Publications

  1. Gudkov AV, Komarova EA, Nikiforov MA, Zaitsevskaya TE. ART-CH, a new chicken retrovirus-like element. 
    J Virol 1992; 66:1726-173.
  2. Nikiforov MA, Gudkov AV. 1994. ART-CH: a VL-30 in chickens.   
    J Virol 1994; 68:846-853.
  3. Bacus SS, Yarden Y, Oren M, Chin DM, Lyass L, Zelnick CR, Kazarov AR, Toyofuku W, Gray-Bablin J, Beerli RR, Nikiforov M, Haffner R, Hynes NE, Gudkov AV, Keyomarsi K.  Neu differentiation factor (heregulin) activates a p53-Cip1/Waf1 pathway in cancer cells.  
    Oncogene 1996; 12:2535-2547.
  4. Deichman GI, Kashkina LM, Mizenina OA, Gorojanskaya AE, Nikiforov MA, Gudkov AV, Dyakova NA, Komelkov AV, Prilutskaya MO, Kushlinsky NE, Tatosyan AG. Mechanisms of unusually high antioxidant activity of RSV-SR-transformed cells and of its suppression by activated p21ras.
    Int J Cancer 1996; 66:747-752.
  5. Nikiforov MA, Hagen K, Ossovskaya VS, Connor TMF, Lowe SW, Deichman GI, Gudkov AV. p53 modulation of anchorage-independent growth and experimental metastasis.  
    Oncogene 1996; 13:1709-1719.
  6. Nikiforov MA, Kwek SSS, Mehta R, Artwohl JE, Lowe SW, Gupta TD, Deichman GI, Gudkov AV. Suppression of apoptosis by Bcl-2 does not prevent p53-mediated control of experimental metastasis and anchorage dependence.
    Oncogene 1997; 15:3007-3012.
  7. Deichman GJ, Matveeva VA, Kashkina LM, Dyakova NA, Uvarova EN, Nikiforov MA, Gudkov AV.  Cell transforming genes and tumor progression: in vivo unified secondary phenotypic cell changes.
    Int J Cancer 1998; 75:277-283.
  8. Maercker C, Kortwig H, Nikiforov MA, Allis CD, Lipps HJ. A Nuclear protein involved in apoptotic-like DNA degradation in Stylonychia: implications for similar mechanisms in differentiating and starved cells.
    Mol Biol Cell 1999; 10:3003-3014.
  9. Nikiforov MA, Smothers JF, Gorovsky MA, Allis CD. Excision of micronuclear-specific DNA requires parental expression of Pdd2p and occurs independently from DNA replication in Tetrahymena thermophila.
    Genes Dev 1999; 13:2852-2862.
  10. Coyne RS*, Nikiforov MA*, Smothers JF, Allis CD, Yao M-C. Parental expression of the chromodomain protein Pdd1p is required for completion of programmed DNA elimination and nuclear differentiation.
    Mol Cell 1999; 4:865-872 *co-first contributors
  11. Nikiforov MA, Gorovsky MA, Allis CD. A novel chromodomain protein Pdd3p associates with internal eliminated sequences during macronuclear development in Tetrahymena thermophila.
    Mol Cell Biol 2000; 20:4128-4134.
  12. Nikiforov MA, Kotenko I, Petrenko O, Beavis A, Valenick L, Lemischka I, Cole MD.  Complementation of Myc-dependent cell proliferation by cDNA expression library screening.
    Oncogene 2000; 19:4828-4831.
  13. Gurova KV, Kwek SSS, Koman IE, Komarov AP, Kandel ES, Nikiforov MA, Gudkov AV. Apoptosis inhibitor as a suppressor of tumor progression: expression of bcl-2 eliminates selective advantages for p53-deficient cells in the tumor.
    Cancer Biol Ther 2002; 1:30-35.
  14. Nikiforov MA, Chandriani S, Petrenko O, O'Connell B, Kotenko I, Beavis A, Sedivy JM, Cole MD.  A functional screening for Myc-induced genes reveals serine hydroxymethyltransferase, a major source of one-carbon unit for cell metabolism.
    Mol Cell Biol 2002; 22: 5793-5800.
  15. Nikiforov  MA, Chandriani S, Park J, Kotenko I, Matheos D, Johnsson A, McMahon SB, Cole MD. TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family proteins.
    Mol Cell Biol 2002; 22:5054-5063.
  16. Nikiforov MA, Popov N, Kotenko I, Henriksson M, Cole MD. The Myc and Mad1 basic domains are functionally equivalent.
    J Biol Chem 2003; 278:11094-11099.
  17. Cole MD, Nikiforov MA. Transcriptional activation by the Myc oncoprotein. In “The Myc/Max/Mad Transcription Factor Network”, Eisenman, R.N. (Ed.)
    Curr Top Microbiol Immunol, 2006; Vol 302:33-50.
  18. Denoyelle C, Abou-Rjaily GV, Bezrookove V, Verhaegen M, Johnson TM, Fullen DR, Pointer JN, Gruber SF, Su LD, Nikiforov MA, Kaufman RJ, Bastian BC, Soengas MS.  Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.
    Nat Cell Biol 2006, 8:1053-63.
  19. Nikiforov MA, Riblett  M, Tang WH, Gratchouck V, Hari M, Fernandez Y, Verhaegen M, Jakubowiak AJ, Soengas MS. Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition.
    Proc Natl Acad Sci 2007; 104:19488-93.
  20. Wang H, Mannava S, Grachtchouk V, Zhuang D, Soengas MS, Gudkov AV, Prochownik EV, Nikiforov MA.  c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle.
    Oncogene 2008; 27:1905-1915.
  21. Mannava S, Grachtchouk V, Wheeler LJ, Im M, Zhuang D, Slavina EG, Mathews CK, Shewach DS,  Nikiforov MA.  Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells.
    Cell Cycle 2008; 7:2392-400. (featured on the cover).
  22. Zhuang D, Mannava S, Grachtchouk V, Tang W-H, Patil S, Wawrzyniak JA, Berman AE, Giordano TJ, Prochownik EV, Soenas MS, Nikiforov MA.  C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells.
    Oncogene 2008; 27:6623-6634. (featured on the cover).
  23. Flanagan SA, Krokosky CM, Mannava S, Nikiforov MA, Shewach DS.
    1. MLH1 Deficiency Enhances Radiosensitization with 5-Fluorodeoxyuridine by Increasing DNA Mismatches.
    2. Mol Pharmacol 2008; 74:863-871.
  24. Bansal R, Nikiforov MA.  Pathways of oncogene-induced senescence in human melanocytic cells.
    Cell Cycle. 2010; 9: 2782-2788.
  25. Shtutman M, Baig M, Levina E, Hurteau G, Lim CU, Broude E, Nikiforov M, Harkins TT, Carmack CS, Ding Y, Wieland F, Buttyan R, Roninson IB. Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1.
    Proc Natl Acad Sci U S A; 2011; 108:12449-12454.
  26. Mannava S, Zhuang D, Nair JR, Bansal R, Wawrzyniak JA, Zucker SN, Fink EE, Moparthy KC, Hu Q, Liu S, Boise LH, Lee KP, Nikiforov MA.  KLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cells.  
    Blood. 2012; 119:1450-1458   
  27. Mannava S, Omilian AR, Wawrzyniak JA, Fink EE, Zhuang D, Miecznikowski JC, Marshall JR, Soengas MS, Sears RC, Morrison CD, Nikiforov MA. PP2A-B56α controls oncogene-induced senescence in normal and tumor human melanocytic cells.  
    Oncogene; 2012; 31:1484-1492
  28. Pabona JPM, Simmen FA, Nikiforov MA, Zhuang D, Shankar K, Zelenko Z, Giudice LC, Simmen RCM.  Krüppel-like Factor 9 and Progesterone Receptor co-regulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis. 
    J Clin Endocrinol Metab; 2012; 97:376-392
  29. Flanagan SA, Cooper KS, Mannava S, Nikiforov MA, Shewach DS. Short Hairpin RNA Suppression of Thymidylate Synthase Produces DNA Mismatches and Results in Excellent Radiosensitization.
    Int J Radiat Oncol; 2012; 84:e613-620
  30. Mannava S, Moparthy KC, Wheeler LJ, Leonova KI, Wawrzyniak JA, Bianch-Smiraglia A, Berman AE, Flanagan S, Schewach DA, Zeitouni NC, Gudkov AV, Mathews CK, Nikiforov MA. Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence-associated phenotypes caused by C-MYC depletion.
    Aging; 2012; 4:917-922
  31. Bianchi-Smiraglia A and Nikiforov MA. Controversial aspects of oncogene-induced senescence.
    Cell Cycle; 2012; 11:4147-4155
  32. Berman AE, Leontieva OV, Natarajan V, McCubrey JA, Demidenko ZN, Nikiforov MA. Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes.
    Oncotarget; 2012; 3:1522-1532
  33. Mannava S, Moparthy KC, Wheeler LJ, Natarajan, V, Zucker SN, Fink EE, Im M, Flanagan S, Shewach DS, Burhans, WC, Mathews CK, Nikiforov MA. Depletion of deoxyribonucleotide pools is an endogenous source of DNA damage in cells undergoing oncogene-induced senescence.
    American Journal of Pathology; 2012; 182:142-151
  34. Burkhart CA Haber M, Norris MD, Gudkov AV, Nikiforov MA. Cell-based methods for the identification of MYC-inhibitory small molecules.
    Methods in Molecular Biology;2013; 1012:255-264
  35. Liu X, Hu Q, Liu S, Tallo LJ, Sadzewicz L, Schettine CA, Nikiforov M, Klyushnenkova EN, Ionov Y. Serum Antibody Repertoire Profiling Using In Silico Antigen Screen.
    PLoS One; 2013; 8(6):e67181
  36. Wawrzyniak JA, Bianchi-Smiraglia A, Bshara W, Mannava S, Ackroyd J, Bagati A, Omilian AR, Im M, Fedtsova N, Miecznikowski JC, Moparthy KC, Zucker SN, Zhu Q, Kozlova NI, Berman AE, Hoek KS, Gudkov AV, Shewach DS, Morrison CD, Nikiforov MA. A purine nucleotide biosynthesis enzyme guanosine monophosphate reductase is a suppressor of melanoma invasion.
    Cell Reports; 2013; 5(2):493-507
  37. Zucker SN, Fink EE, Bagati A. Mannava S, Bianchi-Smiraglia A, Bogner PN, Wawrzyniak JA, Foley C, Leonova KI, Grimm MJ, Moparthy K, Ionov Y, Wang J, Liu S, Bakin AV, Sexton S, Kandel ES, Zhang Y, Kaminski N, Segal BH, Nikiforov MA. Nrf2 amplifies oxidative stress via induction of Klf9.
    Molecular Cell. 2014; 53:916-928.

 

Mikhail A. Nikiforov

Professor

:(716) 845-3374
Fax:(716) 845-3944

  • DEPARTMENT Department of Cell Stress Biology
    Roswell Park Cancer Institute
  • COUNTRY USA