a. Selected articles published in scholarly journals:

  1. Singh PK, Hollingsworth MA. (2006) Cell surface-associated mucins in signal transduction. Trends in Cell Biology 16:467-476. 2011 Impact Factor-12.24; ISSN No:0962-8924
  2. Singh PK, Singh D, Vikas, Garg GK. (2006) RNA interference and gene silencing. Indian J. Crop Sci 1:13-20. ISSN No. 0973-4880
  3. Tsutsumida H., Swanson BJ, Singh PK, Caffrey TC, Kitajima S, Goto M, Yonezawa S, Hollingsworth MA. (2006) RNA Interference Suppression of MUC1Reduces the Growth Rate and Metastatic Phenotype of Human Pancreatic Cancer Cells. Clin Cancer Res 12:2976-2987. 2011 Impact Factor-7.74; ISSN No:1078-0432
  4. Singh PK, Wen Y, Swanson BJ, Shanmugam K, Kazlauskas A, Cerny RL, Gendler SJ, Hollingsworth MA (2007) Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells. Cancer Res 67:5201-5210. 2011 Impact Factor-7.85; ISSN No:0008-5472
  5. Swanson BJ, McDermott KM, Singh PK, Crocker PR, Hollingsworth, MA. (2007) MUC1 is a receptor for Myelin-Associated Glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion. Cancer Res 67:10222-10229. 2011 Impact Factor-7.85; ISSN No:0008-5472
  6. Bailey JM, Singh PK, Hollingsworth MA. (2007) Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins. J Cell Biochem 102:829-839. 2011 Impact Factor-2.868; ISSN No:1097-4644
  7. Bailey JM, Swanson BJ, Hamada T, Eggers JP, Singh PK, Caffery T, Ouellette MM, Hollingsworth MA. (2008) Sonic hedgehog promotes desmoplasia in pancreatic cancer. Clin Cancer Res 14:5995-6004. 2011 Impact Factor-7.74; ISSN No:1078-0432
  8. Chaturvedi P, Singh AP, Chakraborty S, Chauhan SC, Bafna S, Meza JL, Singh PK, Hollingsworth MA, Mehta PP, Batra SK. (2008) MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells. Cancer Res 68:2065-2070. PMCID: PMC2835497; 2011 Impact Factor-7.85; ISSN No:0008-5472
  9. Singh PK, Behrens ME, Eggers JP, Cerny RL, Bailey JM, Shanmugam K, Gendler SJ, Bennett EP, Hollingsworth MA. (2008) Phosphorylation of MUC1 by Met Modulates Interaction with p53 and MMP1 Expression. J Biol Chem 283:26985-26995. PMCID: PMC2556014; 2011 Impact Factor-4.773; ISSN No:0021-9258
  10. Behrens ME, Grandgenett PM, Bailey JM, Singh PK, Yi CH, Yu F, Hollingsworth MA. (2010). The reactive tumor microenvironment: MUC1 signaling directly reprograms transcription of CTGF. Oncogene 29(42):5667-77. PMC journal – In Process; 2011 Impact Factor-6.373; ISSN No:0950-9232
  11. Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim JH, Goode J, Igata M, Paz JC, Hogan MF, Singh PK, Goebel N,Vera L, Miller N, Cui J, Jones MR; CHARGE Consortium; GIANT Consortium, Chen YD, Taylor KD, Hsueh WA, Rotter JI, Montminy M. (2010). CRTC3 links catecholamine signalling to energy balance. Nature 468(7326):933-9. PMCID: PMC3025711 [Available 2011/12/1]; 2011 Impact Factor-36.28; ISSN No:0028-0836
  12. Eggers JP, Grandgenett PM, Collisson EA, Behrens ME, Tremayne J, Singh PK, Swanson BJ, Anderson JM, Caffrey TC, High R, Oullette M, Hollingsworth MA. (2011). Cyclin Dependent Kinase 5 is amplified and over-expressed in pancreatic cancer and activated by mutant K-Ras. Clinical Cancer Res Oct 1 2011; 17:6140-6150; Published OnlineFirst August 8, 2011. PMCID: PMC Journal – in process; 2011 Impact Factor-7.74; ISSN No:1078-0432
  13. Singh PK*, Mehla K, Hollingsworth MA, Johnson KR. (2011) Regulation of aerobic glycolysis by miRNA in Cancer. Molecular and Cellular Pharmacology 2011;3(3):125-134. (* corresponding author). Impact Factor not yet released; ISSN No:19381247
  14. Chaika NV, Yu F, Purohit V, Mehla K, Lazenby AJ, DiMaio D, Anderson JM, Yeh JJ, Johnson KR, Hollingsworth MA and Singh PK*. (2012) Differential expression of metabolic genes in tumor and stromal components in primary and metastatic loci in pancreatic adenocarcinomas. PLoS One. 2012;7(3):e32996. Epub 2012 Mar 7. (* corresponding author); 2011 Impact Factor-4.09; ISSN No: 19326203
  15. Singh PK*, Brand RE and Mehla K. (2012) miRNAs in pancreatic cancer metabolism. Nature Reviews Gastroenterology & Hepatology 2012 Apr 17. doi: 10.1038/nrgastro.2012.63. Epub 2012 (* corresponding author); 2011 Impact Factor-8.1; ISSN No: 1759-5045
  16. Torres MP, Rachagani, S, Purohit V, Pandey P, Joshi S, Moore ED, Johansson SL, Singh, PK, Ganti AK, Batra SK. (2012) Graviola: A novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism. Cancer Letters 2012 Oct 1;323(1):29-40; 2011 Impact Factor-4.03; ISSN No:0304-3835
  17. Dey P, Rachagani S, Chakraborty S, Singh PK, Zhao X, Gurumurthy CB, Anderson J, Lele S, Hollingsworth MA, Band V and Batra SK. Overexpression of Ecdysoneless (Ecd) in Pancreatic Cancer and its Role in Oncogenesis by Regulating Glycolysis. Clinical Cancer Research 2012 Sep 12 (Epub). 2011 Impact Factor-7.74; ISSN No:1078-0432
  18. Chaika NV, Gebregiworgis T, Lewallen ME, Purohit V, Radhakrishnan P, Liu X, Zhang B, Mehla K, Brown RB, Caffrey T, Yu F, Johnson KR, Powers R, Hollingsworth MA, and Singh PK*. (2012) MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer. PNAS, 2012 Aug 21;109(34):13787-92. (direct submission; * corresponding author); 2011 Impact Factor-9.68; ISSN No:1091-6490
  19. Mehla K, Singh D, Chaudhary S, Kumar S and Singh PK (2012). Exome sequencing and advances in crop improvement. Advances in Genetics. 2012;79:87-121. 2012 Impact Factor-4.850 (* corresponding author)
  20. Stark JL, Mehla K, Chaika N, Acton TB, Xiao R, Singh PK, Montelione GT, and Powers R. (2014) The structure and function of human DNAJA1 and its relationship to pancreatic cancer. Manuscript in press for Biochemistry. 2012 Impact Factor-3.377; ISSN No: 0006-2960
  21. Liu X, Caffrey TC, Steele MM, Mohr A, Singh PK, Radhakrishnan P, Kelly DL, Wen Y, Hollingsworth MA (2014). MUC1 regulates cyclin D1 gene expression through p120 catenin and β-catenin. Oncogenesis. Jun 30;3:e107. doi: 10.1038/oncsis.2014.19.
  22. Mehla K and Singh PK*. (2014) MUC1: a novel metabolic regulator. Manuscript in press for BBA Reviews on Cancer. 2014 Apr;1845(2):126-35 (* corresponding author) 2012 Impact Factor-9.033; ISSN No: 0304-419X. (* corresponding author)
  23. Shukla SK, Gebrgioworgis T, Purohit V, Gunda V, Radhakrishnan P, Mehla K, Pipinos II, Powers R, Yu F, Singh PK* (2014). Metabolic Reprogramming Induced by Ketone Bodies Diminishes Pancreatic Cancer Cachexia. Cancer Metab. 2014 Sep 1;2:18. doi: 10.1186/2049-3002-2-18. eCollection 2014. PMCID: PMC4165433. (* corresponding author)

Articles under revision for publication in scholarly journals:

  1. Coothankandaswamy  V, Cao S, Xu Y, Prasad PD, Singh PK, Ganapathy V and YD Bhutia YD. The amino acid transporter SLC6A14 is an effective drug target for treatment of pancreatic cancer. Manuscript currently under revision for Molecular Cancer Research.

Articles submitted for publication in scholarly journals:

  1. Gunda V, Chaika NV, Shukla SK, Yu F, Bessho T, Lin C, and Singh PK*. MUC1-mediated metabolic alterations regulate radiation resistance in pancreatic cancer cells. Manuscript submitted to Oncogene. (* corresponding author)
  2. Shukla SK, Gunda V, Abrego J, Haridas D, Chaika NV, Yu F, Batra SK, and Singh PK*. MUC16-mediated metabolic reprogramming induces motility and invasiveness in pancreatic cancer cells. Manuscript submitted to Cancer Letters. (* corresponding author)
  3. Purohit V, Abrego J, Gunda V, Lankford SN, Chaika NV, Yu F, and Singh PK*. Increased Dependence on Glutamine Metabolism Causes Resistance to Src Inhibitor Saracatinib. Manuscript submitted to Oncotarget. (* corresponding author)

Book Chapters Published:

  • Purohit V, Mehla K and Singh PK*. (2013) Pancreatic Cancer Pathogenesis. In press for Encyclopedia of Cancer. (* corresponding author)


Pankaj Kumar Singh

Associate Professor


  • : 1-402-559-2726

  • DEPARTMENT Eppley Institute for Cancer Research
    The University of Nebraska Medical Center