Education

Biography

Elena V. Batrakova  born in Moscow, USSR in 1960 and graduated with M.S. degree in chemistry from M.V.LomonosovMoscowStateUniversity (MSU) in 1983.  In 1987 she obtained Ph.D. in Polymer chemistry at the Department of Polymers, MSU, Russia. She is an Associate Professor of Pharmaceutical Sciences at the University of North Carolina at Chapel Hill, USA. The main focus of Dr. Batrakova’sgroup investigations is on the development ofpersonalized drug delivery systemsby loading therapeutics into living cellsor exosomesreleased from these cells. We are taking advantageof white blood cells, monocytes and macrophages that can move toward an inflammation site, cross the blood-brain barrier, and release the preloaded drugs in the brain. We demonstrated that these “Trojan Horses” can attenuate inflammation and produce neuroprotection in mouse models of Parkinson’s disease. Several years ago, my interests expanded to the development of a novel class of vectors, genetically modified macrophages, which carry reporter and therapeutic genes to neural cells. These cells can accomplish ‘horizontal gene transfer” to the inflamed tissues, in particular to the brain.  The separate investigations in my lab aim to use exosomes released from macrophagesas drug delivery vehicles to treat pulmonary metastases and brain disorders.Overall, my group has published 87 papers and filed 20 US and foreign patents on the application of drug delivery systems of biologically active molecules. I have 8,259 unique citations with h-index: 45, and i10-index 66.

Research Interest

1. Development of cell-mediated drug delivery systems to attenuate neuroinflammation and produce neuroprotection in patients with PD 
2. Using macrophages as a secondary transfection agents for gene delivery to the brain
3. Development of exosome-based drug delivery systems for treatment of pulmonary metastases
4. Development of polymer-based drug delivery systems for the chemotherapy and brain disorders

Professional Activities:

Publications

1. Egorov V.V., Batrakova E.V., Titkova L.V., Demin V.V., Zubov V.P., and Barnakov A.N. (1982) Characteristics of the behavior of N-cetyl-N,N-diallyl-(dodecyloxycarbonylmethyl)-ammonium bromide in water. Vysokomol. Soedin. [in Russian] Ser. B 24(5), 370-371
2. Batrakova E.V., Orlov Yu.N., Egorov V.V., Zubov V.P., Titkova L.V., Shapiro Yu.E., and Kabanov V.A. (1985) Colloid-chemical properties of cationic surfactant vinyl monomers in water. Kolloidn. Zh. [in Russian] 47(1), 130-134
3. Batrakova E.V., Orlov Yu.N., Egorov V.V., Zubov V.P., and Kabanov V.A. (1985) Effect of structurization on the kinetics of radical polymerization of cationic surface-active vinyl monomers in aqueous dispersions. Vysokomol. Soedin. [in Russian]  Ser. B 27(2), 87-93.
4. Egorov V.V., Ksenofontova O.B., Batrakova E.V., and Zubov V.P.  (1988) Influence of counterion nature on colloidal and chemical properties of surfactant monomers.  Kolloidn. Zh. [in Russian] 50(4), 821-825.
5. Egorov V.V., Batrakova E.V., Ksenofontova O.B., and Zubov V.P. (1988) Radical polymerization in aqueous dispersions of ionic surface-active monomers with different counterions. Vysokomol. Soedin. [in Russian]    Ser. A 30(9), 1854-1858.
6. Egorov V.V., Batrakova E.V., and Zubov V.P. (1988) Effect of initiator nature on the kinetics of radical polymerization of N,N-dimethyl-N-(acetodecyl) [(methacryloyloxy)ethyl] ammonium bromide in water. Vysokomol. Soedin. [in Russian]    Ser. A 30(9), 1859-1861.
7. Egorov V.V., Ksenofontova O.B., Batrakova E.V., and Permin A.M. (1989) Effect of ethanol on the structure formation and kinetics of radical polymerization of cationic surface-active monomers in water. Vestn. Mosk. Univ. [in Russian] Ser. 2: Khim. 30(5), 517-522.
8. Egorov V.V., Batrakova E.V., and Zubov V.P.  (1990) Radical polymerization in spherical micelles of unsaturated alkylammonium halides in water. Vysokomol. Soedin. [in Russian]  Ser. A 32(5), 927-932.
9. Egorov V.V, and Batrakova E.V. (1990) Radical polymerization kinetics of unsaturated alkylammonium halides in ethanol. Vestn. Mosk. Univ. [in Russian] Ser. 2: Khim. 31(2), 199-202
10. Egorov V.V., Ksenofontova O.B., and Batrakova E.V.   (1991) Specific features of the colloid-chemical behavior of surfactant monomers based on dimethylaminoethyl methacrylate in water in the presence of water-soluble polymers. Kolloidn. Zh. [in Russian] 53(2), 351-356.
11. Kabanov A.V., Chekhonin V.P., Alakhov V.Yu., Batrakova E.V., Lebedev A.S., Melik-Nubarov N.S., Arzhakov S.A., Levashov A.V., Morozov G.V., Severin E.S., and Kabanov V.A. (1989) The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles. Micelles as microcontainers for drug targeting. FEBS Lett 258, 343-345. PMID: 2599097
12. Alakhov V.Yu., Kabanov A.V., Batrakova E.V., Koromyslova I.A., Levashov A.V., and Severin E.S. (1990) Increasing cytostatic effects of ricin A chain and Staphylococcus aureus enterotoxin A through in vitro hydrophobization with fatty acid residues. Biotech Appl Biochem 12, 94-98. PMID: 2310510
13. Kabanov A.V., Batrakova E.V., Melik-Nubarov N.S., Fedoseev N.A., Dorodnich T.Yu., Alakhov V.Yu., Chekhonin V.P., Nazarova I.R., and Kabanov V.A. (1992) A new class of drug carriers: micelles of poly(oxyethylene)-poly(oxypropylene) block copolymers as microcontainers for drug targeting from blood in brain. J Contr Release 22, 141-158.
14. Slepnev V.I., Kuznetsova L.E., Gubin A.N., Batrakova E.V., Alakhov V.Yu., and Kabanov A.V. (1992) Micelles of poly(oxyethylene)-poly(oxypropylene) block copolymer (pluronic) as a tool for low-molecular compound delivery into a cell. Phosphorylation of intracellular proteins with micelle incorporated [32P]ATP. Biochem Internat 26, 587-595. PMID: 1610369
15. Kabanov A.V., Slepnev V.I., Kuznetsova L.E., Batrakova E.V., Alakhov V.Yu., Melik-Nubarov N.S., Sveshnikov P.G., and Kabanov V.A. (1992) Pluronic micelles as a tool for low-molecular compound vector delivery into a cell: effect of Staphylococcus aureus enterotoxin B on cell loading with micelle incorporated fluorescent dye. Biochem Internat 26, 1035-1042. PMID: 1632800
16. Kabanov A.V., Nazarova I.R., Astafieva I.V., Batrakova E.V., Alakhov V.Yu., Yaroslavov A.A. and Kabanov V.A. (1995) Micelle formation and solubilization of fluorescent probes in poly(oxyethylene-b-oxypropylene-b-oxyethylene) solutions. Macromolecules 28, 2303-2314.
17. Kabanov, A.V., Nazarova, I.R., Astafieva, I.V., Batrakova, E.V., Alakhov, V.Yu., Yaroslavov, A.A., and Kabanov, V.A. (1996) Micelle formation and solubilization of fluorescent probes in poly-(oxyethylene-b-oxypropylene-b-oxyethylene). Macromolecules, 29(27), 8999.
18. Alakhov V.Yu., Moskaleva E.Yu., Batrakova E.V., and Kabanov A.V. (1996) Hypersensitization of multidrug resistant human ovarian carcinoma cells by Pluronic P85 block copolymer. Bioconjugate Chemistry 7, 209-216. PMID: 8983343
19. Batrakova E.V., Dorodnych T.Yu., Klinskii E.Yu., Kliushnenkova E.N., Shemchukova O.B., Arjakov S.A., Alakhov V.Yu., and Kabanov A.V. (1996) Anthracycline antibiotics non-covalently incorporated into micelles of Pluronic block copolymers: activity against drug sensitive and resistant tumors, Br J Cancer 74, 1545-1552. PMID: 8932333
20. Miller D.W., Batrakova E.V., Waltner T.O., Alakhov V.Yu., and Kabanov A.V. (1997) Interactions of Pluronic block copolymers with brain microvessel endothelial cells: evidence for multiple absorption pathways. Bioconjugate Chemistry 8, 649-657. PMID: 9327127
21. Batrakova E.V., Han H.-Y., Alakhov V.Y., Miller D.W. and Kabanov A.V. (1998) Effects of Pluronic block copolymers on drug absorption in Caco-2 cell monolayers. Pharm Res 15, 850-855. PMID: 9647349
22. Batrakova E.V., Han H.-Y., Miller D.W., and Kabanov A.V. (1998) Effects of Pluronic P85 unimers and micelles on drug permeability in polarized BBMEC and Caco-2 cells. Pharm Res 15, 1525-1532. PMID: 9794493
23. Melik-Nubarov N.S., Dorodnykh T.Y., Batrakova E.V., Kozlov M.Y., Suzdaltseva Y.G., Kabanov A.V., Alakhov V.Yu., Arzhakov S.A. (1999) Synthesis and biological activity of the functional block-copolymers based on Pluronic P85-doxorubicin conjugates. Vysokomol Soed (in Russian) 41, 768-775.
24. Miller D.W., Batrakova E.V., and Kabanov A.V. (1999) Inhibition of multidrug resistance-associated protein (MRP) functional activity with Pluronic block copolymers. Pharm Res 16, 396-401. PMID: 10213370
25. Batrakova E.V., Li S., Miller D.W. and Kabanov A.V. (1999) Pluronic P85 increases permeability of broad spectrum of drugs in polarized BBMEC and Caco-2 cell monolayers. Pharm Res 16, 1368-1374. PMID: 10496651
26. Batrakova E., Lee S., Li S., Venne A., Alakhov V. and Kabanov A. (1999) Fundamental relationships between the composition of Pluronic block copolymers and their hypersensitization effect in MDR cancer cells. Pharm Res 16, 1375-1381. PMID: 10496652
27. Vinogradov S.V., Batrakova E.V., Li S., and Kabanov A.V. (1999. Bioconjugate Chem. 10, 851-860. PMID: 10502353
28. Alakhov V., Klinsky E., Li S., Pietrzynski G., Venne A., Batrakova E., Bronich T., Kabanov A. (1999) Block copolymer-based formulation of doxorubicin. From cell screen to clinical trials. Colloids and Surfaces B: Biointerfaces 16, 113-134.
29. Vinogradov S., Batrakova E., Kabanov A. (1999) Poly(ethylene glycol)-polyethyleneimine NanoGelÔ particles: novel drug delivery systems for antisense oligonucleotides. Colloids and Surfaces B: Biointerfaces 16, 291-304.
30. Kozlov M.Yu., Melik-Nubarov N.S., Batrakova E.V., and Kabanov A.V. (2000) Relationship between Pluronic block copolymer structure, critical micellization concentration and partitioning coefficients of low molecular mass solutes, Macromolecules 33, 3305-3313.
31. Lemieux P., Vinogradov S.V., Gebhart, C.L., Guérin N., Paradis G., Nguyen H.-K., Ochietti B., Suzdaltseva Y.G., Batrakova E.V., Bronich T.K., St-Pierre Y., Alakhov V.Yu., and Kabanov A.V. (2000) Block and graft copolymers and NanogelÔcopolymer networks for DNA delivery into cell. J Drug Targeting, 8(2), 91-105.
32. Batrakova E.V., Miller D.W., Li S., Alakhov V.Yu., Kabanov A.V., and Elmquist W.F. (2001) Pluronic P85 enhances the delivery of digoxin to the brain: in vivo and in vitro studies. JPET 296, 556-562. PMID: 11160643
33. Batrakova E.V., Li S., Vinogradov S.V., Alakhov V.Yu., Miller D.W., and Kabanov A.V. (2001) Mechanism of Pluronic effect on P-glycoprotein efflux system in blood brain barrier: contribution of energy depletion and membrane fluidization. JPET, 299, 483-493. PMID: 11602658
34. Batrakova E.V., Li S., Elmquist W.F., Miller D.W., Alakhov V.Yu., and Kabanov A.V. (2001) Mechanism of sensitization of MDR cancer cells by Pluronic block copolymers: Selective energy depletion. British J. Cancer, 85, 1987-1997. PMID: 11747344
35. Kabanov A.V., Batrakova E.V., and Alakhov V.Yu. (2002) Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery. J. Contrl. Rel., 82, 189-212. PMID: 12175737
36. Kabanov A.V., Batrakova E.V., and Alakhov V.Yu. (2002) Pluronic block copolymers for overcoming drug resistance in cancer. Adv. Drug Deliv. Rev., 54, 759-779. PMID: 12204601
37. Batrakova E.V., Li S., Alakhov V.Yu., Miller D.W., and Kabanov A.V. (2003) Optimal structure requirements for Pluronic block copolymers in modifying drug efflux transporters activity in BBMEC monolayers. JPET, 304, 845-854. PMID: 12538842
38. Kabanov A.V., Batrakova E.V., and Miller D.W. (2003) Pluronic block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier. Adv. Drug Deliv. Rev., 55,151-164. PMID: 12535579
39. Kabanov A.V., Batrakova E.V., and Alakhov V.Yu. (2003) An essential relationship between ATP depletion and chemosensitizing activity of Pluronic block copolymers. J. Contr. Release, 91, 75-83. PMID: 12932639
40. Batrakova E.V., Li S., Elmquist W.F., Miller D.W., Alakhov V.Yu., and Kabanov A.V. (2003) Sensitization of cells overexpressing multidrug resistant protein by Pluronic P85. Pharm. Res., 20, 1581-1590. PMID: 14620511
41. Vinogradov S.V., Batrakova E.V., Kabanov A.V. (2004) Nanogels for oligonucleotide delivery to the brain. Bioconjugate Chem. 15, 50-60. PMID: 14733583
42. Kabanov A.V., Batrakova E.V. (2004) Newtechnologies for drug delivery across the blood brain barrier. Current Pharm. Design, 10, 1355-1363. PMID: 15134486
43. Batrakova E.V.,Zhang Y., Li S., Li Y., Vinogradov S.V., Persidsky Y., Alakhov V.Yu., Miller D.W., and Kabanov A.V.(2004) Effects of Pluronic P85 on GLUT1 and MCT1 transporters in the blood brain barrier. Pharm. Res.,21, 1993-2000.
44. Batrakova E.V., Li S., Li Y., Alakhov V.Yu., and Kabanov A.V. (2004) Effect of Pluronic P85 on ATPase activity of drug efflux transporters., Pharm. Res., 21, 2226-2233. PMID: 15648254
45. Kabanov A.V., Batrakova E.V., Sriadibhatla S., Yang Z, Kelly D.L., and Alakov V.Yu. (2004) Polymer genomics: shifting the drug delivery paradigm. Polym. Prepr. 45, 442-443.
46. Batrakova E.V., Li S., Li Y., Alakhov V.Yu.,Elmquist W.F., and Kabanov A.V. (2004) Distribution kinetics of Pluronic P85, a micelle-forming block copolymer. J. Contr. Release, 100, 389-397. PMID: 15567504
47. Vinogradov S.V., Batrakova E.V., Li S., Kabanov A.V. (2004) Mixed polymer micelles of amphiphilic and cationic copolymers for delivery of antisense oligonucleotides. J. Drug Target.12, 517-526. PMID: 15621677
48. Kabanov A.V., Batrakova E.V., Sriadibhatla S., Yang Z, Kelly D.L., and Alakov V.Yu. (2005) Polymer genomics: shifting the gene and drug delivery paradigms. J. Contr. Release, 101, 259-271. PMID: 15588910
49. Minko T., Batrakova E.V., Li S., Li Y., Pakunlu R.I., Alakhov V.Yu., and Kabanov A.V. (2005) Pluronic block copolymers alter apoptotic signal transduction of doxorubicin in drug-resistant cancer cells. J.Contr. Release,105, 269-278. PMID: 15939500
50. Vinogradov S.V., Zeman A.D., Batrakova E.V., and Kabanov A.V. (2005) Polyplex Nanogel formulations for drug delivery of cytotoxic nucleoside analogs, J. Contr. Release,107, 143-157. PMID: 16039001
51. Batrakova E.V.,Vinogradov S.V., Robinson S.M., Niehoff M.L., Banks W.A., and Kabanov A.V. (2005) Polypeptide point modification with fatty acids and Pluronic block copolymers for enhanced brain delivery. Bioconjugate Chem. 16, 793-802. PMID: 16029020
52. Batrakova E.V., Kelly D.L., Li S., Yili Li, Yang Z., Xiao L., Alakhova D.Y., Sherman S., Alakhov V.Yu., and Kabanov A.V. (2006) Alteration of genomic responses to doxorubicin and prevention of MDR in breast cancer cells by a polymer excipient Pluronic P85. Mol. Pharm. 3,113-123. PMID: 16579640
53. Kabanov A.V., Batrakova E.V., Sherman S., Alakhov V.Y. (2006) Polymer genomics, Adv. Polym. Sci. 193, 1-26.
54. Batrakova E.V., Li S., Li Y., Yang Z., Kelly D.L., Alakhov V.Y., and Kabanov A.V. (2006) Amphiphilic block copolymers alter genetic responses to a drug. Polym. Prepr.
55. Spitzenberger T., Heilman D., Diekmann C., Batrakova E, Kabanov A, Gendelman H., Elmquist W., Persidsky Y. (2007) Novel delivery system enhances efficacy of antiretroviral therapy in animal model for HIV-1 encephalitis (HIVE). JBCFM, 27, 1033-42.PMID: 17063148
56. Batrakova E.V., Kabanov A.V. (2007) Polymers for CNS drug delivery. Pharm. Tech. Europe. 19, 23-31.
57. BatrakovaE.V.,Li S., Reynolds A., Thomas M., Bronich T.K., Kabanov A.V.,andGendelman H.E.(2007)A macrophage-nanozyme delivery system for Parkinson’s Disease, Bioconjugate Chem. 18, 1498-1506. PMID: 17760417
58. Yi X., Batrakova E., Banks W., Vinogradov S., Kabanov A. (2008) Protein Conjugation with Amphiphilic Block Copolymers for Enhanced Cellular Delivery, Bioconjugate Chem. 19,1071-1077. PMID: 18447367
59. Batrakova E.V., Kabanov A.V. (2008)Pluronic Block Copolymers: Evolution of Drug Delivery Concept from Inert Nanocarriers to Biological Response Modifiers, J. Controlled Release. Sep 10;130(2):98-106. PMID: 18534704Senior/Corresponding author. Top Cited Article 2008-2010 in Journal of Controlled Release.
60. Sharma A.K., Zhang L., Li S., Kelly D.L., Alakhov V.Yu., Batrakova E.V.,and Kabanov A.V. (2008) Prevention of MDR development in leukemia cells by micelle-forming polymeric surfactant, J. Controlled Release. Jul 30.131: 220-227. PMID: 18722489
61. Sahay G., Batrakova E.V.,and Kabanov A.V. (2008) Different internalization pathways of polymeric micelles and unimers and their effects on vesicular transport, Bioconjugate Chemistry, Oct;19(10):2023-2029.PMID: 18729494.
62. Zhang X., Batrakova E.V., Li S., Yang Z., Li Y., Zhang L., and Kabanov A.V. (2008) Effect of Pluronic P85 on Amino Acid Transporters in the Blood Brain Barrier, Journal of Neuroimmune Pharmacology, Mar;4(1):35-46. PMID: 18677571.
63. Alakhova DYu., Rapoport N.Y., Batrakova E.V., Timoshin A.A., Li S., Alakhov V.Yu., and Kabanov A.V. (2010) Differential Metabolic Responses to Pluronic in MDR and non-MDR Cells: A Novel Pathway for Chemosensitization of Drug Resistant Cancers, J Control Release. Feb 25;142(1):89-100. Epub 2009 Oct 6. PMID: 19815037, NIHMSID # 156599.
64. Batrakova E.V., Li S., Brynskikh A.M., Sharma A.K., Li Y., Boska M., Mosley R.L., Alakhov V.Yu., Gendelman H.E., and Kabanov A.V. (2010) Effects of Pluronic and Doxorubicin on Drug Uptake, Cellular Metabolism, Apoptosis and Tumor Inhibition in Animal Models of MDR CancersJ Control Release. Jan 11. [Epub ahead of print], PMID: 20074598, NIHMSID # 181167.
65. Price T.O., Farr S.A., Yi X., Vinogradov S.V., Batrakova E.V., Banks W.A., Kabanov A.V. (2010) Transport Across the Blood-Brain Barrier of Pluronic Leptin. J Pharmacol Exp Ther. Apr; 333(1):253-63. Jan 6. [Epub ahead of print], PMID: 20053933.
66. Brynskikh A.M., Li S., Zhao Y., Mosley R.L., Boska M.B., Klyachko N.L., Kabanov A.V., Gendelman H.E., and Batrakova E.V. (2010) A Macrophage-based Delivery System of Antioxidant Enzymes for Parkinson’s Disease: Therapeutic Effect in vivo.  Nanomedicine. Apr; 5(3):379-96, PMID: 20394532, NIHMSID #201534.Senior/Corresponding author.
67. Luxenhofer R., Schulz A., Li S., Bronich T.K., Batrakova E.V., Jordan R., Kabanov A.V. (2010) Doubly-Amphiphilic Polymers as High-Capacity Delivery Systems for Hydrophobic Drugs. Biomaterials. Jun; 31(18):4972-9. Mar 26. [Epub ahead of print], PMID: 20346493.
68. Rosenbaugh E., Roat J., Gao L., Yang R.-F., Manickam D.S., Yin J.-X., Schultz H.D., Bronich T.K., Batrakova E.V., Kabanov A.V., Zucker I.H., Zimmerman M.C. (2010) The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper/zinc superoxide dismutase. Biomaterials. Apr 6. [Epub ahead of print], PMID: 20378166.
69. Zhao Y., Haney M.,Klyachko N.L.,Manickam D.S., Li S., BoothS.L., ZimmermanM.C.,MosleyR.L., Kabanov A.V., Gendelman H.E., BatrakovaE.V. (2011) Polyelectrolyte complex optimization for macrophage delivery of redox enzyme nanoparticles. Nanomedicine, (Lond). Jan;6(1):25-42, PMID: 21182416; NIHMSID #262189.Senior/Corresponding author.
70. Batrakova E.V., Gendelman H.E., and Kabanov A.V. (2011) Cell-Mediated Drug Delivery. Expert Opinion on Drug Delivery, 8(4): 1-19;Apr;8(4):415-33. [Epub ahead of print] PMID: 21348773; NIHMSID #269688.Senior/Corresponding author.
71. Haney M.J., Zhao Y., Li S.,Higginbotham S.M., BoothS.L., Han H-Y., Vetro J.A.,  MosleyR.L., Kabanov A.V., Gendelman H.E., BatrakovaE.V. (2011)Cell-mediated transfer of catalase nanoparticles from macrophages to brain endothelial, glial and neuronal cells, Nanomedicine (Lond). Mar 31. [Epub ahead of print]. PMID: 21449849. Senior/Corresponding author.
72. Klyachko N.L., Manickam D.S., Brynskikh A.M., S.V. Uglanova,Li S., Higginbotham S.M., Bronich T.K.,Batrakova E.V., and Kabanov A.V. (2011) Cross-Linked Antioxidant Nanozymes for Improved Delivery to CNS, Nanomedicine. Jul 29. [Epub ahead of print]PMID: 21703990
73. Banks W.A., Gertler A., Solomon G., Niv-Spector L., Yacobovitz M., Yi X., Batrakova E.V., Vinogradov S.V., Kabanov A.V. (2011) Principles of Strategic Drug Delivery to the Brain (SDDB): Development of Orexigenic and Anorectic Analogs of Leptin, Physiol Behav. Jun 6. [Epub ahead of print] PMID: 21669216.
74. Batrakova E.V. (2011) Overcoming multidrug resistance using silica nanoparticles PEG-b-PLA polymeric micelles loaded with doxorubicin.Nanomedicine (Lond), Nov;6(9):1492-3. PMID: 22187740. Senior/Corresponding author.
75. Batrakova E.V. (2011) Reversal of multidrug resistance by PEG-b-PLA polymeric micelles loaded with paclitaxel. Nanomedicine (Lond), Nov; 6 (9):1493-4. 22187741. Senior/Corresponding author.
76. McMillan J., Batrakova E., Gendelman H.E. (2011) Cell delivery of therapeutic nanoparticles. Prog Mol Biol Transl Sci. 104:563-601. [Epub ahead of print] PMID: 22093229.
77. Batrakova E.V. (2011) Sensitizing of gemcitabine-resistant human leukemia cells by stearoyl gemcitabine nanoparticles. Nanomedicine (Lond), Nov; 6 (9):1491-2. 22077460. Senior/Corresponding author.
78. Zhao Y., Haney M.J., Mahajan V., Reiner B.C., Dunaevsky A., Mosley R.L., Kabanov A.V., Gendelman H.E., Batrakova E.V. (2011) Active Targeted Macrophage-mediated Delivery of catalase to Affected Brain Regions in Models of Parkinson’s Disease. J Nanomed Nanotechnol. 2011 Sep 10; S4. pii: 003. PMID: 22288024. NIHMSID # 333947, Senior/Corresponding author.
79. Haney M.J., Suresh P., Zhao Y., Kanmogne G.D., Kadiu I., Sokolsky-Papkov M., Klyachko N.L., Mosley R.L., Kabanov A.V., Gendelman H.E., Batrakova E.V. (2012) Blood-Borne Macrophage-Neural Cell Hitchhike Endosome Networks for Cell-Based Nanozyme Brain Delivery. Nanomedicine (Lond),Nanomedicine (Lond)7:815-33. PMID: 22236307. Senior/Corresponding author.
80. Manickam, D.S., Brynskikh, A.M. Kopanic, J.L., Sorgen, P.L.,  Klyachko, N.L., Bronich, T.K.,  Batrakova, E.V., Kabanov, A.V. (2012) Well-defined Cross-Linked Antioxidant Nanozymes for Treatment of Ischemic Brain Injury,  J. Controlled Release, Sep 28;162(3):636-45. PMID: 22902590 [PubMed - indexed for MEDLINE].
81. Rosenbaugh, E.G., Manickam D.S., Batrakova E.V., Kabanov A.V., Zimmerman M.C. (2012) Neuronal uptake and subcellular localization of functional nanoformulated copper/zinc superoxide dismutase (SOD nano), FASEB JOURNAL, Volume: 26, April.
82. Haney M.J., Zhao Y., Harrison E.B., Mahajan V., Ahmed S., He Z., Suresh P., Hingtgen S.D., Klyachko N.L., Mosley R.L., Gendelman H.E., Kabanov A.V., Batrakova E.V. (2013) Specific Transfection of Inflamed Brain by Macrophages: A New Therapeutic Strategy for Neurodegenerative Diseases, PLoS ONE Apr 19;8(4):e61852. doi:10.1371/ journal.pone.0061852. PMID: 23620794 [PubMed - in process]; Senior/Corresponding author. The article summarizing this work was published in MIT Technology Review magazine.
83. Batrakova E.V., and Kabanov A.V. (2013) Cell-Mediated Drug Delivery to the brain. J. Drug Del. Sci. Tech., 23 (5) 419-433. Senior/Corresponding author.
84. Klyachko N.L., Haney M.H., Zhao Y., Manickam D.S., Mahajan V., Suresh P., Shawn D. Hingtgen Mosley R.L., Gendelman H.E., Kabanov A.V., Batrakova E.V. (2013) Macrophages Offer a Paradigm Switch for CNS NanozymeDelivery, Nanomedicine (Lond). 2013 Nov 18. [Epub ahead of print]; PMID: 24237263;NIHMS542061, Senior/Corresponding author.
85. Zhao Y., Haney M.J., Gupta R., Bohnsack J.R., He Z., Kabanov A.V., Batrakova E.V. (2014) GDNF-transfected Macrophages Produce Potent Neuroprotective Effects in Parkinson’s Disease Mouse Model, PLoS One. Sep 17;9(9):PMID: 25229627. Senior/Corresponding author.
86. Haney M.H., Klyachko N.L., Zhao Y., Gupta R., He Z., Patel T., Piroyan A., Sokolsky M., Kabanov A.V., Batrakova E.V. (2015) Exosomes as Drug Delivery Vehicles for Parkinson’s Disease Therapy, J. Controlled Release, 2015 Mar 31; 207:18-30. doi: 10.1016/j.jconrel.2015.03.033. [Epub ahead of print] PMID: 25836593; Senior/Corresponding author.
87. Roy U., Hong Ding H., Kanthikeel S.P., Raymond A., Atluri V.,Yndart A., Kaftanovskaya E.M., Batrakova E.V., Nair M. (2015) Preparation, Characterization and Efficacy of Anti-HIV Nanodrug Targeting to Microfold cell (M cell) of the Gut-associated lymphoid Tissue (GALT),International Journal of Nanomedicine, accepted.
88. Batrakova E.V. and Kim M.S. (2015) Using naturally-equipped nanocarriers, exosomes, for drug delivery, J. Control Release, pii: S0168-3659(15)30042-0. doi: 10.1016/j.jconrel.2015.07.030. [Epub ahead of print]. PMID:26241750;NIHMS #713725. Senior/Corresponding author.
89. Roy U., Barber P., Tse-Dinh Y.C., Batrakova E.V., Mondal D., and Nair M. (2015) Role of MRP transporters in regulating antimicrobial drug inefficacy and oxidative stress-induced pathogenesis during HIV-1 and TB infections, Frontiers in Microbiology, Front Microbiol. 2015 Sep 17;6:948. doi: 10.3389/fmicb.2015.00948. eCollection 2015: PMID:26441882, [PubMed] PMCID: PMC4585023.
90. Kim M.S., Haney M.J., Zhao Y., Gupta R., Mahajan V., Inskoe E., Piroyan A., Sokolsky M., Okolie O., Hingtgen S.D., Kabanov A.V., and Batrakova E.V. (2015) Development of Exosome-encapsulated Paclitaxel to Overcome MDR in Cancer cells, J Control Release, accepted. Senior/Corresponding author.
91. Klyachko N.L., Haney M.H., Zhao Y., Polak R., Cohen R.E., Rubner M.F. and Batrakova E.V. (2015) Monocyte-mediated delivery of polymeric backpacks to inflamed brain tissues, Nanomedicine: Nanotechnology, Biology and Medicine, in preparation. Senior/Corresponding author.
92. Batrakova E.V. and Kabanov A.V. (2015) Cells as carriers to deliver therapy to the brain, Frontiers, in preparation. Senior/Corresponding author.
93. Kim M.S., Haney M.J., Zhao Y., Kabanov A.V., and Batrakova E.V. (2015) Intracellular trafficking of exosome-based formulations of Paclitaxel in MDR cancer cells. Molecular Pharmaceutics, in preparation. Senior/Corresponding author.