Education

Experience

Biography

Dr. Bill Tawil obtained his Bachelor degree in Biochemistry from the University of California at Berkeley. He then completed his Master and Doctorate degrees in Neuroscience at McGill University in Montreal studying the expression and function of adhesion cell surface receptors (integrins) in the Central Nervous System and during tumor metastasis. Subsequently, he spent four years of postdoctoral training at the Center for Cancer Research at MIT under the supervision of Dr. Richard Hynes investigating cell adhesion during the cell cycle. As a Scientist and a Senior Scientist at U.S. Surgical Corporation and at Baxter BioSurgery, he worked in the field of Tissue Regeneration examining products (synthetic and biologics) that successfully deliver bioactive substances and cells to enhance healing in soft and hard tissue defects. He, then, acted as a director of global expansion at Baxter BioSurgery responsible for scientific initiatives related to tissue engineering establishing collaborations between Baxter and other companies and academic institutions. Presently, Bill is a Director of R&D at CR Bard. Bill is also an adjunct professor in the Bioengineering Department at UCLA where he is continuing his research in Tissue Engineering, specifically on 3D constructs. He is on council for the Tissue Engineering and Regenerative Medicine (TERMIS) – North America society and on the Executive Editorial Board for the Tissue Engineering Journal. Bill was the co – Chair for TERMIS 2008 meeting and the Co – Chair for 2016 meeting. He has been the treasurer for TERMIS since 2009. Bill served on the BOD for the Wound Healing Society (WHS) from 2000 to 2005 and he was the treasurer from 2002 to 2005. He was on the Program Committee for the WHS from 1998 – 2000 and again from 2005 – 2008 including the co – chair for the 2007 meeting. Bill believes strongly that the interaction between academia and industry is an expedient and successful way to get products to the patients.

Research Interest

• Bioengineering & Tissue Engineering
• Molecular Biology
• Biotechnology Engineering & Medical Device Engineering
• Wound Healing & Tissue Engineering
• Introduction to Drug Design and Development

Scientific Activities:

Honors & Awards

• FRSQ Postdoctoral Fellow.  1992-1995
• The Distinguished Service Award, The Wound Healing Society. 2000            
• Baxter Technical Award, Outstanding Special Accomplishment. 2000
• Baxter Technical Award, Outstanding Special Accomplishment. 2001
• Participation and Leadership Award – Society for Biomaterials. 2002
• Distinguished Invited Professor, CLU. 2004
• Outstanding Speaker, IEEE – EMBS. 2004
• Baxter 5 Years Recognition. 2005
• Treasurer Award, The Wound Healing Society.  2005
• Program Chair Award, The Wound Healing Society. 2007
• Program Chair Award, Tissue Engineering & Regenerative Medicine 
• International Society (TERMIS) – NA Chapter. 2008.

Patents

• Genetically Altered Mesenchymal Stem Cells and Methods of Use Thereof WO 00/49136 – Issued 2000.
• Tissue Compositions using Cultured Fibroblasts and Keratinocytes and Methods of Use Thereof  -   W00166695 – Issued 2001.

Grants

1. 1997-1998: Buehler Award.
   PI: Dr. Thomas Mustoe - Northwestern Medical School, Chicago, Illinois.
   Title: Impaired Wound Healing in the Elderly: Why? Studies on Aged Fibroblast Migration.
2. 1998-2001: NIST/ATP Grant.
   Joint Venture USSC-Alexion.
   Title: Xenogeneic Cartilage Transplantation.
3. 2006-2013: NIH grant
   Title: Modeling Biomechanical Transformation of Keratinocyte or Fibroblast/ Fibrin Gels
4. 2014-2015: Stem Cell Research Innovation Awards. UCLA.
   Title: Non-Viral Strategy for Generation of Hematopoietic Stem Cells
5. 2014-2016: R21 NIH Grant.
   Title: Growth factor delivery using light-sensitive fibrin to treat chronic wounds

Publications

1. Tawil N.J., Houde M., Blacher R., Esch F., Reichardt L.F., Turner D.C., and Carbonetto S. 1990.  integrin heterodimer functions as a dual laminin/ collagen receptor in neural cells.  Biochem 29: 6540-6544
2. Ignatius M. J., Large T.H., Houde M., Tawil N.J., Barton A., Esch F., Carbonetto S. and Reichardt L.F. 1990. Molecular cloning of the rat integrin a1 subunit: a receptor for laminin and collagen.  J. Cell Biology 111:709-720.
3. Tawil N.J., Wilson P., and Carbonetto S. 1993. Integrins in point contacts mediate cell spreading: factors that regulate integrin accumulation in point contacts and focal contacts. J. Cell Biol.  120 (1): 261-271.
4. Tawil N.J., Wilson P., and Carbonetto S. 1994. Characterization and distribution of functional integrins in rat CNS.  J. Neuros. Research 39: 436-447.
5. Tawil N.J., Gowri V., Djoneid M., Nip J., Carbonetto S., and Brodt P. 1996. Integrin Alpha1Beta1 can promote adhesion and spreading of metastatic carcinoma cells on the lymph node stroma.  Int. J. Cancer 66: 703-710.
6. Burgess E, Hollinger J, Gruskin E, Bennett S, Scmitt J, Buck D, Shannon R, Joh S-P, Choi J, Mustoe TA, Lin H, Skalia W, Christoforou, C, Tawil N.J., Connors D. 1998. Charged beads promote cutaneous wound healing in Rhesus non-human primates.Plastic and Reconstructive Surgery. 102:2395-2403.
7. Tawil N.J., Connors D., Gies D., Lin H., Mustoe T. and Gruskin E. 1999. Stimulation of wound healing by positively charged dextran beads depends upon clustering of beads and cells in close proximity to the wound. Wound Reapir and Regeneration.  7:389-399.
8. Tawil N.J. 1999. Integrins.  Wound Repair and Regeneration Newsletter.  9:1.
9. Connors D., Gies D., Cristoforou C., Lin H., Gruskin E,  Mustoe T., Tawil N.J.  2000. Increase in wound braking strength in rats in the presence of positively charged dextran beads correlates with an increase in endogenous TGFb1 and its receptor TGFbR1 in close proximity to the wound.  Wound Repair and Regeneration.  8:292-303.
10. Mogford J, Tawil N.J., Chen A., Xia Y, Gruskin E., Mustoe T., 2002. Effect of age and hypoxia on TGFbeta1 receptor expression and signal transduction in human dermal fibroblasts: impact on cell migration. J Cell Physiol. 190(2):259-65.
11. Tawil N.J.  2003. Fibrin and its Characteristics.  Wound Repair and Regeneration Newsletter.  11.2.
12. Cox S., Cole M., Mankarious S., Tawil N.J. 2003. The Effect of Tranexamic Acid Incorporated in Fibrin Sealant Clots on Cell Behavior of Neuronal and Non-Neuronal Cells. J. Neuronal Research. 72: 734-746.
13. Nien Y.-D., Han Y.-P. , Tawil N.J., Chan L.S., Tuan T.-L. and Garner W. 2003. Fibrinogen Inhibits Fibroblast Mediated Contraction of Collagen. Wound Repair and Regeneration.  Wound Repair and Regeneration 11:380-385.
14. Helgerson S., Seelich T., Di Orio J., Tawil N.J., Bittner K., and Spaethe R. 2004. Fibrin. Review. Encyclopedia of Biomaterials and Biomedical Engineering.  Book Chapter.
15. Cox S., Cole M., and Tawil N. 2004. The Behavior of Human Dermal Fibroblasts In 3 Dimensional Fibrin Clots: Dependence on the Fibrinogen and Thrombin Concentration.  Tissue Engineering.  Vol 10 (5/6): 942
16. Deiters U., Barsig J., Tawil N., and Mühlradt P. 2004.  The Macrophage Activating Lipopeptide MALP-2 Accelerates Wound Healing in Diabetic Mice.  Exp Dermatol. Dec;13(12):731-9.
17. Mooney R.G., Costales C.A., Curtin J.M., Tawil B., C. Shaw. 2005.  Indentation Micromechanics of Fibroblast-Populated Fibrin Constructs.  Materials Research Society 874: 205 - 210.
18. Tawil B.. 2005.  Fibrin and Its Applications. Review. An Introduction to Biomaterials. Chapter 7: 105 – 120. Editors: S.A. Guelcher & J.O. Hollinger. Publisher: CRC Taylor & Francis.
19. Mana M, Cole M., Cox S. and Tawil B. 2006.  Human U937 monocyte behavior and protein expression on various formulations of three-dimensional fibrin clots Wound Repair and Regeneration. 14 Issue 1 Page 72.
20. Ho W., Tawil B., Dunn J. C.Y., B. M. Wu. 2006. The Behavior of Human Mesenchymal Stem Cells In 3D Fibrin Clots: Dependence on Fibrinogen Concentration and Clot Structure. Tissue Engineering. Vol 12(6): 1-9.
21. Catelas I., Sese N., Wu B., Dunn J., Helgerson S., Tawil B... 2006.  Human Mesenchymal Stem Cells Proliferation and Osteogenic Differentiation in Fibrin Gels in vitro.  Tissue Engineering. Vol 12(8): 1-9.
22. Cole M., Cox S., Inman E., Chan C., Mana M., Helgerson S. and Tawil B.  2007.  Fibrin Sealant TisseelR as a Delivery Vehicle for Active Macrophage Activator LipoProtein - 2 Peptide: In Vitro Studies. Wound Repair and Regeneration. Volume 15 Issue 4 Page 521-529.
23. Haison Duong, Benjamin Wu, and Bill Tawil. 2008. Fibrin Matrices in Tissue Engineering.  Review Article in Natural Based Polymers.
24. Mogford J., Tawil B., Jia S. and. Mustoe T. 2009.  Fibrin Sealant Combined with Fibroblasts and PDGF Enhance Wound Healing in Excisional Wounds.  Wound Repair & Regeneration. 17: 405–410.
25. Haison Duong, M.Sc., Benjamin Wu DDS., Ph.D., and Bill Tawil, Ph.D.  2009 Mdulation of 3-Dimensional Fibrin Matrix Stiffness by Intrinsic Fibrinogen-Thrombin Compositions and by Extrinsic Cellular Activity.  Tissue Engineering. Vol 15(7): 1865-1876. PMC2749875.
26. Rachael Mooney, Bill Tawil, Melissa Mahoney. 2010. Specific fibrinogen and thrombin concentrations promote neuronal rather than glial growth when primary neural cells are seeded within plasma-derived fibrin gels. Tissue Engineering. Vol 16(5): 1607-1619.
27. Kiki B. Hellman, Peter C. Johnson, Timothy A. Bertram, and Bill Tawil. 2010. Challenges in Tissue Engineering and Regenerative Medicine Product Commercialization: Building an Industry. Tissue Engineering. Volume 17, (1&2):  1-3.
28. Peter C. Johnson, Timothy A. Bertram, Bill Tawil, Kiki B. Hellman. 2010. Hurdles in Tissue Engineering/Regenerative Medicine Product Commercialization: A Survey of North American Academia and Industry. Tissue Engineering. Volume 17, (1&2):  5-15.
29. Nadjah Sese, Marietta Cole and  Bill Tawil. 2011. Cross – Talk Between Human Dermal Fibroblasts and Keratinocytes Co – Cultured in 3 Dimensional Fibrin Clots. Tissue Engineering. Volume 17, Numbers 3 and 4: 429 – 437.
30. Cecilia Chiu, Vivian Hecht, Haison Duong, Ben Wu, and Bill Tawil. 2012. Permeability of Three-Dimensional Fibrin Constructs Corresponds to Fibrinogen and Thrombin Concentrations. BioResearch Open Access Volume 1, Number 1:34-40.
31. Timothy A. Bertram, Edward Tentoff, Peter C. Johnson, Bill Tawil, Mark Van Dyke, and Kiki B. Hellman. 2012. Hurdles in Tissue Engineering/Regenerative Medicine Product Commercialization: A Pilot Survey of Governmental Funding Agencies and the Financial Industry. Tissue Engineering. Volume 18, Numbers 21-22.
32. Timothy A. Bertram1, Edward Tentoff, Peter C. Johnson, Bill Tawil, Mark Van Dyke, Kiki B. Hellman. 2012. Hurdles In Tissue Engineering/Regenerative Medicine Product Commercialization A Survey of the Financial Industry. Tissue Engineering. Volume 18, Numbers 21-22: 2187 – 2194.
33. Bill Tawil and Ben Wu.  Three – Dimensional Fibrin Constructs in Tissue Engineering.  Review. An Introduction to Biomaterials 2nd edition.. Chapter 15: 249 – 262 . Editors: J.O. Hollinger. Publisher: CRC Taylor & Francis
34. Chase Linsley, Ben Wu, Bill Tawil. 2013. The Effect of Fibrinogen, Collagen Type I and Fibronectin on Mesenchymal Stem Cells Growth and Differentiation into Osteoblasts. Tissue Engineering. Volume 19, Numbers 11 - 12: 1416 – 1423
35. Maria Rahmany, Bill Tawil, Kiki Hellman, Peter Johnson, Mark Van Dyke, Tim Bertram. 2013. Bench to Business: A Framework to Assess Technology Readiness.  Tissue Engineering. Volume 19, Numbers 21 - 22: 2314 – 2317
36. Tim Bertram, Bill Tawil, Kiki Hellman, Peter Johnson, Mark Van Dyke. 2013. Enhancing Tissue Engineering/Regenerative Medical Product Commercialization: The Role of Science in Regulatory Decision Making for Tissue Engineering/Regenerative Medicine Product Development.  Tissue Engineering. Volume 19, Numbers 21 - 22: 2313.
37. Peter C Johnson, Tim Bertram, Kiki B Hellman, Bill J Tawil, Mark Van Dyke, Neal Carty. 2014.  Awareness of the Role of Science in the FDA Regulatory Submission Process: A Survey of the TERMIS-Americas Membership. Tissue Engineering. Accepted
38. Erik Reinertsen, Michael Skinner, Ben Wu, and Bill Tawil. 2014. Concentration of Fibrin and Presence of Plasminogen Affect Proliferation, Fibrinolytic Activity, and Morphology of Human Fibroblasts and Keratinocytes in 3D Fibrin Constructs. Tissue Engineering. Accepted. 
39. Linsley C, Boardman L, Tawil B. 2014. Fibrin-Based Matrices for Tissue Engineering. Austin Journal of Biomedical Engineering. Editorial. Volume 1 Issue 2: 2-3 .
40. 40.Zhuo J. Chen, Jessica Wang, Ben Wu, and Bill Tawil.  2015. A Novel 3Dimentional Wound Healing Model.  Journal of Developmental Biology.  2(4), 198-209.
41. Chase Linsley, Roxana Fard, Ben Wu and Bill Tawil. 2016. Mesenchymal stem cell growth on and mechanical properties of fibrin-based biomimetic bone scaffolds.  Journal of Biomedical Materials Research. Accepted.
42. Kritika Iyer, B.S., Zhuo Chen, B.S., Teja Ganapa, B.S., Benjamin Wu, D.D.S., Ph.D. and Bill Tawil, Ph.D. 2016. Effect of Fibroblasts on Keratinocyte Behavior in Three-dimensional Collagen Constructs. In Preparation.
43. Hull, Brandi, M.Sc. Barreras, Arnold, M.Sc., Parris, Shelby, M.Sc., Tawil, Bill, Ph.D. 2016. The Effects of Oils with and without Nciotine used in Vaporizer Pens (E-Cigarettes) on Human Foreskin Fibroblast and Human Mesenchymal Stem Cell Behavior. In Preparation. 
44. Chase Linsley, Bill Tawil, Benjamin Wu. 2016.  Recent advances in light-responsive smart drug delivery systems. In Preparation.

Abstracts:                                                                                                            

45. Tawil N.J., Houde M. and Carbonetto S. 1989. Isolation and partial characterization of a laminin/collagen receptor on astrocytes.  Soc.Neurosc.Abstr.15:230.5.
46. Houde M., Tawil N.J., Blacher R., Esch F., Reichardt L.F., Turner D.C. and Carbonetto S. 1989. Partial sequence of a rat laminin/collagen receptor identifies it as a VLA-1 type of integrin.  Journal of Cell Biology. 29:565.
47. Tawil N.J. and Carbonetto S. 1990. Cultured rat astrocytes express functional integrins.  Soc. Neurosc. Abstr.,16:412.6
48. Ignatius M. J., Large T.H., Houde M., Tawil N.J., Barton A., Esch F., Carbonetto S. and Reichardt L.F. 1990. Molecular cloning of the rat integrin 1 subunit: a receptor for laminin and collagen.  Journal of Cell Biology Abstr. 30:770
49. Wilson P., Tawil N.J., Carbonetto S. 1991. Integrin distribution and cell-substratum attachment in astrocytes.  International Brain Research Organization P6.24 pp:59
50. Tawil N.J. and Carbonetto S. 1991. Immunocytochemical Studies of  Integrins in Type-2 Astrocytes and Oligodendrocytes.  Journal of Cell Biology Abstr.
51. Tawil N.J., and Hynes R. 1993. Why do cells round up during mitosis.  Whitehead Institute/MIT Meeting.
52. Tawil N.J., Grandori C., and R.O. Hynes. 1994. 1 integrin phosphorylation during the cell cycle.  Whitehead Institute/MIT Meeting.
53. Tawil N.J., Grandori C., and R.O. Hynes. 1995. Do integrins have an effect on cell cycle?  Gordon Conference, Fibronectin, Integrins and Related molecules, Oxnard, California.
54. Tawil N.J., Connors D., Chrisoforou C., Mustoe T., and Gruskin E. 1996. Positively charged beads create an enhancing environment for wound healing.  ASCB Meeting.
55. Connors D., Tawil N.J., Christoforou C., Mustoe T., and Gruskin E. 1996. Positively charged beads enhance the wound healing in rats.  6Th European Conference on Advances in Wound Management.
56. Christoforou C., Connors D., Lin H., Bennett S., Skalla W., Tawil N.J., Brucker M., Corral C., Lee D., Arnold F., Gruskin E. , Mustoe T.  1996. Effects of a degradable charged polymer on wound healing.  Wound Healing Society.
57. Gruskin E., Christoforou C., Connors D., Tawil N.J., Lin H., Bennett S., Skalla W., Lee D., Mustoe T. 1996. A novel wound dressing for the treatment of chronic and acute wounds.  European Tissue Repair Society.
58. Gruskin E., Christoforou C., Connors D., Tawil N.J., Lin H., Bennett S., Skalla W., Lee D., Mustoe T. 1996. A novel approach to the treatment of chronic and acute wounds- resorbable, charged microbeads.  European Tissue Repair Society.
59.  Christoforou C., Connors D., Lin H., Bennett S., Tawil N.J., Skalla W.,  Lee D., Arnold F., Gruskin E., Mustoe T.  1996. Effects of a hydrolytically degradable charged polymer on wound healing.  American College of Surgeons.
60. Tawil N.J., Connors D., Christoforou C., Mustoe T. and Gruskin E. 1997. Adhesion and biological studies on positively charged beads.  Gordon Conference, Fibronectin, Integrins and Related molecules, Oxnard, California.
61. Tawil N.J., Connors D., Christoforou C., Mustoe T.,  and Gruskin E. 1997. Cellular studies on positively charged beads.  Society for  Biomaterials.
62. Chen A., Tawil N.J., Xia Y., Gruskin E., and Mustoe T. 1997. The effects of TGFb1 in hypoxia on aged fibroblast migration.  Wound Healing Society.
63. Connors D., Gies D., Cristoforou C., Lin H., Mustoe T., Tawil N.J. and Gruskin E. 1997. The effects of Hydrageltm (a hydrolytically degradable charged polymer) on wound healing-  a time course study.  Wound Healing Society.
64. Gies D., Connors D., Cristoforou C., Lin H., Mustoe T., Gruskin E, and Tawil N.J. 1997. Effect of Hydrageltm (positively charged beads) on macrophage recruitment to wounds.  Wound Healing Society.\
65. Tawil N.J., Connors D., Gies D., Cristoforou C., Mustoe T., and Gruskin E. 1997. Positively charged beads: in vitro studies.  Wound Healing Society.
66. Bennett S., Tawil N.J., Lee D., Skalla W. and Gruskin E. 1997. Osteoblasts adhesion to polymers: in vitro studies.  Society for  Biomaterials.
67. Connors D., Gies D., Christoforou C., Lin H, Mustoe T., Buck D., Burgess E., Hollinger J., Tawil N.J. and Gruskin E. 1997. Degradable positively charged polymer enhances wound healing in non - human primates.  European Tissue Repair Society.
68. Gies D., Connors D., Christoforou C., Lin H., Mustoe T., Gruskin E., and Tawil N.J. 1997. Effect of positively charged beads on cell behavior: macrophage recruitment to wounds.  European Tissue Repair Society.
69. Tawil N.J., Connors D., Gies D., Christoforou C.,  Mustoe T., Hollinger J., Buck D., Burgess E. and Gruskin E. 1997. How positively charged beads (Hydragel AC preparation) enhance wound healing.  American College of Surgeons.
70. D. Gies, D. Connors, C. Christoforou, S. Bennett, T. Mustoe, J. Hollinger, E. Gruskin and N. Tawil. 1998.  Effect of positively charged beads on the distribution of macrophages during wound healing in rats and monkeys.  Keystone Meeting.
71. Bennett S., Tawil N., Lee D., Skalla W., Hollinger J. and Gruskin E. 1998. Optimizing polymer scaffolds for bony in-growth.  Keystone Meeting.
72. Bennett S., Tawil N., Lee D., Skalla W., Hollinger J. and Gruskin E. 1998. Optimization of biodegradable polyurea surfaces: in vitro and in vivo studies.  Society for Biomaterials.
73. Tawil N., Gies D., Connors D., Christoforou C., Bennett S., Mustoe T., Hollinger J., and Gruskin E. 1998. Effect of positively charged beads on the distribution of macrophages and TGFb family and its receptors in rats, adult and geriatric rhesus monkeys.  Society for Biomaterials.
74. Tawil N., Connors D., Gies D., Christoforou C., Mustoe T, and E. Gruskin. 1998. The effect of various types of positively charged beads (Hydragel A preparation) on wound healing: In Vivo and In Vitro studies.  Wound Healing Society.
75. Gies D., Connors D., Mustoe T., Gruskin E. and Tawil N. 1998. The effects of positively charged beads (Hydragel A Preparation) on cellular infiltration and matrix molecules deposition in rat and monkey wounds.  Wound Healing Society.
76. Connors D., Gies D., Lin H., Mustoe T., Gruskin E. and Tawil N. 1998. Positively charged beads (Hydragel A Preparation) alter the expression and distribution of TGFb receptor I in rat incisional wounds.  Wound Healing Society.
77. Cisek L., Peters C., Forse R. A., Tawil N., and Gruskin E. 1998. Positively charged beads do not promote intra-abdominal adhesions.  Wound Healing Society.
78. Cisek L., Gobet R.M., Peters C., Gruskin E., and Tawil N. 1998. Positively charged beads as wound healing accelerants in hollow viscus incisions.  Wound Healing Society.
79. Tawil N. , Gies D., Connors D., Mustoe T., and Gruskin E.A. 1998. Positively charged beads (Hydragel A) enhance wound healing: cellular distribution and extracellular matrix and growth factor expression.  American College of Surgeons.
80. Cisek L. J., Gobet R. M., Peters C. A., Forse R. A., Gruskin E.A., and Tawil N. 1998. Positively charged beads as wound healing accelerants in hollow viscus anastomoses.  American College of Surgeons.
81. Gies D., Connors D., Gruskin E., and Tawil N. 1998. Modification of cellular distribution enhances wound healing.  ASCB meeting.
82. Chen A., Gies D., Tyrone J., Mustoe T., Gruskin E., Xia Y. and Tawil N. 1999. A differential adhesion and migration in aged vs young human fibroblasts: a role for integrins, hypoxia and TGFb1.  Gordon Conference, Fibronectin, Integrins and Related molecules, Oxnard, California.
83. Lott K., Connors D., Gies D., Mustoe T. Gruskin E., and Tawil N. 1999. The expression of PDGFA and PDGFB is altered in wounds treated with charged dextran: correlation with an increase in the wound healing.  Society for Biomaterials.
84. Gies D., Connors D., Bennett S., Skalla W., Fodor B., Brokaw J., Williams B., Gruskin E., and Tawil N. 1999. Seeding of PGA/PLA materials with transgenic porcine mesenchymal cells.  Society for Biomaterials.
85. Cole M., Cox S., Helgerson S., Mankarious S. and Tawil N.   2000.  The effect of fibrin sealant (Tisseel) on the adhesion, proliferation and cell migration of human monocytes U937 cell line and human-derived fibroblasts. The Wound Healing Society 10th Annual Conference, Toronto, Canada.  
86. Cole M., Cox S., Mogford J., Mana M., Ho W., Eggleston A., Mustoe T. and Tawil N. 2001. Fibrin sealant TISSEEL is a biocombatible polymer for human-derived monocytes, fibroblasts and keratinocytes. The Wound Healing Society 11th Annual Conference, Albuquerque, NM.       
87. Cox S., Cole M., Mankarious S. and Tawil N. 2001. The effect of tranexamic acid mixed in fibrin sealant clots and solution on the behavior of neuronal and non-neuronal cells. The 1st Biennial meeting of the European Tissue Engineering Society ETES, Freiburg, Germany.
88. Cox S., Mogford J., Cole M., Mustoe T. and Tawil N. 2002. Fibrin Sealant is an Excellent Biologic Polymer for Cell Delivery: Fibroblasts – Fibrin Sealant construct for Treating Chronic Wounds: In Vitro and In Vivo Studies. Society for Biomaterials, Tampa, Florida
89. Cox S., Cole M., and Tawil N.  2002. The Expression of PDGF, PDGF Receptors, IL-8 and Beta 1 Integrin by Fibroblasts in Response to Fibrin Sealant. The Wound Healing Society 12th Annual Conference, Baltimore, MD.
90. Cole M., Cox S., Inman E., Chan C. and Tawil             N. 2002. Fibrin Sealant TisseelR as a Vehicle for Peptide Delivery: IN VITRO STUDIES. The Wound Healing Society 12th Annual Conference, Baltimore, MD.
91. Deiters U., Barsig J., Tawil N., and Mühlradt P. 2002. The Macrophage Activator MALP-2 Accelerates Wound Healing in Diabetic Mice. The Wound Healing Society 12th Annual Conference, Baltimore, MD
92. Wiedemann U., Cox S., Cole M. and Tawil N. 2002. The Use of Fibrin Sealant for the Delivery of Human Mesenchymal Stem Cells: In Vitro Studies. The Wound Healing Society 12th Annual Conference, Baltimore, MD.
93. N. Sese, M. Cole, S. Cox, N. Tawil. 2003. Delivering Human Keratinocytes Using Fibrin Sealant: In Vitro Studies.  The Wound Healing Society. 13th Annual Conference, Seattle, Washington
94. W. Ho, I. Catelas, N. Sese, M. Cole and N. Tawil.  2003. Mesenchymal Stem Cell Behavior in Fibrin Sealant: In Vitro Studies.  Society for Biomaterials. 29th Annual Meeting. Reno, Nevada
95. R. Ferguson, S. Cox, N. Sese, M. Cole, and N. Tawil. 2003. The Use of Fibrin Sealant to Deliver Neuronal Stem Cell: In Vitro Studies. Society for Biomaterials. 29th Annual Meeting. Reno, Nevada.
96. P.C. Yiu, H. Wu,  N. Tawil, W.L. Garner, T. L. Tuan. 2003.  Cellular Expression and Activation of Extracellular Matrix Degrading Proteases and Protease Inhibitors are Modulated by the Nature of Biomatrix.  California Tissue Engineering, 2nd Annual Meeting. San Diego, California.
97. I. Catelas, N. Sese, W. Ho, B. Wu, S. Helgerson, N.Tawil. 2003. Mesenchymal Stem Cell Behavior in Fibrin Sealant In Vitro. Gordon Conference.
98. I.Catelas, N. Sese, S. Helgerson, N.Tawil. 2003. Proliferation and Differentiation of Mesenchymal Stem Cells in Fibrin Gel. Tissue Engineering Society International. Orlando, Florida .
99. Tawil B. 2004. Delivering Cells and Bioactive Substances Using Synthetic and Biologic Delivery Vehicles. Medical Devices and Manufacturing / West Coast.
100. Catelas, I; *Sese, N; Helgerson, S; Tawil, B.  2004.  Fibrin Gel: a Scaffold for Proliferation and Differentiation of Mesenchymal Stem Cells.  ORS, New Orleans .
101. Catelas, I; *Sese, N; Helgerson, S; Tawil, B.  2004.  Effects of Fibrin Gel Formulation on Mesenchymal Stem Cell Proliferation and Differentiation.  8th World Biomaterials Congress, Sydney, Australia.
102. N. Sese, M. Cole, and B. Tawil.  2004.  Cross – Talk Between Fibroblasts and Keratinocytes in 3-D Fibrin Clots. In Vitro Studies.  The Wound Healing Society 14th Annual Conference, Atlanta, GA.
103. J. E. Mogford, B. Tawil and T. A. Mustoe.  2004.  Fibrin Sealant Combined with Fibroblasts and PDGF Enhance Wound Healing in Excisional Wounds.  The Wound Healing Society 14th Annual Conference, Atlanta, GA.
104. N. Sese, M. Cole, and B. Tawil.  2004. C Delivering Fibroblasts and Keratinocytes in 3-D Fibrin Clots. In Vitro Studies.  Regenerate, Seattle, CA.
105. R.G. Mooney, C. Costales, A. Doerfler, G. Toland, W. Garner, B. Tawil, T.-L. Tuan, B. Wu and M.C. Shaw.  2004.  Indentation Micromechanics of Fibroblast-Fibrin and Keratinocyte- Fibrin Constructs.  Society for Biomaterials, Philadelphia, PA.
106. Catelas, I; Sese, N; Wu, B M; Dunn, J; Helgerson, S; Tawil, B.  2005. Osteogenic Differentiation of Human Mesenchymal Stem Cells in Fibrin Gels IN VITRO. ORS, Washington, DC.
107. Costales C., Mooney R.G., Curtin J., Garner W., Tawil B., Tuan T.-L., Wu B. and  Shaw M.C. 2005. Indentation Micromechanics of Cell-Populated Fibrin/Collagen Constructs.  MRS. San Francisco, CA
108. R.G. Mooney, C. Costales, M.C. Shaw, B. Tawil. 2005.  Mechanical Characteristics of Fibroblast – Fibrin Constructs: Effect of Fibrinogen and Thrombin Concentration.  The Wound Healing Society 15th Annual Conference, Chicago, IL
109. W. Ho, T-L Tuan, B. Tawil, B.M. Wu.  2005. Formulational Dependence of Human Mesenchymal Stem Cell Behavior in Fibrin Sealant. The Wound Healing Society 15th Annual Conference, Chicago, IL.
110. Catelas, N. Sese, B.M. Wu, J. Dunn, S. Helgerson, B. Tawil.  2005. Fibrin Gel:  A Scaffold for Mesenchymal Stem Cells.  4th Annual meeting of the European Tissue Engineering Society, Munich, Germany.
111. E. Freeman, B. Tawil, and M.C. Shaw. 2005.  Rate-Dependent mechanical Properties of Fibrin Biomaterial Scaffolds. Southern California Conference on Undergraduate Research, Long Beach, CA.
112. Shaw M. & Tawil B. 2006.  Structure/ Function Relationships in Fibrin/ Collagen Biomaterial Scaffolds for Wound Healing Applications.  Pan American Health Care Engineering Conference. Long Beach, CA.
113. A. Corrin, E. Freeman, B. Tawil and M. Shaw.  2006. Structure-Function Micromechanics of Cell-Populated Fibrin Biomaterials: Role of Matrix Elasticity in Remodeling in vitro.  MRS, San Francisco, CA
114. J.T. Lee, E. Freeman, S. Reynolds, M.C. Shaw and B. Tawil .  2006. Mechanical Characteristics of 3D Collagen Scaffolds. Regenerate World Congress on Tissue Engineering & Regenerative Medicine, Pittsburgh, PA.
115. J.A. Curtin, B. Tawil and M.C. Shaw.  2006.  High-Resolution Displacement Mapping of Fibril Structural Changes Under Tensile Strain Relaxation Conditions.  Regenerate World Congress on Tissue Engineering & Regenerative Medicine, Pittsburgh, PA.
116. A. Corrin, B. Tawil, M.C. Shaw.  2006.  Structure-Function Micromechanics of Fibrin Biomaterial Scaffolds. Society for Biomaterials, Pittsburgh, PA.
117. E. Freeman, B. Tawil and M.C. 2006. Shaw Rate-Dependent Mechanical Properties of Fibrin Biomaterial Scaffolds. Society for Biomaterials, Pittsburgh, PA
118. Chow, M., Duong, H.S., Wu, B., and Tawil, B. 2007. Mesenchymal Stem Cells and Osteogenesis in Fibrin Scaffolds. California Tissue Engineering Meeting, Los Angeles, California.
119. Hecht, V., Duong, H.S., Wu, B., and Tawil, B. 2007  Determination of Relationship of Fibrinogen and Thrombin Concentration to Fibrin Scaffold Properties Through the Use of Dextran Nanoparticles. California Tissue Engineering Meeting, Los Angeles, California.
120. Chow, M., Duong, H.S., Wu, B., and Tawil, B. 2008. Mesenchymal Stem Cells and Osteogenesis in 2-D Substrates and 3-D Fibrin Matrices. Wound Healing Symposium, San Diego, California.
121. Hecht, V., Duong, H.S., Wu, B., and Tawil, B. 2008. Use of Dextran Nanoparticles to assess porosity of fibrin gel scaffold. Wound Healing Symposium. San Diego, California,
122. Hecht, V., Duong, H.S., Wu, B., and Tawil, B. 2008. Use of Dextran Nanoparticles to assess porosity of fibrin gel scaffold. World Biomaterial Congress. Netherland, Amsterdam.
123. Motlagh D., Huang Li Ting, Cohen A, Tawil B, Catelas I,Smith S., Donovan S., Yardimci A., Mckee J., Brooks B., StojanovicL., Diorio J., Amrani D. 2008.  Fibrin Sealant Structure impacts CD34+ Cell Function: Outcomes of Fibrin Scaffold Stem Cell in Preclinical Studies of Critical LimbIschemia. Fibrinogen International Meeting.
124. Tawil B. 2008. Use of Fibrin in Scaffold for Skin and Bone Tissue Engineering Invited Speaker.  MRS, Boston, Massachusetts.
125. Cecilia L. Chiu, Haison Duong, Bill Tawil, Ben Wu. 2008. Characteristics of Fibrin Scaffolds Predicted from Darcy’s Law and Dextran Molecular Probes Over Varying Concentrations of Fibrinogen and Thrombin. TERMIS NA, San Diego, California.
126. Haison Duong, Ben Wu, Bill Tawil.  2008. Modulation of 3-Dimensional Fibrin Matrix Stiffness by Intrinsic Fibrinogen-Thrombin Compositions and by Extrinsic Cellular Activity. TERMIS NA, San Diego, California.
127. Melissa Chow, Haison Duong, Ben Wu, Bill Tawil.  2008. Mesenchymal Stem Cells Differentiation into Osteoblasts on 2D and in 3D Fibrin Scaffolds.  TERMIS NA, San Diego, California.
128. Stephanie Reed, Bill Tawil, Benjamin Wu. 2009. Cartilage Regeneration: A Macrodesigned, Acellular Scaffold Promoting Endogenous Cell Influx and Chondrogenesis. UC – Wide system Biology, Merced, CA.
129. Cecilia Chiu, Vivian Hecht, Haison Duong, Ben Wu, and Bill Tawil. 2009.  Fibrinogen and Thrombin Concentrations Modulate the Diffusion and Flow Rates of Fibrin Matrices. Society for Biomaterials, San Antonio, TX .
130. Soma Esmailian, Haison Duong, Ben Wu, and Bill Tawil. 2009.  Effect of Ultraviolet Light Crosslinking on Mechanical Stiffness of Fibrin Scaffolds. Wound Healing Society, Dallas, TX
131. Haison Duong, Ben Wu, and Bill Tawil. 2010. Release Kinetics of FITC-Dextran Particles from Bioerodible Multi-layered Fibrin Matrices: A Study of Peripheral and Local Diffusion.  Society for Biomaterials, Seattle, WA
132. Stephanie Reed, Bill Tawil, Benjamin Wu. 2010. A Macrodesigned, Acellular Scaffold Promoting Endogenous Cell Influx and Viability for Cartilage Regeneration. Society for Biomaterials, Seattle, WA
133. Haison Duong, Nasim Zarkesh, Ben Wu, and Bill Tawil.  2010. Assessment of Keratinocyte Migration on Fibrin and Collagen Matrices of Different Compositions in a Modified Skin Equivalent Wound Model. Wound Healing Society, Orlando, FL
134. Haison Duong, Ben Wu, and Bill Tawil. 2010. Comparison of Fibrinolytic Protease Activity and Collagen Production of Keratinocytes and Fibroblasts Cultured in 3-D Fibrin Matrices. Wound Healing Society, Orlando, FL
135. Chase Linsley, Benjamin Wu, Bill Tawil. 2010. Osteogenic Differentiation of Mesenchymal Stem Cells on Various 2-D Substrates. TERMIS NA, Orlando, Florida
136. Erik P. Reinertsen, Benjamin M. Wu, Bill J. Tawil. 2010. 3-D Fibrin Composition Modifies Mechanical and Biological Properties of Fibroblasts and Keratinocytes. TERMIS NA, Orlando, Florida
137. Roxana Fard and Bill Tawil. 2010. Optimization of Hydroxyapatite b-Tricalcium Phosphate – Fibrin Constructs for Human Mesenchymal Stem Cell Proliferation and Mechanical strength.  TERMIS NA, Orlando, Florida
138. Erik Reinertsen, Benjamin Wu, Bill Tawil. 2011. 3-D Fibrin Composition Affects Human Fibroblast Proliferation and Fibrinolysis.  Wound Healing Society, Dallas, TX
139. Jessica Yang, Benjamin Wu, Bill Tawil. 2011. Assessment of keratinocyte and fibroblast migration on fibrin and collagen matrices of different compositions in a 3D modified skin equivalent model. Wound Healing Society, Dallas, TX
140. Jessica Yang, Benjamin Wu, Bill Tawil. 2011. Assessment of Keratinocyte and Fibroblast Migration on Fibrin and Collagen Matrices of Different Compositions on a Novel 3D Skin Equivalent Wound Model. TERMIS NA, Houston, CA
141. Chase Linsley, Benjamin Wu, Bill Tawil. 2011. Fabrication and characterization of multi-component biomimetic scaffold for bone tissue engineering. TERMIS NA, Houston, CA
142. Alvarado, R ,Burke, K, Dalton, J, Sidhu, R, Soto, R, McCoy, M,  Tawil, B. 2012. Human Foreskin Fibroblast and Mouse Mesenchymal Stem Cell Behavior in 3D Fibrin Constructs. 24th Annual CSU Biotechnology Symposium, Santa Clara, CA. 
143. Erik Reinertsen, Benjamin Wu, Bill Tawil. 2012. 3D FIBRIN HYDROGEL CONCENTRATION AND FORMULATION AFFECTS HUMAN FIBROBLAST PROLIFERATION, MORPHOLOGY, AND FIBRINOLYSIS. Wound Healing Society, Atlanta, Georgia
144. Zhuo J. Chen, Benjamin M. Wu, Bill Tawil. 2013. THE FEASIBILITY OF CELL-ENCAPSULATED FIBRIN BEADS. Wound Healing Society, Denver, Colorado
145. Michael Skinner, Erik Reinertsen, Benjamin M. Wu,  Bill Tawil.  2013. FIBRINOGEN FORMULATION AND CONCENTRATION AFFECTS HUMAN KERATINOCYTE PROLIFERATION AND DEGRADATION. Wound Healing Society, Denver, Colorado
146. Chase Linsley, Roxana Fard, Benjamin Wu, Bill Tawil. 2013.  Mechanical Properties of and Mesenchymal Stem Cell Growth on Three-Dimensional Biomimetic Bone Scaffolds. TERMIS NA, Atlanta, Georgia
147. Vincent Siu, Stephanie DeSanti, Victor Mikhaltsevich, Danny Tran, Melissa McCoy, Bill Tawil. 2013. The Effects of Various Fruit Extracts, Collagen, and Fibronectin on the Proliferation and Migration of the Rhabdomyosarcoma-derived (RD) Cell Line. TERMIS NA, Atlanta, Georgia
148. Armaun Emami, Jesus Fajardo, Mai Nguyen, Takahiro Watanabe, Elaheh Asghari, Surbhi Dutta, Arthela Osorio, Tom Velasco, Melissa McCoy, Bill Tawil. 2013.  Impact of Fibroblast Growth Factor on Mesenchymal Stem Cell Osteogenic Differentiation and Migration. TERMIS NA, Atlanta, Georgia
149. Zeel Amin, Aimee Flores, Prathyusha Garimidi, Margarita Martinez, Viet Nhan, Mellissa McCoy, Bill Tawil. 2014.  The Influence of Fibronectin, bFGF, and VEGF on Human Foreskin Fibroblast Cells. TERMIS NA, Washington, DC
150. Kristin Chiniaeff, Ramsinh Dodia, Bora Kim, Tanya Rami, Divya Suresh, Melissa McCoy, Bill Tawil. 2014.  The Effect of Fibronectin, FGF, IGF, and TGFβ on Proliferation and Migration of Human Mesenchymal Stem Cells. TERMIS NA, Washington, DC
151. Vivianna C. Day, Shanah M. Elliott, Khachik Najaryan, Christopher F. Ngo, Nicole M. Sarris, Melissa McCoy, Bill Tawil. 2014.  The Effect of FGF and VEGF in the Presence of Collagen on Human Foreskin Fibroblast Proliferation, Migration, and Integrin Expression TERMIS NA, Washington, DC
152. Dominique Burns, Derrick Hau, Artemis Naderkhani, Joshua Plat, Melissa McCoy, Bill Tawil. 2014.  The Effects of FGF, TGFb, and IGF on Mesenchymal Stem Cells Seeded on a Collagen Matrix. TERMIS NA, Washington, DC
153. Chase Linsley, Laura Boardman, Benjamin Wu, Bill Tawil. 2014.  Cellular Response of Mesenchymal Stem Cells in Three-Dimensional Fibrin-Collagen-Calcium Phosphate Scaffolds TERMIS NA, Washington, DC
154. Chase Linsley, Laura Boardman, Benjamin Wu, Bill Tawil. 2015.  Optimizing peptide incorporation efficiency and characterizing changes in the physical properties of fibrin gels. TERMIS International Meeting, Boston, MA.
155. Ben Fox, Pauline Simmons, Bradley Neill, Melissa McCoy, Tawil, B. 2015. The Effects of Fibronectin, Collagen, and Static Electricity (SE) on Proliferation and Morphology of Human Mesenchymal Stem Cells. TERMIS International Meeting, Boston, MA.
156. Prachi Javale, Neda Marhamati, Angad Maroke, Scott Silver, Melissa McCoy, Tawil, B. 2015. The Effects of Fibronectin, Collagen, TGF-β, EGF and IGF on Proliferation and Morphology of Human Mesenchymal Stem Cells.  TERMIS International Meeting, Boston, MA.
157. Chase S. Linsley , Kevin Sung , Yoonjung Shin , Bill Tawil  and Benjamin M. Wu. 2016. Photothermally-Responsive Fibrin Gels. Wolrd Biomaterials Congress, Montreal, Canada
158. Babak Tofig, Andrew Diaz, Jonathan Verham, Jared Petit, Mellissa McCoy, Bill Tawil, 2016. Composite Effects of Fibronectin, Collagen, and VEGF on Human Foreskin Fibroblast Cells: Proliferation and Migration. TERMIS NA, San Diego, CA
159. Ali Al-hatrashi, Chelsea Balli, Mohamed Faynus, Danielle Zapparelli, Melissa McCoy, Bill Tawil. 2016. The Effect of Fibronectin, Collagen, and Ethanol on human Mesenchymal Stem Cell Adhesion, Proliferation and Migration. TERMIS NA, San Diego, CA
160. Sarah Majidian, Lauren Petta, Lance Johnson, Jeff Brown, Melissa McCoy, Bill Tawil. 2016. The Effects of Collagen, Fibronectin, Sucrose, and Sucralose on Human Foreskin Fibroblast Adhesion, Proliferation, and Migration. TERMIS NA, San Diego, CA
161. Kritika Iyer, Ben Wu, Bill Tawil. 2016.  Effect of Fibroblasts on Keratinocyte Behavior in Three-dimensional Collagen Constructs. TERMIS NA, San Diego, CA
162. Hull, Brandi • Sassen, Amanda • Walcott, MC • Anand, Ranauq •  McCoy, Melissa • Tawil, Bill. 2016.  The Effects of Nicotine Oils, Collagen and Fibronectin on the Initial Adhesion, Cell Proliferation and Morphology Of Human Mesenchymal Stem Cells. TERMIS NA, San Diego, CA
163. Diba Kamali, Arnold Barreras, Noel Silva, Alexander Mueting, Melissa McCoy, Bill Tawil, PhD. 2016.  The Effects of Fibronectin, Collagen, and Green Tea on the Proliferation, Morphology, Migration and Integrin Expression of Human Foreskin Fibroblast Cells. TERMIS NA, San Diego, CA
164. Chase S. Linsle, Yoonjung Shin, Kevin Sung, Bill Tawil and Benjamin M. Wu. 2016. Platelet Derived Growth Factor (PDGF) Mimetic Peptide for Skin Tissue Engineering. TERMIS NA, San Diego, CA