Publications

Primary Research Papers:

1. UXue B.U, Moustaid N. Wilkison W.O. and Zemel M. The agouti gene product inhibits lipolysis in human adipocytes via a Ca2+-dependent mechanism. FASEB J. 1998;  12: 1391-1396
2. UXue B. Z.U, Wilkison W.O., Mynatt R.L., Moustaid N., Goldman M. and Zemel M. B. The agouti gene product stimulates pancreatic b-cell Ca2+ signaling and insulin release. Physiol. Genomics. 1999; 1: 11-19
3. Claycombe K., UXue B. Z.U, Mynatt R. J., Wilkison W. O., Zemel M. B. and Moustaid-Moussa N. Regulation of leptin by agouti and insulin. Physiol. Genomics. 2000; 2 (3): 101-105
4. UXue B.U and Zemel M. B. Relationship between human adipose tissue agouti and fatty acid synthase (FAS). J. Nutr. 2000; 130 (10): 2478-2481
5. UXue, B. U and Zemel M. B. The agouti gene product stimulates islet amyloid polypeptide (amylin) secretion in pancreatic b-cells. Exp. Biol. Med. 2001; 226 (6): 565-569
6. UXue, B.U, Greenberg A. G., Kraemer F. B. and Zemel M. B. Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes. FASEB J. 2001; 15 (13): 2527-2529
7. Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, UXue BU, Mu J, Foufelle F, Ferre P, Birnbaum MJ, Stuck BJ and Kahn BB. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature. 2004  428 (6982): 569-574.
8. Rim JS, UXue BU, Gawronska-Kozak B and Kozak LP. Sequestration of Thermogenic Transcription Factors in the Cytoplasm during Development of Brown Adipose Tissue. J Biol Chem. 2004; 279 (24): 25916-26.
9. UXue B.U, Coulter A., Rim J. S., Koza R. A. And Kozak L. P. Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots. Mol. Cell. Biol. 2005. 25: 8311-8322. PMCID: PMC1234324
10. Bence K. K., Delibegovic M., UXue B.U, Gorgun C. Z., Hotamisligil G. S., Neel B. G. and Kahn B. B. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat. Med. 2006. 12: 917-924.
11. UXue B.U, Rim J. S., Hogan J. C., Coulter A. A., Koza R. A. and Kozak L. P. Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat. J. Lipid Res. 2007. 48: 41-51.
12. Kennedy A. R., Pissios P., Out H., UXue B.U, Asakura K., Furukawa N., Marino F. E., Liu F. F., Kahn B. B., Litermann T. A. and Maratos-Flier E. A high-fat, ketogenic diet induces a unique metabolic state in mice. Am. J. Physiol. Endocrinol. Metab. 2007. 292: E1724-1739.
13. UXue B.U, Kim Y. B., Lee A., Toschi E., Bonner-Weir S., Kahn C. R., Neel B. G. and Kahn B. B. Protein tyrosine phosphatase 1B (PTP1B) deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance. J. Bio. Chem. 2007. 282: 23829-23840.
14. Sutton, B. S., Palmer, N. D., Langefeld, C. D., Xue, B. Z., Proctor, A., Ziegler, J. T., Haffner, S. M., Norris, J. M. and Bowden, D. W.   Association of SSTR2 polymorphisms and glucose homeostasis phenotypes: the Insulin Resistance Atherosclerosis Family Study.   Diabetes. 2009 Jun;58(6):1457-62. PMCID: PMC2682669
15. UXue, B.U, Pulinilkunnil, T., Murano, I., Bence, K. K., He, H., Minokoshi, Y., Asakura, K., Lee, A., Haj, F., Furukawa, N., Balschi, J. A., Cinti, S., Neel, B. G. and Kahn, B. B. Neuronal PTP1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues. Mol. Cell. Biol. 2009. 29 (16): 4563-4573. PMCID: PMC2725736.
16. Brown J.M., Betters J.L., Lord C.,Ma Y., Han X., Yang K., Alger H.M., Melchior J., Sawyer J., Shah R., Wilson M.D., Liu X., Graham M.J., Lee R., Cooke R., Shulman G.I., UXue B.U, Shi H. and Yu L. CGI-58 knockdown in mice causes hepatic steatosis, but prevents diet-induced obesity and glucose intolerance. J. Lipid Res. 2010; 51: 3306-3315. PMCID: PMC2952571.
17. Yang,Z., Kahn, B.B., Shi,H. and UXue, B.ZU. Macrophage α1AMP-activated protein kinase (α1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J. Biol. Chem. 2010. 285 (25): 19051-19059. PMCID: PMC2885183.  
18. **Wang, X., Yang, Z., Xue, B.* and Shi, H.* (* Co-corresponding authors). Activation of the cholinergic anti-inflammatory pathway ameliorates obesity-induced inflammation and insulin resistance. Endocrinology 2011. 152 (3): 836-846. PMCID: PMC3040050. **Editorial Commentary Article.
19. Delbono O, Messi ML, Wang ZM, Treves S, Mosca B, Bergamelli L, Nishi M, Takeshima H, Shi H, Xue B, Zorzato F. Endogenously determined restriction of food intake overcomes excitation-contraction uncoupling in JP45KO mice with aging. Exp. Gerontology. 2012, 47: 304-316. PMCID: PMC3307889
20. Yang, Z., Hulver, M., McMillan, R. P., Kershaw, E. E., Yu, L., Xue, B.*, and Shi, H*. (* Co-corresponding authors). Regulation of leptin and insulin action by muscle suppressor of cytokine signaling 3 (SOCS3). PLoS ONE, 2012; 7 (10): e47493. doi: 10.1371/journal.pone.0047493. Epub 2012 Oct. 24. PMCID: PMC3480378
21. Xue, B.*, Wang, X., Yang, Z., Shi, H*.(* Co-corresponding authors).  w-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway. PLoS ONE, 2012; 7 (10): e45990. doi: 10.1371/journal.pone.0045990.Epub 2012 Oct. 5. PMCID: PMC3465287
22. Yang, Z., Wang, X., He, Y., Qi, L., Xue, B.*, and Shi, H*. (* Co-corresponding authors). The capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1. PLoS ONE, 2012; 7 (11): e49935. doi: 10.1371/journal.pone.0049935.  Epub 2012 Nov 21. PMCID: PMC3503857
23. Guo F, Ma Y, Kadegowda AK, Xie P, Liu G, Liu X, Miao H, Ou J, Su X, Zheng Z, Xue B, Shi H, Yu L. Deficiency of Liver Comparative Gene Identification-58 (CGI-58) Causes Steatohepatitis and Fibrosis in Mice. J Lipid Res. 2013 Aug; 54(8):2109-20. doi: 10.1194/jlr.M035519. Epub 2013 Jun 3. PMCID: PMC3708361
24. Xie, P., Guo, F., Ma, Y., Wang, F., Xue, B., Shi, H., Yang, J., Yu, L. Intestinal CGI-58 deficiency reduces post-prandial lipid absorption. PLoS ONE. 2014 Mar 11; 9(3):e91652. doi: 10.1371/journal.pone.0091652. eCollection 2014. PMCID: PMC3950255
25. Yang, X., Wang, X., Liu, D., Yu, L., Xue, B. and Shi, H. Epigenetic Regulation of Macrophage Polarization by DNA Methyltransferase 3b. Mol. Endocrinol. 2014 Apr; 28(4):565-74. doi: 10.1210/me.2013-1293. Epub 2014 Mar 5. PMCID: PMC3968399
26. Yang, X., Liu, M., Zhang, H., Xue, B., Shi, H. and Liu, D. Protein kinase C-δ Mediates Sepsis-induced Activation of Complement 5a and Urokinase-type Plasminogen Activator Signaling in Macrophages. Inflamm. Res. 2014 Jul;63(7):581-9. doi: 10.1007/s00011-014-0729-1. Epub 2014 Mar 30.
27. Miao H, Ou J, Ma Y, Guo F, Yang Z, Wiggins M, Liu C, Song W, Han X, Wang M, Cao Q, Chung BH, Yang D, Liang H, Xue B, Shi H, Gan L, Yu L. Macrophage CGI-58 deficiency activates ROS-inflammasome pathway to promote insulin resistance in mice. Cell Rep. 2014 Apr 10;7(1):223-35. doi: 10.1016/j.celrep.2014.02.047. Epub 2014 Apr 3. PMCID: PMC4040312
28. Sha, H., Francisco, A., Sun, S., Ehrhardt, N., Xue, Z., Guber, R., Panhwar, M.S., Liu, L., Brenna, T.J., Hang, S., Xue, B., Kersten, S., Bendadoun, A., Peterfy, M., Long, Q. and Qi, L. 2014. The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism. Cell Metab. 2014 Sep 2;20(3):458-70. doi: 10.1016/j.cmet.2014.06.015. Epub 2014 Jul 24. PMCID: PMC4156539
29. Cao, Q., Wang, X., Jia, L., Mishra, N., Parks, J., Yu, L., Shi, H., Xue, B. Inhibiting DNA methylation by 5-aza-2’-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation. Endocrinology. 2014 Sep 24:en20141595. [Epub ahead of print]
30. Xie, P., Lin, J., Ma, Y., Zhu, H., Xue, B., Shi, H., Yu, L. Genetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels. Accepted, Atherosclerosis.
31. Wang, X., Cao, Q., Yu, L., Shi, H., Xue, B.*, Shi, H*. (* Co-corresponding authors). Epigenetic regulation of macrophage polarization and inflammation by DNA methylation. Under review by the Journal of Clinical Investigation.
32. Xie,P., Xue, B., Shi, H., Yu, L. Muscle-specific inactivation of comparative gene identification (CGI-58) causes severe cardiac steatosis and systolic dysfunction in mice.  Cell Metab. Under review.
33. Fu, L., Bruckbauer, A., Li, F., Cao, Q., Cui, X., Wu, R., Shi, H., Zemel, M. B. and Xue, B. Leucine Amplifies the Effects of Metformin on Insulin Sensitivity and Glycemic Control in Diet-Induced Obese Mice. Under review by Metabolism.
34. Fu, L., Bruckbauer, A., Li, F., Cao, Q., Cui, X., Wu, R., Shi, H., Zemel, M. B. and Xue, B. Synergy between Metformin and Leucine in Reducing Steatosis in Diet-Induced Obese mice. Submitted to Journal of Endocrinology
35. Li, J., Ferry, R. J., Jr., Gong, S., Xue, B., Bahouth, S. W., and Liao, F. NEDD4 Ubiquitin Ligase Suppresses Lipolysis and Accelerates Adipogenesis via β2-Adrenergic Receptor and PPARγ pathways. Journal of Clinical Investigation. Submitted.
36. Rajan, A., Shi, H., and Xue, B. Histone acetylation modulates uncoupling protein 1 expression in brown adipocytes. Manuscript in preparation
37. Chen, Y., Rui, W., Yang, X., Shi, H., and Xue, B. Role of DNA methylation in adipogenesis. Manuscript in preparation.
38. Li, F., Shi, H., and Xue, B. Histone deacetylase 1 (HDAC1) plays an important role in brown adipogenesis. Manuscript in preparation.

Invited Reviews:

1. Zemel, M. B. and Xue, B. Z. Agouti/Melanocortin interactions with leptin pathways in obesity. Nutrition Reviews. 1998; 56 (9): 271-274.
2. Xue B. and Kahn B. B. AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J. Physiol. 2006. 574: 73-83. PMCID: PMC1817809

Book Chapters:

1. Zemel, M. B., UXue, B. Z.U and Shi, H. The agouti gene in obesity: central and peripheral mechanism, and therapeutic implications. In: Nutrient-gene Interactions in Health and Disease. 2001; Ed: Moustaid-Moussa, N and Berdanier, C. D. CRC Press, Boca Raton, FL
2. Kozak, L. P., Xue, B. Z., Rim, J., Coulter, A. and Koza, R. Genetics of brown adipocyte development. In: Progress in Obesity Research: Proceedings of the 9th International Congress on Obesity. 2003; Ed: Medeiros-Neto, G., Halpern, A and Bouchard, C. John Libbey Eurotext, Montrouge, France.

Presentations and Addresses:

1. The agouti gene product stimulates pancreatic β cell Ca2+ signaling and insulin release. Experimental Biology 1997, New Orleans, LA, April 19-23, 1997.
2. The agouti gene product inhibits lipolysis in human adipocytes via a Ca2+-dependent mechanism. Experimental Biology 1998, San Francisco, CA, April 18-22, 1998
3. The agouti gene product stimulates islet amyloid polypeptide (amylin) secretion in pancreatic β-cells. Experimental Biology 1999, Washington, DC, April 17-21, 1999
4. Agouti regulates in vivo expression and activity of human adipose tissue fatty acid synthase. Annual meeting of the North American Association for the Study of Obesity (NAASO), Charleston, SC, November 14-18, 1999
5. Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes. Experimental Biology 2000, San Diego, CA, April 15-18, 2000
6. Genetic Regulation of Brown Adipocyte in White Fat during Development and Cold Exposure. Pennington Biomedical Research Center, Baton Rouge, LA, February 3, 2003
7. Muscle-specific leptin receptor deletion: does the leptin receptor in muscle play a role in whole body energy homeostasis? Beth Israel Deaconess Medical Center, Harvard Medical School. Boston, MA, November 2, 2004
8. Coordinated Regulation of AMP-Activated Protein Kinase (AMPK) Activity in Peripheral Tissues and Hypothalamus in Protein Tyrosine Phosphatase 1B Deficient (PTP1B-/-) Mice: Contribution to Altered Energy Homeostasis. The 65th American Diabetes Association Scientific Sessions, San Diego, CA, June 10-14, 2005
9. The α7 Cholinergic Receptor Signaling: A Key Regulator in Insulin Sensitivity and Energy Homeostasis. William R. Hazzard Translational Research in Aging Symposium "Connecting Brain and Body", Winston-Salem, NC, September 26, 2008
10. The Cholinergic Anti-inflammatory Pathway in Obesity, Inflammation and Insulin Resistance: Role of the α7 Nicotinic Cholinergic Receptor. Wake Forest University School of Medicine. Winston-Salem, NC, October 28, 2009
11. Leptin receptors in muscle contribute to energy homeostasis. The 70th American Diabetes Association Annual Meeting, Orlando, FL, June 25-29, 2010
12. Nutrients and Inflammation: Roles of Macrophage AMPK and SIRT1. Wake Forest University School of Medicine. Winston-Salem, NC, March 4, 2011
13. Epigenetic Programming in Metabolic Diseases. Wake Forest University School of Medicine. Winston-Salem, NC, February 10, 2012
14. Epigenetic regulation of macrophage polarization by DNA methylation in obesity. The 72nd American Diabetes Association  Scientific Sessions, Philadelphia, PA, June 8-12, 2012
15. Brown Adipocyte Function and Adiposity. GSU/CMU Biotech Symposium 2012, Atlanta, GA, November 16, 2012
16. Epigenetic regulation of lipid-induced macrophage inflammation in metabolic diseases. The 22nd South East Lipid Research Conference (SELRC), Pine Mountain, GA, September 26-28, 2013
17. Epigenetic regulation of macrophage inflammation in metabolic diseases. Georgia Regents University, Augusta, GA, November 7, 2013
18. Epigenetic regulation of macrophage polarization by DNA methyltransferase 3b (DNMT3b). The Obesity Society Annual Meeting, the Obesity Week 2013, Atlanta, GA, November 11-16, 2013
19. Brown and beige adipocyte development and function. Department of Biology, Georgia State University, Atlanta, GA, February 28, 2014
20. Brown adipocyte function and obesity. Department of Chemistry, Georgia State University, Atlanta, GA, August 25, 2014

Abstracts and Conference Presentations:

1. Xue, B. Z., Wilkison, W. O., Mynatt, R. L., Moustaid, N. and Zemel, M. B. The agouti gene product stimulates pancreatic β cell Ca2+ signaling and insulin release. Experimental Biology, New Orleans, LA, April 19-23, 1997 (oral).
2. Xue, B. Z., Moustaid, N. and Zemel, M. B. The agouti gene product inhibits lipolysis in human adipocytes via a Ca2+-dependent mechanism. Experimental Biology, San Francisco, CA, April 18-22, 1998 (oral).
3. Xue, B. Z., Moustaid-Moussa, N. and Zemel, M. B. The agouti gene product stimulates islet amyloid polypeptide (amylin) secretion in pancreatic β-cells. Experimental Biology, Washington, DC, April 17-21, 1999 (oral).
4. Xue, B. Z. and Zemel, M. B. Agouti regulates in vivo expression and activity of human adipose tissue fatty acid synthase. Annual meeting of the North American Association for the Study of Obesity (NAASO), Charleston, SC, November 14-18, 1999 (oral).
5. Xue, B. Z. and Zemel, M. B. Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes. Experimental Biology, San Diego, CA, April 15-18, 2000  (oral).
6. Xue, B. Z. and  Kozak, L. P. Genetic Programming of Uncoupling Protein (Ucp1) Induction in White Fat during Development. Obesity: new insights into pathogenesis and treatment. Keystone meeting, Keystone, CO, Jan21-26, 2003 (Poster).
7. Xue, B. Z., Lee, A., Kahn, C. R., Neel, B. G And Kahn, B. B.Protein Tyrosine Phosphatase 1B (PTP1B) Deficiency Rescues Insulin Resistance and the Diabetic Phenotype in Mice Heterozygous for Insulin Receptor (IR) and Insulin Receptor Substrate 1 (IRS1) Null Alleles. 65th American Diabetes Association Annual Meeting, San Diego, CA, Jun10-14, 2005 (Poster).
8. Xue, B. Z., Asakura, K., Minokoshi, Y, Haj, F, Bence, K, Furukawa, N, Neel, B. G. And Kahn, B. B. Coordinated Regulation of AMP-activated Protein Kinase (AMPK) Activity in Peripheral Tissues and Hypothalamus in Protein Tyrosine Phosphatase 1B Deficient (PTP1B-/-) Mice: Contribution to Altered Energy Homeostasis. 65th American Diabetes Association Annual Meeting, San Diego, CA, Jun10-14, 2005 (Oral).
9. Wang X., Yang Z., Shi H and Xue B. The cholinergic anti-inflammatory pathway ameliorates obesity-induced insulin resistance via the α7 nicotinic cholinergic receptor. Keystone Symposia on Molecular and Cellular Biology: Adipose Tissue Biology. Keystone Resort, Keystone, CO. January 24 - January 29, 2010 (Poster).
10. Catalano, K., Furukawa, N., Peroni, O.D., Xue, B., Kim, Y., Lee, A., Asakura, K., Araki, K., Asilmaz, E., Friedman, J. M., and Kahn, B. B. Leptin receptors in muscle contribute to energy homeostasis. 70th American Diabetes Association Annual Meeting, Orlando, FL, June 25-29, 2010 (Oral).
11. Wang, X., Shi, H., and Xue, B. Epigenetic programming of PPARγ1 regulates macrophage polarization in obesity. Keystone Symposia, Pathogenesis of Diabetes: Emerging insights into Molecular Mechanisms. Santa Fe, NM, January 29-February 3, 2012 (poster).
12. Wang, X., Shi, H., and Xue, B. Epigenetic regulation of macrophage polarization by DNA methylation in obesity. American Diabetes Association 72th Scientific Sessions, Philadelphia, PA, June 8-12, 2012 (Oral).
13. Yang, Z., Wang, X., He, Y., Ling, Q., Xue, B*., and Shi, H*.(Corresponding authors). The capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1.  This abstract has been selected to be showcased in a Guided Audio Poster Tour at the 2012 ADA Annual Meeting, Philadelphia, June 2012 (Poster).
14. Wang, X., Cao, Q., Yu, L., Xue, B. and Hang Shi. 5-aza-2 deoxycytidine improves insulin sensitivity through promoting macrophage alternative activation. The 31st Annual Scientific Meeting of The Obesity Society, The Obesity Week 2013, Atlanta, GA, November 11-16, 2013 (Poster)
15. Wang, X., Cao, Q., Yu, L., Xue, B. and Hang Shi. Epigenetic regulation of macrophage polarization by DNA methyltransferase 1 (DNMT1). The 31st Annual Scientific Meeting of The Obesity Society, The Obesity Week 2013, Atlanta, GA, November 11-16, 2013 (Poster)
16. Cao, Q., Wang, X., Jia, L., Mondal, A. K., Diallo, A., Hawkins, G. A., Das, S. K., Parks, J. S., Yu, L., Shi, H. and Xue, B. 5-aza-2 deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation. The 31st Annual Scientific Meeting of The Obesity Society, The Obesity Week 2013, Atlanta, GA, November 11-16, 2013 (Poster).
17. Yang, X., Wang, X., Liu, D., Yu, L., Xue, B. and Shi, H. Epigenetic regulation of macrophage polarization by DNA methyltransferase 3b (DNMT3b). The 31st Annual Scientific Meeting of The Obesity Society, The Obesity Week 2013, Atlanta, GA, November 11-16, 2013 (Oral).
18. Xue, B., Wang, X., Cao, Q., Yu, L. and Shi, H. Epigenetic regulation of macrophage inflammation in metabolic diseases. Keystone Symposia on Challenges and Opportunities in Diabetes Research and Treatment. Vancouver, Canada, January 12-17, 2014 (poster).
19. Li, F., Shi, H., and Xue, B. Histone deacetylase 1 (HDAC1) plays an important role in brown adipogenesis. Experimental Biology 2014, San Diego, CA, April 26-30, 2014 (poster)
20. Fu, L., Li, F., Bruckbauer, A., Cao, Q., Cui, X., Wu, R., Shi, H, Zemel, M. B., and Xue, B. Synergistic effects of leucine with Phosphodiesterase 5 (PDE5) inhibition on insulin sensitivity. Experimental Biology 2014, San Diego, CA, April 26-30, 2014 (Poster)
21. Wu, R., Choi, J., Shi, H., Shi, H. D., and Xue, B. Dynamic Regulation of DNA Methylomes in Fat, Liver and Muscle in Obesity. The 74th American Diabetes Association Scientific Sessions, San Francisco, CA, June 13-17, 2014 (Poster)
22. Xue, B., Fu, L., Li, F., Bruckbauer, A., Cao, Q., Cui, X., Wu, R., Zemel, M. B., and Shi, H. Leucine Amplifies the Effects of Metformin on Insulin Sensitivity and Glycemic Control in Diet-Induced Obese Mice. The 74th American Diabetes Association Scientific Sessions, San Francisco, CA, June 13-17, 2014 (Poster)
23. Shi, H., Fu, L., Li, F., Bruckbauer, A., Cao, Q., Cui, X., Wu, R., Zemel, M. B., and Xue, B. Synergy between Metformin and Leucine in Sirtuin Signaling and Fat Oxidation in vitro, and in Reducing Lipid Accumulation in Diet-Induced Obese Mice. The 74th American Diabetes Association Scientific Sessions, San Francisco, CA, June 13-17, 2014 (Poster)