Education

Biography

Dr. Maria Longeri is Assistant Professor of Genetics and Genomics of domestic animals at University of Milan (Italy) – Dept. Veterinary Medicine. After a degree in Veterinary Medicine (University of Milan) and a Master in Zooprophylaxis (IZSLER Brescia) she took a PhD (University of Milan – ILRAD Nairobi, Kenya) on the immunogenetics of the bovine tuberculosis. Moving towards the molecular genetics, she participated to the first public construction of a domestic animal genetic map (EU Bovine Gene Mapping project) and was involved in several studies on the in genetic basis of disease resistance, biodiversity and the first genome wide association studies on single gene traits. She holds two patents. In the last ten years she moved her main interest from cattle to pets (genetic variability and inherited diseases). She is the scientific advisor for genetics of the Italian Veterinary Observatory on Cardiopathies, a national network project started in 2008 and aimed to collect clinical data and biologic samples for the monitoring, the genetic counseling and the studies on the natural history of inherited/familial disorders both cardiac and genitourinary of pets.

Research Interest

Familial Amyloidosis. She is leading an international effort to determine the molecular basis of the feline Amyloidosis via genomic and proteomic approaches.
Genomic predisposition to Cardiopathies and genitor-urinary disorders in pets.
Disease genomic predisposition and genomic variability in felids and farm animals.

Scientific Activities

Professional activities

Offices held

Publications

1. Cozzi MC, Valiati P, Cherchi R, Gorla E, Prinsen RT, Longeri M, Bagnato A, Strillacci MG. Mitochondrial DNA genetic diversity in six Italian donkey breeds (Equus asinus). Mitochondrial DNA A DNA Mapp Seq Anal. 2017 Feb 28:1-10. doi:10.1080/24701394.2017.1292505
2. Lyons LA, Grahn RA, Genova F, Beccaglia M, Hopwood JJ, Longeri M. Mucopolysaccharidosis VI in cats - clarification regarding genetic testing. BMC Vet Res. 2016 Jul 2;12(1):136.1-136.6. doi: 10.1186/s12917-016-0764-y. PubMed PMID: 27370326; PubMed Central PMCID: PMC4930586
3. Gandolfi B, Grahn RA, Creighton EK, Williams DC, Dickinson PJ, Sturges BK, Guo LT, Shelton GD, Leegwater PA, Longeri M, Malik R, Lyons LA. COLQ variant associated with Devon Rex and Sphynx feline hereditary myopathy. Anim Genet. 2015 Dec;46(6):711-5. doi: 10.1111/age.12350. Epub 2015 Sep 16. PubMed PMID: 26374066;
4. Paltrinieri S, Sironi G, Giori L, Faverzani S, Longeri M. Changes in serum and urine SAA concentrations and qualitative and quantitative proteinuria in Abyssinian cats with familial amyloidosis: a five-year longitudinal study (2009-2014). J Vet Intern Med. 2015 Mar-Apr;29(2):505-12. doi: 10.1111/jvim.12561. Epub 2015 Mar 16. PubMed PMID: 25776129; PubMed Central PMCID: PMC4895502.
5. Alhaddad H, Khan R, Grahn RA, Gandolfi B, Mullikin JC, Cole SA, Gruffydd-Jones TJ, Häggström J, Lohi H, Longeri M, Lyons LA. Extent of linkage disequilibrium in the domestic cat, Felis silvestris catus, and its breeds. PLoS One. 2013;8(1):e53537. doi: 10.1371/journal.pone.0053537. Epub 2013 Jan 7. PubMed PMID: 23308248; PubMed Central PMCID: PMC3538540
6. Tremolada G, Longeri M, Polli M, Parma P, Acocella F. Persistent right aortic arch and associated axial skeletal malformations in cats. J Feline Med Surg. 2013 Feb;15(2):68-73. doi: 10.1177/1098612X12459736. Epub 2012 Sep 18. PubMed PMID: 22989559.
7. Edwards CJ, Ginja C, Kantanen J, Pérez-Pardal L, Tresset A, Stock F; Collaborators (54) Baumung R, Mommens G, Holm Le, Withen Kb, Pedersen Bv, Gravlund P, Moazami-Goudarzi K, Gautier M, Laloë D, Oulmouden A, Levéziel H, Taberlet P, Simianer H, Täubert H, Erhardt G, Medugorac I, Eythorsdottir E, Marsan Pa, Negrini R, Lasagna E, Landi V, Panella F, Sarti Fm, Longeri M, Ceriotti G, Zanotti M, Marletta D, Criscione A, Valentini A, Savarese Mc, Pilla F, Grislis Z, Van Boxtel Dc, Cuppen E, Van Haeringen W, Van De Goor L, Felius M, Olsaker I, Ivanova Z, Popov R, Ammosov I, Kiselyova T, Ćinkulov M, Stojanovic S, Dunner S, Rodellar C, Azor Pj, Molina A, Rodero E, Goyache F, Götherström A, Dolf G, Williams Jl, Wiener P. European Cattle Genetic Diversity Consortium., Gama LT, Penedo MC, Bradley DG, Lenstra JA,Nijman IJ. Dual origins of dairy cattle farming--evidence from a comprehensive survey of European Y-chromosomal variation. PLoS One. 2011 Jan 6;6(1):e15922.doi: 10.1371/journal.pone.0015922. PubMed PMID: 21253012; PubMed Central PMCID:
8. Pertica G, Riva J, Strillacci MG, Cozzi MC, Longeri M, Polli M. Prevalence of  inherited junctional epidermolysis bullosa in German shorthaired pointers bred in Italy. Vet Rec. 2010 Nov 6;167(19):751-2. doi: 10.1136/vr.c5178. PubMed PMID: 21257512.
9. Strillacci MG, Marelli SP, Cozzi MC, Colombo E, Polli M, Gualtieri M, Cristalli A, Pignattelli P, Longeri M, Guidobono Cavalchini L. Italian autochthonous chicken breeds conservation: evaluation of biodiversity in Valdarnese Bianca breed (Gallus gallus domesticus) 2009. Avian Biology Research 2 (4), 229–233
10. Longeri M, Parma P, Polli M, Cozzi MC, Valiati P, De Lorenzi L, Pertica G, Gandolfi B, Strillacci MG, Molteni L. Genetic screening of the inherited Ichtyosis causative mutation in Chianina cattle. Italian. 2009 Journal of Animal Science, 8(2): 102-104
11. Zuccaro A, Bordonaro S, Longeri M, COZZI MC, GUASTELLA AM, CRISCIONE A, D’URSO G, MARLETTA D. Mitochondrial DNA control region variation in Sanfratellano Horse and two other Sicilian autochtonous breeds. 2009 Italian Journal of Animal Science, 8(2): 180-182
12. Bonazzi M, Volta A, Gnudi G, Cozzi MC, Strillacci MG, Polli M, Longeri M, Manfredi S, Bertoni G. Comparison between ultrasound and genetic testing for the early diagnosis of polycystic kidney disease in Persian and Exotic Shorthair cats. J Feline Med Surg. 2009 Jun;11(6):430-4. doi: 10.1016/j.jfms.2008.10.003. Epub 2008 Nov 28. PubMed PMID: 19046910.
13. Charlier C, Coppieters W, Rollin F, Desmecht D, Agerholm JS, Cambisano N, Carta E, Dardano S, Dive M, Fasquelle C, Frennet JC, Hanset R, Hubin X, Jorgensen C, Karim L, Kent M, Harvey K, Pearce BR, Simon P, Tama N, Nie H, Vandeputte S, Lien S, Longeri M, Fredholm M, Harvey RJ, Georges M. Highly effective SNP-based association mapping and management of recessive defects in livestock. Nat Genet.  2008 Apr;40(4):449-54. doi: 10.1038/ng.96. Epub 2008 Mar 16. PubMed PMID: 18344998.
14. Lipinski MJ, Froenicke L, Baysac KC, Billings NC, Leutenegger CM, Levy AM, Longeri M, Niini T, Ozpinar H, Slater MR, Pedersen NC, Lyons LA. The ascent of cat breeds: genetic evaluations of breeds and worldwide random-bred populations.  Genomics. 2008 Jan;91(1):12-21. Epub 2007 Dec 3. PubMed PMID: 18060738; PubMed Central PMCID: PMC2267438.
15. Dardano S, Gandolfi B, Parma P, Polli M, Bighignoli B, Strillacci MG, Cozzi MC, Molteni L, Longeri M. Characterization of bovine TGM1 and exclusion as candidate gene for ichthyosis in Chianina. J Hered. 2008 Jan-Feb;99(1):81-3. doi: 10.1093/jhered/esm101. Epub 2007 Dec 28. PubMed PMID: 18165261.
16. Bighignoli B, Niini T, Grahn RA, Pedersen NC, Millon LV, Polli M, Longeri M, Lyons LA. Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domestic cat AB blood group. BMC Genet. 2007 Jun 6;8:27. PubMed PMID: 17553163; PubMed Central PMCID: PMC1913925.
17. Lipinski MJ, Amigues Y, Blasi M, Broad TE, Cherbonnel C, Cho GJ, Corley S, Daftari P, Delattre DR, Dileanis S, Flynn JM, Grattapaglia D, Guthrie A, Harper C, Karttunen PL, Kimura H, Lewis GM, Longeri M, Meriaux JC, Morita M, Morrin-O'donnell RC, Niini T, Pedersen NC, Perrotta G, Polli M, Rittler S, Schubbert R, Strillacci MG, Van Haeringen H, Van Haeringen W, Lyons LA. An international parentage and identification panel for the domestic cat (Felis catus). Anim Genet. 2007 Aug;38(4):371-7. PubMed PMID: 17655554; PubMed Central PMCID: PMC1974777.
18. Longeri M, Polli M, Strillacci MG, Samorè AB, Zanotti M. Short communication:  quantitative trait loci affecting the somatic cell score on chromosomes 4 and 26  in Italian Holstein cattle. J Dairy Sci. 2006 Aug;89(8):3175-7. PubMed PMID: 16840634.
19. Molteni L, Dardano S, Parma P, Polli M, De Giovanni AM, Sironi G, Longeri M. Ichthyosis in Chianina cattle. Vet Rec. 2006 Mar 25;158(12):412-4. PubMed PMID:1 6565341.
20. Iannuzzi L, Di Meo GP, Perucatti A, Rullo R, Incarnato D, Longeri M, Bongioni  G, Molteni L, Galli A, Zanotti M, Eggen A. Comparative FISH-mapping of the survival of motor neuron gene (SMN) in domestic bovids. Cytogenet Genome Res. 2003;102(1-4):39-41. PubMed PMID: 14970676.
21. Longeri M, Perrone T, Bongioni G, Bona M, Zanotti M, Galli A. Survival motor neuron (SMN) polymorphism in relation to congenital arthrogryposis in two Piedmont calves (piemontese). Genet Sel Evol. 2003;35 Suppl 1:S167-75. PubMed PMID: 12927089; PubMed Central PMCID: PMC3231758.
22. Longeri M, Zanotti M, Damiani G. Recombinant DRB sequences produced by mismatch repair of heteroduplexes during cloning in Escherichia coli. Eur J Immunogenet. 2002 Dec;29(6):517-23. PubMed PMID: 12437611.
23. Del Bo L, Polli M, Longeri M, Ceriotti G, Looft C, Barre-Dirie A, Dolf G, Zanotti M, Genetic diversity among some cattle breeds in the Alpine area. Journal of Animal Breeding and Genetics. 2001, 118: 317–325. ISSN 0931-2668 elettr 1439-0388
24. Zanotti M, Del Bo L, Longeri M, Polli M, Ceriotti G, Kemp SJ. Two polymorphic  microsatellite markers in sheep. Anim Genet. 1997 Feb;28(1):68-9. PubMed PMID: 9124720
25. Zanotti M, Poli G, Ponti W, Polli M, Rocchi M, Bolzani E, Longeri M, Russo S, Lewin HA, van Eijk MJ. Association of BoLA class II haplotypes with subclinical progression of bovine leukaemia virus infection in Holstein-Friesian cattle. Anim Genet. 1996 Oct;27(5):337-41. PubMed PMID: 8930075.
26. Kemp SJ, Hishida O, Wambugu J, Rink A, Longeri ML, Ma RZ, Da Y, Lewin HA, Barendse W, Teale AJ. A panel of polymorphic bovine, ovine and caprine microsatellite markers. Anim Genet. 1995 Oct;26(5):299-306. PubMed PMID: 7486246.
27. Longeri M, Polli M, Ponti W, Zanotti M. BoLA class I polymorphism and in vitro immune response to M. bovis antigens. J Anim Breed Genet. 1993 Jan 12;110(1-6):335-45. doi: 10.1111/j.1439-0388.1993.tb00746.x. PubMed PMID: 21395732.
28. Longeri M, Polli M, Ponti W, Zanotti M. BoLA class I polymorphism and in vitro immune response to M. bovis antigens. J Anim Breed Genet. 1993 Jan 12;110(1-6):335-45. doi: 10.1111/j.1439-0388.1993.tb00746.x. PubMed PMID: 21395732.