K., Hayashi S. Obayashi K., Xie L.H., Yuzuki Y., Takahashi A., Sasayama S. Autonomic regulation of cardiac ATP-sensitive K+ channel activation. In Recent Progress in Electropharmacology of the Heart 1996. Eds. J. Toyama, M. Hiraoka, and I. Kodama. pp73-82. Florida: CRC Press Inc.
  10. Xie L.H., Xie J.T., Guo S.D. Ion-sensitive microelectrode technique and its application to cardiac electrophysiology. (review in Chinese)  Physiological Science 8: 505-510, 1988.

Abstracts

  1. Gordan R., Fefelova N., Gwathmey J. K., and  Xie L.H. Iron Overload Promotes Arrhythmias via ROS Production and Mitochondrial Membrane Potential Depolarization. Biophysical Society 59th Annual Meeting, Feb 2015, Baltimore Maryland. Biophysical J. 2015; 108:273a.
  2. Wen H., Yan L., Kudej RK., Fefelova N., Gordan R., Vatner DE., Vatner SF., Xie L-H.  Reducing Oxidative Stress and CaMKII Activity as an Antiarrhythmic Strategy in Woodchucks in Winter. Biophysical Society Meeting. 2014, San Francisco, CA. Biophysical Journal, 2014;106: 121a,
  3. Gordan R., Fefelova N., Xie L.H. Cyclophilin D Deficiency Attenuates Ca2+ Waves During Mitochondrial Depolarization in Mouse Cardiomyocytes The AHA Scientific Sessions. November 2013, Dallas, TX
  4. Wen H., Gordan R., Fefelova N., Xie L.H. TRPC6 activator hyperforin facilitates arrhythmias via activating store-operated calcium entry. AHA BCVSScientific Sessions, July 2013,  Las Vegas.
  5. Umemura M., Balijinnyam E., Feske S.,. De LorenzoM.S., Xie L.H., Ishikawa Y., and Iwatsubo K. Store-operated Ca2+ entry (SOCE) regulates melanoma progression. AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC.  Cancer Research 2013;73 (8), Supplement 1.
  6. Wen H., Allen C., Fefelova N., Xie L.H. Expression and Role of TRPC Channels in Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells. The AHA Scientific Sessions. November 2012, Los Angeles, CA
  7. Zhao Z., Wen H., Fefelova N., Allen C., Guillaume N., Xiao D., Huang C., Zang W. Gwathmey J. K., Xie L.H Docosahexaenoic Acid Reduces the Incidence of Early Afterdepolarizations caused by Oxidative Stress in Rabbit Ventricular Myocytes. Cardiac Electrophysiology Society annual Meeting. 2012, Los Angeles, CA  
  8. Xie L.H., Wilcox W.C, Gwathmey J.K. Sickle Cell Anemia: Impact of Discovery, Politics, and Business. 13th RCMI International Symposium on Health Disparities, Dec 2012, San Juan, Puerto Rico
  9. Xie L.H., Martin J.M, Doye A.A., Wilcox W.C, Gwathmey J.K. Health Outcomes in Patients with Sickle Cell Anemia: Link with Social and Economic Disadvantage. Science of Eliminating Health Disparities Summit Oct. 2012, Washington DC
  10. Umemura M., Baljinnyam E., De Lorenzo M., Feske S., Xie L.H., Iwatsubo K. Role of store-operated Ca2+ entry in cell migration, proliferation and cell cycle in melanoma. American Association for Cancer Research Annual Meeting. March 2012, Chicago, IL. Cancer Research: 2012; 72 (8) Supplement: 1864
  11. Xie L.H., Wen H,  Zhao Z., Fefelova N, Allen C. Calcium handling properties in a Hibernating animal: Insights into antiarrhythmic Mechanisms. Biophysical Society Meeting. 2012, San Diego, CA. Biophysical Journal, 2012;102: 102a, (appeared in the Meeting Highlights and News Releases in numerous biomedical news websites).
  12. Wen H, Zhao Z., Fefelova N, Allen C, Xie L.H. Arrhythmogenic Effect of Store-operated Calcium Entry in Mouse Ventricular Myocytes. Circulation. 2011; 124: A15884. The AHA Scientific Sessions. November 2011, Olando, FL.
  13. Xie L.H., Wen H,  Zhao Z., Fefelova N, Allen C. A. Unique “Cellular Fibrillation” Status In Mouse Ventricular Myocytes.Circulation. 2011; 124: A17427. The AHA Scientific Sessions. November 2011, Olando, FL.
  14. Shanmugam M, Wen H,  Jaeggi E T. Chitayat D, Taylor G, Xie L.H., Babu G. J. Identification of a novel somatic mutation in sarcolipin gene in human fetal atrial standstill. Circulation. 2011; 124: A13613. The AHA Scientific Sessions. November 2011, Olando, FL.
  15. Park M., Lee J.A., Gao S., Yoon S., Xie L.H., Charles L., Laibovich S.J., Kitsis R.N., Vatner S.F. Vatner D.E. Caspase inhibition Prevents Hypertrophy and Improves Cardiac Function with Chronic Pressure Overload. Circulation. 2011; 124: A17318. The AHA Scientific Sessions. November 2011, Olando, FL.
  16. Zhao Z., Fefelova N., Xie L.H. Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents? Biophysical Society Meeting. 2011, Baltimore, Maryland.
  17. M. Umemura, E. Baljinnyam, S. Feske, L.H. Xie, M. Nowycky, K. Iwatsubo.  Role of Orai1 and STIM1 in store-operated Ca2+ entry and cell migration in melanoma. American Association for Cancer Research Annual Meeting. 2011,  Orlando, FL
  18.  Zhao Z., Babu G.J., Fefelova N., Ishikawa Y., Iwatsubo K., Lai L., Yan L., Vatner D.E., Vatner S.F., Xie L.H. Overexpression of Adenylyl Cyclase Type 5 (AC5) in the Heart Predisposes to Cardiac Arrhythmias. Circulation 2010;122:S. The AHA Scientific Sessions. November 2010, Chicago, IL
  19.  Zhao Z., Fefelova N., Xie L.H. Regulation of Intracellular Ca2+ Waves and Triggered Activities by Mitochondrial Ca2+ Flux in Mouse Cardiomyocytes. Circulation 2010;122: A17464. The AHA Scientific Sessions. November 2010, Chicago, IL.
  20.  Shanmugam M., Gao S., Xie L.H., Babu G.J.  Atrial Fibrillation and Diastolic Dysfunction in Transgenic Mice Expressing Phosphorylation-Defective Mutant Sarcolipin. Circulation 2010;122:S. The AHA Scientific Sessions. November 2010, Chicago, IL. Circulation. 2010; 122: A12081
  21.  Xie Y., Zhao Z., Weiss J.N., Qu Z., Xie L.H. The Transient Outward Current Ito Promotes Early Afterdepolarizations. Biophysical Journal 2010; 98; 531a. Biophysical Society Meeting, Feb 2010, San Francisco, CA
  22.  Zhao Z., Fefelova N., Xie L.H. Angiotensin II Induces Afterdepolarizations via Reactive Oxygen Species and Calmodulin Kinase II Signaling. Circulation 2009;120:S708. The AHA Scientific Sessions. November 2009, Olando, FL
  23.  Xie L.H., Yan ., Kudej R. K., Peppas A.P., Zhao Z., Ge H., Fefelova N., You B., Shen Y.T., Vatner D.E., Vatner S.F. Arrhythmia Protection Insights From a Hibernating Animal. Circulation 2009;120:S674. The AHA Scientific Sessions. November 2009, Olando, FL
  24.  Xie L.H., Shanmugam M., Park J.Y., Zhao Z., Tian B., Periasamy M., Babu G.J. Loss of Sarcolipin is Associated With Structural and Electrical Remodeling of Atria. Circulation 2009;120:S675-S676. The AHA Scientific Sessions. November 2009, Olando, FL
  25.  Sato D. *, Xie L.H. *, Sovari A.A., Tran, D.X. Morita N., Xie F., Karagueuzian H., Garfinkel A., Weiss J.N., Qu Z. Chaos Synchronization in the Genesis of Cardiac Arrhythmias. Biophysical Journal 2009;96:666a. Biophysical Society Meeting March 2009, Boston, MA.
  26. Xie L.H., Weiss J. N. Origin of Subcellular Spatially Discordant Intracellular Calcium Alternans. Circulation. 2008; 118:S_437. The AHA Scientific Sessions. November 2008, New Orleans, LA.
  27.  Xie L.H., Chen F., Weiss J.N. Hydrogen Peroxide-Induced Afterdepolarizations are Dependent on Calmodulin Kinase II Signaling. Circulation. 2008;118:S437. The AHA Scientific Sessions. November 2008, New Orleans, LA.
  28.  Xie L.H.Regulation of inwardly rectifying potassium channels by phospholipids an polyamines. The AHA Research Symposium.  New Orleans, LA, November 2008.
  29.  Xie L.H., Sato D., Garfinkel A., Qu Z., Weiss J.N. Intracellular Ca Alternans:  Coordinated Regulation by Sarcoplasmic Reticulum Release, Uptake and Leak. Biophysical Society Meeting 2008, Long Beach, CA
  30.  Hanna R.L., De Diego C., Rongey C., Del Monte F., Xie L.H., Weiss J. N. Sarcoplasmic Reticulum Calcium ATPase Overexpression Abolishes Calcium Alternans in Ventricular Myocyte Monolayers. Heart Rhythm, 2007: 4; S. Denver, CO. May 9-12, 2007.
  31. Xie L.H., John S., Ribalet B., Weiss J. N. Regulation of single channel gating in the strong inward rectifier potassium channel (Kir2.1) by phosphatidylinositol-4,5-biphosphate (PIP2). Biophysical Society Annual Meeting,  2007, Baltimore, Maryland. Biophysical Journal 2007;108a.
  32. Mahajan A., Shiferaw Y., Xie L.H., Baher A., Olcese R., Qu Z., Weiss J.N. A new model of rabbit L-type calcium current and action potential predicts ventricular dynamics at rapid heart rates.  Heart Rhythm, 2006: 3; S227.
  33. Mahajan A., Shiferaw Y., Xie L.H., Olcease R., Weiss J.N. A New Cardiac Action Potential Model Predicts Therapeutic Strategies for Ventricular Fibrillation. 2006 American Society of Anesthesiologists  Annual Meeting,Chicago, IL. Anesthesiology 2006; 105: A277
  34. Xie L.H., John S., Ribalet B., Weiss J. N. Correlations between subconductance levels and phosphatidylinosital-4,5-bisphosphate (PIP2) interaction in strong inward rectifier potassium (Kir) channels. Biophysical Society Meeting 2006, Salt Lake City, UT
  35. Mahajan A., Baher A., Xie L.H., Shiferaw Y., Peralta R., Qu Z., Weiss J.N. Modifying L-type calcium current to prevent ventricular fibrillation. Heart Rhythm Society Meeting 2005, New Orleans, LA. Heart Rhythm  2005: 2; S106
  36. Xie L.H., John S., Ribalet B., Weiss J. N. Long Polyamines Stabilize the Inward Rectifier Potassium (Kir) Channel Activity by Strengthening the Channel-PIP2 Interaction. Biophysical Society Meeting 2005, Long Beach, CA
  37. Xie L.H., John S., Weiss J. N. Charge groups in the cytoplasmic pore affect K+ permeation in Kir2.1 channels. Biophysical Society Meeting 2004, Biophysical Journal 2004; 86 (1): 124a.
  38. Xie L.H., John S., Weiss J. N. Inward rectification by polyamines in Kir2.1 channels: Analysis of multiple blocking components. Biophysical Society Meeting 2003, Biophysical Journal 2003; 84 (2): 79a.
  39. Xie L.H., John S., Weiss J. N.. Spermine block of the strong inward rectifier potassium channel Kir2.1. Biophysical Society Meeting 2002, Biophysical Journal 2002; 82: 587a.
  40. Xie L.H., John S., Lee J.K., Yang L., Weiss J. N. Inward rectification in Kir2.1: voltage-dependent interaction between polyamine block and intrinsic gating. Biophysical Society Meeting 2001, Biophysical Journal 2001; 80: 628a.
  41. Xie L.H., Horie M., Takano M. Phospholipase C-linked receptors regulate the ATP-sensitive potassium channel via depletion of phosphatidylinositol-4,5-bisphosphate. The AHA Scientific Sessions 1999, Circulation. 1999;100:I-845.
  42. Kono, Y., Horie M., Takano M., Otani H., Xie L.H., Tsuji K., Akao M., Murakai T., and Sasayama S. 1998. Properties of Kir6.1-6.2 tandem protein co-expressed with SUR2A: Does Kir6.1 upregulation after myocardial infarction alter the function of ATP-sensitive K channels? The AHA Scientific Sessions. November 1998, Circulation. 98:I819.
  43. Xie L.H., Takano M., Noma A. Wortmannin, an inhibitor of phosphatidylinositol kinase, blocks the MgATP-dependent recovery of Kir6.2-SUR2A channel. Annual Meeting of the Physiological Society of Japan, 1998, Japanese Journal of Physiology. 1998; 48:S.
  44. Xie L.H., Takano M., Noma A. The inhibitory effect of propranolol on ATP-sensitive potassium channels in neonatal rat heart. Annual Meeting of the Physiological Society of Japan 1997, Japanese Journal of Physiology. 1997; 47:S.
  45. Washizuka T., Watanuki M., Xie L.H., and Horie M. Endothelin-1 inhibits slow component of cardiac delayed rectifier K+ currents via pertussis toxin-sensitive mechanism. The AHA Scientific Sessions 1996, Circulation. 94:I528.
  46. Ai T., Obayashi K., Xie L.H., Noma A., and Horie M. "Accentuated antagonistic" action of angiotensin II on cardiac L-type Ca-currents. The AHA Scientific Sessions 1996, Circulation. 94:I224.
  47. Xie L.H., Takano M., Noma A. Development of inwardly rectifier and ATP-sensitive K+ channels in rat ventricular myocytes. Annual Meeting of the Physiological Society of Japan, 1996, Japanese Journal of Physiology. 1996; 46:S.
  48. Obayashi K., Horie M., Yuzuki Y., Watanuki M., Tsuchiya K., Xie L.H., and Sasayama S. Angiotensin-II inhibits protein kinase A-dependent Cl- conductance in heart via PTX-sensitive G-proteins. 1995.  Circulation 1995. 92:I637.
  49. Watanuki M., Yuzuki Y., Tsuchiya K., Obayashi K., Xie L.H., and Horie M. 1995. Endothelin-1 inhibition of cardiac ATP-sensitive K+ channels. 1995, Circulation. 1995; 92:I639.
  50. Xie L.H., Horie M., James A. F., and Sasayama S. The effects of endothelin-1 on the L-type calcium current in the heart. Annual Meeting of the Physiological Society of Japan 1995, Japanese Journal of Physiology. 1995; 45:S74.
  51. Horie M., Hwang T. C., Xie L.H., and Gadsby D. C. Forskolin binds to adenylate cyclase via intramembrane pathway. Annual Meeting of the Physiological Society of Japan 1995, Japanese Journal of Physiology 1995; 45:S75.
  52. Jin B.L., Xie J.T., Chen D.C., Xie L.H. Effects of b, a, M-receptor antagonists on rhubarb-induced positive inotropic action in cat heart in vivo. FASEB Journal 1991; 5: A1744

Presentions:

  1. Invited lecturer
    UMDNJ-New Jersey Medical School, Department of Physiology and Pharmacology, Feb, 2013
    “Cardiac Oxidative Stress and Arrhythmias”
  2. Member of Chairperson group, International Faculty member and speaker
    The 23rd Great Wall International Congress of Cardiology (GW-ICC) & Asia Pacific Heart Federation Scientific Congress, Beijing, October, 2012
  3. Invited lecturer
    Xi’an Jiaotong University y College of Medicine, Xi’an, China, October, 2012
    “Progress in cardiac electrophysiology and arrhythmias”
  4. Invited lecturer
    Thomas Jefferson University, April 2012
    “Cardiac Arrhythmogenic Effects of Reactive Oxygen Species (ROS)”
  5. Discussion panelist
    UC Davis Cardiovascular Symposium 2012 (March)
    Systems Approach to Understanding Cardiac Excitation–Contraction Coupling & Arrhythmias: Ca²+ Current and SR Ca²+ Release
  6. Invited lecturer
    Beijing Normal University, Beijing, China. June, 2011
    “How does the heart beat regularly? -Frontiers in Cardiac Electrophysiology”
  7. Invited lecturer
    Nankai Univercity, Tianjin, China. June, 2011
    “Oxidative Stress, Activation of CaMKII, and Cardiac Arrhythmias”
  8. Invited speaker
    The Joint Meeting of The 24th Annual Meeting of the Japanese Heart Rhythm Society  and The 26th Annual Meeting of the Japanese Society of Electrocardiology. July 2009.
    “Calcium waves, Ca alternans and cardiac arrhythmogenesis”

 

Lai-Hua Xie

Associate Professor

 

  • :973-972-2411
  • DEPARTMENT Department of Cell Biology and Molecular Medicine
    Rutgers-New Jersey Medical School
  • COUNTRY USA