Mohammad Moshahid Khan, Phd
Mohammad Moshahid Khan, Phd
Research Associate of Neurology

University of Tennessee Health Science Center
USA

Education

2009 Ph.D Toxicology, Hamdard University, Delhi, India
2005 M.Sc Organic Chemistry, Aligarh Muslim University, Aligarh, India
2003 B.Sc Chemistry & Biology, Aligarh Muslim University, Aligarh, India

 

Profile

Dr. Khan is a Staff Scientist in the Department of Neurology at University of Tennessee Health Science Center, Memphis USA. Over the past 10 years, Dr. Khan is working on regulation and resolution of neuroinflammation and neurodegeneration in experimental models of neurodegenerative diseases. His research investigates the molecular mechanisms that regulate inflammation in the central nervous system that are critical to our understanding of a broad spectrum of neurodegenerative diseases, including Parkinson’s disease, Stroke, Alzheimer’s disease, multiple sclerosis and Dystonia and to discovering new treatments for these incurable diseases. Dr. Khan has published more than 40 research articles in preclinical CNS models. His research work has been recognized both at national and international levels and has received over 1250 citation scores with h-index 22 by other scientists. Dr. Khan’s works has been highlighted by Editorial commentary and captured by several electronic  media. One of his research article has been featured as Most Cited Brain Research article. Dr. Khan been served as Academic Editor for several manuscripts submitted for the peer review process. He is an active member for several professional societies related to neuroscience and officially review the manuscripts, case reports, and Data sheet for several journals of high impact and international repute. He has been enlisted as Lead editor and editorial board member of many journals in his field and has been selected as International reviewer for National Research Foundation, South Africa. Dr. Khan’s long term research is committed to unraveling the mysteries of neurodegenerative diseases and to discovering new treatments for these incurable diseases.

 

Research Interest

  • Neurodegeneration and neuroinflammation in brain injuries and diseases
  • Movement disorder and Parkinson’s disease
  • Traumatic brain injury and stroke
  • Neuronal Stem Cells
  • Oxidative stress in neuropathogenesis
  • Endoplasmic reticulum stress
  • Neurobehavioral alterations in neurodegeneration
  • Antioxidants and neuroprotection
  • Apoptosis
  • Neuroinflammation in multiple sclerosis and stroke
  • Neuroinflammatory mediators in CNS
  • SiRNA mediated down regulation of inflammatory mediators and cytokines in CNS
  • Stress-activated protein kinases in inflammatory signal transduction
  • Endothelial dysfunction, BBB disruption and immune cell mediated injury in sub- acute/ chronic phase of stroke.
  • Brain lipids and their metabolism in neurodegeneration
  • Vascular cognitive impairment

Professional Activities:

2015-Present Research Associate Department of Neurology, University of Tennessee Health Science Center Memphis, 38105 TN USA
2014-2015  Research Scientist Department of Surgery, Feinstein,institute for Medical Research North Shore University Hospital Manhasset, New York, 11030 USA
2011-2014  Associate Research Scientist Department of Neurology University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
2009-2011 Post-Doctoral Fellow Department of Internal Medicine, University of Iowa, Iowa, USA
2008-2009 Senior Research Fellow Neurotoxicology lab Department of Toxicology, Hamdard University, Delhi, India
2006-2008 Senior Research Fellow CCRUM, Ministry of Health & Family Welfare Government of India, Delhi

Editorial Board Member:

  • Journal of Alzheimer’s Disease & Parkinsonism
  • Journal Molecular Biology and Genetic Engineering
  • Advance in Neuroscience
  • Journal of Neurology & Translational Neuroscience
  • Neurological Disorders and Therapy
  • Journal of Neuroinfectious Diseases
  • JSM Alzheimer's Disease and Related Dementia
  • International Journal of Pharmaceutical Sciences
  • Guest lead Editor for special issue in Stroke Research and Treatment
  • Guest Editor for special issues in Journal of Parkinson Disease
  • Guest lead Editor for special issue in BioMed Research International

 

Honors and Awards

 

 

 

Publications

  1. Mulchandani N, Yang WL, Khan MM, Zhang F, Marambaud P, Nicastro J, Coppa GF, Wang P. Stimulation of Brain AMP-activated Protein Kinase Attenuates Inflammation and Acute Lung Injury in Sepsis. Mol Med. 2015: 30; 21(1):637-44 PMID: 26252187
  2. Khan MM, Yang WL, Wang P. Endoplasmic reticulum stress in sepsis. Shock, 2015; 44(4):294- 304. PMID: 26125088
  3. Khan MM, Zaheer S, Thangavel R, Patel M, Kempuraj D, Zaheer A. Absence of Glia Maturation Factor Protects Dopaminergic Neurons and Improves Motor Behavior in Mouse Model of Parkinsonism. Neurochem Res. 2015 Mar 10. PMID: 25754447.
  4. Khan MM, Zaheer S, Nehman J, Zaheer A Suppression of glia maturation factor expression prevents 1-methyl-4-phenylpyridinium (MPP+)-induced loss of mesencephalic dopaminergic neurons. Neuroscience 2014, 277:196-205 PMID: 25016212.
  5. Khan MM, Kempuraj D, Zaheer S, Zaheer A. Glia Maturation Factor Deficiency Suppresses 1- Methyl-4-Phenylpyridinium-Induced Oxidative Stress in Astrocytes. J Mol Neurosci. 2014 Jan 16. PMID: 24430624
  6. Khan A, Vaibhav K, Javed H, Tabassum R, Ahmed ME, Khan MM, Khan MB, Shrivastava P, Islam F, Siddiqui MS, Safhi MM, Islam F 1,8-Cineole (Eucalyptol) Mitigates Inflammation in Amyloid Beta Toxicated PC12 Cells: Relevance to Alzheimer's Disease. Neurochem Res. 2013 Dec 31 PMID: 24379109
  7. Khan MM* (Corresponding Author), Kempuraj D, Thangavel R, Zaheer A. Protection of MPTP-induced neuroinflammation and neurodegeneration by Pycnogenol. Neurochemistry International 2013; 62:379-88 PMID: 23391521
  8. Kempuraj D, Khan MM, Thangavel R, Evert B, Xe H, Zaheer A. Glia Maturation Factor Induces Interleukin-33 Release from Astrocytes: Implications for Neurodegenerative Diseases J. Neuroimmune Pharmacology 2013 8(3):643-50 PMID: 23397250.
  9. Raza SS*, Khan MM* (Co First Author), Ahmad A, Ashafaq M, Islam F, Wagner AP, Safhi MM, Islam F Neuroprotective effect of naringenin is mediated through suppression of NF-κB signaling pathway in experimental stroke. Neuroscience. 2013 Jan 29; 230:157-71. PMID: 23103795
  10. Ahmad ME, Khan MM, Javed H, Vaibhav K, Khan A, Tabassum R, Ashafaq M, Islam F, Safhi MM, Islam F. Amelioration of cognitive impairment and neurodegeneration by catechin hydrate in rat model of streptozotocin-induced experimental dementia of Alzheimer's type. Neurochemistry International 2013 62(4) 492-501. PMID: 23411413
  11. Ahmed ME, Javed H, Khan MM, Vaibhav K, Ahmad A, Khan A, Tabassum R, Islam F, Safhi MM, Islam F. Attenuation of oxidative damage-associated cognitive decline by Withania somnifera in rat model of streptozotocin-induced cognitive impairment. Protoplasma. 2013 Jan 23. PMID: 23340606
  12. Zaheer S, Thangavel R, Wu Y, Khan MM, Kempuraj D, Zaheer A. Enhanced expression of glia maturation factor correlates with glial activation in the brain of triple transgenic Alzheimer's disease mice. Neurochem Res. 2013 Jan; 38 (1):218-25 PMID: 23086473
  13. Thangavel R, Kempuraj D, Stolmeier D, Anantharam P, Khan M, Zaheer A. Glia Maturation Factor Expression in Entorhinal Cortex of Alzheimer's Disease Brain. Neurochem Res. 2013 May 29 PMID: 23715664
  14. Stolmeier D, Thangavel R, Anantharam P, Khan MM, Kempuraj D, Zaheer A. Glia Maturation Factor Expression in Hippocampus of Human Alzheimer's Disease. Neurochem Res. 2013 May 3. PMID: 23640177
  15. Javed H, Khan A, Vaibhav K, Moshahid Khan M, Ahmad A, Ejaz Ahmad M, Ahmad A, Tabassum R, Islam F, Safhi MM, Islam F. Taurine ameliorates neurobehavioral, neurochemical and immunohistochemical changes in sporadic dementia of Alzheimer's type (SDAT) caused by intracerebroventricular streptozotocin in rats. Neurol Sci. 2013 May 17. PMID: 23681104.
  16. Khan MM, Motto DG, Lentz SR, Chauhan AK. ADAMTS13 reduces VWF-mediated acute vascular inflammation following focal cerebral ischemia in mice. J. Thrombosis and Hemostasis, 2012,10(8):1665-71 PMID: 22712744
  17. Khan MM, Gandhi C, Chauhan N, Steven JW, Motto DG, Lentz SR, Chauhan AK Alternatively- spliced extra domain A of fibronectin promotes acute inflammation and brain injury following cerebral ischemia in mice. Stroke 2012 May;43(5):1376-82 PMID: 22363055
  18. Javed H*, Khan MM* (Co First Author), Ahmad A, Vaibhav K, Ahmed ME, Khan A, Ashafaq M, Islam F, Siddique MS, Safhi MM, Islam F Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer's type. Neuroscience 2012 May 17;210:340-52 PMID: 22441036
  19. Ashafaq M, Khan MM, Raza SS, Ahmad A, Khuwaja G, Javed H, Khan A, Islam F, Siddique MS, Safhi MM, Islam F. S-allyl cysteine mitigates oxidative damage and improves neurologic deficit in a rat model of focal cerebral ischemia Nutrition Research 2012; 32:133-143. PMID: 22348462
  20. Ahmad A, Khan MM, Raza SS, Javed H, Ashafaq M, Islam F, Safhi MM, Islam F. Ocimum sanctum attenuates oxidative damage and neurological deficits following focal cerebral ischemia/reperfusion injury in rats. Neurol Sci. 2012; 33:1239-47. PMID: 22278208
  21. Ahmad A, Khan MM, Javed H, Raza SS, Ishrat T, Khan MB, Safhi MM, Islam F Edaravone ameliorates oxidative stress associated cholinergic dysfunction and limits apoptotic response following focal cerebral ischemia in rat. Mol Cell Biochem. 2012; 367:215-25 PMID: 22648734
  22. Khan MB, Khan MM, Khan A, Ahmad ME, Ishrat T, Vaibhav K, Ahmad A, Islam F. Naringenin ameliorates Alzheimer's disease (AD)-type neurodegeneration with cognitive impairment (AD- TNDCI) caused by the intracerebroventricular-streptozotocin in rat model. Neurochemistry International 2012 Dec; 61(7):1081-93. PMID: 22898296
  23. Ashafaq M, Raza SS, Khan MM, Ahmad A, Ahmed ME, Tabassum R, Islam F, Siddique MS, Safhi MM, Islam F. Catechin hydrate ameliorates redox imbalance and limits inflammatory response in focal cerebral ischemia. Neurochemical Research 2012; 37:1747-60. PMID: 22570178
  24. Khan A, Vaibhav K, Javed H, Khan MM, Tabassum R, Ahmed ME, Srivastawa P, Islam F, Siddique MS, Safhi MM, Islam F Attenuation of Aβ-induced neurotoxicity by thymoquinone via inhibition of mitochondrial dysfunction and oxidative stress Mol Cell Biochem. 2012 July 1. PMID: 22752387
  25. Srivastava P, Vaibhav K, Tabassum R, Khan A, Ishrat T, Khan MM, Ahmad A, Islam F, Safhi MM, Islam F. Anti-apoptotic and Anti-inflammatory effect of Piperine on 6-OHDA induced Parkinson's Rat model. 2012 Journal of Nutritional Biochemistry PMID: 22819561
  26. Vaibhav K, Shrivastava P, Javed H, Khan A, Ahmed ME, Tabassum R, Khan MM, Khuwaja G, Islam F, Saeed Siddiqui M, Safhi MM, Islam F. Piperine suppresses cerebral ischemia- reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model. Mol Cell Biochem. 2012 Jun 6. PMID: 22669728
  27. Vaibhav K, Shrivastava P, Khan A, Javed H, Tabassum R, Ahmed ME, Khan MB, Moshahid Khan M, Islam F, Ahmad S, Siddiqui MS, Safhi MM, Islam F. Azadirachta indica mitigates behavioral impairments, oxidative damage, histological alterations and apoptosis in focal cerebral ischemia-reperfusion model of rats. Neurol Sci. 2012 Nov 28. PMID: 23187787
  28. Khan MM, Raza SS, Javed H, Ahmad A, Khan A, Islam F, Safhi MM, Islam F. Rutin Protects Dopaminergic Neurons from Oxidative Stress in an Animal Model of Parkinson's disease. Neurotox Res. 2011 Dec 23 PMID: 22194158
  29. Gandhi C, Khan MM, Lentz SR, Chauhan AK. ADAMTS13 reduces vascular inflammation and the development of early atherosclerosis in mice. Blood 2011 119(10):2385-91. PMID: 22123843
  30. Raza SS, Khan MM, Ahmad A, Ashafaq M, Khuwaja G, Tabassum R, Javed H, Siddiqui MS, Safhi MM, Islam F. Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke Brain Res. 2011 Oct 28;1420:93-105 PMID: 21959178
  31. Raza SS, Khan MM, Ashafaq M, Ahmad A, Khuwaja G, Khan A, Siddique MS, Safhi MM, and Islam F. Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: A behavioral, biochemical and immunohistological study in Wistar rats. Journal of the Neurological Sciences 2011; 309:45-54. PMID: 21840019
  32. Ahmad A, Khan MM, Hoda MN, Raza SS, Khan MB, Javed H, Ishrat T, Ashafaq M, Ahmad ME, Safhi MM, Islam F Quercetin Protects Against Oxidative Stress Associated Damages in a Rat Model of Transient Focal Cerebral Ischemia and Reperfusion. Neurochem Res. 2011, 36(8):1360-71. PMID: 21472457
  33. Javed H, Khan MM, Khan A, Vaibhav K, Ahmad A, Khuwaja G, Raza SS,  Ashafaq M, Siddique MS, Safhi MM, Islam F. S-allyl cysteine attenuates oxidative stress associated cognitive impairment and neurodegeneration in mouse model of streptozotocin-induced experimental dementia of Alzheimer's type. Brain Research 2011, 1389:133-142. PMID:  21376020
  34. Khuwaja G, Khan MM, Ishrat T, Ahmad A, Raza SS, Ashafaq M, Javed H, Khan MB, Khan A, Vaibhav K, Safhi MM, Islam F. Neuroprotective effects of curcumin on 6-hydroxydopamine- induced Parkinsonism in rats: behavioral, neurochemical and immunohistochemical studies. Brain Res. 2011; 1368:254-63 PMID: 20951685
  35. Ahmad A, Khan MM, Ishrat T, Khan MB, Khuwaja G, Raza SS, Srivastava P, Islam F. Synergistic Effect of Selenium and Melatonin on Neuroprotection in Cerebral Ischemia in Rats. Biol Trace Elem Res. 2011; 139(1):81-96 PMID: 20358308
  36. Khan MB, Hoda MN, Ishrat T, Ahmad S, Khan MM, Ahmad A, Yusuf S, Islam F. Neuroprotective efficacy of Nardostachys jatamansi and crocetin in conjunction with selenium in cognitive impairment. Neurol Sci. 2011 Dec 15. PMID: 22170092
  37. Khan A, Vaibhav K, Javed H, Khan MM, Tabassum R, Ahmed ME, Raza SS, Ashafaq M, Khuwaja G, Gupta V, Deora AK, Pant AB, Siddique MS, Islam F Neuroprotective effect of Bellis perennis and hypericum perforatum on PC12 cells. Indian Journal of Research in Homeopathy. 2011; 5 (3).
  38. Khuwaja G, Ishrat T, Khan MB,  Raza SS,  Khan MM, Ahmad A, Vaibhav K, Khurana A, Fakhrul Islam F. Protective role of homoeopathic medicines on cerebral ischaemia in animals. Indian J Res Homoeopathy 2014, 8:209-217
  39. Khan MM, Ahmad A, Ishrat T, Khan MB, Hoda MN, Khuwaja G, Raza SS, Khan A, Javed H, Vaibhav K, and Islam F. Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease. Brain Res. 2010; 1328:139-51. PMID: 20167206 (Most cited research article in Brain Research)
  40. Khan MM, Hoda MN, Ishrat T, Ahmad A, Khan MB, Raza SS, Khuwaja G, and Islam F. Amelioration of MPTP induced behavioural dysfunction and oxidative stress by Pycnogenol® in mouse model of Parkinson’s disease. Behavioural Pharmacology, 2010; 21(5-6):563-71. PMID: 20657266
  41. Khan MM, Ishrat T, Ahmad A, Hoda MN, Khan MB, Khuwaja G, Srivastava P, Raza SS and Islam
  42. F. Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats. Chem  Biol Interact.  2010;  183:255-63. PMID: 19835851
  43. Khan MM, Ahmad A, Ishrat T, Khuwaja G, Srivastawa P, Khan MB, Raza SS, Javed H, Vaibhav K, Khan A, and Islam F. Rutin protects the neural damage induced by transient focal ischemia in rats. Brain Res. 2009; 1292:123-35. PMID: 19631195
  44. Ishrat T, Parveen K, Khan MM, Khuwaja G, Khan MB, Yousuf S, Ahmad A, Shrivastav P, Islam
  45. F. Selenium prevents learning and memory decline and oxidative damage in rat model of experimental dementia of Alzheimer's disease. Brain Research, 2009, 1281:117-27. PMID: 19374888
  46. Ishrat T, Hoda MN, Khan MB, Yousuf S, Ahmad M, Khan MM, Ahmad A, Islam F. Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer’s type (SDAT). European Neuropsychopharmacology 2009, 19:636-47. PMID: 19329286

 

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