Publications

Selected peer-reviewed publications (from over 110)

1. Ghosh SC, Auzenne E, Khodadadian M, Farquhar D, Klostergaard J. N,N-Dimethylsphingosine conjugates of poly-L-glutamic acid: synthesis, characterization, and initial biological evaluation. Bioorg Med Chem Lett
19(3):1012-7, 2/1/2009. e-Pub 11/27/2008. PMID: 19097786.

2. Somasunderam A, Thiviyanathan V, Tanaka T, Li X, Neerathilingam M, Lokesh GL, Mann A, Peng Y, Ferrari M, Klostergaard J, Gorenstein DG. Combinatorial selection of DNA thioaptamers targeted to the HA binding domain of human CD44. Biochemistry. 2010 Oct 26;49(42):9106-12.PMID: 20843027

3. Klostergaard J, Bankson J, Woodward W, Gibson D, Seeney C. Magnetically-Responsive Nanoparticles for
Vectored Delivery of Cancer Therapeutics.  AIP Conf. Proc. 1311: 382-387, 2010.

4. Zou Y, Fu H, Ghosh S, Farquhar D, Klostergaard J. Antitumor activity of hydrophilic Paclitaxel copolymer prodrug using locoregional delivery in human orthotopic non-small cell lung cancer xenograft models. Clin Cancer Res 10:7382-91, 11/2004. PMID: 15534115.

5. Klostergaard J, Auzenne E, Ghosh S, Farquhar D, Rivera B, Price RE. Magnetic resonance imaging-based prospective detection of intraperitoneal human ovarian carcinoma xenografts treatment response. Int J Gynecol Cancer 16 Suppl 1:111-7, 2006. PMID: 16515577.

6. Auzenne E, Ghosh SC, Khodadadian M, Rivera B, Farquhar D, Price RE, Ravoori M, Kundra V, Freedman RS, Klostergaard J. Hyaluronic acid-paclitaxel: antitumor efficacy against CD44(+) human ovarian carcinoma xenografts. Neoplasia 9:479-86, 2007.

7. Khodadadian M, Leroux ME, Auzenne E, Ghosh SC, Farquhar D, Evans R, Spohn W, Zou Y, Klostergaard J MRP- and BCL-2 mediated drug resistance in human SCLC: Effects of apoptotic sphingolipids in vitro. Lung Cancer 66(1):48-57, 10/2009. e-Pub 2/4/2009. PMID: 19195736.

8. Yan H, Chen X, Zhang Q, Qin J, Li H, Liu C, Calhoun-Davis T, Coletta LD, Klostergaard J, Fokt I, Skora S, Priebe W, Bi Y, Tang DG. Drug-tolerant cancer cells show reduced tumor-initiating capacity: depletion of CD44 cells and evidence for epigenetic mechanisms. PLoS One. 2011;6(9):e24397.

9. Galer CE, Sano D, Ghosh SC, Hah JH, Auzenne E, Hamir AN, Myers JN, Klostergaard J. Hyaluronic acid-paclitaxel conjugate inhibits growth of human squamous cell carcinomas of the head and neck via a hyaluronic acid-mediated mechanism. Oral Oncol. 2011 Nov;47(11):1039-47.

10. Seeney C, Ojwang JO, Weiss RD, Klostergaard J. Magnetically vectored platforms for the targeted delivery of therapeutics to tumors: history and current status. NanoMedicine (Lond.) 2012 Feb;7(2):289-99.

11. Seeney C, Klostergaard J. Magnetic nanovectors for drug delivery Nanomedicine: NBM and Maturitas on
Nanotechnology for Healthy Aging. Maturitas. 2012 73(1): 33-44; Nanomedicine. 2012 8 Suppl 1:S37-50.

12. Ghosh SC, Neslihan Alpay S, Klostergaard J. CD44: a validated target for improved delivery of cancer therapeutics. Expert Opin Ther Targets. 2012 16(7): 635-50.

13. Lee SJ, Ghosh SC, Han HD, Stone RL, Bottsford-Miller J, Shen de Y, Auzenne EJ, Lopez-Araujo A, Lu C, Nishimura M, Pecot CV, Zand B, Thanapprapasr D, Jennings NB, Kang Y, Huang J, Hu W, Klostergaard J, Sood AK. Metronomic activity of CD44-targeted hyaluronic acid-paclitaxel in ovarian carcinoma. Clin Cancer Res. 2012 18(15): 4114-21.

14. McMurray JS, Mandal PK, Liao WS, Klostergaard J, Robertson FM. The consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domain. JAKSTAT. 2012 Oct 1; 1(4):263-347. Review.

15. Auzenne EJ, Klostergaard J, Mandal PK, Liao WS, Lu Z, Gao F, Bast RC Jr, Robertson FM, McMurray JS. A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis. J Exp Ther Oncol. 2012; 10(2): 155-62.

16. Alpay NS and Klostergaard J. The EPR Effect as THE Critical Event in the Decathlon of Nanoparticle Targeting to Tumors. JSM Nanotechnology and Nanomedicine (in press).

17. Alpay NS and Klostergaard J. Enhanced Permeability and Retention Effect: Insights Impacting Nanoscale Drug Delivery systems In: Recent Advances in Drug Delivery Research Nova V. Voliani, Ed. 2013.