Othman Ghribi, Phd
Othman Ghribi, Phd
Associate Professor of Basic Sciences

University of North Dakota
USA

Education

  • Ph.D.in Pharmacological Sciences, School of Pharmaceutical and Biological Sciences, René Descartes University, Paris, France, 1994
  • Master's in Experimental and Clinical Pharmacology, Saint-Antoine School of Medicine, Pierre et Marie Curie University, Paris, 1990
  • Bachelor in Biological and Medical Sciences in Pharmacology, School of Medicine Lariboisière Saint-Louis, Paris, 1988.
  • Certificate in Pharmacokinetic and Drug Monitoring, St-Antoine School of Medicine, Paris, France 1989 Certificate in Pharmacology of Psychotropic Drugs, Pitié-Salpêtrière, Paris, France, 1988
  • Certificate in Clinical trial management, Saint-Antoine School of Medicine, Paris France 1988

 

Profile

Othman Ghribi has completed his Ph.D in 1994 at the University René Descartes, Paris France, and postdoctoral studies from The University of Quebec and the University of Virginia. He has published more than 70 papers in reputed journals and serving on the editorial Board of The Journal of Alzheimer’s Disease, Current Alzheimer’s disease the Journal of Neurodegenerative Diseases.

Research Interest

  1. Role of environmental factors (chemical and dietary) and genetic susceptibility in the pathophysiology of Alzheimer’s and Parkinson’s diseases
  2. Role of estrogen receptors and liver X receptors modulations in age-related macular degeneration
  3. Role of the cholesterol oxidized metabolites (oxysterols) in the pathophysiology of breast and prostate cancers

 

Professional Activities:

  • 7/2010-present: Associate Professor (with tenure), Department of Basic Sciences, University of North Dakota School of Medicine.
  • 2004-2010: Assistant Professor (Tenure track) , Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine.
  • 2001-2004: Assistant Professor of Pathology (non-tenure track), University of Virginia Health System, Charlottesville, VA.
  • 1999-2001: Research Associate, Department of Pathology, University of Virginia Health system 1996-1999: Postdoctoral Fellow, Department of Biochemistry, University of Quebec, Canada. 1994-1996: Clinical Pharmacologist: Pharmacokinetic and drug monitoring, Clinical Pharmacology and Toxicology Unit, Ville-Evrard Hospital, Neuilly sur Marne, France.
  • 1987-1992:   Intern, Clinical Pharmacology Unit, Ville-Evrard Hospital, Neuilly sur Marne, France

Membership in professional organizations:

  • 1998-present: Society for Neuroscience
  • 2008-present:  International Society to Advance Alzheimer Research and Treatment
  • 2010-present: Alzheimer’s Association Minnesota-North Dakota Medical and Scientific Advisory Council 2011-present: The Association for Research in Vision and Ophthalmology

Organizing Committee member:

  • International Conference and Exhibition on Neurology & Therapeutics-Novel Therapies in Neurosciences 14-16 May 2012, Las Vegas, USA
  • International Conference on Central Nervous System - Drugs Effects & Novel Drug Development 5-7 September 2012, Philadelphia, USA
  • 2nd International Conference and Exhibition on Neurology and Therapeutics, June 17–19, 2013, Chicago/Northbrook

Review and referee work:  I review an average of 2-3 papers per week
Editorial Boards

  • Senior Handling Editor:  The Journal of Alzheimer Disease (2008-present)
  • Handling Associate Editor:  The Journal of Alzheimer’s disease and Parkinsonism (2011-present)
  • British Journal of Pharmaceutical Research (2011-present)
  • Senior Editor:     American Journal of Neurodegenerative Disease (2012-present)
  • Associate Editor: The International Journal of Clinical and Experimental Medicine (2009-present)
  • The International Journal of Medical and Clinical Research (2010-peresent)
  • Conference Papers in Neuroscience (2012-present)
  • Clinical Immunology, Endocrine & Metabolic Drugs (2011-present)
  • Current Alzheimer Research (2013-present)
  • Advances in Geriatrics (2013-present).

Ad-hoc reviewer for:
Basic and Clinical Pharmacology and Toxicology, BMC Cell Biology, BMC Genomics, Brain pathology, Brain Research, Brain Research Bulletin,Canadian Journal of Physiology and Pharmacology, Cellular and Molecular Life Science, Current eye research, Current Alzheimer’s Research, in Dementia and Geriatric Cognitive Disorders. Essential and Toxic Trace Elements, Experimental Neurology, Expert Review of Neurotherapeutics, FASEB, Future Lipidology, Journal of Alzheimer’s Disease, Journal of Molecular Signaling, Journal of Inorganic Chemistry, Journal of Neurochemistry, Journal of Neuroinflammation, Journal of Neurochemistry Research, Journal of the Neurological Sciences, Journal of Neurotoxicology, Journal of Pharmacology and Experimental Therapeutics, Journal of Psychiatry & Neuroscience, Journal of Visualized Experiments, Life Science, Medical Science Monitor, Molecular Brain Research, Neurodegenerative Diseases, Neurobiology of Disease, Neuroscience, Neuroscience Letters, Neurotoxicology, Neurotoxicity Research, Pharmacological Research, Pharmacology, PLoS ONE, Recent Patents on CNS Drug Discovery, Therapy.

Committees and service responsibilities:

  1. Member of the Steering Committee for drafting guidelines for promotion and tenure for the Department of Basic Science CPT (2014)
  2. Member of the Department of Basic Sciences Graduate Studies Admission Committee (2014)
  3. Member of the Self-Study Task Force Committee for the Medical Students; LCME 2012/2013
  4. Member of the Graduate Studies Committee for the Department of PPT (2012-2013)
  5. SMHS Committee on Promotion and Tenure (2012-present)
  6. Departmental Committee on Promotion and Tenure (2010-present)
  7. UND Medical School Program Admission Committee (2010-present)
  8. UND Institutional Animal care and use Committee member (2009-present)
  9. Health Sciences Curriculum Committee (2009-2012)
  10. Search committee for recruiting new faculty for the Department of Pharmacology, Physiology and Therapeutics (2009)
  11. UND Senate Committee (2007- 2008)
  12. Organizer and moderator of the Departmental Journal club meetings 2005, 2006
  13. Organizer of the Research progress report for fall 2004; spring 2005; fall 2005; and spring 2006
  14. Graduate Advisory Committee for the following students:

Teaching activities
Graduate teaching
PPT 500: Antiparkinsonians (1hr), Antidepressants (2 hr); Calcium (1 ½ hr) PPT 503: Cell culture and organotypic slices (1 hr)
PPT 511: Apoptosis and kinase signaling (2008; 9 hr) PPT 521: Seminar (3 hr)
PPT 535:  Alzheimer’s disease (2 hr)
PPT 540: Molecular Neuropharmacology, Course director (21 hr; every other year) BIMD500: Plasma membrane (2 hr), Apoptosis (1hr)

MIMD module 4.
Medical teaching

Block Facilitation: Block III (2006), Block I (2006; 2007; 2008), Block IV (2010; 2011), Block V (2012; 2013); Block VII (2015).
Lectures: Issues in Dementia (1 hr), Parkinson’s disease (1 hr), Diuretics (1 hr), Calcium (1hr).

  1. Interprofessional Health Care Course.
    Facilitation: Fall 2010, Session I
  2. Nursing program teaching
    N528: Gerantological problems (Spring 2009-present): Alzheimer’s disease (1 hr), Atherosclerosis (1hr) N528: Gerantological problems (Fall 2009-present): Parkinson’s disease (1 hr)
    N528: Registered Nurses program (Spring 2013): What’s new in Alzheimer’s disease? 1.5hr

 

Honors and Awards

Honors and awards

2010; 2012; 2014   Outstanding Block Instructor Award, Medical Students
2010: Dean David Wilson Academic Award in Neuroscience
2009: North Dakota Spirit Faculty Achievement Award
2007: University of North Dakota Faculty Star.
2002: Alzheimer's & Related Diseases Research Award, Virginia Center On Aging
1997:Alzheimer’s Society of Canada postdoctoral grant (1997 -1999).
1994:Laureate of Pharmaceutical and Biological Sciences School, René Descartes University, Paris, France.
1994:Roussel Laboratories (France) First price Award for Thesis Dissertation.

 

Publications

Papers (peer-reviewed;h factor: 25)

  1. Lekieffre,D., Ghribi,O., Callebert,J., Plotkine,M., & Boulu,R.G. (1992) Involvement of glutamic acid and adenosine in the consequences of forebrain ischemia in the rat. Circulation et Metabolisme du Cerveau 9, 31-46.
  2. Lekieffre,D., Ghribi,O., Callebert,J., Allix,M., Plotkine,M., & Boulu,R.G. (1992) Inhibition of glutamate release in rat hippocampus by kynurenic acid does not protect CA1 cells from forebrain ischemia. Brain Research 592, 333-337.
  3. Beaudeux,C., Dumortier,G., Ghribi,O., & Degrassat,K. (1993) Dispensing clozapine at the specialized hospital of Ville-Evrard: Report of seven hematological side effects. Journal de Pharmacie Clinique 12, 312-313.
  4. Ghribi,O., Callebert,J., Plotkine,M., & Boulu,R.G. (1994) Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia. NeuroReport 5, 1253-1255.
  5. Ghribi,O., Callebert,J., Plotkine,M., & Boulu,R.G. (1994) Effect of kynurenic acid on the ischaemia-induced accumulation of glutamate in rat striatum. NeuroReport 5, 435-437.
  6. Ghribi,O., Callebert,J., Plotkine,M., & Boulu,R.G. (1994) L-NAME modulates glutamate accumulation induced by K+-depolarization but not by forebrain ischaemia in the rat striatum. Neuroscience Letters 174, 34-38.
  7. Ghribi,O., Callebert,J., Verrecchia,C., Plotkine,M., & Boulu,R.G. (1995) Blockers of NMDA-operated channels decrease glutamate and aspartate extracellular accumulation m striatum during forebrain ischaemia in rats. Fundamental and Clinical Pharmacology 9, 141-146.
  8. Dumortier,G., Lochu,A., De Melo,P.C., Ghribi,O., Rabreau,D.R., Degrassat,K., & Desce,J.M. (1996) Elevated clozapine plasma concentrations after fluvoxamine initiation [12]. American Journal of Psychiatry 153, 738-739.
  9. Feldman,D., Ghribi,O., Ouary,J., Dumortier,G., Degrassat,K., & Leverge,R. (1998) Quality control of 7 drugs unit doses. Journal de Pharmacie Clinique 17, 268-271.
  10. Krzywkowski,P., Ghribi,O., Gagn+¬,J., Chabot,C., Kar,S., Rochford,J., Massicotte,G., & Poirier,J. (1999) Cholinergic systems and long-term potentiation in memory-impaired apolipoprotein E-deficient mice. Neuroscience 92, 1273-1286.
  11. Ghribi,O., Lapierre,L., Girard,M., Ohayon,M., Nalbantoglu,J., & Massicotte,G. (1999) Hypoxia-induced loss of synaptic transmission is exacerbated in hippocampal slices of transgenic mice expressing C-terminal fragments of Alzheimer amyloid precursor protein. Hippocampus 9, 201-205.
  12. Furling,D., Ghribi,O., Lahsaini,A., Mirault,M.E., & Massicotte,G. (2000) Impairment of synaptic transmission by transient hypoxia in hippocampal slices: Improved recovery in glutathione peroxidase transgenic mice. Proceedings of the National Academy of Sciences of the United States of America 97, 4351-4356.
  13. Cyr,M., Ghribi,O., & Di Paolo,T. (2000) Regional and selective effects of oestradiol and progesterone on NMDA and AMPA receptors in the rat brain. Journal of Neuroendocrinology 12, 445-452.
  14. Valastro,B., Ghribi,O., Poirier,J., Krzywkowski,P., & Massicotte,G. (2001) AMPA receptor regulation and LTP in the hippocampus of young and aged apolipoprotein E-deficient mice. Neurobiology of Aging 22, 9-15.
  15. Ghribi,O., DeWitt,D.A., Forbes,M.S., Herman,M.M., & Savory,J. (2001) Co-involvement of mitochondria and endoplasmic reticulum in regulation of apoptosis: Changes in cytochrome c, Bcl-2 and Bax in the hippocampus of aluminum-treated rabbits. Brain Research 903, 66-73.
  16. Ghribi,O., DeWitt,D.A., Forbes,M.S., Arad,A., Herman,M.M., & Savory,J. (2001) Cyclosporin A inhibits Al-induced cytochrome c release from mitochondria in aged rabbits. Journal of Alzheimer's Disease 3, 387-391.
  17. Savory,J., Ghribi,O., Forbes,M.S., & Herman,M.M. (2001) Aluminium and neuronal cell injury: Inter-relationships between neurofilamentous arrays and apoptosis. Journal of Inorganic Biochemistry 87, 15-19.
  18. Ghribi,O., Herman,M.M., Forbes,M.S., DeWitt,D.A., & Savory,J. (2001) GDNF protects against aluminum-induced apoptosis in rabbits by upregulating Bcl-2 and Bcl-X L and inhibiting mitochondrial Bax translocation. Neurobiology of Disease 8, 764-773.
  19. Ghribi,O., Herman,M.M., DeWitt,D.A., Forbes,M.S., & Savory,J. (2001) A+¦(1-42) and aluminum induce stress in the endoplasmic reticulum in rabbit hippocampus, involving nuclear translocation of gadd 153 and NF-+¦B. Molecular Brain Research 96, 30-38.
  20. Cyr,M., Ghribi,O., Thibault,C., Morissette,M., Landry,M., & Di Paolo,T. (2001) Ovarian steroids and selective estrogen receptor modulators activity on rat brain NMDA and AMPA receptors. Brain Research Reviews 37, 153-161.
  21. Calon,F., Morissette,M., Ghribi,O., Goulet,M., Grondin,R., Blanchet,P.J., B+¬dard,P.J., & DiPaolo,T. (2002) Alteration of glutamate receptors in the striatum of dyskinetic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys following dopamine agonist treatment. Progress in Neuro- Psychopharmacology and Biological Psychiatry 26, 127-138.
  22. Forbes,M.S., Ghribi,O., Herman,M.M., & Savory,J. (2002) Aluminum-induced dendritic pathology revisited: Cytochemical and electron microscopic studies of rabbit cortical pyramidal neurons. Annals of Clinical and Laboratory Science 32, 75-86.
  23. Ghribi,O., Herman,M.M., & Savory,J. (2002) The endoplasmic reticulum is the main site for caspase-3 activation following aluminum-induced neurotoxicity in rabbit hippocampus. Neuroscience Letters 324, 217-221.
  24. Ghribi,O., Herman,M.M., Spaulding,N.K., & Savory,J. (2002) Lithium inhibits aluminum-induced apoptosis in rabbit hippocampus, by preventing cytochrome c translocation, Bcl-2 decrease, Bax elevation and caspase-3 activation. Journal of Neurochemistry 82, 137-145.
  25. Savory,J., Ghribi,O., & Herman,M.M. (2002) Is amyloid +¦-peptide neurotoxic or neuroprotective and what is its role in the binding of metal ions? Neurobiology of Aging 23, 1089-1092.
  26. Ghribi,O., Herman,M.M., & Savory,J. (2003) Lithium inhibits A+¦-induced stress in endoplasmic reticulum of rabbit hippocampus but does not prevent oxidative damage and tau phosphorylation. Journal of Neuroscience Research 71, 853-862.
  27. Savory,J., Herman,M.M., & Ghribi,O. (2003) Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain. Journal of Inorganic Biochemistry 97, 151-154.
  28. Ghribi,O., Herman,M.M., Pramoonjago,P., & Savory,J. (2003) MPP + Induces the Endoplasmic Reticulum Stress Response in Rabbit Brain Involving Activation of the ATF-6 and NF-+¦B Signaling Pathways. Journal of Neuropathology and Experimental Neurology 62, 1144-1153.
  29. Ghribi,O., Prammonjago,P., Herman,M.M., Spaulding,N.K., & Savory,J. (2003) A+¦(1-42)-induced JNK and ERK activation in rabbit hippocampus is differentially regulated by lithium but is not involved in the phosphorylation of tau. Molecular Brain Research 119, 201-206.
  30. Ghribi,O., Herman,M.M., Pramoonjago,P., Spaulding,N.K., & Savory,J. (2004) GDNF regulates the A+¦-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases. Neurobiology of Disease 16, 417-427.
  31. Griffioen,K.J.S., Ghribi,O., Fox,N., Savory,J., & DeWitt,D.A. (2004) Aluminum maltolate-induced toxicity in NT2 cells occurs through apoptosis and includes cytochrome c release. NeuroToxicology 25, 859-867.
  32. Ghribi,O. (2006) The role of the endoplasmic reticulum in the accumulation of +¦-amyloid peptide in Alzheimer's disease. Current Molecular Medicine 6, 119-133.
  33. DeWitt,D.A., Hurd,J.A., Fox,N., Townsend,B.E., Griffioen,K.J.S., Ghribi,O., & Savory,J. (2006) Peri-nuclear clustering of mitochondria is triggered during aluminum maltolate induced apoptosis. Journal of Alzheimer's Disease 9, 195-205.
  34. Ghribi,O., Larsen,B., Schrag,M., & Herman,M.M. (2006) High cholesterol content in neurons increases BACE, +¦-amyloid, and phosphorylated tau levels in rabbit hippocampus. Experimental Neurology 200, 460-467.
  35. Savory,J., Herman,M.M., & Ghribi,O. (2006) Supplementation of the diet with silicic acid to reduce body burden of aluminum: A miracle cure or useless treatment for Alzheimer's disease? Journal of Alzheimer's Disease 10, 25-27.
  36. Ghribi,O., Golovko,M.Y., Larsen,B., Schrag,M., & Murphy,E.J. (2006) Deposition of iron and +¦-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets. Journal of Neurochemistry 99, 438-449.
  37. Savory,J., Herman,M.M., & Ghribi,O. (2006) Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease. Journal of Alzheimer's Disease 10, 135-144.
  38. Ghribi,O. (2006) Preservation of the blood brain barrier integrity may underlie neuroprotective effects of statins in Alzheimer's disease. Journal of Alzheimer's Disease 10, 407-408.
  39. Savory,J. & Ghribi,O. (2007) Can studies of aluminum toxicity in vivo and in vitro provide relevant information on the pathogenesis and etiology of Alzheimer's disease? Journal of Alzheimer's Disease 11, 429-430.
  40. Ghribi,O., Golovko,M.Y., Larsen,B., Schrag,M., & Murphy,E.J. (2007) Erratum: Deposition of iron and +¦-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets (Journal of Neurochemistry (2006) 99, (435-449)). Journal of Neurochemistry 103, 423-424.
  41. Chen,X., Ghribi,O., & Geiger,J.D. (2008) Rabbits fed cholesterol-enriched diets exhibit pathological features of inclusion body myositis. American Journal of Physiology - Regulatory Integrative and Comparative Physiology 294, R829-R835.
  42. Schrag,M., Sharma,S., Brown-Borg,H., & Ghribi,O. (2008) Hippocampus of Ames dwarf mice is resistant to +¦-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels. Hippocampus 18, 239-244.
  43. Chen,X., Gawryluk,J.W., Wagener,J.F., Ghribi,O., & Geiger,J.D. (2008) Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease. Journal of Neuroinflammation 5. Ref ID: 43
  44. Jaya Prasanthi,R.P., Schommer,E., Thomasson,S., Thompson,A., Feist,G., & Ghribi,O. (2008) Regulation of +¦-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's disease. Mechanisms of Ageing and Development 129, 649-655.
  45. Rantham Prabhakara,J.P., Feist,G., Thomasson,S., Thompson,A., Schommer,E., & Ghribi,O. (2008) Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and +¦-synuclein in human neuroblastoma SH-SY5Y cells. Journal of Neurochemistry 107, 1722-1729.
  46. Ghribi,O. (2008) Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle. Journal of Alzheimer's Disease 15, 673-684.
  47. Sharma,S., Prasanthi,R.P., Schommer,E., Feist,G., & Ghribi,O. (2008) Hypercholesterolemia-induced A+¦ accumulation in rabbit brain is associated with alteration in IGF-1 signaling. Neurobiology of Disease 32, 426-432.
  48. Prasanthi,J.R.P., Huls,A., Thomasson,S., Thompson,A., Schommer,E., & Ghribi,O. (2009) Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on +¦-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. Molecular Neurodegeneration 4.
  49. Wu,M., Audet,A., Cusic,J., Seeger,D., Cochran,R., & Ghribi,O. (2009) Broad DNA repair responses in neural injury are associated with activation of the IL-6 pathway in cholesterol-fed rabbits. Journal of Neurochemistry 111, 1011-1021.
  50. Marwarha,G., Dasari,B., Prasanthi,J.R.P., Schommer,J., & Ghribi,O. (2010) Leptin reduces the accumulation of A+¦ and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. Journal of Alzheimer's Disease 19, 1007-1019.
  51. Chen,X., Ghribi,O., & Geiger,J.D. (2010) Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases. Journal of Alzheimer's Disease 20, S127-S141.
  52. Dasari,B., Prasanthi,J.R., Marwarha,G., Singh,B.B., & Ghribi,O. (2010) The oxysterol 27-hydroxycholesterol increases +¦-amyloid and oxidative stress in retinal pigment epithelial cells. BMC Ophthalmology 10.
  53. Marwarha,G., Dasari,B., Prabhakara,J.P.R., Schommer,J., & Ghribi,O. (2010) +¦-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway. Journal of Neurochemistry 115, 373-384.
  54. Prasanthi,J.R.P., Dasari,B., Marwarha,G., Larson,T., Chen,X., Geiger,J.D., & Ghribi,O. (2010) Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. Free Radical Biology and Medicine 49, 1212-1220.
  55. Chen,X., Wagener,J.F., Morgan,D.H., Hui,L., Ghribi,O., & Geiger,J.D. (2010) Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet. Journal of Alzheimer's Disease 22, 1289-1303.
  56. Marwarha,G., Prasanthi,J.R., Schommer,J., Dasari,B., & Ghribi,O. (2011) Molecular interplay between leptin, insulin-like growth factor-1, and +¦-amyloid in organotypic slices from rabbit hippocampus. Molecular Neurodegeneration 6.
  57. Dasari,B., Prasanthi,J.R., Marwarha,G., Singh,B.B., & Ghribi,O. (2011) Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina. BMC Ophthalmology 11.
  58. Prasanthi,J.R.P., Larson,T., Schommer,J., & Ghribi,O. (2011) Silencing gadd153/chop gene expression protects against alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus. PLoS ONE 6.
  59. Prasanthi, R. P. J., Marwarha, G., and Ghribi, O. The cholesterol-fed rabbit as a model system for cholesterol-Alzheimer's disease studies. 1, 163-178. 2011.
  60. Marwarha,G., Rhen,T., Schommer,T., & Ghribi,O. (2011) The oxysterol 27-hydroxycholesterol regulates +¦-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors-relevance to Parkinson's disease. Journal of Neurochemistry 119, 1119-1136.
  61. Marwarha,G. & Ghribi,O. (2012) Cellular model of Alzheimer's disease - Relevance to therapeutic testing. Experimental Neurology 233, 733-739.
  62. Marwarha,G., Dasari,B., & Ghribi,O. (2012) Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol. Cellular Signalling 24, 484-492.
  63. Liu,R., Lei,J.X., Luo,C., Lan,X., Chi,L., Deng,P., Lei,S., Ghribi,O., & Liu,Q.Y. (2012) Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer's disease. Neurobiology of Disease 45, 902-912.
  64. Prasanthi,J.R.P., Schrag,M., Dasari,B., Marwarha,G., Dickson,A., Kirsch,W.M., & Ghribi,O. (2012) Deferiprone reduces amyloid-+¦ and tau phosphorylation levels but not reactive oxygen species generation in hippocampus of rabbits fed a cholesterol-enriched diet. Journal of Alzheimer's Disease 30, 167-182.
  65. Zhang,H., Wang,Z., Stupak,J., Ghribi,O., Geiger,J.D., Liu,Q.Y., & Li,J. (2012) Targeted glycomics by selected reaction monitoring for highly sensitive glycan compositional analysis. Proteomics 12, 2510-2522.
  66. Mital Y. Patel, Hirenkumar V. Panchal, Othman Ghribi, and Kenza E. Benzeroual. (2012) The neuroprotective effect of fisetin in the MPTP model of Parkinson’s disease. Journal of Parkinson’s Disease 2: 287-302
  67. Gurdeep Marwarha, Othman Ghribi (2012) Leptin signaling and Alzheimer’s disease. Am J Neurodegener Dis 1:245-265
  68. Bhanu Dasari, Jaya RP Prasanthi, Craig Meiers, Brij B Singh, Othman Ghribi. (2013) Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells. Current Eye Research 2013.
  69. Gurdeep Marwarha, Shaneabbas Raza, Jaya R.P Prasanthi, and Othman Ghribi. (2013)Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells. PLoS ONE 2013 Aug 9;8(8):e70773. doi: 10.1371/journal.pone.0070773.
  70. Schrag M, Mueller C, Zabel M, Crofton A, Kirsch WM, Ghribi O, Squitti R, Perry G. Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: A meta-analysis. Neurobiol Dis. 2013 Jul 15. pii: S0969-9961(13)00199-X. doi: 10.1016/j.nbd.2013.07.005
  71. Qing Yan Liu, Marilyn N. Vera Chang, Joy X Lei, Roger Koukiekolo, Brandon Smith, Dongling Zhang and Othman Ghribi (2014) Identification of microRNAs involved in Alzheimer’s progression using a rabbit model of the disease. Am J Neurodegener Dis. 2014 Mar 28;3(1):33-44.
  72. Marwarha G, Raza S, Meiers C, Ghribi O. Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway. Biochim Biophys Acta. 2014 May 27. pii: S0925-4439(14)00143-4. doi: 10.1016/j.bbadis.2014.05.015.
  73. Shaneabbas Raza, Joyce E Ohm, Archana Dhasarathy, Jared Schommer, Conor Roche, Kimberly DP Hammer, and Othman Ghribi. The cholesterol metabolite 27-hydroxycholesterol attenuates p53 activity and increases cell proliferation via MDM2 in the breast cancer MCF7 cells. Submitted, Molecular Carcinogenesis
  74. Kate J. Claycombe, Catherine Brissette, and Othman Ghribi. Epigenetics of Inflammation and Immune Dysfunction: The Role of Maternal Infection and Nutrition. Journal of Nutrition (Accepted).
  75. Kate J. Claycombea, Emilie E. Vomhof-DeKrey, James N. Roemmich, Amy Bundy, Othman Ghribi, and Turk Rhen. Maternal low protein diet causes body weight loss in male, neonate Sprague-1 Dawley rats involving UCP-1 mediated thermogenesis. In revision, Journal of Nutritional Biochemistry
  76. Xuesong Chen, John F Wagener, Othman Ghribi, Jonathan D Geige. Role of endolysosomes in skeletal muscle pathology observed in rabbits fed a cholesterol enriched diet. Submitted, Neuromuscular Disorders
  77. Gurdeep Marwarha and Othman Ghribi. Does the oxysterol 27-hydroxycholesterol underlies Alzheimer’s disease-Parkinson’s disease overlap? Experimental Gerontology (Accepted) doi.10.1016/j.exger.2014.09.013
  78. Danielle Morgan, Othman Ghribi, Liang Hui, Jonathan D. Geiger, and Xuesong Chen. Cholesterol-enriched diet disrupts the blood-testis barrier in rabbits. American Journal of Physiology - Endocrinology and Metabolism Accepted
Invited presentations
  1. Oxysterols and Neurodegenerative diseases. Abbvie laboratories (former Abbot), Chicago, IL. October 29th, 2014
  2. Does the oxysterol 27-hgydroxycholesterol underlie Alzheimer’s disease/Parkinson’s disease overlap? The 12th International symposium on neurobiology and neuroendocrinology of aging, Bregenz, Austria, July 2014.
  3. The role of the oxysterol 27-hydroxycholesterol in Alzheimer’s disease-like pathology. Loma Linda University, January 30th, 2014 (Host: Dr. Soriano).
  4. The multifaceted roles of the oxysterol 27-hydroxycholesterol. West Virginia University at Morgantown, December 3, 2013 (Host: Dr. Schreurs).
  5. Saturated free fatty acid consumption may increase the risk for Alzheimer’s disease. Nanosymposium on Alzheimer’s disease and inflammation, Neuroscience meeting, October 2012, New Orleans.
  6. Alzheimer’s disease and Parkinson’s disease overlap-A role for Oxysterols? International Conference and Exhibition on Neurology & Therapeutics-Novel Therapies in Neurosciences, May 14, 2012. Las Vegas, NV.
  7. Cholesterol and Age-Related Macular Degeneration. Loma Linda School of Medicine, June 2, 2011 (Host Dr. Kirsch).
  8. Regulation of Tyrosine hydroxylase and α-synuclein levels by LXR and estrogen receptors-relevance to Parkinson’s disease. The 10th Annual International Conference AD/PD, Barcelona, Spain, March 9-13, 2011.
  9. Cholesterol and Alzheimer’s disease-Is there a connection? The Alzheimer's Association Minnesota-North Dakota Chapter. Minneapolis, March 19, 2011.
  10. Cholesterol and Alzheimer’s disease. Annual conference sponsored by St. Alexius, the ND Hospice Organization, and the Alzheimer's Association Minnesota-North Dakota. Bismarck, ND October 16, 2009.
  11. Common pathological hallmarks for Alzheimer’s disease and age-related macular degeneration in the cholesterol-fed rabbit model. Department of Anatomy, University of North Dakota School of Medicine. November 2, 2009
  12. Oxysterols alter expression levels of tyrosine hydroxylase, alpha-synuclein, and beta-amyloid: relevance to Parkinson’s and Alzheimers’s diseases. The 9th Annual International Conference AD/PD, Prague, Czech Republic, March 11-15, 2009.
  13. Cholesterol-Induced Alzheimer’s Disease-like pathology in rabbit brain. Loma Linda University, School of Medicine, January 4th 2008.
  14. Alzheimer’s disease: social impact and care givers role. Department of Sociology, University of North Dakota, February 7th 2008.
  15. Nutrition and neurodegenerative disorders. University Senghor, Alexandria, Egypt, February 2008.
  16. Alzheimer Disease: a cause of pathological aging. Department of Sociology, University of North Dakota, February 9, 2006
  17. Cholesterol-Induced Oxidative Stress & the Pathogenesis of Alzheimer’s Disease. Department of Anatomy, University of North Dakota School of Medicine. November 21st, 2005.
  18. Neurotoxic Injury: Regulation by Mitochondrial-Endoplasmic Reticulum Cross-talk. University of Quebec at Trois-Rivieres, March 2004.
  19. Aβ(1-42)-induced phosphorylation of tau and apoptosis in an in vivo model: mechanisms and pathways. St Elizabeth Medical Center, Boston, MA, January 7, 2004.
  20. Mechanisms of Neuronal Death in Experimental Degeneration, DRDC Suffield, Alberta, Canada, June 2003.
  21. Lithium inhibits Aß-induced caspase-3 activation, GSK-3 AND JNK phosphorylation, but not oxidative stress, in rabbit brain hippocampus. The 8th international conference on Alzheimer’s disease and related disorders. Stockholm, Sweden, July 20-25, 2002. Neurobiology of aging 23 (1): 510 Suppl. 1 JUL-AUG 2002
  22. Mitochondrial injury and apoptosis in Aluminum-induced neurotoxicity. Robert O. Lawson Chair in Neural Repair and Regeneration, Head Spinal Program, Toronto Western Hospital, University Health Network, January 8, 2001.
  23. Changes in protein-regulating apoptosis in an experimental model of neurodegeneration: Institute of Biological Sciences, NRC, Ottawa, Canada, February 2, 2001
  24. Local NMDA receptor blockade decreases extracellular glutamate and aspartate levels during forebrain ischaemia in rat striatum. 50th meeting of l'Association Française des Pharmacologistes. Lille, October 6-9, 1993. Fund. Clin. Pharmacol, 7:360, 1993.
  25. Les antagonistes des récepteurs NMDA réduisent l'accumulation des acides aminés excitateurs induite par une ischémie cérébrale chez le rat. Circulation et Métabolisme du Cerveau, 10:168-176 1993.
  26. Kynurenic acid but not MK-801 reduces the extracellular amino acid accumulation in rat striatum and hippocampus during cerebral ischaemia. 48th Meeting of l'Association Française des Pharmacologistes. Montpelier, October 1-2, 1992. Fund. Clin. Pharmacol. 6:393, 1992.

Book chapters

  1. Prasanthi J.R.P., Marwarha G and Ghribi O. The Cholesterol-Fed Rabbit as a Model System for Cholesterol-Alzheimer’s Disease Studies. Handbook of Animal Models in Alzheimer’s Disease. G. Casadesus (Ed.). IOS Press, 2011
  2. O. Ghribi, Endoplasmic Reticulum, β-Amyloid Peptide, and Alzheimer’s Disease in “ Protein misfolding disorders; A trip into the ER”Ed Claudio Hetz, Bentham Science Publishers Ltd, 2009.
  3. The rabbit model system for studies of Aluminum-induced Neurofibrillary Degeneration. Savory J, Ghribi O, Martin B, and Herman MM. In “Aluminum in Alzheimer’s Disease”. Ed., Christopher Exley, Staffordshire, UK, pp 203-219, 2001
  4. Savory J, Martin B, Ghribi O, and Herman MM. Aluminum. In "Handbook of Heavy Metals in the Environment" 2000, Ed., B. Sarkar, Marcel Dekker, Inc. New York.
  5. Lekieffre D, Ghribi O, Callebert J, Plotkine M and Boulu RG. Effect of kynurenic acid on ischaemia-induced glutamate accumulation in the hippocampus during 4-vessel occlusion. In "Pharmacology of Cerebral Ischaemia" 1992, Ed., J. Krieglstein, WVG Press, Stuttgart, p. 105-112, 1992.
Selected Abstracts (from over 150)
  1. Marwarha G, Ghribi O. Cholesterol causes AD pathology through Akt/mTOR inhibition. International Conference on Alzheimer’s Disease, Vancouver, BC July 2012
  2. Prasanthi J, Thompson G, Geiger J, Ghribi O. Neuroscience Annual Meeting-2012, New Orleans, USA
  3. Bhanu Dasari, Jaya Prasanthi R.P., Gurdeep Marwarha, Brij B Singh, Othman Ghribi. Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina Society for Neuroscience Annual Meeting-2011, Washington DC, USA
  4. Tyler Larson, Jaya Prasanthi R.P., Jared Schommer, Othman Ghribi. siRNA to gadd153 reduces 27-hydroxycholesterol-induced Alzheimer’s disease pathology. 31stAnnual Frank N. Low Research Day,Grand Forks, North Dakota, USA, April 21, 2011.
  5. Eric Schommer, Jaya Prasanthi R.P. and Othman Ghribi. Is iron chelator protective against hypercholesterolemia-induced Alzheimer’s disease pathology? 31st Annual Frank N. Low Research Day, Grand Forks, North Dakota, USA, April 21, 2011.
  6. Ghribi O. International Conference on Alzheimer’s Disease, Paris, France July 2011
  7. Bhanu Dasari, Jaya Prasanthi R.P., Gurdeep Marwarha, Brij B Singh, Othman Ghribi. Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina. 10th Anniversary, the Graduate School Scholarly Forum. Grand Forks, North Dakota, USA, March 8-9, 2011.
  8. Bhanu Dasari, Othman Ghribi. The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. Society for Neuroscience Annual Meeting-2010, San Diego, CA, USA
  9. Ghribi O, Cholesterol and the cholesterol metabolite 27-hydroxycholesterol cause Alzheimer’s Disease-like pathology through inhibition of leptin, AkT/mTORC1 signaling pathway. International Conference on Alzheimer’s Disease, Hawaii, July 2010.
  10. J. P. Rantham Prabhakara, T. Larson, J. Schommer, O. Ghribi. siRNA to gadd153 reduces 27-hydroxycholesterol-induced Alzheimer’s disease pathology. Neuroscience Meeting 2010, San Diego,California, USA, November 13-17, 2010.
  11. Jaya Prasanthi R.P., T. Larson, J. Schommer, O. Ghribi. Reducing gadd153 levels reverse 27-hydroxycholesterol-induced Alzheimer’s disease pathology. Neuroscience Symposium, Grand Forks, ND,USA, October 14-15, 2010.
  12. Jaya R.P. Prasanthi, Jonathan D. Geiger, and Othman Ghribi. Caffeine protects against Alzheimer’s disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. National IDeASymposium of Biomedical Research Excellence (NISBRE), Bethesda, MD, USA, June 16–18, 2010.
  13. Jaya Prasanthi R.P., Tyler Larson, Jared Schommer, Othman Ghribi. Silencing gadd153 gene prevents 27-hydroxycholesterol-induced endoplasmic reticulum stress, oxidative damage and Alzheimer’s disease like pathology. 30thAnnual Frank N. Low Research Day, Grand Forks, ND, USA, April 22, 2010.
  14. Gwen Feist, Jaya Prasanthi R.P., Ghribi O. Activation of liver X receptors are involved in the pathogenesis of Parkinson’s disease. 30thAnnual Frank N. Low Research Day, Grand Forks, ND, USA, April 22, 2010.
  15. Kristen Fried, Jaya Prasanthi R.P., Othman Ghribi. Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid production in human neuroblastoma SH-SY5Y cells. 30thAnnual FrankN. Low Research Day, Grand Forks, ND, USA, April 22, 2010.
  16. Eric Schommer, Jaya Prasanthi R.P., Jared Schommer, Othman Ghribi. The cholesterol metabolite 27-hydroxycholesterol triggers Alzheimer’s disease-like pathology by increasing Aβ, dysregulating iron homeostasis, and inducing apoptosis. 30thAnnual Frank N. Low Research Day, Grand Forks, ND, USA,April 22, 2010.
  17. Leptin signaling in the cholesterol-fed rabbit, a model system of Alzheimer’s disease. 39th Annual Neuroscience Meeting 2009, Chicago, Illinois, USA, October 17-21, 2009
  18. Bhanu Dasari, Othman Ghribi. Is cholesterol a common risk factor for Alzheimer's disease and age-related macular degeneration? 39th Annual Neuroscience Meeting 2009, Chicago, Illinois, USA, October, 2009.
  19. Ghribi o, Caffeine reduces cholesterol-induced Alzheimer’s disease like pathology by preventing endoplasmic reticulum stress in the rabbit hippocampus. 39th Annual Neuroscience Meeting 2009, Chicago, Illinois, USA, October 17-21, 2009.
  20. Ghribi O, The cholesterol metabolite 27-Hydroxycholesterol triggers Alzheimer’s disease like pathology by increasing Aβ, dysregulating iron homeostasis, and inducing apoptosis. 39th Annual Neuroscience Meeting, Chicago, Illinois, USA, October 17-21, 2009.
  21. Ghribi O, Involvement of adenosine A1 receptor in cholesterol-induced Alzheimer’s disease like pathology. IDeA Central Region Conference, Oklahoma City, Oklahoma, USA, May 28-29, 2009.
  22. Ghribi O, 27-Hydroxycholesterol as the missing link between circulating cholesterol and AD-like pathology. International Conference on Alzheimer’s disease, Vienna, Austria, July 11-16, 2009.
  23. Ghribi O, Protective effects of Adenosine A1 receptor in cholesterol-induced Alzheimer’s disease like pathology. 29th Annual Frank N. Low Research Day, University of North Dakota School of Medicine and Health Sciences, April 30, 2009.
  24. Ghribi O, Hypercholesterolemia and regulation of β-amyloid levels in the rabbit, a model system for sporadic Alzheimer’s disease. 28th Annual Frank N Low Research Day, University of North Dakota School of Medicine and Health Sciences, March 27, 2008.
  25. Ghribi O, Hypercholesterolemia induced alteration in insulin signaling: Implications in a model for sporadic Alzheimer Disease. 27th Annual Frank N Low Research Day, University of North Dakota School of Medicine and Health Sciences, 2007.
  26. Ghribi O, Regulation of β-amyloid levels in the cholesterol-fed rabbit brain, a model system for sporadic Alzheimer’s disease. 38th Annual Neuroscience Meeting, Washington, DC, USA, November, 2008
  27. Oxysterols are linked to the pathogenesis of Parkinson's disease. Society for Neuroscience, 38th Annual Neuroscience Meeting. Washington DC, November 2008.
  28. Hypercholesterolemia and regulation of Beta-amyloid levels in the rabbit, a model system for sporadic Alzheimer’s disease. Society for Neuroscience, 38th Annual Meeting. Washington DC, November 2008.
  29. Oxysterols induce Alzheimer's disease-like pathological hallmarks, Alzheimer's Association International Conference on Alzheimer's Disease 2008, Chicago.
  30. 27-hydroxycholesterol activates GSK-3β and the ATP-binding cassette transporters, ABCA1 and ABCG1, in organotypic slices from adult rabbit hippocampus. Society for Neuroscience, 37th Annual Meeting in San Diego, CA, February 2007.
  31. Hypercholesterolemia-induced alteration in insulin signaling: Implications in a model for sporadic Alzheimer’s disease. Society for Neuroscience, 37th Annual Meeting in San Diego, CA, Feb 2007.
  32. Caffeine prevents cholesterol-induced β-amyloid overproduction and tau hyperphosphorylation in rabbit hippocampus. Society for Neuroscience, 36th Annual Meeting in Atlanta, GA, October 14-18, 2006.
  33. Caffeine prevents cholesterol-induced β-amyloid overproduction and tau hyperphosphorylation in rabbit hippocampus. The 2006 Biennial Institutional Development Award (IDeA) Program. Wardman Park Marriott Hotel, Washington, D.C. on July 20th-22nd, 2006.
  34. β-amyloid induces endoplasmic reticulum stress response in rabbit hippocampus. Society for Neuroscience, 36th Annual Meeting in Atlanta, GA, October 14-18, 2006.
  35. Stabilization of Blood-Brain Barrier by Caffeine in Cholesterol-Fed Rabbits. Society for Neuroscience, 36th Annual Meeting in Atlanta, GA, October 14-18, 2006.
  36. Cholesterol-enriched diets induce Aβ accumulation, tau hyperphosphorylation, and cellular redistribution of cholesterol in rabbit brain. Society for Neuroscience, 35th Annual Meeting in Washington, DC, November 12-16, 2005
  37. Organelle clustering and transport disruption occurs during apoptosis induced by aluminum maltolate and staurosporine. Society for Neuroscience, 35th Annual Meeting in Washington, DC, November 12-16, 2005
  38. Aβ-induced p-tau and apoptosis in rabbit brain are two independent events, The 9th International Conference on Alzheimer's Disease and Related Disorders, July 17-22, 2004 Philadelphia, PA. Citation: Neurobiology of Aging, Volume 25, Number S2, July 2004, Page 199.
  39. Savory J and Ghribi O. The role of metal ions as initiators of neurodegeneration. Ann Clin Lab Sci 34: 360, 2004.
  40. Ghribi O, Mary M. Herman, John Savory, Aβ-induced p-tau and apoptosis in rabbit brain are two independent events, The 9th International Conference on alzheimer's Disease and Related Disorders, July 17-22, 2004 Philadelphia, PA. Citation: NeuroBiology of Aging, Volume 25, Number S2 , July 2004, Page 199.
  41. Ghribi O; M.M.Herman; P.Pramoonjago; J.Savory1 . MPP+ induces the endoplasmic reticulum stress response in rabbit brain involving the activation of ATF-6 and NF-KB signaling pathways. 33 th Annual Meeting in New orleans, November 9-13, 2003
  42. Ghribi O, Mary Herman, John Savory. A induces hyperphosphorylation of tau and apoptosis in rabbit brain, involving activation of the GSK-3b AND JNK pathways. Society for Neuroscience 32th Annual Meeting, Orlando FL, November 2-7, 2001.
  43. Ghrib O, Mary Herman, John Savory. Endoplasmic reticulum-specific apoptosis in experimental neurodegeneration and reversal by lithium. 78th Annual Meeting of the American Association of Neuropathologists (AANP), Denver, CO, June 20-23, 2002. J. Neuropath.Exp. Neurology 61 (5): 63, 2002.
  44. Ghribi O, DeWitt,DA, Forbes MS, Herman MM and Savory J. Ab(1-42) or aluminum, administered to rabbits induce stress in the endoplasmic reticulum in hippocampus involving nuclear translocation of gadd 153 and NF-kB. Society for Neuroscience 31th Annual Meeting, San Diego CA, 10-15 November, 2001.
  45. Ghribi O, DeWitt,DA, Forbes MS, Herman MM and Savory J. Cross-talk between endoplasmic reticulum and mitochondria regulates apoptosis in experimental neurodegeneration. Annual meeting of the association of clinical Scientists in Chapel Hill, NC, 9-12 May 2001.
  46. Ghribi O, DeWitt,DA, Forbes MS, Herman MM and Savory J. MTP opening and expression of cytochrome c, Bcl-2 and Bax in aluminum-treated aged rabbits. Society for Neuroscience 30th Annual Meeting, New Orleans, LA. November 4-9, 2000.
  47. B. Valastro; O. Ghribi; J. Poirier; P. Krzywkowski; G. Massicotte. AMPA receptors regulation and LTP in the hippocampus of young and aged apolipoprotein E-deficient mice. Society for Neuroscience 30th Meeting, New Orleans, LA. November 4-9, 2000.
  48. T. Di Paolo; F. Calon; M. Morissette; O. Ghribi; R. Grondin; M. Goulet; P.J. Blanchet; P.J. Bédard. Striatal glutamate receptors in dyskinetic MPTP monkeys. Society for Neuroscience 30th Annual Meeting, New Orleans, LA. November 4-9, 2000.
  49. Ghribi O, DeWitt,DA, Forbes MS, Herman MM and Savory J. Cyclosporin A prevents Cytochrome C release in Al-treated aged rabbit brain. World Alzheimer Congress 2000, Pivotal Research, Washington D.C. July 11, 2000 published in Neurobiology of Aging 21: S154, 2000.
  50. Ghribi O, Lahsaini A, Furling D, Mirault M.E, Lapierre L and Massicotte G. Impairement of synaptic transmission by transient hypoxia in hippocampal slices: improved recovery in glutathione peroxidase transgenic mice. 28th Meeting of Society of Neurosciences, Los Angeles, November 7-12, 1998.
  51. Cyr M, Ghribi O and Di Paolo T. Ovariectomy and gonadal steroids modulation of glutamate levels and glutamate receptors of the NMDA and AMPA subtypes. 28th Annual Meeting of Society of Neurosciences, Los Angeles, November 7-12, 1998.
  52. Champagne D, Ghribi O, Dupuy I.B, Aumont N, Rochford I, Massicotte G and Poirier J. Neurophysiological and behavioral effects of chronic infusion of human recombinant apolipoproteine E (ApoE) in ApoE knockout mice. 28th Annual Meeting of Society of Neurosciences, Los Angeles November 7-12, 1998.
  53. Cyr M, Vaillancourt C, Ghribi O, Boksa P and Di Paolo T. Steroid modulation of 5 HT2A receptors in the rat brain: further characterization and steroid specificity. Annual Meeting of Society of Neuroscience, New Orleans, October 25-30, 1997.
  54. Ghribi O, Morissette M, Goulet M, Grondin R, Pelletier G, Bédard PJ and Di Paolo T. Effect of dopamine agonist treatmant on excitatory amino acid binding sites in MPTP lesioned monkeys. Annual Meeting of Society of Neuroscience, New Orleans, October 25-30, 1997.
  55. Ghribi O, Boulu RG and Plotkine M. Mechanisms involved in excitatory amino acid accumulation induced by forebrain ischaemia in rat striatum. First European Meeting of Pharmacology, Milano, Italy, June 16-19, 1995.
  56. Boulu RG, Ghribi O, Callebert J and Plotkine M. Antagonists of N-methyl-D-aspartate receptors reduce extracellular striatal glutamate and aspartate accumulation induced by forebrain ischaemia in rats. XIIth Meeting of International Union of Pharmacologists, Montreal, July, 1994.
  57. Lekieffre D, Ghribi O and Boulu RG. Effect of kynurenic acid on ischaemia-induced glutamate accumulation in the hippocampus of the four-vessel model. 4th International Symposium on Pharmacology of Cerebral Ischaemia, Marburg, Germany, July 20-22, 1992.

 

 

 

 

 

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