Education

Experience

Biography

Boonchoy Soontornworajit was born in 1979, in Nongkai, Thailand. He received his B.S. in Chemistry at Khon Kean University in May 2002, and M.S. in Polymer Science at the Petroleum and Petrochemical College, Chulalongkorn University in May 2004. From 2004-2006, he worked as a research assistant at the National Metal and Materials Technology Center. In fall 2011, he received his Ph.D. in Chemical Engineering from the University of Connecticut. Now, he is an Assistant Professor in Chemistry at Department of Chemistry, Faculty of Science and Technology, Thammasat University, Thailand.

Research Interest

Our main theme of research is the development of diagnostic techniques and biomimetic materials for combating human diseases and disorders, Biosensor for pathological tests and Hydrogel for clinical usages.

Diagnostic techniques

The early diagnostic is crucial for a recovery of patients. Therefore, the diagnostic techniques are required to improve their efficacy in several aspects such as precision, sensitivity, and not limit to duration time of measurement. We currently develop diagnostic assays which fundamentally based on interaction between aptamers and their targets. The projects include the synthesis of recognition molecules, fabrication of the assay materials and test the proposed techniques. The research outcomes would be benefit for the people’s well-being.

Biomimetic material

Biomaterials as regenerating tissues might be the key answer for treatments of human diseases and disorders. Herein, we are seeking for biomimetic materials that are capable of entrapping and releasing bioactive molecules (e.g. antigen, antibody, and growth factor) in a desired time frame. Such precious functionality of the material is expectedly come from a specific molecular recognition between nucleic acid aptamers and their targets. Research activities are designed in a variety ways for investigating the molecular interaction, preparing the materials, incorporating the molecular recognition part, and testing the materials property. The successfulness of this project would enable us to create a novel biomimetic material that is promising to combat the current diseases and disorders.

Scientific Activities:

Award and Honors

Research Grants

Publications

1. Sangkeaw P, Saengkaew, J.; Soontornworajit, B.*, Development of Aptamer-Coated Beads for PDGF-BB Capture. Thai Journal of Science and Technology, 2017 (inpress).
2. Vu, Q.C.; Tantirungrotechai, Y.; Soontornworajit, B.*; Rotkrua, P., Truncation of PDGF-BB Aptamer by Secondary Structural Analysis and Immunoassay. International Journal of Pharma Medicine and Biological Sciences 2016, 5(1), 86-90.
3. Soontornworajit, B.; Rotkrua P.*; Targeted Drug Delivery via Recognition Molecules and Amphiphilic Carriers. Thammasat Medical Journal 2016, 16(2); 273-284.
4. Soontornworajit, B*.; Srakaew, P.; Naramitpanich, P., Aptamer-Gelatin Composite for a Trigger Release System Mediated by Oligonucleotide Hybridization. Journal of Biomaterials Science, Polymer Edition 2014, 25 (18), 2042-2052.
5. Battig, M. R.; Soontornworajit, B.; Wang, Y., Programmable Release of Multiple Protein Drugs from Aptamer-Functionalized Hydrogels via Nucleic Acid Hybridization. Journal of the American Chemical Society 2012,134 (30), 12410-12413.
6. Zhang, X. L.; Soontornworajit, B.; Zhang, Z. Y.; Chen, N. C.; Wang, Y., Enhanced Loading and Controlled Release of Antibiotics Using Nucleic Acids As an Antibiotic-Binding Effector in Hydrogels. Biomacromolecules2012,13 (7), 2202-2210.
7. Chen, N., Zhang, Z., Soontornworajit, B., Zhou, J., Wang, Y.* Cell adhesion on an artificial extracellular matrix using aptamer-functionalized PEG hydrogels. Biomaterials.2012, 33: 1353-1362.
8. Fan, T.H.*, Soontornworajit, B., Karzar-Jeddi, M., Wang, Y.* Aptamer-functionalized hydrogel for controlled protein release: a modeling study. Soft Matter.2011, 7: 9326-9334.
9. Soontornworajit, B., Zhou, J., Snipes M., Battig, M., Wang, Y.* Affinity hydrogels for controlled protein release using nucleic acid aptamers and complementary oligonucleotides. Biomaterials.2011, 32: 6839-6849.
10. Soontornworajit, B., Wang, Y.* Nucleic acid aptamers for clinical diagnosis: cell detection and molecular imaging. Analytical and Bioanalytical Chemistry.2011, 399:1591-1599. (Invited review)
11. Zhou, J., Soontornworajit, B., Snipes, M., Wang, Y.* Structural prediction and binding analysis of hybridized Aptamers. Journal of Molecular Recognition.2011, 24:119-126.
12. Soontornworajit, B., Zhou, J., Zhang, Z., Wang, Y.* Aptamer-functionalized in situ injectable hydrogel for controlled protein release. Biomacromolecules. 2010, 11, 2724-2730.
13. Soontornworajit, B., Zhou, J., Wang, Y.* A hybrid particle-hydrogel composite for oligonucleotide-mediated pulsatile protein release. Soft Matter. 2010, 6, 4255–4261.
14. Zhou, J., Soontornworajit, B., Wang, Y.* A temperature-responsive antibody-like nanostructure. Biomacromolecules. 2010. 11: 2087–2093.
15. Soontornworajit, B., Zhou, J., Shaw, M.T., Fan, T.H., Wang, Y.* Hydrogel functionalization with DNA aptamers for sustained PDGF-BB release. Chemical Communications.2010; 46: 1857–1859.
16. Zhou, J., Soontornworajit, B., Martin, J., Sullenger, B.A., Gilboa, E., Wang, Y.* A hybrid DNA aptamer-dendrimer nanomaterial for targeted cell labeling. Macromolecular Bioscience.2009; 9: 831-835.
17. Zhou, J., Soontornworajit, B., Snipes, M., Wang, Y.* Development of a novel pretargeting system with bifunctional nucleic acid molecules. Biochemical and Biophysical Research Communications.2009; 386: 521-525.
18. Soontornworajit B., Wannatong L., Hiamtup P., Niamlang S., Chotpattananont D., Sirivat A., Schwank J. Induced interaction between polypyrrole and SO2 via molecular sieve 13x. Mat SciEng B-Solid.2007; 136: 78-86.
19. Jaroenworaluck A, Panyathanmaporn T, Soontornworajit B, Supothina S, Tawkaew S, Jiamsakul S, et al. Synthesis, preparation and catalytic activities of V-doped TiO2 gel coating on porous α-Al2O3 beads.  Materials Science Forum2007. p. 147-50.
20. Jaroenworaluck A., Panyathanmaporn T., Soontornworajit B., Supothina S., (2006) Fabrication and characteristics of TiO2 films by a microwave drying technique. Surf Interface Anal 38 (4):765-768
21. Soontornworajit B, Panyathanmaporn T, Jaroenworaluck A, Supothina S. Preparation of TiO2 coating on glass substrate by non-aqueous SOL and comparison of controled atmosphere and microwave drying technique.  Ceramic Transactions2006. p. 225-31.