Publications

Published and accepted research articles in refereed journals:

  1. Murali-Krishna K, Ravi V, Manjunath R. 1994. Cytotoxic T lymphocytes raised against Japanese encephalitis virus: effector cell phenotype, target specificity and in vitro virus clearance. J Gen Virol. 75: 799-807.
  2. Murali-Krishna K, Ravi V, Manjunath R. 1995. Japanese encephalitis virus infection of mouse cell lines: ability to prime mice for generation of virus specific cytotoxic T lymphocytes and differences in CTL recognisable viral determinants. Arch Virol. 140:127-43.
  3. Murali-Krishna K, Ramireddy B, Ravi V, Manjunath R. 1995. Recognition of nonstructural protein peptides by cytotoxic T lymphocytes raised against Japanese encephalitis virus. Microbiol Immunol. 39:1021-24.
  4. Murali-Krishna K, Ravi V, Manjunath R. 1996. Protection of adult but not newborn mice against lethal intracerebral challenge with Japanese encephalitis virus by adoptively transferred virusspecificcytotoxic T lymphocytes: requirement for L3T4+ T cells. J Gen Virol. 77:705-14.
  5. Khar AK, Murali-Krishna K, Varalakshmi. C. 1997. High intratumoral level of cytokines mediates efficient regression of a rat histiocytoma. Clin Exp Immunol. 100:127-31.
  6. Desai A, Murali-Krishna K, Ramireddy B, Ravi V, Manjunath R. 1997. In vivo clearance of Japanese Encephalitis Virus in mice adoptively transferred with virus specific cytotoxic T lymphocytes. J Biosci 22:33-45.
  7. Murali-Krishna K, Altman JD, Suresh M, Sourdive D, Zajac A, Miller J, Slansky J, Ahmed R. 1998.Counting antigen specific CD8 T cells: A re-evaluation of bystander activation during viral infection. Immunity 8:177-187.
  8. Sourdive DJD, Murali-Krishna K, Altman JD, Zajac AJ, Whitmire J, Pannetier C, Kourilsky P, EvavoldB, Sette A, Ahmed R. 1998. Conserved TCR repertoire in primary and memory CD8 T cell responses to an acute viral infection. J Exp Med. 19:71-82.
  9. Galvan M, Murali-Krishna K, Ming LL, Baum L, Ahmed R. 1998. Alterations in cell surface carbohydrates on T cells from virally infected mice can distinguish effector and memory CD8+ T cells from naïve cells. J Immunol. 160:5007-5017.
  10. Zajac AJ, Blattman JN, Murali-Krishna K, Sourdive DJ, Suresh M, Altman J, Ahmed R. 1 998. Viral immune evasion due to persistence of activated T-cells without effector function. J Exp Med 188:2205-13.
  11. Whitmire JK, Asano MS, Murali-Krishna M, Suresh M, Ahmed R. 1998. Long-term CD4+ Th1 and Th2 memory following acute lymphocytic choriomeningitis virus infection. J Virol. 72:8281-8288.
  12. van der Most RG, Murali-Krishna K, Whitton JL, Oseroff C, Alexander J, Southwood S, Sidney J, Chestnut RW, Sette A, Ahmed R. 1998. Identification of Db- an Kb-restricted subdominant cytotoxic T-cell responses in lymphocytic choriomeningitis virus-infected mice. Virology 240:158-167.
  13. Dolin AM, Ballard DJ, Shen H, Murali-Krishna K, Ahmed R, Collier RJ, Starnbach MN. 1999. Cytotoxic T lymphocyte epitopes fused to anthrax toxin induce protective anti-viral immunity. Infect Immun 67:3290-96.
  14. Murali-Krishna K, Lau LL, Sambhara S, Lemonnier F, Altman J, Ahmed R. 1999. Persistence of memory CD8 T cells in MHC class-I deficient mice. Science 286: 1377-1381.
  15. Tan JT, Whitmire JK, Murali-Krishna K, Ahmed R, Altman J, Sette A, Pearson CT, Larsen CP. 2000. 4-1BB co-stimulation is required for long-term protective anti-viral immunity after peptide vaccination. J Immunol. 164: 2320-2325.
  16. Murali-Krishna K, Ahmed R. 2000. Cutting Edge:Naïve T cells masquerading as memory cells. J Immunol. 165: 1733-1737.
  17. Van der Most RG, Murali-Krishna K, Ahmed R, Strauss JH. 2000. Chimeric yellow fever/dengue virus as a candidate dengue vaccine: characterization of the dengue virus specific CD8 T cell response. J Virol. 74: 8094-8101.
  18. Blattman JN, Sourdive DJ, Murali-Krishna K, Ahmed R, Altman J. 2000. Evolution of the T cell repertoire during primary, memory and recall responses to viral infection. J Immunol. 165: 6081-90.
  19. Grayson JM, Murali-Krishna K, Altman JD, Ahmed R. 2000. Gene expression in antigen specific CD8+ T cells during viral infection. J Immunol. 166: 795-799.
  20. King C, Hoenger RR, Cleary MM, Murali-Krishna K, Ahmed R, King E, Sarvetnick N. 2001. Interleukin-4 acts at the locus of the APC to counter-regulate cytotoxic CD8+ T cell response. Nat Med. 7:206-14.
  21. De Boer RJ, Oprea M, Antia R, Murali-Krishna K, Ahmed R, Perelson A. 2001. Recruitment times, proliferation and apoptosis rates during the CD8+ T cell response to LCMV. J Virol. 75:10663-9.
  22. Blattman JN, Antia R, Sourdive D, Kaech S, Murali-Krishna K, Altman J, Ahmed R. 2002. Estimating the precursor frequency ofnaive antigen specific CD8 T cells. J Exp Med. 195:657-64.
  23. Becker TC*, Wherry EJ*, Boone D*, Murali-Krishna K*, Antia R, Ma A, Ahmed R. 2002. IL-15 is required for proliferative renewal of virus specific memory CD8 T cells. J Exp Med. 195: 1541-8. (*Equal contrib.)
  24. Kapasi ZF, Murali-Krishna K, McRae ML, Ahmed R. 2002. Defective generation but normal maintenance of memory T cells in old mice. E J Immunol. 32: 1567-73.
  25. Most RG, Murali-Krishna K, Ahmed R. 2003. Prolonged presence of effector-memory CD8 T cells in the central nervous system after dengue virus encephalitis. Int Immunol. 15: 119-125.
  26. Wherry EJ, Blattman JN, Murali-Krishna K, Most RV, Ahmed R. 2003. Viral persistence alters CD8 T cell immunodominance, tissue distribution, and results in distinct stages of functional impairment J Virol. 77:4911-27.
  27. Pilyugin SS, Ganusov VV, Murali-Krishna K, Ahmed R, Antia R. 2003. The rescaling method for quantifying the turnover of cell populations. J Theor Biol. 225:275-83.
  28. van der Most RG, Murali-Krishna K, Lanier JG, Wherry EJ, Puglielli MT, Blattman JN, Sette A, Ahmed R. 2003. Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation. Virology 315:93-102.
  29. Yankee TM, Yun TJ, Draves KE, Ganesh K, Bevan MJ, Murali-Krishna K, Clark EA. 2004. The Gads (GrpL) adaptor protein regulates T cell homeostatis. J Immunol 173:1711-1720.
  30. Teague RM, Temperso RM, Thomas S, Murali-Krishna K, Nelson BH. 2004. Proliferation and differentiation of CD8+ T cells in the absence of IL-2/15 receptor β-chain expression or STAT5 activation. J Immunol 173:3131-3139.
  31. Ganusov VV, Pilyugin SS, de Boer RJ, Murali-Krishna K, Ahmed R, Antia R. 2005. Quantifying cell turnover using CFSE data. J Immunol 298:183-200.
  32. Kolumam GA, Thomas S, Thompson LJ, Sprent J, Murali-Krishna K. 2005. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med 202:637-50.
  33. Havenar-Daughton C, Kolumam GA, Murali-Krishna K. 2006. Cutting Edge: The direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection. J Immunol 176:3315-9.
  34. Kersh EN, Fitzpatrick DR, Murali-Krishna K, Shires J, Speck SH, Boss JM, Ahmed R. 2006. Rapid demethylmation of the IFN- gene occurs in memory but not naïve CD8 T cells. J Immunol 176:4083 93.
  35. Rouzine I, Murali-Krishna K, Ahmed R. 2005. Modeling immune response to HIV. J. Comp. Appl. Math. 184: 258-274.
  36. Thompson LJ, Kolumam GA, Thomas S, Murali-Krishna K. 2006. Innate inflammatory signals induced by various pathogens differentially dictate the IFN-I dependence of CD8 T cells for clonal expansion and memory formation. J Immunol 177:1746-54.
  37. Nurieva R, Thomas S, Nguyen T, Martin-Orozco N, Murali-Krishna K, Yu XZ, Dong C. 2006. T cell tolerance or function is determined by a combination of costimulatory signals. EMBO J. 25: 2623-33.
  38. Masopust D, Murali-Krishna K, Ahmed R. 2007. Quantitating the magnitude of the LCMV-specific CD8 t cell response: it’s even bigger than we thought. J Virol. 81: 2002-11.
  39. Way SS, Havenar-Daughton C, Kolumam G, Orgun N, Murali-Krishna K. 2007. IL-12 and type-I interferon synergize IFN-g production by CD4 T cells while neither are required for IFN-g production by CD8 T cells after Listeria monocytogenes infection. J Immunol 278:4498-505.
  40. Thomas S. Kolumam G, Murali-Krishna K. 2007. Antigen presentation by non-hematopietic cells amplifies effector CD8 T cell expansion in a pathogen-specific manner. J Immunol 178:5801-11.
  41. Baskin CR, Bielefeldt-Ohmann H, García-Sastre A, Tumpey TN, Van Hoeven N, Carter VS, Thomas MJ, Proll S, Solórzano S, Billharz R, Fornek JL, Thomas S, Chen CH, Clark EA, Murali-Krishna K, Katze MG. 2007. Functional Genomic and Serological Analysis of the Protective Immune Response Resulting from Vaccination of Macaques with an NS1-Truncated Influenza Virus. J. Virol. 81: 11817-27.
  42. 2008. Hughes GC, Thomas S, Murali-Krishna K, Clark EA. 2008. Cutting Edge: Progesterone Regulates IFN- Production by Plasmacytoid Dendritic Cells. J.Immunol. 180:2029-33.
  43. Shaulov A & Murali-Krishna K. 2008. CD8 T cell expansion and memory differentiation are facilitated by simultaneous and sustained exposure to antigenic and inflammatory milieu. J . Immunol. 180: 1131-8.
  44. Dudani R, Murali-Krishna K, Krishnan L, Sad S. 2008.  IFN-gamma induces the erosion of preexisting CD8 T cell memory during infection with a heterologous intracellular bacterium. J Immunol. 2008 181:1700-9.
  45. Miller JD, van der Most RG, Akondy RS, Glidewell JT, Albott S, Masopust D, Murali-Krishna K, Mahar PL, Edupuganti S, Lalor S, Germon S, Del Rio C, Mulligan MJ, Staprans SI, Altman JD, Feinberg MB, Ahmed R. 2008. Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines. Immunity. 2008 28:710-22.
  46. Baskin C, Bielefeldt-Ohman H, Tumpeye TM, Sabourin PJ, Longf JM,  García-Sastre A, Tolnayd AE, Albrechtg R, Pyles JA, Olsonf P, Aicheri LD,  Rosenzweigi ER, Murali-Krishna K, Clark EA, Kotur MA, Fornek JL,  Proll S, Palermo R, Sabourin CL, Katze MG.  2008. Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus. Proc Natl Acad Sci. 106: 3455-60.
  47. Di Paolo NC, Miao EA, Iwakura Y, Murali-Krishna K, Aderem A, Flavell RA,Papayannopoulou T, Shayakhmetov DM. 2009. Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. Immunity. 31:110-21.
  48. Suthar MS, Ma DY, Thomas S, Lund JM, Zhang N, Daffis S, Rudensky AY, Bevan MJ, Clark EA, Kaja MK, Diamond MS, Gale M Jr. 2010. IPS-1 is essential for the control of West Nile virus infection and immunity. PLoS Pathog. 6:e1000757.
  49. Martin DL, Murali-Krishna K, Tarleton RL. 2010. Generation of    Trypanosoma cruzi-Specific    CD8+ T-Cell Immunity is unaffected by the absence of type I interferon signaling. Infection and Immunity. 78: 3154-9.
  50. Choo DK, Murali-Krishna K, Antia R, Ahmed R. 2010. Homeostatic turnover of virus-specific memory CD8 T ells occurs stochastically and is independent of CD4 T cells. J. Immunol. 185: 3436-44
  51. Chiu D, Zhou W, Kitayaporn S, Schwartz DT, Murali-Krishna K, Kavanagh TJ, Baneyx F. Biomineralization and size control of stable calcium phosphate core-protein shell nanoparticles: potential for vaccine applications. Bioconjug Chem. 2012 Mar 21;23(3):610-7.
  52. Zhou W, Moguche A, Chiu D, Murali-Krishna K, Baneyx F. ust-in-time vaccines: Biomineralized calcium phosphate core-immunogen shell nanoparticles induce long-lasting CD8+ T cell responses in mice. Nanomedicine 2013. Nov 22.
  53. Verma AK, Chandele A, Murali-Krishna K, Arulandu A, Ray P. Cloning, expression and purification of Chikungunya virus E2 recombinant protein in E.coli. BMC. Infectious Diseases. 2014, 14(Suppl 3):P66
  54. Kukarni R, Rasheed A, Bhaumik S, Davis C, Ranjan P, Sambhara S, Murali-Krishna K. Activation of RIG-I pathway during influenza vaccination enhances germinal center reactions, T follicular helper cell induction and, provides dose-sparing effect and protective immunity. J.Virol, 2014 (in press)

Selected Peer-reviewed Publications (Selected from 50+ peer-reviewed publications)

  1. Murali-Krishna K, Altman JD, Suresh M, Sourdive D, Zajac A, Miller J, Slansky J, Ahmed R.  1998.  Counting antigen specific CD8 T cells:  A re-evaluation of bystander activation during viral infection.  Immunity8:177-187.Cited more than1000 times
  2. Sourdive DJD, Murali-Krishna K, Altman JD, Zajac AJ, Whitmire J, Pannetier C,  Kourilsky P, Evavold B, Sette A, Ahmed R.  1998.  Conserved TCR repertoire in primary and memory CD8 T cell responses to an acute viral infection.  J  Exp Med. 19:71-82.Cited more than 300 times
  3. Murali-Krishna K, Lau LL, Sambhara S,  Lemonnier F, Altman J, Ahmed R. 1999. Persistence of memory CD8 T cells in MHC class-I deficient mice.Science286: 1377-1381.Cited more than 500 times
  4. Murali-Krishna K, Ahmed R. 2000. Cutting Edge:Naïve T cells masquerading as memory cells. J Immunol. 165: 1733-1737.Cited more than 300 times
  5. Van der Most RG, Murali-Krishna K, Ahmed R, Strauss JH. 2000. Chimeric yellow fever/dengue virus as a candidate dengue vaccine: characterization of the dengue virus specific CD8 T cell response. J Virol.74: 8094-8101.Cited more than 100 times
  6. Becker TC*, Wherry EJ*, Boone D*, Murali-Krishna K*, Antia R, Ma A, Ahmed R. 2002. IL-15 is required for proliferative renewal of virus specific memory CD8 T cells. J Exp Med.195: 1541-8. (* Equal contrib.)Cited more than 300 times
  7. Kolumam GA, Thomas S, Thompson LJ, Sprent J, Murali-Krishna K. 2005.  Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med 202:637-50. PMCID:PMC2212878Cited more than 400 times
  8. Havenar-Daughton C, Kolumam GA, Murali-Krishna K.  2006.  Cutting Edge:  The direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection.  J Immunol 176:3315-9.Cited more than 100 times
  9. Thompson LJ, Kolumam GA, Thomas S, Murali-Krishna K.  2006.  Innate inflammatory signals induced by various pathogens differentially dictate the IFN-I dependence of CD8 T cells for clonal expansion and memory formation.  J Immunol 177:1746-54..Cited more than 100 times
  10. Way SS, Havenar-Daughton C, Kolumam G, Orgun N, Murali-Krishna K. 2007. IL-12 and type-I interferon synergize IFN-g production by CD4 T cells while neither are required for IFN-g production by CD8 T cells after Listeria monocytogenes infection. J Immunol 278:4498-505.PMCID:PMC2626161
  11. Thomas S. Kolumam G, Murali-Krishna K. 2007. Antigen presentation by non-hematopietic cells amplifies effector CD8 T cell expansion in a pathogen-specific manner. J Immunol 178:5801-11.
  12. Shaulov A & Murali-Krishna K. 2008. CD8 T cell expansion and memory differentiation are facilitated by simultaneous and sustained exposure to antigenic and inflammatory milieu.  J .Immunol. 180:1131-8.
  13. Miller JD, van der Most RG, Akondy RS, Glidewell JT, Albott S, Masopust D, Murali-Krishna K, Mahar PL, Edupuganti S, Lalor S, Germon S, Del Rio C, Mulligan  MJ, Staprans SI, Altman JD, Feinberg MB, Ahmed R. 2008. Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines. Immunity. 2008 28:710-22.
  14. Baskin C, Bielefeldt-Ohman H, Tumpeye TM, Sabourin PJ, Longf JM,  García-Sastre A, Tolnayd AE, Albrechtg R, Pyles JA, Olsonf P, Aicheri LD,  Rosenzweigi ER, Murali-Krishna K, Clark EA, Kotur MA, Fornek JL,  Proll S, Palermo R, Sabourin CL, Katze MG. Early and sustained innate immune response defines  pathology and death in nonhuman primates infected  by highly pathogenic influenza virus. ProcNatlAcad Sci.2009  106:3455-60. PMCID:PMC2642661.
  15. Di Paolo NC, Miao EA, Iwakura Y, Murali-Krishna K, Aderem A, FlavellRA,Papayannopoulou T, Shayakhmetov DM. 2009. Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. Immunity. 31:110-21.
  16. Suthar MS, Ma DY, Thomas S, Lund JM, Zhang N, Daffis S, Rudensky AY, Bevan MJ, Clark EA, Kaja MK, Diamond MS, Gale M Jr. 2010. IPS-1 is essential for the control of West Nile virus infection and immunity. PLoSPathog. 6:e1000757.
  17. Martin DL, Murali-Krishna K, Tarleton RL. 2010. Generation of    Trypanosomacruzi-Specific    CD8+ T-Cell Immunity is unaffected by the absence of type I interferon signaling. Infection and Immunity. 78: 315
  18. Choo DK, Murali-Krishna K, Antia R, Ahmed R. 2010. Homeostatic turnover of virus-specific memory CD8 T ells occurs stochastically and is independent of CD4 T cells. J. Immunol. 185: 3436-44
  19. Chiu D, Zhou W, Kitayaporn S, Schwartz DT, Murali-Krishna K, Kavanagh TJ, Baneyx F. Biomineralization and size control of stable calcium phosphate core-protein shell nanoparticles: potential for vaccine applications. Bioconjug Chem. 2012 Mar 21;23(3):610-7.
  20. Yang D, Sun YY, Bhaumik SK, Li Y, Baumann JM, Lin X, Zhang Y, Lin SH, Dunn RS, Liu CY, Shie FS, Lee YH, Wills-Karp M, Chougnet CA, Kallapur SG, Lewkowich IP, Lindquist DM, Murali-Krishna K, Kuan C. 2014.  Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns. J. Neuroscience 34:16467-16481
  21. Kukarni R, Rasheed A, Bhaumik S, Davis C, Ranjan P, Sambhara S, Murali-Krishna K. 2014. Activation of RIG-I pathway during influenza vaccination enhances germinal center reactions, T follicular helper cell induction and, provides dose-sparing effect and protective immunity. J.Virol, 88: 13990-001

Review articles:

  1. Zajac AJ, Murali-Krishna K, Blattman JN,  Ahmed R.  1998.  Therapeutic vaccination against chronic viral infection:  Importance of CD4-CD8 T cell cooperation.  Curr. Opin. Immunol. 10:444-49.
  2. Wherry EJ, Becker TC, Boone D, Murali-Krishna K, Ma A, Ahmed R. 2002. Homeostatic proliferation but not the generation of virus specific memory CD8 T cells is impaired in the absence of IL-15 or IL-15Ralpha. Adv. Exp. Med. Biol. 512: 165-75.

Symposium Proceedings:

  1. Whitmire JK, Murali-Krishna K, Altman J, Ahmed R. 2000. Anti viral CD4 and CD8 T cell memory: differences in size of the response and activation requirements. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 355: 373-379.

Book Chapters:

  1. Murali-Krishna K. Altman JD, Suresh M, Sourdive D, Zajac A, Ahmed R.  1998.  In vivo dynamics of anti-viral CD8 T cell responses.  IN: Mechanisms of Lymphocyte Activation and Immune Regulation VII: Molecular Determinants of Microbial Immunity, Plenum Press, pp 123-142.
  2. Blattman JN, Zajac AJ,  Murali-Krishna K, Sourdive DJD, Suresh M, Altman J. Ahmed R.  1999.  T-cell anergy during chronic viral infection.  IN Factors in the Emergence and Control of Rodent-Borne Viral Diseases (Hantaviral and Arenal Diseases), J.F. Saluzzo and B. Dodet, eds., Elsevier, New York, pp. 243-253.
  3. Wrammert J & Murali-Krishna K. Cellular screens to interrogate the human T and B cell repertoires and design better vaccines. Vaccine design 2014 (in press).

 

Murali-Krishna Kaja, PhD

Associate Professor of Pediatrics

 

  • :404-727-3544

  • DEPARTMENT Emory University
  • COUNTRYUSA