Publications

1. L.A. Distiller, B.I. Joffe, H.C. Seftel : Adrenergic-Blocking drugs in Hyperthyroidism. Annals of Internal Medicine.  l973;79:l053
2. B.I. Joffe, H.C. Seftel, L.A. Distiller: Asymptomatic Bacteruria in Diabetes Mellitus.   South African Medical Journal. l974;48:l306-l308
3. L.A. Distiller, J.E .Morley, S.Zail: The role of Releasing Hormones in the Diagnosis of Hypopituitarism.   South African Medical Journal l974;48:l6l2-l6l4
4. Brian Dubowitz, Larry Distiller, Julius Sagle, Norman Miller, Louis Gecelter Pituitary Gonadotrophin Response to Luteinizing Hormone-Releasing Hormone (LH-RH) in Males with Azo - and Oligospermia  International Journal of Fertility l975;20:l-4
5. L.A. Distiller, J. Sagel, E.S. Polakow, J.E. Morley :  A Therapeutic Response to a Single Diagnostic Dose of Luteinizing Hormone-Releasing Hormone. South African Medical Journal. 1975;49:50-52
6. L.A. Distiller, J. Sagel, S. Jacobson :  Thyroid Function in Osteogenesis Imperfecta.  Hormone and Metabolic Research l975;7:l73-l76
7. Larry A. Distlller, Julius Sagel, John E. Morley : Assessment of Pituitary Gonadotrophin Reserve using Luteinizing Hormone-Releasing Hormone (LRH) in States of Altered Thyroid Function. The Journal of Clinical Endocrinology and Metabolism l975;40:5l2-5l5
8. Larry A. Distiller, Julius Sagel, John E. Morley, B.I. Joffe, H.C. Seftel :Pituitary Responsiveness to Luteinizing Hormone-Releasing Hormone in Insulin-Dependent Diabetes Mellitus. Diabetes.  1975;24 378-380
9. George R. Beaton, Julius Sagel, Larry A. Distiller : Somatomedin Activity in Cerebrospinal Fluid.   The Journal of Clinical Endocrinology and Metabolism. l975;40:736-737
10. Barry I. Joffe, Ronald B. Goldberg, Harold C. Seftel, Larry A.Distiller : Insulin, Glucose and Triglyceride Relationships to ObeseAfrican Subjects. The American Journal of Clinical Nutrition.l975;28:6l6-620
11. Larry A. Distiller, John E. Morley, Julius Sagel, Michael Pokroy,Ralph Rabkin : Pituitary-Gonadal Function in Chronic Renal Failure :The effect of Luteinizing Hormone-Releasing Hormone and the Influence of Dialysis. Metabolism. l975;24:7ll-720
12. Julius Sagel, Larry A. Distiller, John E. Morley, Hyam Isaacs :Myotonia Dystrophica : Studies on Gonadal Function Using Luteinizing Hormone-Releasing Hormone (LRH). Journal of Clinical Endocrinology and Metabolism. l975;40:lll0-lll3.
13. Julius Sagel, Larry A. Distiller, Barry I. Joffe :  The Role of Luteinizing Hormone-Releasing Hormone in the Diagnosis of Constitutional Delayed Puberty. Postgraduate Medical Journal l975;5l:6ll-6l4 
14. L.A. Distiller, B.I. Joffe :  Transient Hypothyroidism after withdrawal of Thyroxin Therapy.   Postgraduate Medical Journal1975;5l:665-666
15. John E. Morley, Larry A. Distiller, Julius Sagel and E. Oxenham :The Diagnostic Application of Clomophene Citrate and Luteinizing Hormone-Releasing Hormone in Patients with Amenorrhoea and Oligomenorrhoea. International Journal of Fertility.1976:20:225-227.
16. A.I. Vinik, B.I. Joffe, H.C.Seftel, L.A. Distiller, W.P.U. Jackson :Clinical Aspects of Monocomponent Insulins in the Treatment of Diabetes.S.A. Medical Journal l976;50:587-59l
17. J. Sagel, L.A. Distiller, J.E. Morley, H. Isaacs : Normal Thyrotropin-Releasing Hormone Response in Myotonia Dystrophica.   Archives of Neurology l976;33:520.
18. L.A. Distiller, J. Sagel, B. Dubowitz, G. Kay, P.J. Carr, M. Katz, M.C. Kew : Pituitary-Gonadal Function in Men with Alcoholic Cirrhosis of the Liver. Hormone and Metabolic Research l976;8:46l-465.
19. John E. Morley, Larry A. Distiller, Julius Sagel, S.H. Kok, Graham Kay,Peter Carr, Maurice Katz :  Hormonal Changes Associated with Testicular Atrophy and Gynaecomastia in Patients with Leprosy.   Clinical Endocrinology.l977;6:299-303.
20. B.I. Joffe, L.A. Distiller, J. Sagel, M. Lawson., J.E. Morley, H.C.Seftel. Luteinizing Hormone-Releasing Hormone and Serum Growth Hormone in Insulin-Dependent Diabetics. South African Medical Journal1977l5l:979-980
21. B.I. Joffe, L.A. Distiller, H.C. Seftel.   Bromocriptine - A Versatile Remedy. Guest Editorial.  South African Medical Journal l977;5l:412
22. L.A. Distiller.   The Pathophysiology of Cushing's Syndrome. Guest .Review Article. The Leech.   l977;47:25-26.
23. J.E. Morley, C. Klein, W.J. Kalk, B.I. Joffe, D. Saffer, L.A. Distiller, H.C. Seftel :   Pituitary Responsiveness to Thyrotropin Releasing Hormone in Insulin-Dependent Diabetes Mellitus.   Hormone and Metabolic Research  l978:l0:23l-232
24. I.R. Livingstone, J. Sagel, L.A. Distiller, J. Morley, M. Katz.   The effect of Luteinizing Hormone-Releasing Hormone (LRH) on Pituitary Gonadotrophins in Male Homosexuals.   Hormone and Metabolic Research l978;l0:248-249
25. R.J. Jacobson, J. Sagel, L.A. Distiller, J.E. Morley.   Leydig Cell Dysfunction in Male Patients with Hodgkin's Disease Receiving Chemotherapy. Clinical Research l978;426:437.
26. John E. Morley, Larry A. Distiller, Stephen Unterhalter, John B. Meyers, Ralph Rabkin, Maurice Katz.   Effect of Renal Transplantation on Pituitary Gonadal Function. Metabolism l978;27:78l-785
27. J.E. Morley, C.Gold, W.J. Kalk and L.A. Distiller.   Hormonal Alterations in Haemodialysis Patients (HD'S). Clinical Research.  1979;27:63A.
28. J.E. Morley, L.A. Distiller, S.Epstein, M. Katz, C. Gold, J. Sagel, G. Kaye, M. Pokroy and J. Kalk.   Menstrual Disturbances in Chronic Renal Failure.Hormone and Metabolic Research.l979;II:68-72
29. L.A. Distiller, S.S. Zail.   The Use of Glycosylated Haemoglobin Measurements in Control of the Diabetic Patient.  S.A. Medical Journal l979;55:335-337.
30. Ian M.Evans, Larry Distiller.   Effects of Luteinizing Hormone-Releasing Hormone on Sexual Arousal in Normal Men.   Archives of Sexual Behaviour l979;8:385-395.  .
31. J.E. Morley, L.A. Distiller, I. Lissoos, R. Lipschitz, G. Kay, D.L. Searle and M. Katz. Testicular Function in Patients with Spinal Cord Damage. Hormone and Metabolic Research.1979;II:679-682.
32. L.A. Distiller, B.I. Joffe, M. Sandler, A. Kark and H.C. Seftel.The Effect of Alrestatin on Alanine - Stimulated Release of Insulin and Glucagon in Man. Journal of Endocrinological Investigation l98l;4: ll5-118
33. L.A. Distiller, I. Lissoos, R.B.Skudowitz.   Gynaecomastia due to a Leydig Cell Tumour of the Testes.  S.A. Journal of Surgery l98l;l9:l73-6.
34. L.A. Distiller.   Thyroid Dysfunction.   Family Practice.(Review)1982;3:26-29
35. L.A. Distiller.  Portable Insulin Infusion Pumps as an alternative means of Insulin delivery in Type I diabetic patients :  Report on 11 patients.   S. African Med. Journal l983;63:475-479.
36. L.A.Distiller.   The Achievement of Diabetic Control.   S. African Journal of Continuing Medical Education l983;l:25-29.
37. L.A. Distiller, L.I. Robertson, R. Moore, F. Bonnici.   A Basal/Bolus Multiple Injection Regime in Type I Diabetes.   S. African Med. Journal l987;67:749-752
38. L.A. Distiller.   Insulin Regimens for Patients with Insulin-Dependent Diabetes Mellitus.   S. African Journal of Continuing Medical Education l989;7:407-4l3  .
39. L.A. Distiller.   The Management of the Diabetic Child.   Pedmed l989;3:4-6
40. B.D. Kramer, L.A. Distiller.   Diabetic Ketoacidosis.  Specialist Medicine.l995;2:26-37
41. L.A. Distiller, B.D. Kramer. Driving and Diabetics on insulin therapy.S. Afr Med J. l996;86:l0l8- 22,.
42. L.A. Distiller, B.D. Kramer.   Diabetes in Industry.  Occup Health SA l996;2:24-28.
43. L.A. Distiller.   Diabetes Mellitus as a Model for Disease Management in the South African context   Specialist Medicine 1998;3:35-42.
44. J Kennedy, CE Morgenson, SG Ball, AD Castaigne, PJ Commerford, L Distiller et al.   What is the Relevance of the HOPE Study in General Practice? International Journal of  Clinical Practice  2001;55:449-457
45. Larry A. Distiller  The Treatment of Type 2 Diabetes - A Shifting Paradigm.   Specialist Forum 2002;2:32-40
46. Larry A Distiller. Diagnosis of the Insulin Resistant syndrome. Hospital Update 2004;1:1-3   
47. Larry A Distiller. New Concepts in the diagnosis of the Insulin Resistant Syndrome.                    Specialist Forum 2004;1:10-19
48. Larry A Distiller Can Type 2 Diabetes be Prevented? SA Journal of Diabetes and                   Vascular Disease. Editorial 2004;1:8-9
49. Barry I Joffe, Larry A Distiller, W John Kalk  Lipid Levels in Black South Africans with Type 2        Diabetes – Dispelling misconceptions. Diabetes Care 2004;27:1839-1840
50. Larry A Distiller.   Type 2 Diabetes and coronary heart disease: the two sides of the same             coin. SA Journal of Diabetes and Vascular Disease 2004;1:59-61
51. Larry A Distiller and Brian D Kramer. The case for mandatory aspirin therapy in all patients with type 2 diabetes, Specialist Forum 2005;5:4-10
52. Larry A Distiller, Stan Landau, Barry Joffe, Brian Kramer and Laura Blacking: The ‘worried well’, insulin resistances and metformin therapy. SA Medical J (letter) 2005;95:366.
53. Larry A Distiller.  Of Adiposity, inflammation and new treatments for type 2 diabetes.    SA Journal of Diabetes and Vascular Disease. 2005;2;3:06-108
54. Larry A Distiller. The future is here – new treatment modalities for type 2 diabetes. Specialist Forum 2006;6:13-20
55. Larry A Distiller Insulin Resistance Syndrome: Diagnosis and Management. (Review) MIMS Disease Review. 2006. 310-316
56. Larry A Distiller. Microvascular disease and blood pressure control: implications of the 2006 South African Hypertension Guideline. (Editorial) SA Journal of Diabetes and Vascular Disease 2006;3:61-62
57. Larry A Distiller, Barry I Joffe, Vanessa Melville, Tania Welman, Greg B Distiller: Carotid artery intima-media complex thickening in patients with relatively long-surviving type 1 diabetes mellitus. Journal of Diabetes and its Complications  2006;20:280-284
58. L A Distiller. BI Joffe : From the coalface: does glargine insulin improve hypoglycaemic episodes, glycaemic control  or affect body mass in type 1 diabetic subjects who are attending a “routine” diabetes clinic?  Diabetologia 2006;49:2793-94.
59. Larry A Distiller: Unlikely Bedfellows? Management of diabetes and cardiovascular disease: the new ESC-EASD joint guidelines. (Editorial) SA Journal of Diabetes and Vascular Disease 2007;4:6-7
60. Larry A Distiller and Barry I Joffe. Long-term survival in patients with type 1 diabetes. The Specialist Forum 2007;7:34-39..
61. Brian D Kramer, Larry A Distiller, Barry I Joffe: Treating to Target in Type 2 diabetes: the impossible dream? SA Journal of Diabetes and Vascular Disease (Editorial)  2007;4:157-58.
62. Barry I Joffe and Larry A Distiller. Diabetic microvascular disease: from biochemical determinants to therapeutic applications. International Diabetes Monitor.2008;20;51-57.
63. Larry A Distiller. Cardioprotection using insulin: the case for early introduction of insulin SA Journal of Diabetes and Vascular Disease 2008;5:52-53
64. Segal D, Bonnici F and Distiller LA. South African Continuous Insulin Infusion Pump Guidelines SA Journal of Diabetes and Vascular Disease Vol 5, No 4 173-175, 2008
65. Distiller LA, Ruus P, ACT6011 Study Group. Pharmacokinetics and pharmacodynamics of a newGLP-1 agonist AVE0010 in type 2 diabetes patients (Abstract). Diabetes 2008;57(Suppl. 1):A154–A155
66. Barry I Joffe and Larry Distiller. Insulin response in relation to insulin sensitivity: an appropriate β-cell response in black South African Women (Letter). Diabetes Care 2009;32:e123. DOI:10.2337/dc09-1077
67. Larry A Distiller. Setting Glycaemic targets in patients with type 2 diabetes...Where to now? (Guest Editorial) Jnl of Endocrin Metab and Diabetes of SA. 2010;14:125-128
68. L. A. Distiller, M. A. Brown, B. I. Joffe and B. D. Kramer. Striving for the impossible dream: a community-based multi-practice collaborative model of diabetes Management. Diabetic Medicine, 2010; 27: 197–202
69. Larry A Distiller, Barry I Joffe, Vanessa Brown, and Greg B Distiller. The Effect of Features of the Metabolic Syndrome on Atherosclerotic  Risk in Relatively long-Surviving Patients with Type 1 Diabetes. Metabolic Synd and Rel Disord.2010;8:1-5
70. Barry Joffe, Larry Distiller, Stanley Landau, Laura Blacking, Anna Klisiewicz. Spectrum of autoimmune disorders in type 1 diabetes –a cross-sectional clinical audit J Diabet Metabol. 2010;1:112.doi:10.4172/2155-6156.1000112
71. Larry A Distiller and Brian Kramer. Gestational Diabetes Mellitus. The Specialist Forum 2011;11:46-52
72. Larry A Distiller. The infamous sliding scale: the myth persists. Specialist Forum 2011;12:26-30
73. Anna Maria Klisiewicz, Larry Distiller, Pandelani D Rambaub. Euthyroid hyperthyroxinaemia due to assay interference JEMDSA 2011;16:155-158
74. Larry A Distiller. Placing the Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial in context JEMDSA 2012;17:118-120
75. Rebecca L. Thomas, Larry Distiller, Stephen D. Luzio, Sharmistha Roy Chowdhury, Vanessa J. Melville, Brian Kramer, and David R. Owens  Ethnic Differences in the Prevalence of Diabetic Retinopathy in Persons With Diabetes When First Presenting at a Diabetes Clinic in South Africa Diabetes Care2013;36:336-341
76. David Segal and Larry Distiller. New Guidelines for the use of Insulin Infusion pumps in South Africa: a welcome document which is well overdue.(Guest Editorial) JEMDSA 2013;18:13-14
77. A Amod, M Carrihill, JA Dave, LA Distiller, W May, I Paruk, D Segal. Continuous subcutaneous insulin infusion therapy in type 1 diabetes: clinical guidelines and recommendations form the Association of Clinical Endocrinologists of South Africa (ACE-SA). JEMDSA 2013; 18; 15-19
78. David Segal, Daniela Tupy, Larry Distiller. The Biosulin equivalence in standard therapy (BEST) study − a multicentre, open-label, non-randomised, interventional, observational study in subjects using Biosulin 30/70 for the treatment of insulin-dependent type 1 and type 2 diabetes mellitus. South African Medical Journal 2013; 103(7):458-460.
79. Nam Han Cho, Stephen Colagiuri, Larry Distiller, Birong Dong, Trisha Dunning, Roger Gadsby, Ashish Goel, Medha Munshi, Alan Sinclair, Isaac Sinay (on behalf of IDF Working Group). International Diabetes Federation. Managing Older People with type 2 diabetes: Global Guideline. Available at: http://www.idf.org/guidelines
80. Distiller LA, Polakow ES, Joffe BI. Type 2 diabetes mellitus and hypothyroidism: the possible influence of metformin therapy. Diabetic Med 2014;31:172-175
81. Itamar Raz, Anette G. Ziegler, Thomas Linn, Guntram Schernthaner, Francois Bonnici,Larry A. Distiller, Carla Giordano, Francesco Giorgino, Liat de Vries, Didac Mauricio, Vlastimil Procházka, Julio Wainstein, Dana Elias, Ann Avron, Merana Tamir, Rachel Eren, Dana Peled, Shlomo Dagan, Irun R. Cohen, Paolo Pozzilli, the DIA-AID 1 Writing Group. Treatment of Recent-Onset Type 1 Diabetic Patients With DiaPep277: Results of a Double-Blind, Placebo-Controlled, Randomized Phase 3 Trial. Diabetes Care 2014; 37:5 1384-1391
82. Andrew Jacovides, Manpedi Bogoshi, Larry A Distiller, Ehab Y Mahgoub, Mahomed KA Omar, Ismail A Tarek and Dalia B Wajsbrot. An epidemiological study to assess the prevalence of diabetic peripheral neuropathic pain among adults with diabetes attending private and institutional outpatient clinics in South Africa. Jnl of International Medical Research 2014; DOI: 10.1177/0300060514525759
83. Distiller LA. Why do some patients with type 1 diabetes live so long? World J Diabetes 2014; 5(3): 282-287
84. Larry A Distiller, Hendrik Nortje, Holger Wellmann, Aslam Amod and Landman Lombard. Treatment of the Obese Type 2 Diabetes Patient with Severe Insulin Resistance: A 24-Week, Prospective, Randomized, Open-Label, Treat-to-Target Study: A Pilot Study to Compare the Efficacy of U-500 Regular Insulin Plus Metformin with U-500 Regular Insulin, Metformin, and Exenatide. Endocrine Practice2014;20:1143-1150
85. Joffe BI and Distiller LA. Diabetes mellitus and hypothyroidism: Strange bedfellows or mutual companions? World J Diabetes. 2014 December 15; 5(6): 901-904.
86. Larry A Distiller. The use of highly concentrated U-500 Regular Insulin for the severely insulin resistant patient with type 2 diabetes. Comment. Endocrine Practice 2014. DOI:10.4158/EP14444.CO

Presentations / Posters at International Meetings

1. Areti Philotheou, Larry Distiller, Francois Bonnici et al:  A Randomized Placebo-Controlled, Multicenter, Sequential, Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of NBI-6024 in Adolescent Patients with Insulin Dependant Type 1 Diabetes Mellitus. (Abstract 453-P). American Diabetes Association 62nd Scientific Session  2002.
2. Distiller LA, Malik RA, Degenhardt TP, et al Clinical Investigation of pyridoxamine in Type 1     and Type 2 diabetic patients  with overt diabetic nephropathy.  (Abstract) 232-OP EASD 40th Annual Meeting, Munich 2004.
3. Larry A Distiller. Incentivizing Diabetes Care in A Primary Care setting, (Invited Speaker). IDF World Diabetes Congress. Cape Town, South Africa Dec 2006.
4. Lorgat M, Distiller L A and Segal D. Carbohydrate to insulin matching on a South African urban diet in adolescents with Type 1 diabetes. ISPAD, Berlin 2007
5. L A Distiller and P Ruus. A new GLP-1 agonist AVE0010 in patients with type 2 diabetes: results of a Pharmacodynamics study. American Diabetes Association 68th Scientific Session  San Francisco June 2008.
6. Thomas RL, Chowdhury SR, Distiller LA, Brown V, Kramer BD, Luzio SD and Owens DR. Development of Diabetic Retinopathy in subjects attending a Diabetes and Endocrinology clinic in Johannesburg, Suoth Africa. (Abstract) 2134-PO American Diabetes Association 71th Scientific Session  San Diego June 2011.
7. Chowdhury SR, Thomas RL, Distiller LA, Brown V, Kramer BD, Luzio SD and Owens DR. Prevalence of Diabetic Retinopathy in a Diabetes and Endocrinology Centre (CDE) in South Africa. . (Abstract) 2138-PO American Diabetes Association 71th Scientific Session  San Diego June 2011

Books

1. "So You have Diabetes".   Dr. Larry A. Distiller.   MTP.   Press l980.
2. L .A. Distiller - Chapter l0 Endocrinology and Metabolism In CLINICAL INTERNAL MEDICINE, Ed.  B. Reller, S. Sahn and R. Schreier.   Little Brown & Co. Boston  l983.
3. "So you have Diabetes".   Dr. Larry A. Distiller.   2nd Edition.  Alex White & Co.(Pty.) Ltd.     l994.

Editorial  Posts

• National Editorial Board.  SA Journal of Diabetes and Vascular Disease.
• Editorial Panel, SA Cardiology and Stroke Journal
• Associate Editor, Jnl of Endocrinology, Metabolism and Diabetes of southern Africa (JEMDSA)