Publications (Peer Reviewed Journals)

  1. Bakin, A.V., Evstafieva, A.G., Borisova, O.F., Shatsky, I.N., Bogdanov, A.A. (1987) Measurement of the Distance between 5' and 3' ends of ribosome-bound messenger RNA by singlet-singlet energy transfer method.  Dokl. Akad. Nauk USSR 294;(4):988-991.
  2. Bakin, A.V., Borisova, O.F., Shatsky, I.N., Bogdanov, A.A. (1988) Topography of mRNA-binding site of Escherichia coli ribosomal protein S1.  Dokl. Akad. Nauk USSR 300;(1) 237-240.
  3. Bakin, A.V., and Shatsky, I.N. (1989) Selective fluorescent labelling of the RNA to study its macromolecule structure in the solution.  Biopolim. and Kletka 5;(3):71-76.
  4. Bakin, A.V., Borisova, O.F., Shatsky, I.N., Bogdanov, A.A. (1991) Spatial organization of template polynucleotides on the ribosome determined by fluorescent methods.  J. Mol. Biol. 221; 441-453.
  5. Shatsky, I. N., Bakin, A.V., Bogdanov, A. A., Vasiliev, V. D.,(1991) How does the mRNA pass through the ribosome?  Biochimie 73;937-945.
  6. Bakin, A.V., and Ofengand, J. (1992) A high sensitivity method for sequencing RNA: Application to ribosomal RNA.  BioTechniques 13;(5):682-683.
  7. Cunningham, P. R., Nurse, K. N., Bakin, A.V., Weitzmann C. J, Pflumm, M., Ofengand, J. (1992) Interaction between the two conserved single-stranded regions at the decoding site of small subunit ribosomal RNA is essential for ribosome function.  Biochemistry 31:12012-12022.
  8. Santer, M., Santer, U., Nurse, K.N., Bakin, A.V., Cunningham, P.R., Zain, M., O'Connel, D.,  Ofengand, J. (1993) Functional effects of a G to U base changeat position 530 in a highly conserved loop of Escherichia coli 16S rRNA.  Biochemistry 32:5539-5547.
  9. Bakin, A., and Ofengand, J. (1993) Four newly located pseudouridylate residues in Escherichia coli  23S ribosomal RNA are all at the peptidyl transferase center: analysis by the application of a new sequencing technique.  Biochemistry 32:9754-9762. *** over 200 citations in Google Scholar.
  10. Bakin, A., Kowalak, J., McCloskey, J., Ofengand, J. (1994) The single pseudouridine residue in E.scherihia coli  16S RNA is located at position 516.  Nucleic Acids Res. 22:3681-3684. 
  11. Bakin, A., Lane, B., Ofengand, J. (1994) Clustering of pseudoridines at the peptidyl transferase center of yeast ribosomes. Biochemistry 33:13475-13483. 
  12. Nurse, K., Wrzesinski, J., Bakin, A., Lane, B., Ofengand, J. (1995) Purification, cloning, and properties of the tRNA 55 synthase from E.scherihia coli .  RNA 1:102-112. 
  13. Wrzesinski, J., Bakin, A., Nurse, K., Lane, B., Ofengand, J. (1995) Purification, cloning, and properties of the 16S RNA 516 synthase from E.scherihia coli. Biochemistry 34: 8904-8913.
  14. Bakin, A., and Ofengand, J. (1995) Mapping of the thirteen pseudouridine residues in Saccharomyces cerevisiae  small subunit ribosomal RNA to nucleotide resolution. Nucleic Acids Res. 23;(16):3290-3294. 
  15. Ofengand, J., Bakin, A., Wrzesinski, J., Nurse, K., Lane, B.G. (1995) The pseudouridine residue of Ribosomal RNA.  Biochemistry and Cell Biology, 73;(11-12):915-924. Review.
  16. Ofengand, J., Bakin, A., Wrzesinski, J., Nurse, K., Lane, B.G. (1995) The pseudouridine residue of Ribosomal RNA.  Biochemistry and Cell Biology, 73;(11-12):915-924.
  17. Ofengand, J., Bakin, A., (1995) Pseudouridine residues at active-sites in ribosomal-rna from Escherichia-coli to man. Journal Of Cellular Biochemistry, p.212;
  18. Bakin, A., and Ofengand, J. (1997) Mapping to nucleotide resolution of pseudouridine residues in large subunit ribosomal RNAs from representative eukaryotes, prokaryotes, archaebacteria, mitochondria and chloroplasts.  J. Mol. Biol. 266;(2):246-268.
  19. Bakin, A., and Curran, T. (1999) Cell transformation by the fos oncogene is mediated by DNA 5-methylcytosine transferase. Science 283:(5400):387-390.
  20. Bakin, A., Tomlinson, A. K., Bhowmick, N.A., Moses, H.L., Arteaga, C. L. (2000) Phosphatidylinositol-3 kinase function is required for TGFb-mediated epithelial to mesenchymal transition and cell migration. J. Biol. Chem. 275:36803-36810.  *** over 600 citations in Google Scholar.
  21. Wrzesinski, J., Bakin, A., Ofengand, J., Lane, B.G. (2000) Isolation and properties of Escherichia coli 23S-RNA pseudouridine 1911, 1915, 1917 synthase. IUBMB Life 50:33-37.
  22. Bhowmick, N.A., Ghiassi, M., Bakin A., Aakre, M., Lundquist, C.A., Engel, M., Arteaga C. L., Moses, H.L. (2001) TGFb mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol. Biol. Cell 12:27-36.
  23. Shin, I., Bakin, A.V., Rodeck, U., Brunet, A., Arteaga, C.L. (2001) TGFbeta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1 Mol. Biol. Cell 12;(11)3328-3339.
  24. Bakin, A., Rinehart, C., Tomlinson A. K., Arteaga, C. L. (2002) p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration. J. Cell Sci. 115; (Pt 15):3193-3206. *** over 300 citations in Google Scholar.
  25. Shin, I., Yakes, F.M., Rojo, F., Shin, N.-Y., Bakin, A.V., Baselga, J., Arteaga, C.L. (2002) PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization. Nat. Med. 10:1145-1152.
  26. Dumont, N., Bakin, A.V., Arteaga,C.L. (2003) Autocrine TGF-beta signaling mediates smad-independent motility in human cancer cells. J. Biol. Chem. 278;(5):3275-3285.
  27. Bakin, A.V., Rinehart, C., Safina, A., Daroqui, C., Darbary, H., Helfman, D. (2004) A critical role of tropomyosins in TGF-b regulation of the actin cytoskeleton and cell motility in epithelial cells. Mol. Biol. Cell 15:(10):4682-4694.
  28. Bakin, A.V., Sekhar, K.R., Stourman, N.V., Rinehart,C., Yan, X., Meredith, M.J., Arteaga, C.L.,  Freeman, M.L. (2005) Smad Signaling Suppresses Phase II Gene Expression. Free Radical Biol. Med. 38;(3):375-387.
  29. Varga, A.E., Quan, L., Stourman, NV, Safina, A, Li, X., Sossey-Alaoui, K., Bakin, AV. (2005) Silencing of the tropomyosin 1 gene by DNA methylation alters tumor suppressor function of TGF beta. Oncogene 24;(32):5043-5052.
  30. Rossi, M.R., Ionov, Y., Bakin, A.V., Cowell, J.K.  (2005) Truncating mutations in the ACVR2 gene attenuates activin signaling in prostate cancer cells.  Cancer Genet. Cytogenet. 163:123-129.
  31. Sossey-Alaoui, K., Ranalli, T.A., Li, X., Bakin, A., Cowell, J.K. (2005) WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3 and MMP-9- expression.  Exp. Cell Res. 308:135-145.
  32. Safina, A., Vandette, E., Bakin, A.V. (2007)  ALK5 promotes tumor angiogenesis by upregulating matrix metalloproteinase-9 in tumor cells.  Oncogene 26:2407-2422.
  33. Daroqui, C.M., Ilarregui, J.M., Rubinstein, N., Salatino, M., Toscano, M.A., Vazquez, P., Bakin, A., Puricelli, L., Cal de Kier Joffe, E., Rabinovich, G.A. (2007)  Regulation of galectin-1 expression by transforming growth factor beta1 in metastatic mammary adenocarcinoma cells:  implication for tumor-immune escape.  Cancer Immunol. Immunother. 2007; 4:491-499.
  34. Sossey-Alaoui, K., Safina, A., Li, X., Vaughan, M.M., Hicks, D.G., Bakin, A.V., Cowell, J.K. (2007) Down-regulation of WAVE3, a metastasis promoter gene, inhibits invasion and metastasis of breast cancer cells. Am. J. Pathol. 170:2112-2121.
  35. Zheng, Q., Safina, A., Bakin, A.V. (2008) Role of high-molecular weight tropomyosins in TGF-beta-mediated control of cell motility. Int. J. Cancer 122(1):78-90.
  36. Safina, A., Ren, M-Q, Bakin, A.V. TAK1 is critical for TGF-β1-mediated regulation of matrix metalloproteinase-9 and metastasis. Oncogene 2008; 27(9):1198-1207.
  37. Kulawiec M, Safina A, Desouki MM, Still I, Matsui S-I, Bakin AV, Singh KK. Tumorigenic transformation of breast epithelial cells induced by depletion of mtDNA. Cancer Biol Ther 2008; 7(10):1732-1743.  PMC2783327
  38. Safina A, Varga AE, Bianchi A, Zheng Q, Kunnev D, Liang P, Bakin AV. Ras alters epithelial-mesenchymal transition in response to TGF-beta by reducing actin fibers and cell-matrix adhesion. Cell Cycle 2009; 8(2):284-98. PMID: 19177011
  39. Bianchi, A, Gervasi M, and Bakin AV. Role of beta5-integrin in epithelial-mesenchymal transition in response to TGF-beta. Cell Cycle 2010; 9(8): 1647-1659. PMID 20404485
  40. Safina, A., P. Sotomayor, M. Limoge, C. Morrison, and Bakin A.V. 2011. TAK1-TAB2 Signaling Contributes to Bone Destruction by Breast Carcinoma Cells. Molecular Cancer Research. 9:1042-1053. PMID 21700681
  41. Ayyasamy, V., K.M. Owens, M.M. Desouki, P. Liang, A. Bakin, K. Thangaraj, D.J. Buchsbaum, A.F. LoBuglio, and K.K. Singh. 2011. Cellular Model of Warburg Effect Identifies Tumor Promoting Function of UCP2 in Breast Cancer and Its Suppression by Genipin. PLoS ONE. 6:e24792. PMID 21935467
  42. Gervasi M, Bianchi-Smiraglia A, Cummings M, Zheng Q, Wang D, Liu S, Bakin AV. 2012. JunB contributes to Id2 repression and the epithelial-mesenchymal transition in response to transforming growth factor-β. J Cell Biol. Mar 5;196(5):589-603. PMID: 223910
  43. Bianchi-Smiraglia A, Paesante S, Bakin AV. Integrin β5 contributes to the tumorigenic potential of breast cancer cells through the Src-FAK and MEK-ERK signaling pathways. Oncogene. 2012 Jul 23. PMID:2282479
  44. Daroqui MC, Vazquez P, Bal de Kier Joffé E, Bakin AV, Puricelli LI. TGF-β autocrine pathway and MAPK signaling promote cell invasiveness and in vivo mammary adenocarcinoma tumor progression. Oncol Rep. 2012 Aug;28(2):567-75. PMID: 22614218
  45. Bianchi-Smiraglia A, Kunnev D, Limoge M, Lee A, Beckerle MC, Bakin AV. Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β. Cell Cycle. 2013 Nov 1;12(21):3377-89. PMID: 24036928
  46. Verone AR, Duncan K, Godoy A, Yadav N, Bakin A, Koochekpour S, Jin JP, Heemers HV. Androgen-responsive serum response factor target genes regulate prostate cancer cell migration. Carcinogenesis. 2013 Aug;34(8):1737-46. PMID: 23576568
  47. Ivanova OA, Budynina EM, Skvortsov DA, Limoge M, Bakin AV, Chagarovskiy AO, Trushkov IV, Melnikov MY. A bioinspired route to indanes and cyclopentannulated hetarenes via (3+2)-cyclodimerization of donor-acceptor cyclopropanes. Chem Commun (Camb). 2013 Dec 21;49(98):11482-4. PMID: 23900594
  48. Zucker SN, Fink EE, Bagati A, Mannava S, Bianchi-Smiraglia A, Bogner PN, Wawrzyniak JA, Foley C, Leonova KI, Grimm MJ, Moparthy K, Ionov Y, Wang J, Liu S, Sexton S, Kandel ES, Bakin AV, Zhang Y, Kaminski N, Segal BH, Nikiforov MA. Nrf2 amplifies oxidative stress via induction of Klf9.Mol Cell. 2014 Mar 20;53(6):916-28. PMID: 24613345

Publications In Press/Preparation

  1. Limoge M, Bakin AV. TAK1-TAB2 signaling in breast carcinoma survival. (In preparation)
  2. Gervasi M, Bakin AV. TGF-beta-mediated control of epithelium-immune system crosstalk. (In preparation)

Book Chapters

  1. Ofengand, J., Bakin, A., and Nurse, K. (1993) The functional role of conserved sequences of 16S ribosomal RNA in protein synthesis.  In The Translational Apparatus (eds. K.H. Nierhaus, A.R. Subramanian, V.A. Erdmann, F. Franceschi, and B.Wittman-Liebold), Plenum Press, NY.
  2. Bakin, A., and Ofengand, J., (1997) Mapping pseudouridine residues in RNA to nucleotide resolution. In Methods in Molecular Biology: Protein Synthesis: Methods and Protocols (ed., R. Martin), Humana Press, Totowa, NJ, pp.297-309.

Abstracts Published

  1. Rho-Dependent Phosphatidylinositol-3 Kinase (PI-3K) Function is Required for TGFβ-mediated Fibroblastoid Transition in Epithelial Cells. Bakin A.V., Tomlinson A.K., and Arteaga C. L. AACR Proceedings, Abstract #1620, Volume 42, 2001.
  2. TGF-b regulates Forkhead transcription factors via PI3-kinase-Akt signaling. Incheol Shin, Andrei Bakin, Ulrich Rodeck, and Carlos Arteaga. AACR Proceedings, Abstract #2821, Volume 42, 2001.
  3. Oncogene-activated Akt directly phosphorylates the CDK inhibitor p27KIP1 and mediates cell-cycle progression. FM Yakes, MB Carter, AV Bakin, CL Arteaga. AACR Proceedings, Abstract #1393, Volume 42, 2001.
  4. p38 MAPK is required for TGF-beta-mediated fibroblastic transition and cell migration.  Andrei Bakin, Cammie Rinehart, and Carlos Arteaga. AACR Proceedings, Abstract #764, Volume 43, 2002.
  5. Smad signaling suppresses NRF2-mediated gene expression. AV Bakin, KR Sekhar, C. Rinehart, X. Yan, M. Meredith, K. Flanders, CL Arteaga, ML Freeman. AACR Proceedings, Abstract #375, Volume 44, 2003.
  6. TGF-beta regulates expression of target genes and p38MAPK signaling to induce changes in the actin cytoskeleton. AACR Proceedings, Abstract #5229, Volume 44, 2003.
  7. TGF-b and ERK signaling differentially regulate genes involved in actin stress fiber formation. AV Bakin, CM Daroqui, A Safina. AACR Proceedings, Abstract #130, Volume 45, 2004.
  8. Smad3 suppresses NRF2-mediated expression of GCLC. AV Bakin, KR Sekhar, C. Rinehart, M. Meredith, CL Arteaga, ML Freeman. AACR Proceedings, Abstract #3491, Volume 45, 2004.
  9. TGF-beta regulation of epithelial cell motility via tropomyosin-mediated actin stress fibers. AV. Bakin, A. Safina, CM Daroqui, Q. Lei, A. Varga, and D. Helfman. Metastasis Research Society 10th Congress, Italy. Abstract #2, 2004.
  10. p38 MAPK contributes to tumor invasionand metastasis associated with TGF-beta. AV Bakin, Q. Zheng, A Safina. Era of Hope Proceedings, Abstract #P28-1, 2005.
  11. The role of tropomyosin in metastatic switch in transforming growth factor beta function during cancer progression. A. Safina, AV Bakin. A. Varga, Q. Zheng, A. Safina. AACR Proceedings, Abstract #228, Volume 46, 2005.
  12. Epigenetic silencing of tropomyosin alters transforming growth factor beta control of cell invasion and metastasis, A Bakin, A Varga, Q Zheng and A Safina. Breast Cancer Research 2005, 7 (Suppl 2):P4.15doi:10.1186/bcr1145
  13. A critical role of tropomyosin in TGF-beta-mediated control EMT, invasion, and metastasis. AV Bakin, A Varga, Q Zheng, A Safina. AACR Proceedings, Abstract #2763, Volume 47, 2006.
  14. TGF-b1 signaling in tumor angiogenesis and metastasis. AV Bakin, A. Safina, R. Mazurchuck, J. Spernyak. Metastasis Research Society 11th Congress, Japan. Abstract #PD4-4, 2006.
  15. TGF-b1 signaling enhances tumor angiogenesis and metastasis. AV Bakin, A. Safina, R. Mazurchuck, J. Spernyak. AACR Proceedings, Abstract #4166, Volume 48, 2007.
  16. TGF-b1 in regulation of glutathione and drug sensitivity of normal and metastatic cells MC Eaton, Q Zheng, A Bakin CLINICAL & EXPERIMENTAL METASTASIS 2007, 24 (4), 308-309
  17. High molecular weight-tropomyosins in TGF-b-mediated regulation of invasion and metastasis AE Varga, Q Zheng, NV Stourman, AF Safina, AV Bakin. CLINICAL & EXPERIMENTAL METASTASIS 2007, 24 (4), 257-258
  18. Dissecting the role of IKKβ in tumor-specific cell death (2014) P Fields, A Beattie, M Limoge, A Bakin; The FASEB Journal 28 (1 Supplement), 1048.1


Andrei Bakin

Associate Professor


  • DEPARTMENTDepartment of Cancer Genetics
    Roswell Park Cancer Institute